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Article Open Access

Prognostic biomarker NRG2 correlates with autophagy and epithelial‑mesenchymal transition in breast cancer

  • Authors:
    • Ruijie Zhou
    • Jinjin Dai
    • Runlong Zhou
    • Mengyi Wang
    • Xiaotong Deng
    • Qing Zhuo
    • Zhenrong Wang
    • Fan Li
    • Di Yao
    • Yao Xu
  • View Affiliations / Copyright

    Affiliations: Institute of Biology and Medicine, College of Life Science and Health, Wuhan University of Science and Technology, Wuhan, Hubei 430081, P.R. China, Wuhan Bio‑Raid Biotechnology Co., Ltd., Wuhan, Hubei 430075, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 277
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    Published online on: April 23, 2024
       https://doi.org/10.3892/ol.2024.14410
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Abstract

Breast cancer (BRCA) is a leading cause of death in women worldwide, accounting for 31% of female cancer. Autophagy plays a crucial role in cancer progression, however, the function of autophagy‑related gene neuroregulatory protein 2 (NRG2) in BRCA and its underlying molecular mechanisms remain unclear. In the present study, the expression of the NRG2 gene in BRCA was significantly down‑regulated compared with the normal controls. The low expression level of NRG2 was related to poor survival rate of BRCA. The receiver operating characteristic curve of NRG2 showed a good diagnostic value for distinguishing BRCA from normal tissues (AUC=0.932). GO‑KEGG analysis and GSEA enrichment analysis showed that NRG2 and its regulated genes were enriched in autophagy‑related and immune‑related pathways, and NRG2 was positively correlated with a number of immune cells and immune checkpoint genes. In addition, knockdown of NRG2 significantly promoted the proliferation, invasion and migration of BRCA cells. The autophagy marker, LC3‑II and epithelial‑mesenchymal transition (EMT) marker, vimentin were increased, while P62 and E‑cadherin were decreased in response to NRG2 depletion. The findings of the present study demonstrated that NRG2 acts as a tumor suppressor factor that contributes to the immune escape and anti‑tumor immunity inhibition by regulating the pathological process of autophagy and EMT, suggesting that NRG2 could be used as a prognostic biomarker and clinical target for BRCA therapy.
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View References

1 

Torre LA, Islami F, Siegel RL, Ward EM and Jemal A: Global Cancer in Women: Burden and Trends. Cancer Epidemiol Biomarkers Prev. 26:444–457. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Fan L, Strasser-Weippl K, Li JJ, St Louis J, Finkelstein DM, Yu KD, Chen WQ, Shao ZM and Goss PE: Breast cancer in China. Lancet Oncol. 15:e279–e289. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

4 

Siegel RL, Miller KD, Wagle NS and Jemal A: Cancer statistics, 2023. CA Cancer J Clin. 73:17–48. 2023. View Article : Google Scholar : PubMed/NCBI

5 

Zhang L, Chen W, Liu S and Chen C: Targeting breast cancer stem cells. Int J Biol Sci. 19:552–570. 2023. View Article : Google Scholar : PubMed/NCBI

6 

Yun CW and Lee SH: The roles of autophagy in cancer. Int J Mol Sci. 19:34662018. View Article : Google Scholar : PubMed/NCBI

7 

Levine B and Kroemer G: Biological functions of autophagy genes: A disease perspective. Cell. 176:11–42. 2019. View Article : Google Scholar : PubMed/NCBI

8 

He C and Klionsky DJ: Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet. 43:67–93. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Jain V, Singh MP and Amaravadi RK: Amaravadi, Recent advances in targeting autophagy in cancer. Trends Pharmacol Sci. 44:290–302. 2023. View Article : Google Scholar : PubMed/NCBI

10 

Debnath J, Gammoh N and Ryan KM: Autophagy and autophagy-related pathways in cancer. Nat Rev Mol Cell Biol. 24:560–575. 2023. View Article : Google Scholar : PubMed/NCBI

11 

Gundamaraju R, Lu W, Paul MK, Jha NK, Gupta PK, Ojha S, Chattopadhyay I, Rao PV and Ghavami S: Autophagy and EMT in cancer and metastasis: Who controls whom? Biochim Biophys Acta Mol Basis Dis. 1868:1664312022. View Article : Google Scholar : PubMed/NCBI

12 

Si L and Yang Z: Regulatory effects of lncRNAs and miRNAs on the crosstalk between autophagy and EMT in cancer: A new era for cancer treatment. J Cancer Res Clin Oncol. 148:547–564. 2022. View Article : Google Scholar : PubMed/NCBI

13 

Babaei G, Aziz SG and Jaghi NZZ: EMT, cancer stem cells and autophagy; The three main axes of metastasis. Biomed Pharmacother. 133:1109092021. View Article : Google Scholar : PubMed/NCBI

14 

Akalay I, Janji B, Hasmim M, Noman MZ, Thiery JP, Mami-Chouaib F and Chouaib S: EMT impairs breast carcinoma cell susceptibility to CTL-mediated lysis through autophagy induction. Autophagy. 9:1104–1106. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Li Z, Lu C, Wang F, Guo H, Wang Z, Yin H and Li J: Heat treatment-induced autophagy promotes breast cancer cell invasion and metastasis via TGF-β2-mediated epithelial-mesenchymal transitions. PeerJ. 11:e146402023. View Article : Google Scholar : PubMed/NCBI

16 

Marshall C, Blackburn E, Clark M, Humphreys S and Gullick WJ: Neuregulins 1–4 are expressed in the cytoplasm or nuclei of ductal carcinoma (in situ) of the human breast. Breast Cancer Res Treat. 96:163–168. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Karthaus WR and Hofree M: Regenerative potential of prostate luminal cells revealed by single-cell analysis. Science. 368:497–505. 2020. View Article : Google Scholar : PubMed/NCBI

18 

Trombetta D, Sparaneo A, Fabrizio FP, Di Micco CM, Rossi A and Muscarella LA: NRG1 and NRG2 fusions in non-small cell lung cancer (NSCLC): Seven years between lights and shadows. Expert Opin Ther Targets. 25:865–875. 2021. View Article : Google Scholar : PubMed/NCBI

19 

Yarden Y and Sliwkowski MX: Untangling the ErbB signalling network. Nat Rev Mol Cell Biol. 2:127–137. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Zhao WJ, Yi SJ, Ou GY and Qiao XY: Neuregulin 2 (NRG2) is expressed in gliomas and promotes migration of human glioma cells. Folia Neuropathol. 59:189–197. 2021. View Article : Google Scholar : PubMed/NCBI

21 

Li F, Shang Y, Zhang H, She J, Wang G and Sun Q: Development of a novel autophagy-related gene prognostic signature for gastric cancer. Transl Cancer Res. 10:2790–2800. 2021. View Article : Google Scholar : PubMed/NCBI

22 

Hu D, Jiang L, Luo S, Zhao X, Hu H, Zhao G and Tang W: Development of an autophagy-related gene expression signature for prognosis prediction in prostate cancer patients. J Transl Med. 18:1602020. View Article : Google Scholar : PubMed/NCBI

23 

Sepulveda JL: Using R and bioconductor in clinical genomics and transcriptomics. J Mol Diagn. 22:3–20. 2020. View Article : Google Scholar : PubMed/NCBI

24 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Chin CH, Chen SH, Wu HH, Ho CW, Ko MT and Lin CY: cytoHubba: Identifying hub objects and sub-networks from complex interactome. BMC Syst Biol. 8 (Suppl 4):S112014. View Article : Google Scholar : PubMed/NCBI

26 

Muggerud AA, Hallett M, Johnsen H, Kleivi K, Zhou W, Tahmasebpoor S, Amini RM, Botling J, Børresen-Dale AL, Sørlie T and Wärnberg F: Molecular diversity in ductal carcinoma in situ (DCIS) and early invasive breast cancer. Mol Oncol. 4:357–368. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Gruosso T, Mieulet V, Cardon M, Bourachot B, Kieffer Y, Devun F, Dubois T, Dutreix M, Vincent-Salomon A, Miller KM and Mechta-Grigoriou F: Chronic oxidative stress promotes H2AX protein degradation and enhances chemosensitivity in breast cancer patients. EMBO Mol Med. 8:527–549. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Vasaikar SV, Straub P, Wang J and Zhang B: LinkedOmics: Analyzing multi-omics data within and across 32 cancer types. Nucleic Acids Res. 46:D956–D963. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Wu T, Hu E, Xu S, Chen M, Guo P, Dai Z, Feng T, Zhou L, Tang W, Zhan L, et al: clusterProfiler 4.0: A universal enrichment tool for interpreting omics data. Innovation (Camb). 2:1001412021.PubMed/NCBI

30 

Walter W, Sánchez-Cabo F and Ricote M: GOplot: An R package for visually combining expression data with functional analysis. Bioinformatics. 31:2912–2914. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Bindea G, Mlecnik B, Tosolini M, Kirilovsky A, Waldner M, Obenauf AC, Angell H, Fredriksen T, Lafontaine L, Berger A, et al: Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity. 39:782–795. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Hänzelmann S, Castelo R and Guinney J: GSVA: Gene set variation analysis for microarray and RNA-seq data. BMC Bioinformatics. 14:72013. View Article : Google Scholar : PubMed/NCBI

33 

Ru B, Wong CN, Tong Y, Zhong JY, Zhong SSW, Wu WC, Chu KC, Wong CY, Lau CY, Chen I, et al: TISIDB: An integrated repository portal for tumor-immune system interactions. Bioinformatics. 35:4200–4202. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

35 

Niklaus NJ, Tokarchuk I, Zbinden M, Schläfli AM, Maycotte P and Tschan MP: The multifaceted functions of autophagy in breast cancer development and treatment. Cells. 10:14472021. View Article : Google Scholar : PubMed/NCBI

36 

Jin L, Chen Y, Cheng D, He Z, Shi X, Du B, Xi X, Gao Y and Guo Y: YAP inhibits autophagy and promotes progression of colorectal cancer via upregulating Bcl-2 expression. Cell Death Dis. 12:4572021. View Article : Google Scholar : PubMed/NCBI

37 

Liu X, Ma B, Chen M, Zhang Y, Ma Z and Chen H: Prognostic Autophagy-Related genes of gastric cancer patients on chemotherapy. Front Genet. 12:7208492021. View Article : Google Scholar : PubMed/NCBI

38 

Ding J, Wang C, Sun Y, Guo J, Liu S and Cheng Z: Identification of an Autophagy-Related signature for prognosis and immunotherapy response prediction in ovarian cancer. Biomolecules. 13:3392023. View Article : Google Scholar : PubMed/NCBI

39 

Poe JC, Fujimoto Y, Hasegawa M, Haas KM, Miller AS, Sanford IG, Bock CB, Fujimoto M and Tedder TF: CD22 regulates B lymphocyte function in vivo through both ligand-dependent and ligand-independent mechanisms. Nat Immunol. 5:1078–1087. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Harwood NE and Batista FD: Early events in B cell activation. Annu Rev Immunol. 28:185–210. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Zhou C, Gao Y, Ding P, Wu T and Ji G: The role of CXCL family members in different diseases. Cell Death Discov. 9:2122023. View Article : Google Scholar : PubMed/NCBI

42 

Gonçalves PR, Rocha-Brito KJ, Fernandes MR, Abrantes JL, Durán N and Ferreira-Halder CV: Violacein induces death of RAS-mutated metastatic melanoma by impairing autophagy process. Tumour Biol. 37:14049–14058. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Su H, Yang F, Fu R, Li X, French R, Mose E, Pu X, Trinh B, Kumar A, Liu J, et al: Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis. Cancer Cell. 39:678–693.e11. 2021. View Article : Google Scholar : PubMed/NCBI

44 

Lee JJ and Jain V: Clinical translation of combined MAPK and autophagy inhibition in RAS mutant cancer. Int J Mol Sci. 22:124022021. View Article : Google Scholar : PubMed/NCBI

45 

Malla RR and Kiran P: Tumor microenvironment pathways: Cross regulation in breast cancer metastasis. Genes Dis. 9:310–324. 2022. View Article : Google Scholar : PubMed/NCBI

46 

Gonzalez DM and Medici D: Signaling mechanisms of the epithelial-mesenchymal transition. Sci Signal. 7:re82014. View Article : Google Scholar : PubMed/NCBI

47 

Mirzaei S, Saghari S, Bassiri F, Raesi R, Zarrabi A, Hushmandi K, Sethi G and Tergaonkar V: NF-κB as a regulator of cancer metastasis and therapy response: A focus on epithelial-mesenchymal transition. J Cell Physiol. 237:2770–2795. 2022. View Article : Google Scholar : PubMed/NCBI

48 

Copetti T, Bertoli C, Dalla E, Demarchi F and Schneider C: p65/RelA modulates BECN1 transcription and autophagy. Mol Cell Biol. 29:2594–2608. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Xu K, Chen W, Wang X, Peng Y, Liang A, Huang D, Li C and Ye W: Autophagy attenuates the catabolic effect during inflammatory conditions in nucleus pulposus cells, as sustained by NF-κB and JNK inhibition. Int J Mol Med. 36:661–668. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhou R, Dai J, Zhou R, Wang M, Deng X, Zhuo Q, Wang Z, Li F, Yao D, Xu Y, Xu Y, et al: Prognostic biomarker NRG2 correlates with autophagy and epithelial‑mesenchymal transition in breast cancer. Oncol Lett 27: 277, 2024.
APA
Zhou, R., Dai, J., Zhou, R., Wang, M., Deng, X., Zhuo, Q. ... Xu, Y. (2024). Prognostic biomarker NRG2 correlates with autophagy and epithelial‑mesenchymal transition in breast cancer. Oncology Letters, 27, 277. https://doi.org/10.3892/ol.2024.14410
MLA
Zhou, R., Dai, J., Zhou, R., Wang, M., Deng, X., Zhuo, Q., Wang, Z., Li, F., Yao, D., Xu, Y."Prognostic biomarker NRG2 correlates with autophagy and epithelial‑mesenchymal transition in breast cancer". Oncology Letters 27.6 (2024): 277.
Chicago
Zhou, R., Dai, J., Zhou, R., Wang, M., Deng, X., Zhuo, Q., Wang, Z., Li, F., Yao, D., Xu, Y."Prognostic biomarker NRG2 correlates with autophagy and epithelial‑mesenchymal transition in breast cancer". Oncology Letters 27, no. 6 (2024): 277. https://doi.org/10.3892/ol.2024.14410
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou R, Dai J, Zhou R, Wang M, Deng X, Zhuo Q, Wang Z, Li F, Yao D, Xu Y, Xu Y, et al: Prognostic biomarker NRG2 correlates with autophagy and epithelial‑mesenchymal transition in breast cancer. Oncol Lett 27: 277, 2024.
APA
Zhou, R., Dai, J., Zhou, R., Wang, M., Deng, X., Zhuo, Q. ... Xu, Y. (2024). Prognostic biomarker NRG2 correlates with autophagy and epithelial‑mesenchymal transition in breast cancer. Oncology Letters, 27, 277. https://doi.org/10.3892/ol.2024.14410
MLA
Zhou, R., Dai, J., Zhou, R., Wang, M., Deng, X., Zhuo, Q., Wang, Z., Li, F., Yao, D., Xu, Y."Prognostic biomarker NRG2 correlates with autophagy and epithelial‑mesenchymal transition in breast cancer". Oncology Letters 27.6 (2024): 277.
Chicago
Zhou, R., Dai, J., Zhou, R., Wang, M., Deng, X., Zhuo, Q., Wang, Z., Li, F., Yao, D., Xu, Y."Prognostic biomarker NRG2 correlates with autophagy and epithelial‑mesenchymal transition in breast cancer". Oncology Letters 27, no. 6 (2024): 277. https://doi.org/10.3892/ol.2024.14410
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