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Article Open Access

Lenvatinib‑based treatment regimens in conversion therapy of unresectable hepatocellular carcinoma: A systematic review and meta‑analysis

  • Authors:
    • Saixin Li
    • Zeyu Zhang
    • Zheng Wang
    • Kenan Wang
    • Minghao Sui
    • Dongbin Liu
    • Kuo Liang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, P.R. China, Department of Hepatobiliary Surgery, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu 223001, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 265
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    Published online on: April 12, 2024
       https://doi.org/10.3892/ol.2024.14398
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Abstract

Hepatocellular carcinoma (HCC) is a malignancy associated with high morbidity and mortality rates. Conversion therapy provides patients with unresectable HCC (uHCC) the opportunity to undergo radical treatment and achieve long‑term survival. Despite accumulating evidence regarding the efficacy of conversion therapy, the optimal treatment approach for such therapy remains uncertain. Lenvatinib (LEN) has shown efficacy and tolerable rates of adverse events (AEs) when applied in combination with immune checkpoint inhibitors (ICIs) or locoregional therapy (LRT) over the past decade. Therefore, the present meta‑analysis was performed to systematically assess the safety and efficacy of LEN‑based treatment regimens in conversion therapies for uHCC. Data on outcomes, including the conversion rate, objective response rate (ORR), disease control rate (DCR) and AE incidence in patients with uHCC, were collected. A systematic literature search was performed using MEDLINE, Embase, Web of Science and Cochrane Library databases, up to the date of September 1, 2023. In total, 16 studies, encompassing a total of 1,650 cases of uHCC, were included in the final meta‑analysis. The pooled conversion rates for LEN alone, LEN + ICI, LEN + LRT and LEN + ICI + LRT were calculated to be 0.04 (95% CI, 0.00‑0.07; I²=77%), 0.23 (95% CI, 0.16‑0.30; I²=66%), 0.14 (95% CI, 0.10‑0.18; I²=0%) and 0.35 (95% CI, 0.23‑0.47; I²=88%), respectively. The pooled ORRs for LEN alone, LEN + ICI, LEN + LRT and LEN + ICI + LRT were found to be 0.45 (95% CI, 0.23‑0.67; I²=96%), 0.49 (95% CI, 0.39‑0.60; I²=78%), 0.43 (95% CI, 0.24‑0.62; I²=88%) and 0.69 (95% CI, 0.56‑0.82; I²=92%), respectively. The pooled DCRs for LEN alone, LEN + ICI, LEN + LRT and LEN + ICI + LRT were observed to be 0.77 (95% CI, 0.73‑0.81; I²=23%), 0.82 (95% CI, 0.69‑0.95; I²=90%), 0.67 (95% CI, 0.39‑0.94; I²=94%) and 0.87 (95% CI, 0.82‑0.93; I²=67%), respectively. The pooled grade ≥3 AEs for LEN alone, LEN + ICI, LEN + LRT and LEN + ICI + LRT were 0.25 (95% CI, 0.14‑0.36; I²=89%), 0.43 (95% CI, 0.34‑0.53; I²=23%), 0.42 (95% CI, 0.19‑0.66; I²=81%) and 0.35 (95% CI, 0.17‑0.54; I²=94%), respectively. These findings suggested that LEN‑based combination strategies may confer efficacy and acceptable tolerability for patients with uHCC. In particular, LEN + ICI, with or without LRT, appears to represent a highly effective conversion regimen, with an acceptable conversion rate and well‑characterized safety profile.
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View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Forner A, Reig M and Bruix J: Hepatocellular carcinoma. Lancet. 391:1301–1314. 2018. View Article : Google Scholar

3 

Vogel A, Cervantes A, Chau I, Daniele B, Llovet JM, Meyer T, Nault JC, Neumann U, Ricke J, Sangro B, et al: Hepatocellular carcinoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 29 (Suppl 4):iv238–iv255. 2018. View Article : Google Scholar

4 

Dimitroulis D, Damaskos C, Valsami S, Davakis S, Garmpis N, Spartalis E, Athanasiou A, Moris D, Sakellariou S, Kykalos S, et al: From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world. World J Gastroenterol. 23:5282–5294. 2017. View Article : Google Scholar

5 

Llovet JM, De Baere T, Kulik L, Haber PK, Greten TF, Meyer T and Lencioni R: Locoregional therapies in the era of molecular and immune treatments for hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol. 18:293–313. 2021. View Article : Google Scholar

6 

Huang A, Yang XR, Chung WY, Dennison AR and Zhou J: Targeted therapy for hepatocellular carcinoma. Signal Transduct Target Ther. 5:1462020. View Article : Google Scholar : PubMed/NCBI

7 

Brown ZJ, Tsilimigras DI, Ruff SM, Mohseni A, Kamel IR, Cloyd JM and Pawlik TM: Management of hepatocellular carcinoma: A review. JAMA Surg. 158:410–420. 2023. View Article : Google Scholar : PubMed/NCBI

8 

Rizzo A, Ricci AD and Brandi G: Systemic adjuvant treatment in hepatocellular carcinoma: Tempted to do something rather than nothing. Future Oncol. 16:2587–2589. 2020. View Article : Google Scholar

9 

Matsuki R, Kogure M, Hasui N, Momose H, Suzuki Y and Sakamoto Y: Development of conversion therapy for advanced hepatocellular carcinoma. Hepatobiliary Surg Nutr. 12:453–456. 2023. View Article : Google Scholar : PubMed/NCBI

10 

Kudo M: Atezolizumab plus bevacizumab followed by curative conversion (ABC conversion) in patients with unresectable, TACE-unsuitable intermediate-stage hepatocellular carcinoma. Liver Cancer. 11:399–406. 2022. View Article : Google Scholar : PubMed/NCBI

11 

Chiang CL, Chiu KWH, Chan KSK, Lee FAS, Li JCB, Wan CWS, Dai WC, Lam TC, Chen W, Wong NSM, et al: Sequential transarterial chemoembolisation and stereotactic body radiotherapy followed by immunotherapy as conversion therapy for patients with locally advanced, unresectable hepatocellular carcinoma (START-FIT): A single-arm, phase 2 trial. Lancet Gastroenterol Hepatol. 8:169–178. 2023. View Article : Google Scholar

12 

Qu WF, Ding ZB, Qu XD, Tang Z, Zhu GQ, Fu XT, Zhang ZH, Zhang X, Huang A, Tang M, et al: Conversion therapy for initially unresectable hepatocellular carcinoma using a combination of toripalimab, lenvatinib plus TACE: Real-world study. BJS Open. 6:zrac1142022. View Article : Google Scholar : PubMed/NCBI

13 

Zhang Z and Zhang E: Conversion therapy for advanced hepatocellular carcinoma with vascular invasion: A comprehensive review. Front Immunol. 14:10735312023. View Article : Google Scholar

14 

Benson AB, D'Angelica MI, Abbott DE, Anaya DA, Anders R, Are C, Bachini M, Borad M, Brown D, Burgoyne A, et al: Hepatobiliary cancers, version 2.2021, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 19:541–565. 2021. View Article : Google Scholar : PubMed/NCBI

15 

European Association for the Study of the Liver. lectronic address, . simpleeasloffice@easloffice.eu; European Association for the Study of the Liverr: EASL clinical practice guidelines: Management of hepatocellular carcinoma. J Hepatol. 69:182–236. 2018. View Article : Google Scholar

16 

Lee JJX, Tai DWM and Choo SP: Locoregional therapy in hepatocellular carcinoma: When to start and when to stop and when to revisit. ESMO Open. 6:1001292021. View Article : Google Scholar : PubMed/NCBI

17 

Llovet JM, Pinyol R, Kelley RK, El-Khoueiry A, Reeves HL, Wang XW, Gores GJ and Villanueva A: Molecular pathogenesis and systemic therapies for hepatocellular carcinoma. Nat Cancer. 3:386–401. 2022. View Article : Google Scholar : PubMed/NCBI

18 

Rizzo A, Ricci AD and Brandi G: Trans-arterial chemoembolization plus systemic treatments for hepatocellular carcinoma: An update. J Pers Med. 12:17882022. View Article : Google Scholar : PubMed/NCBI

19 

Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Piscaglia F, Baron A, Park JW, Han G, Jassem J, et al: Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: A randomised phase 3 non-inferiority trial. Lancet. 391:1163–1173. 2018. View Article : Google Scholar

20 

Abou-Alfa GK, Meyer T, Cheng AL, El-Khoueiry AB, Rimassa L, Ryoo BY, Cicin I, Merle P, Chen Y, Park JW, et al: Cabozantinib in patients with advanced and progressing hepatocellular carcinoma. N Engl J Med. 379:54–63. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Zhu AX, Kang YK, Yen CJ, Finn RS, Galle PR, Llovet JM, Assenat E, Brandi G, Pracht M, Lim HY, et al: Ramucirumab after sorafenib in patients with advanced hepatocellular carcinoma and increased α-fetoprotein concentrations (REACH-2): A randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol. 20:282–296. 2019. View Article : Google Scholar

22 

Al-Salama ZT, Syed YY and Scott LJ: Lenvatinib: A review in hepatocellular carcinoma. Drugs. 79:665–674. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Yamashita T, Kudo M, Ikeda K, Izumi N, Tateishi R, Ikeda M, Aikata H, Kawaguchi Y, Wada Y, Numata K, et al: REFLECT-a phase 3 trial comparing efficacy and safety of lenvatinib to sorafenib for the treatment of unresectable hepatocellular carcinoma: An analysis of Japanese subset. J Gastroenterol. 55:113–122. 2020. View Article : Google Scholar

24 

He MK, Liang RB, Zhao Y, Xu YJ, Chen HW, Zhou YM, Lai ZC, Xu L, Wei W, Zhang YJ, et al: Lenvatinib, toripalimab, plus hepatic arterial infusion chemotherapy versus lenvatinib alone for advanced hepatocellular carcinoma. Ther Adv Med Oncol. 13:175883592110027202021. View Article : Google Scholar

25 

Chen S, Wu Z, Shi F, Mai Q, Wang L, Wang F, Zhuang W, Chen X, Chen H, Xu B, et al: Lenvatinib plus TACE with or without pembrolizumab for the treatment of initially unresectable hepatocellular carcinoma harbouring PD-L1 expression: A retrospective study. J Cancer Res Clin Oncol. 148:2115–2125. 2022. View Article : Google Scholar

26 

Mu C, Shen J, Zhu X, Peng W, Zhang X and Wen T: The efficacy and safety of lenvatinib plus transarterial chemoembolization in combination with PD-1 antibody in treatment of unresectable recurrent hepatocellular carcinoma: A case series report. Front Oncol. 13:10969552023. View Article : Google Scholar

27 

Mollica V, Rizzo A, Marchetti A, Tateo V, Tassinari E, Rosellini M, Massafra R, Santoni M and Massari F: The impact of ECOG performance status on efficacy of immunotherapy and immune-based combinations in cancer patients: The MOUSEION-06 study. Clin Exp Med. 23:5039–5049. 2023. View Article : Google Scholar : PubMed/NCBI

28 

Rizzo A, Mollica V, Tateo V, Tassinari E, Marchetti A, Rosellini M, De Luca R, Santoni M and Massari F: Hypertransaminasemia in cancer patients receiving immunotherapy and immune-based combinations: The MOUSEION-05 study. Cancer Immunol Immunother. 72:1381–1394. 2023. View Article : Google Scholar : PubMed/NCBI

29 

Sangro B, Sarobe P, Hervás-Stubbs S and Melero I: Advances in immunotherapy for hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol. 18:525–543. 2021. View Article : Google Scholar

30 

Pei Y, Li W, Wang Z and Liu J: Successful conversion therapy for unresectable hepatocellular carcinoma is getting closer: A systematic review and meta-analysis. Front Oncol. 12:9788232022. View Article : Google Scholar

31 

Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J and Moher D: The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: Explanation and elaboration. BMJ. 339:b27002009. View Article : Google Scholar : PubMed/NCBI

32 

Cumpston M, Li T, Page MJ, Chandler J, Welch VA, Higgins JP and Thomas J: Updated guidance for trusted systematic reviews: A new edition of the cochrane handbook for systematic reviews of interventions. Cochrane Database Syst Rev. 10:ED0001422019.PubMed/NCBI

33 

Lencioni R and Llovet JM: Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Semin Liver Dis. 30:52–60. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Slim K, Nini E, Forestier D, Kwiatkowski F, Panis Y and Chipponi J: Methodological index for non-randomized studies (minors): Development and validation of a new instrument. ANZ J Surg. 73:712–716. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Guo B, Moga C, Harstall C and Schopflocher D: A principal component analysis is conducted for a case series quality appraisal checklist. J Clin Epidemiol. 69:199–207.e2. 2016. View Article : Google Scholar

36 

Higgins JPT and Thompson SG: Quantifying heterogeneity in a meta-analysis. Stat Med. 21:1539–1558. 2002. View Article : Google Scholar : PubMed/NCBI

37 

Egger M, Davey Smith G, Schneider M and Minder C: Bias in meta-analysis detected by a simple, graphical test. BMJ. 315:629–634. 1997. View Article : Google Scholar : PubMed/NCBI

38 

Wang L, Wang H, Cui Y, Liu M, Jin K, Xu D, Wang K and Xing B: Sintilimab plus Lenvatinib conversion therapy for intermediate/locally advanced hepatocellular carcinoma: A phase 2 study. Front Oncol. 13:11151092023. View Article : Google Scholar

39 

Peng Z, Fan W, Zhu B, Wang G, Sun J, Xiao C, Huang F, Tang R, Cheng Y, Huang Z, et al: Lenvatinib combined with transarterial chemoembolization as first-line treatment for advanced hepatocellular carcinoma: A phase III, randomized clinical trial (LAUNCH). J Clin Oncol. 41:117–127. 2023. View Article : Google Scholar

40 

Yi Y, Sun BY, Weng JL, Zhou C, Zhou CH, Cai MH, Zhang JY, Gao H, Sun J, Zhou J, et al: Lenvatinib plus anti-PD-1 therapy represents a feasible conversion resection strategy for patients with initially unresectable hepatocellular carcinoma: A retrospective study. Front Oncol. 12:10465842022. View Article : Google Scholar

41 

Zhu XD, Huang C, Shen YH, Xu B, Ge NL, Ji Y, Qu XD, Chen L, Chen Y, Li ML, et al: Hepatectomy after conversion therapy using tyrosine kinase inhibitors plus anti-PD-1 antibody therapy for patients with unresectable hepatocellular carcinoma. Ann Surg Oncol. 30:2782–2790. 2023. View Article : Google Scholar

42 

Shindoh J, Kawamura Y, Kobayashi Y, Kobayashi M, Akuta N, Okubo S, Suzuki Y and Hashimoto M: Prognostic impact of surgical intervention after lenvatinib treatment for advanced hepatocellular carcinoma. Ann Surg Oncol. 28:7663–7672. 2021. View Article : Google Scholar

43 

Xu B, Zhu XD, Shen YH, Zhu JJ, Liu J, Li ML, Tang PW, Zhou J, Fan J, Sun HC and Huang C: Criteria for identifying potentially resectable patients with initially oncologically unresectable hepatocellular carcinoma before treatment with envatinib plus an anti-PD-1 antibody. Front Immunol. 13:10167362022. View Article : Google Scholar

44 

Niizeki T, Tokunaga T, Takami Y, Wada Y, Harada M, Shibata M, Nakao K, Sasaki R, Hirai F, Shakado S, et al: Comparison of efficacy and safety of atezolizumab plus bevacizumab and lenvatinib as first-line therapy for unresectable hepatocellular carcinoma: A propensity score matching analysis. Target Oncol. 17:643–653. 2022. View Article : Google Scholar

45 

Wu SJ, Ruan DD, Wu QY, Tang Y, Zhang JH, Cai SL, Zhou YF, Luo JW and Fang ZT: Safety and efficacy of drug-eluting bead transarterial chemoembolization combined with lenvatinib and anti-PD-1 antibodies for unresectable hepatocellular carcinoma: A retrospective analysis. J Hepatocell Carcinoma. 10:807–820. 2023. View Article : Google Scholar

46 

Li X, Chen J, Wang X, Bai T, Lu S, Wei T, Tang Z, Huang C, Zhang B, Liu B, et al: Outcomes and prognostic factors in initially unresectable hepatocellular carcinoma treated using conversion therapy with lenvatinib and TACE plus PD-1 inhibitors. Front Oncol. 13:11106892023. View Article : Google Scholar

47 

Gan L, Lang M, Tian X, Ren S, Li G, Liu Y, Han R, Zhu K, Li H, Wu Q, et al: A retrospective analysis of conversion therapy with lenvatinib, sintilimab, and arterially-directed therapy in patients with initially unresectable hepatocellular carcinoma. J Hepatocell Carcinoma. 10:673–686. 2023. View Article : Google Scholar

48 

Zhang J, Zhang X, Mu H, Yu G, Xing W, Wang L and Zhang T: Surgical conversion for initially unresectable locally advanced hepatocellular carcinoma using a triple combination of angiogenesis inhibitors, anti-PD-1 antibodies, and hepatic arterial infusion chemotherapy: A retrospective study. Front Oncol. 11:7297642021. View Article : Google Scholar

49 

Wu JY, Yin ZY, Bai YN, Chen YF, Zhou SQ, Wang SJ, Zhou JY, Li YN, Qiu FN, Li B and Yan ML: Lenvatinib combined with anti-PD-1 antibodies plus transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma: A multicenter retrospective study. J Hepatocell Carcinoma. 8:1233–1240. 2021. View Article : Google Scholar

50 

Zhao Y, Zhang YN, Wang KT and Chen L: Lenvatinib for hepatocellular carcinoma: From preclinical mechanisms to anti-cancer therapy. Biochim Biophys Acta Rev Cancer. 1874:1883912020. View Article : Google Scholar : PubMed/NCBI

51 

Cai M, Huang W, Huang J, Shi W, Guo Y, Liang L, Zhou J, Lin L, Cao B, Chen Y, et al: Transarterial chemoembolization combined with lenvatinib plus PD-1 inhibitor for advanced hepatocellular carcinoma: A retrospective cohort study. Front Immunol. 13:8483872022. View Article : Google Scholar

52 

Hatanaka T, Yata Y, Naganuma A and Kakizaki S: Treatment strategy for intermediate-stage hepatocellular carcinoma: Transarterial chemoembolization, systemic therapy, and conversion therapy. Cancers (Basel). 15:17982023. View Article : Google Scholar : PubMed/NCBI

53 

Hermann RE and Lonsdale D: Chemotherapy, radiotherapy, and hepatic lobectomy for hepatoblastoma in an infant: Report of a survival. Surgery. 68:383–388. 1970.PubMed/NCBI

54 

Tsurusaki M and Murakami T: Surgical and locoregional therapy of HCC: TACE. Liver Cancer. 4:165–175. 2015. View Article : Google Scholar : PubMed/NCBI

55 

Sergio A, Cristofori C, Cardin R, Pivetta G, Ragazzi R, Baldan A, Girardi L, Cillo U, Burra P, Giacomin A and Farinati F: Transcatheter arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC): The role of angiogenesis and invasiveness. Am J Gastroenterol. 103:914–921. 2008. View Article : Google Scholar

56 

Forner A, Llovet JM and Bruix J: Chemoembolization for intermediate HCC: Is there proof of survival benefit? J Hepatol. 56:984–986. 2012. View Article : Google Scholar

57 

Fan J, Tang ZY, Yu YQ, Wu ZQ, Ma ZC, Zhou XD, Zhou J, Qiu SJ and Lu JZ: Improved survival with resection after transcatheter arterial chemoembolization (TACE) for unresectable hepatocellular carcinoma. Dig Surg. 15:674–678. 1998. View Article : Google Scholar : PubMed/NCBI

58 

Lau WY, Ho SKW, Yu SCH, Lai ECH, Liew C and Leung TWT: Salvage surgery following downstaging of unresectable hepatocellular carcinoma. Ann Surg. 240:299–305. 2004. View Article : Google Scholar : PubMed/NCBI

59 

Yamamura K and Beppu T: Conversion surgery for hepatocellular carcinoma after multidisciplinary treatment including lenvatinib. Hepatol Res. 51:1029–1030. 2021. View Article : Google Scholar : PubMed/NCBI

60 

Sun HC, Zhou J, Wang Z, Liu X, Xie Q, Jia W, Zhao M, Bi X, Li G, Bai X, et al: Chinese expert consensus on conversion therapy for hepatocellular carcinoma (2021 edition). Hepatobiliary Surg Nutr. 11:227–252. 2022. View Article : Google Scholar : PubMed/NCBI

61 

Lei Q, Yan X, Zou H, Jiang Y, Lai Y, Ung COL and Hu H: Efficacy and safety of monotherapy and combination therapy of immune checkpoint inhibitors as first-line treatment for unresectable hepatocellular carcinoma: A systematic review, meta-analysis and network meta-analysis. Discov Oncol. 13:952022. View Article : Google Scholar

62 

Arita J, Ichida A, Nagata R, Mihara Y, Kawaguchi Y, Ishizawa T, Akamatsu N, Kaneko J and Hasegawa K: Conversion surgery after preoperative therapy for advanced hepatocellular carcinoma in the era of molecular targeted therapy and immune checkpoint inhibitors. J Hepatobiliary Pancreat Sci. 29:732–740. 2022. View Article : Google Scholar

63 

Chen J, Zhang D and Yuan Y: Anti-PD-1/PD-L1 immunotherapy in conversion treatment of locally advanced hepatocellular carcinoma. Clin Exp Med. 23:579–590. 2023. View Article : Google Scholar : PubMed/NCBI

64 

Killock D: Novel ICI-TKI combination improves HCC outcomes. Nat Rev Clin Oncol. 20:7332023. View Article : Google Scholar

65 

Kudo M: A novel treatment strategy for patients with intermediate-stage HCC who are not suitable for TACE: Upfront systemic therapy followed by curative conversion. Liver Cancer. 10:539–544. 2021. View Article : Google Scholar : PubMed/NCBI

66 

Yamamoto Y, Matsui J, Matsushima T, Obaishi H, Miyazaki K, Nakamura K, Tohyama O, Semba T, Yamaguchi A, Hoshi SS, et al: Lenvatinib, an angiogenesis inhibitor targeting VEGFR/FGFR, shows broad antitumor activity in human tumor xenograft models associated with microvessel density and pericyte coverage. Vasc Cell. 6:182014. View Article : Google Scholar

67 

Kato Y, Tabata K, Kimura T, Yachie-Kinoshita A, Ozawa Y, Yamada K, Ito J, Tachino S, Hori Y, Matsuki M, et al: Lenvatinib plus anti-PD-1 antibody combination treatment activates CD8+ T cells through reduction of tumor-associated macrophage and activation of the interferon pathway. PLoS One. 14:e02125132019. View Article : Google Scholar : PubMed/NCBI

68 

Kimura T, Kato Y, Ozawa Y, Kodama K, Ito J, Ichikawa K, Yamada K, Hori Y, Tabata K, Takase K, et al: Immunomodulatory activity of lenvatinib contributes to antitumor activity in the Hepa1-6 hepatocellular carcinoma model. Cancer Sci. 109:3993–4002. 2018. View Article : Google Scholar

69 

Deng H, Kan A, Lyu N, Mu L, Han Y, Liu L, Zhang Y, Duan Y, Liao S, Li S, et al: Dual vascular endothelial growth factor receptor and fibroblast growth factor receptor inhibition elicits antitumor immunity and enhances programmed cell death-1 checkpoint blockade in hepatocellular carcinoma. Liver Cancer. 9:338–357. 2020. View Article : Google Scholar : PubMed/NCBI

70 

Jiang H, Meng Q, Tan H, Pan S, Sun B, Xu R and Sun X: Antiangiogenic therapy enhances the efficacy of transcatheter arterial embolization for hepatocellular carcinomas. Int J Cancer. 121:416–424. 2007. View Article : Google Scholar : PubMed/NCBI

71 

Pinato DJ, Murray SM, Forner A, Kaneko T, Fessas P, Toniutto P, Mínguez B, Cacciato V, Avellini C, Diaz A, et al: Trans-arterial chemoembolization as a loco-regional inducer of immunogenic cell death in hepatocellular carcinoma: implications for immunotherapy. J Immunother Cancer. 9:e0033112021. View Article : Google Scholar : PubMed/NCBI

72 

Brahmer JR, Lacchetti C, Schneider BJ, Atkins MB, Brassil KJ, Caterino JM, Chau I, Ernstoff MS, Gardner JM, Ginex P, et al: Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy: American society of clinical oncology clinical practice guideline. J Clin Oncol. 36:1714–1768. 2018. View Article : Google Scholar

73 

Llovet JM, Castet F, Heikenwalder M, Maini MK, Mazzaferro V, Pinato DJ, Pikarsky E, Zhu AX and Finn RS: Immunotherapies for hepatocellular carcinoma. Nat Rev Clin Oncol. 19:151–172. 2022. View Article : Google Scholar

74 

Sung MW, Finn RS, Qin S, Han KH, Ikeda K, Cheng AL, Kudo M, Tateishi R, Ikeda M, Breder V, et al: Association between overall survival and adverse events with lenvatinib treatment in patients with hepatocellular carcinoma (REFLECT). J Clin Oncol. 37 (Suppl):S3172019. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Li S, Zhang Z, Wang Z, Wang K, Sui M, Liu D and Liang K: Lenvatinib‑based treatment regimens in conversion therapy of unresectable hepatocellular carcinoma: A systematic review and meta‑analysis. Oncol Lett 27: 265, 2024.
APA
Li, S., Zhang, Z., Wang, Z., Wang, K., Sui, M., Liu, D., & Liang, K. (2024). Lenvatinib‑based treatment regimens in conversion therapy of unresectable hepatocellular carcinoma: A systematic review and meta‑analysis. Oncology Letters, 27, 265. https://doi.org/10.3892/ol.2024.14398
MLA
Li, S., Zhang, Z., Wang, Z., Wang, K., Sui, M., Liu, D., Liang, K."Lenvatinib‑based treatment regimens in conversion therapy of unresectable hepatocellular carcinoma: A systematic review and meta‑analysis". Oncology Letters 27.6 (2024): 265.
Chicago
Li, S., Zhang, Z., Wang, Z., Wang, K., Sui, M., Liu, D., Liang, K."Lenvatinib‑based treatment regimens in conversion therapy of unresectable hepatocellular carcinoma: A systematic review and meta‑analysis". Oncology Letters 27, no. 6 (2024): 265. https://doi.org/10.3892/ol.2024.14398
Copy and paste a formatted citation
x
Spandidos Publications style
Li S, Zhang Z, Wang Z, Wang K, Sui M, Liu D and Liang K: Lenvatinib‑based treatment regimens in conversion therapy of unresectable hepatocellular carcinoma: A systematic review and meta‑analysis. Oncol Lett 27: 265, 2024.
APA
Li, S., Zhang, Z., Wang, Z., Wang, K., Sui, M., Liu, D., & Liang, K. (2024). Lenvatinib‑based treatment regimens in conversion therapy of unresectable hepatocellular carcinoma: A systematic review and meta‑analysis. Oncology Letters, 27, 265. https://doi.org/10.3892/ol.2024.14398
MLA
Li, S., Zhang, Z., Wang, Z., Wang, K., Sui, M., Liu, D., Liang, K."Lenvatinib‑based treatment regimens in conversion therapy of unresectable hepatocellular carcinoma: A systematic review and meta‑analysis". Oncology Letters 27.6 (2024): 265.
Chicago
Li, S., Zhang, Z., Wang, Z., Wang, K., Sui, M., Liu, D., Liang, K."Lenvatinib‑based treatment regimens in conversion therapy of unresectable hepatocellular carcinoma: A systematic review and meta‑analysis". Oncology Letters 27, no. 6 (2024): 265. https://doi.org/10.3892/ol.2024.14398
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