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Construction of an immune-related gene prognostic model with experimental validation and analysis of immune cell infiltration in lung adenocarcinoma

  • Authors:
    • Jialei Yang
    • Chao Tang
    • Chengxia Li
    • Xuesen Li
    • Wenli Yang
  • View Affiliations / Copyright

    Affiliations: Institute for Cancer Medicine, School of Basic Medicine Sciences, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 297
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    Published online on: May 1, 2024
       https://doi.org/10.3892/ol.2024.14430
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Abstract

There is a correlation between tumors and immunity with the degree of immune cell infiltration in tumors being closely related to tumor growth and progression. Therefore, the present study identified immune‑related prognostic genes and evaluated the immune infiltration level in lung adenocarcinoma (LUAD). This study performed Kyoto Encyclopedia of Genes and Genomes, Gene Ontology, and Gene Set Enrichment Analysis (GSEA) enrichment analyses on differential immune‑associated genes. A risk model was created and validated using six immune‑related prognostic genes. Reverse transcription‑quantitative PCR was used to assess the prognostic gene expression in non‑small cell lung cancer cells. Immune cell infiltration in LUAD was analyzed using the CIBERSORT method. Single sample GSEA was used to compare Tumor Immune Dysfunction and Exclusion (TIDE) scores between high and low‑risk groups and to assess the activation of thirteen immune‑related pathways. Multifactor Cox proportional hazards model analysis identified six prognostic risk genes (S100A16, FURIN, FGF2, LGR4, TNFRSF11A and VIPR1) to construct a risk model. The survival and receiver operating characteristic curves indicated that patients with higher risk scores had lower overall survival rates. The expression levels of prognostic genes S100A16, FURIN, LGR4, TNFRSF11A and VIPR1 were significantly increased in LUAD. B cells naive, plasma cells, T cells CD4 memory activated, T cells follicular helper, T cells regulatory, NK cells activated, macrophages M1, macrophages M2, and Dendritic cells resting cells showed elevated expression in LUAD. The prognostic genes were differentially associated with individual immune cells. Immune‑related function scores, such as those for antigen presenting cell (APC) co‑stimulation, APC co‑inhibition, check‑point, Cytolytic‑activity, chemokine receptor, parainflammation, major histocompatibility complex‑class‑I, type‑I‑IFN‑reponse and T‑cell‑co‑inhibition, were higher in the high‑risk group compared with the low‑risk group. Furthermore, the TIDE score of the high‑risk group was significantly lower than the low‑risk group. This immune‑related gene prognostic model has the potential to predict the prognosis of LUAD patients, supporting the development of a personalized clinical diagnosis and treatment plan.
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View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Lahiri A, Maji A, Potdar PD, Singh N, Parikh P, Bisht B, Mukherjee A and Paul MK: Lung cancer immunotherapy: progress, pitfalls, and promises. Mol Cancer. 22:402023. View Article : Google Scholar : PubMed/NCBI

3 

Shi J, Hua X, Zhu B, Ravichandran S, Wang M, Nguyen C, Brodie SA, Palleschi A, Alloisio M, Pariscenti G, et al: Somatic genomics and clinical features of lung adenocarcinoma: A retrospective study. PLoS Med. 13:e10021622016. View Article : Google Scholar : PubMed/NCBI

4 

Ortega MA, Pekarek L, Navarro F, Fraile-Martínez O, García-Montero C, Álvarez-Mon MÁ, Diez-Pedrero R, Boyano-Adánez MDC, Guijarro LG, Barrena-Blázquez S, et al: Updated views in targeted therapy in the patient with non-small cell lung cancer. J Pers Med. 13:1672023. View Article : Google Scholar : PubMed/NCBI

5 

Byun J, Schwartz AG, Lusk C, Wenzlaff AS, de Andrade M, Mandal D, Gaba C, Yang P, You M, Kupert EY, et al: Genome-wide association study of familial lung cancer. Carcinogenesis. 39:1135–1140. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Schreiber RD, Old LJ and Smyth MJ: Cancer immunoediting: Integrating immunity's roles in cancer suppression and promotion. Science. 331:1565–1570. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Joyce JA and Fearon DT: T cell exclusion, immune privilege, and the tumor microenvironment. Science. 348:74–80. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Karasaki T, Nagayama K, Kuwano H, Nitadori JI, Sato M, Anraku M, Hosoi A, Matsushita H, Morishita Y, Kashiwabara K, et al: An immunogram for the cancer-immunity cycle: Towards personalized immunotherapy of lung cancer. J Thorac Oncol. 12:791–803. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Liede A, Hernandez RK, Wade SW, Bo R, Nussbaum NC, Ahern E, Dougall WC and Smyth MJ: An observational study of concomitant immunotherapies and denosumab in patients with advanced melanoma or lung cancer. Oncoimmunology. 7:e14803012018. View Article : Google Scholar : PubMed/NCBI

10 

Mahalingam P and Newsom-Davis T: Cancer immunotherapy and the management of side effects. Clin Med (Lond). 23:56–60. 2023. View Article : Google Scholar : PubMed/NCBI

11 

Luo W: Nasopharyngeal carcinoma ecology theory: Cancer as multidimensional spatiotemporal ‘unity of ecology and evolution’ pathological ecosystem. Theranostics. 13:1607–1631. 2023. View Article : Google Scholar : PubMed/NCBI

12 

Yang Y, Yu Y and Lu S: Effectiveness of PD-1/PD-L1 inhibitors in the treatment of lung cancer: Brightness and challenge. Sci China Life Sci. 63:1499–1514. 2020. View Article : Google Scholar : PubMed/NCBI

13 

Zhang S, Zeng Z, Liu Y, Huang J, Long J, Wang Y, Peng X, Hu Z and Ouyang Y: Prognostic landscape of tumor-infiltrating immune cells and immune-related genes in the tumor microenvironment of gastric cancer. Aging (Albany NY). 12:17958–17975. 2020. View Article : Google Scholar : PubMed/NCBI

14 

Jiang P, Gu S, Pan D, Fu J, Sahu A, Hu X, Li Z, Traugh N, Bu X, Li B, et al: Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response. Nat Med. 24:1550–1558. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Yu G, Wang LG, Han Y and He QY: clusterProfiler: An R package for comparing biological themes among gene clusters. OMICS. 16:284–287. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Heagerty PJ, Lumley T and Pepe MS: Time-dependent ROC curves for censored survival data and a diagnostic marker. Biometrics. 56:337–344. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Li S, Zhu R, Li D, Li N and Zhu X: Prognostic factors of oligometastatic non-small cell lung cancer: A meta-analysis. J Thorac Dis. 10:3701–3713. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Ortega MA, Navarro F, Pekarek L, Fraile-Martínez O, García-Montero C, Saez MA, Arroyo M, Monserrat J and Alvarez-Mon M: Exploring histopathological and serum biomarkers in lung adenocarcinoma: Clinical applications and translational opportunities (review). Int J Oncol. 61:1542022. View Article : Google Scholar : PubMed/NCBI

20 

Leduc C, Antoni D, Charloux A, Falcoz PE and Quoix E: Comorbidities in the management of patients with lung cancer. Eur Respir J. 49:16017212017. View Article : Google Scholar : PubMed/NCBI

21 

Fan T, Lu J, Niu D, Zhang Y, Wang B, Zhang B, Zhang Z, He X, Peng N, Li B, et al: Immune and non-immune cell subtypes identify novel targets for prognostic and therapeutic strategy: A study based on intratumoral heterogenicity analysis of multicenter scRNA-seq datasets in lung adenocarcinoma. Front Immunol. 13:10461212022. View Article : Google Scholar : PubMed/NCBI

22 

Airoldi I, Di Carlo E, Cocco C, Caci E, Cilli M, Sorrentino C, Sozzi G, Ferrini S, Rosini S, Bertolini G, et al: IL-12 can target human lung adenocarcinoma cells and normal bronchial epithelial cells surrounding tumor lesions. PLoS One. 4:e61192009. View Article : Google Scholar : PubMed/NCBI

23 

Huang Q, Duan L, Qian X, Fan J, Lv Z, Zhang X, Han J, Wu F, Guo M, Hu G, et al: IL-17 promotes angiogenic factors IL-6, IL-8, and Vegf production via Stat1 in lung adenocarcinoma. Sci Rep. 6:365512016. View Article : Google Scholar : PubMed/NCBI

24 

Suzuki K, Kadota K, Sima CS, Nitadori J, Rusch VW, Travis WD, Sadelain M and Adusumilli PS: Clinical impact of immune microenvironment in stage I lung adenocarcinoma: Tumor interleukin-12 receptor β2 (IL-12Rβ2), IL-7R, and stromal FoxP3/CD3 ratio are independent predictors of recurrence. J Clin Oncol. 31:490–498. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Domagala-Kulawik J, Kwiecien I, Pankowski J, Pasieka-Lis M, Wolosz D and Zielinski M: Elevated Foxp3/CD8 ratio in lung adenocarcinoma metastatic lymph nodes resected by transcervical extended mediastinal lymphadenectomy. Biomed Res Int. 2017:51850342017. View Article : Google Scholar : PubMed/NCBI

26 

Ma C, Li F, Wang Z and Luo H: A novel immune-related gene signature predicts prognosis of lung adenocarcinoma. Biomed Res Int. 2022:49958742022. View Article : Google Scholar : PubMed/NCBI

27 

Wu X, Zhu J, Liu W, Jin M, Xiong M and Hu K: A novel prognostic and predictive signature for lung adenocarcinoma derived from combined hypoxia and infiltrating immune cell-related genes in TCGA patients. Int J Gen Med. 14:10467–10481. 2021. View Article : Google Scholar : PubMed/NCBI

28 

Yang D, Ma X and Song P: A prognostic model of non small cell lung cancer based on TCGA and ImmPort databases. Sci Rep. 12:4372022. View Article : Google Scholar : PubMed/NCBI

29 

Sun L, Zhang Z, Yao Y, Li WY and Gu J: Analysis of expression differences of immune genes in non-small cell lung cancer based on TCGA and ImmPort data sets and the application of a prognostic model. Ann Transl Med. 8:5502020. View Article : Google Scholar : PubMed/NCBI

30 

Sun S, Guo W, Wang Z, Wang X, Zhang G, Zhang H, Li R, Gao Y, Qiu B, Tan F, et al: Development and validation of an immune-related prognostic signature in lung adenocarcinoma. Cancer Med. 9:5960–5975. 2020. View Article : Google Scholar : PubMed/NCBI

31 

Qi C, Ma J, Sun J, Wu X and Ding J: The role of molecular subtypes and immune infiltration characteristics based on disulfidptosis-associated genes in lung adenocarcinoma. Aging (Albany NY). 15:5075–5095. 2023.PubMed/NCBI

32 

Babini E, Bertini I, Borsi V, Calderone V, Hu X, Luchinat C and Parigi G: Structural characterization of human S100A16, a low-affinity calcium binder. J Biol Inorg Chem. 16:243–256. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Basnet S, Vallenari EM, Maharjan U, Sharma S, Schreurs O and Sapkota D: An update on S100A16 in human cancer. Biomolecules. 13:10702023. View Article : Google Scholar : PubMed/NCBI

34 

Chen D, Luo L and Liang C: Aberrant S100A16 expression might be an independent prognostic indicator of unfavorable survival in non-small cell lung adenocarcinoma. PLoS One. 13:e01974022018. View Article : Google Scholar : PubMed/NCBI

35 

Sun X, Wang T, Zhang C, Ning K, Guan ZR, Chen SX, Hong TT and Hua D: S100A16 is a prognostic marker for colorectal cancer. J Surg Oncol. 117:275–283. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Bassi DE, Mahloogi H, Al-Saleem L, Lopez De Cicco R, Ridge JA and Klein-Szanto AJ: Elevated furin expression in aggressive human head and neck tumors and tumor cell lines. Mol Carcinog. 31:224–232. 2001. View Article : Google Scholar : PubMed/NCBI

37 

Braun E and Sauter D: Furin-mediated protein processing in infectious diseases and cancer. Clin Transl Immunology. 8:e10732019. View Article : Google Scholar : PubMed/NCBI

38 

Babina IS and Turner NC: Advances and challenges in targeting FGFR signalling in cancer. Nat Rev Cancer. 17:318–332. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Im JH, Buzzelli JN, Jones K, Franchini F, Gordon-Weeks A, Markelc B, Chen J, Kim J, Cao Y and Muschel RJ: FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy. Nat Commun. 11:40642020. View Article : Google Scholar : PubMed/NCBI

40 

Gong X, Yi J, Carmon KS, Crumbley CA, Xiong W, Thomas A, Fan X, Guo S, An Z, Chang JT and Liu QJ: Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness. Oncogene. 34:4692–4701. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Luo J, Yang Z, Ma Y, Yue Z, Lin H, Qu G, Huang J, Dai W, Li C, Zheng C, et al: LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption. Nat Med. 22:539–546. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Glinka A, Dolde C, Kirsch N, Huang YL, Kazanskaya O, Ingelfinger D, Boutros M, Cruciat CM and Niehrs C: LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling. EMBO Rep. 12:1055–1061. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Ruffner H, Sprunger J, Charlat O, Leighton-Davies J, Grosshans B, Salathe A, Zietzling S, Beck V, Therier M, Isken A, et al: R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5. PLoS One. 7:e409762012. View Article : Google Scholar : PubMed/NCBI

44 

Ono T, Hayashi M, Sasaki F and Nakashima T: RANKL biology: Bone metabolism, the immune system, and beyond. Inflamm Regen. 40:22020. View Article : Google Scholar : PubMed/NCBI

45 

Shang WQ, Li H, Liu LB, Chang KK and Yu JJ, Xie F, Li MQ and Yu JJ: RANKL/RANK interaction promotes the growth of cervical cancer cells by strengthening the dialogue between cervical cancer cells and regulation of IL-8 secretion. Oncol Rep. 34:3007–3016. 2015. View Article : Google Scholar : PubMed/NCBI

46 

Szilasi M, Buglyo A, Treszl A, Kiss L, Schally AV and Halmos G: Gene expression of vasoactive intestinal peptide receptors in human lung cancer. Int J Oncol. 39:1019–1024. 2011.PubMed/NCBI

47 

Moody TW, Leyton J, Chan D, Brenneman DC, Fridkin M, Gelber E, Levy A and Gozes I: VIP receptor antagonists and chemotherapeutic drugs inhibit the growth of breast cancer cells. Breast Cancer Res Treat. 68:55–64. 2001. View Article : Google Scholar : PubMed/NCBI

48 

Yassin MA, Datiko DG, Tulloch O, Markos P, Aschalew M, Shargie EB, Dangisso MH, Komatsu R, Sahu S, Blok L, et al: Innovative community-based approaches doubled tuberculosis case notification and improve treatment outcome in Southern Ethiopia. PLoS One. 8:e631742013. View Article : Google Scholar : PubMed/NCBI

49 

Zhao L, Yu Z and Zhao B: Mechanism of VIPR1 gene regulating human lung adenocarcinoma H1299 cells. Med Oncol. 36:912019. View Article : Google Scholar : PubMed/NCBI

50 

Tong Z, Wang X, Liu H, Ding J, Chu Y and Zhou X: The relationship between tumor infiltrating immune cells and the prognosis of patients with lung adenocarcinoma. J Thorac Dis. 15:600–610. 2023. View Article : Google Scholar : PubMed/NCBI

51 

Aras S and Zaidi MR: TAMeless traitors: Macrophages in cancer progression and metastasis. Br J Cancer. 117:1583–1591. 2017. View Article : Google Scholar : PubMed/NCBI

52 

Wolf D, Sopper S, Pircher A, Gastl G and Wolf AM: Treg(s) in cancer: Friends or foe? J Cell Physiol. 230:2598–2605. 2015. View Article : Google Scholar : PubMed/NCBI

53 

Platonova S, Cherfils-Vicini J, Damotte D, Crozet L, Vieillard V, Validire P, André P, Dieu-Nosjean MC, Alifano M, Régnard JF, et al: Profound coordinated alterations of intratumoral NK cell phenotype and function in lung carcinoma. Cancer Res. 71:5412–5422. 2011. View Article : Google Scholar : PubMed/NCBI

54 

Yuan D, Koh CY and Wilder JA: Interactions between B lymphocytes and NK cells. FASEB J. 8:1012–1018. 1994. View Article : Google Scholar : PubMed/NCBI

55 

Garaud S, Buisseret L, Solinas C, Gu-Trantien C, de Wind A, Van den Eynden G, Naveaux C, Lodewyckx JN, Boisson A, Duvillier H, et al: Tumor infiltrating B-cells signal functional humoral immune responses in breast cancer. JCI Insight. 5:e1296412019. View Article : Google Scholar : PubMed/NCBI

56 

Tsou P, Katayama H, Ostrin EJ and Hanash SM: The emerging role of B cells in tumor immunity. Cancer Res. 76:5597–5601. 2016. View Article : Google Scholar : PubMed/NCBI

57 

Tian J, Fu C, Peng Q, Yang J, Fan X, Zeng X, Qing W and Wu Y: Construction of immune cell infiltration score model to assess prognostic ability of tumor immune environment in lung adenocarcinoma. Am J Transl Res. 15:1730–1743. 2023.PubMed/NCBI

58 

Chen C, Huang H and Wu CH: Protein bioinformatics databases and resources. Methods Mol Biol. 694:3–24. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang J, Tang C, Li C, Li X and Yang W: Construction of an immune-related gene prognostic model with experimental validation and analysis of immune cell infiltration in lung adenocarcinoma. Oncol Lett 28: 297, 2024.
APA
Yang, J., Tang, C., Li, C., Li, X., & Yang, W. (2024). Construction of an immune-related gene prognostic model with experimental validation and analysis of immune cell infiltration in lung adenocarcinoma. Oncology Letters, 28, 297. https://doi.org/10.3892/ol.2024.14430
MLA
Yang, J., Tang, C., Li, C., Li, X., Yang, W."Construction of an immune-related gene prognostic model with experimental validation and analysis of immune cell infiltration in lung adenocarcinoma". Oncology Letters 28.1 (2024): 297.
Chicago
Yang, J., Tang, C., Li, C., Li, X., Yang, W."Construction of an immune-related gene prognostic model with experimental validation and analysis of immune cell infiltration in lung adenocarcinoma". Oncology Letters 28, no. 1 (2024): 297. https://doi.org/10.3892/ol.2024.14430
Copy and paste a formatted citation
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Spandidos Publications style
Yang J, Tang C, Li C, Li X and Yang W: Construction of an immune-related gene prognostic model with experimental validation and analysis of immune cell infiltration in lung adenocarcinoma. Oncol Lett 28: 297, 2024.
APA
Yang, J., Tang, C., Li, C., Li, X., & Yang, W. (2024). Construction of an immune-related gene prognostic model with experimental validation and analysis of immune cell infiltration in lung adenocarcinoma. Oncology Letters, 28, 297. https://doi.org/10.3892/ol.2024.14430
MLA
Yang, J., Tang, C., Li, C., Li, X., Yang, W."Construction of an immune-related gene prognostic model with experimental validation and analysis of immune cell infiltration in lung adenocarcinoma". Oncology Letters 28.1 (2024): 297.
Chicago
Yang, J., Tang, C., Li, C., Li, X., Yang, W."Construction of an immune-related gene prognostic model with experimental validation and analysis of immune cell infiltration in lung adenocarcinoma". Oncology Letters 28, no. 1 (2024): 297. https://doi.org/10.3892/ol.2024.14430
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