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Transfer RNA‑derived small RNAs: A class of potential biomarkers in multiple cancers (Review)

  • Authors:
    • Chunyan Mao
    • Wentao Yuan
    • Ronghua Fang
    • Yi Wu
    • Zhihan Zhang
    • Hui Cong
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China
    Copyright: © Mao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 293
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    Published online on: May 1, 2024
       https://doi.org/10.3892/ol.2024.14427
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Abstract

Transfer (t)RNA‑derived small RNAs (tsRNAs) are a class of novel non‑coding small RNAs that are created via precise cleavage of tRNAs or tRNA precursors by different enzymes. tsRNAs are specific biological molecules that serve essential roles in cell proliferation, apoptosis, transcriptional regulation, post‑transcriptional modification and translational regulation. Additionally, tsRNAs participate in the pathogenesis of several diseases, particularly in the development of malignant tumors. At present, the process of discovering and understanding the functions of tsRNAs is still in its early stages. The present review introduces the known biological functions and mechanisms of tsRNAs, and discusses the tsRNAs progression in several types of cancers as well as the possibility of tsRNAs becoming novel tumor biomarkers. Furthermore, tsRNAs may promote and hinder tumor formation according to different mechanisms and act as oncogenic or oncostatic molecules. Therefore, tsRNAs may be future potential tumor biomarkers or therapeutic targets.
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Copy and paste a formatted citation
Spandidos Publications style
Mao C, Yuan W, Fang R, Wu Y, Zhang Z and Cong H: Transfer RNA‑derived small RNAs: A class of potential biomarkers in multiple cancers (Review). Oncol Lett 28: 293, 2024.
APA
Mao, C., Yuan, W., Fang, R., Wu, Y., Zhang, Z., & Cong, H. (2024). Transfer RNA‑derived small RNAs: A class of potential biomarkers in multiple cancers (Review). Oncology Letters, 28, 293. https://doi.org/10.3892/ol.2024.14427
MLA
Mao, C., Yuan, W., Fang, R., Wu, Y., Zhang, Z., Cong, H."Transfer RNA‑derived small RNAs: A class of potential biomarkers in multiple cancers (Review)". Oncology Letters 28.1 (2024): 293.
Chicago
Mao, C., Yuan, W., Fang, R., Wu, Y., Zhang, Z., Cong, H."Transfer RNA‑derived small RNAs: A class of potential biomarkers in multiple cancers (Review)". Oncology Letters 28, no. 1 (2024): 293. https://doi.org/10.3892/ol.2024.14427
Copy and paste a formatted citation
x
Spandidos Publications style
Mao C, Yuan W, Fang R, Wu Y, Zhang Z and Cong H: Transfer RNA‑derived small RNAs: A class of potential biomarkers in multiple cancers (Review). Oncol Lett 28: 293, 2024.
APA
Mao, C., Yuan, W., Fang, R., Wu, Y., Zhang, Z., & Cong, H. (2024). Transfer RNA‑derived small RNAs: A class of potential biomarkers in multiple cancers (Review). Oncology Letters, 28, 293. https://doi.org/10.3892/ol.2024.14427
MLA
Mao, C., Yuan, W., Fang, R., Wu, Y., Zhang, Z., Cong, H."Transfer RNA‑derived small RNAs: A class of potential biomarkers in multiple cancers (Review)". Oncology Letters 28.1 (2024): 293.
Chicago
Mao, C., Yuan, W., Fang, R., Wu, Y., Zhang, Z., Cong, H."Transfer RNA‑derived small RNAs: A class of potential biomarkers in multiple cancers (Review)". Oncology Letters 28, no. 1 (2024): 293. https://doi.org/10.3892/ol.2024.14427
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