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Case Report Open Access

Primary lung adenocarcinoma with breast metastasis harboring the EML4‑ALK fusion: A case report

  • Authors:
    • Wenwen Zhang
    • Yu Zhang
    • Lei Zhou
    • Na Tan
    • Yuju Bai
    • Shiyun Xing
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China, Department of Pathology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 276
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    Published online on: April 22, 2024
       https://doi.org/10.3892/ol.2024.14409
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Abstract

Pulmonary adenocarcinoma with breast metastasis is rarely encountered in clinical practice. Therefore, precise clinical diagnosis of patients with this disease is crucial when selecting subsequent treatment modalities and for overall prognosis assessment. The present study reported on a case of lung cancer with breast metastasis harboring the EML4‑ALK fusion. The patient was initially diagnosed with triple‑negative breast cancer with lung metastasis, but comprehensive breast cancer treatment was ineffective. Reevaluation of the patient's condition via lung biopsy revealed primary lung adenocarcinoma. In addition, the results of genetic testing revealed the EML4‑ALK fusion protein in both lung and breast tissues. After treatment with ALK inhibitors, the patient's symptoms improved rapidly. This case highlights the prolonged diagnostic journey from presentation with a breast mass to ultimately being diagnosed with lung cancer with breast metastasis, underscoring the critical need for heightened awareness among clinicians regarding the possibility of rare metastatic patterns. Timely identification of lung cancer with breast metastasis, facilitated by comprehensive genetic testing, not only refines treatment decisions but also emphasizes the importance of interdisciplinary collaboration in navigating complex clinical scenarios. Such insight contributes to the ongoing development of personalized cancer care that guides clinicians toward more effective and tailored therapeutic strategies for patients with similar diagnostic challenges.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang W, Zhang Y, Zhou L, Tan N, Bai Y and Xing S: Primary lung adenocarcinoma with breast metastasis harboring the EML4‑ALK fusion: A case report. Oncol Lett 27: 276, 2024.
APA
Zhang, W., Zhang, Y., Zhou, L., Tan, N., Bai, Y., & Xing, S. (2024). Primary lung adenocarcinoma with breast metastasis harboring the EML4‑ALK fusion: A case report. Oncology Letters, 27, 276. https://doi.org/10.3892/ol.2024.14409
MLA
Zhang, W., Zhang, Y., Zhou, L., Tan, N., Bai, Y., Xing, S."Primary lung adenocarcinoma with breast metastasis harboring the EML4‑ALK fusion: A case report". Oncology Letters 27.6 (2024): 276.
Chicago
Zhang, W., Zhang, Y., Zhou, L., Tan, N., Bai, Y., Xing, S."Primary lung adenocarcinoma with breast metastasis harboring the EML4‑ALK fusion: A case report". Oncology Letters 27, no. 6 (2024): 276. https://doi.org/10.3892/ol.2024.14409
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang W, Zhang Y, Zhou L, Tan N, Bai Y and Xing S: Primary lung adenocarcinoma with breast metastasis harboring the EML4‑ALK fusion: A case report. Oncol Lett 27: 276, 2024.
APA
Zhang, W., Zhang, Y., Zhou, L., Tan, N., Bai, Y., & Xing, S. (2024). Primary lung adenocarcinoma with breast metastasis harboring the EML4‑ALK fusion: A case report. Oncology Letters, 27, 276. https://doi.org/10.3892/ol.2024.14409
MLA
Zhang, W., Zhang, Y., Zhou, L., Tan, N., Bai, Y., Xing, S."Primary lung adenocarcinoma with breast metastasis harboring the EML4‑ALK fusion: A case report". Oncology Letters 27.6 (2024): 276.
Chicago
Zhang, W., Zhang, Y., Zhou, L., Tan, N., Bai, Y., Xing, S."Primary lung adenocarcinoma with breast metastasis harboring the EML4‑ALK fusion: A case report". Oncology Letters 27, no. 6 (2024): 276. https://doi.org/10.3892/ol.2024.14409
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