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Review Open Access

Perfusion drugs for non‑muscle invasive bladder cancer (Review)

  • Authors:
    • Jingyuan Qian
    • Qiuchen Zhang
    • Yang Cao
    • Xi Chu
    • Yiyang Gao
    • Haifei Xu
    • Hongzhou Cai
    • Jiajia Wu
  • View Affiliations / Copyright

    Affiliations: Department of Nursing, Jiangsu Cancer Hospital and The Affiliated Cancer Hospital of Nanjing Medical University and Jiangsu Institute of Cancer Research, Nanjing, Jiangsu 210009, P.R. China, Department of Urology, Jiangsu Cancer Hospital and The Affiliated Cancer Hospital of Nanjing Medical University and Jiangsu Institute of Cancer Research, Nanjing, Jiangsu 210009, P.R. China, Department of Urology, Jiangsu Cancer Hospital and The Affiliated Cancer Hospital of Nanjing Medical University and Jiangsu Institute of Cancer Research, Nanjing, Jiangsu 210009, P.R. China, Department of Urology, Nantong Tumor Hospital, Nantong, Jiangsu 226006, P.R. China, Department of Nursing, Jiangsu Cancer Hospital and The Affiliated Cancer Hospital of Nanjing Medical University and Jiangsu Institute of Cancer Research, Nanjing, Jiangsu 210009, P.R. China
    Copyright: © Qian et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 267
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    Published online on: April 15, 2024
       https://doi.org/10.3892/ol.2024.14400
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Abstract

The high recurrence rate and poor prognosis of non‑muscle invasive bladder cancer (BC) are challenges that need to be urgently addressed. Transurethral cystectomy for bladder tumors is often combined with bladder perfusion therapy, which can effectively reduce the recurrence and progression rates of BC. The present review integrated and analyzed currently available bladder perfusion drugs, mainly including chemotherapeutic agents, immunotherapeutic agents and other adjuvant perfusion drugs. Bacillus Calmette‑Guerin (BCG) perfusion was the pioneering immunotherapy for early BC and still ranks high in the selection of perfusion drugs. However, BCG infusion has a high toxicity profile and has been shown to be ineffective in some patients. Due to the limitations of BCG, new bladder perfusion drugs are constantly being developed. Immunotherapeutic agents have opened a whole new chapter in the selection of therapeutic agents for bladder perfusion. The present review explored the mechanism of action, clinical dosage and adverse effects of a variety of bladder perfusion drugs currently in common use, described combined perfusion and compared the effects of certain drugs on BC.
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Copy and paste a formatted citation
Spandidos Publications style
Qian J, Zhang Q, Cao Y, Chu X, Gao Y, Xu H, Cai H and Wu J: Perfusion drugs for non‑muscle invasive bladder cancer (Review). Oncol Lett 27: 267, 2024.
APA
Qian, J., Zhang, Q., Cao, Y., Chu, X., Gao, Y., Xu, H. ... Wu, J. (2024). Perfusion drugs for non‑muscle invasive bladder cancer (Review). Oncology Letters, 27, 267. https://doi.org/10.3892/ol.2024.14400
MLA
Qian, J., Zhang, Q., Cao, Y., Chu, X., Gao, Y., Xu, H., Cai, H., Wu, J."Perfusion drugs for non‑muscle invasive bladder cancer (Review)". Oncology Letters 27.6 (2024): 267.
Chicago
Qian, J., Zhang, Q., Cao, Y., Chu, X., Gao, Y., Xu, H., Cai, H., Wu, J."Perfusion drugs for non‑muscle invasive bladder cancer (Review)". Oncology Letters 27, no. 6 (2024): 267. https://doi.org/10.3892/ol.2024.14400
Copy and paste a formatted citation
x
Spandidos Publications style
Qian J, Zhang Q, Cao Y, Chu X, Gao Y, Xu H, Cai H and Wu J: Perfusion drugs for non‑muscle invasive bladder cancer (Review). Oncol Lett 27: 267, 2024.
APA
Qian, J., Zhang, Q., Cao, Y., Chu, X., Gao, Y., Xu, H. ... Wu, J. (2024). Perfusion drugs for non‑muscle invasive bladder cancer (Review). Oncology Letters, 27, 267. https://doi.org/10.3892/ol.2024.14400
MLA
Qian, J., Zhang, Q., Cao, Y., Chu, X., Gao, Y., Xu, H., Cai, H., Wu, J."Perfusion drugs for non‑muscle invasive bladder cancer (Review)". Oncology Letters 27.6 (2024): 267.
Chicago
Qian, J., Zhang, Q., Cao, Y., Chu, X., Gao, Y., Xu, H., Cai, H., Wu, J."Perfusion drugs for non‑muscle invasive bladder cancer (Review)". Oncology Letters 27, no. 6 (2024): 267. https://doi.org/10.3892/ol.2024.14400
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