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Investigating the efficacy of tissue factor pathway inhibitor‑2 as a promising prognostic marker for ovarian cancer

Corrigendum in: /10.3892/ol.2025.14978
  • Authors:
    • Tomoka Maehana
    • Ryuji Kawaguchi
    • Kyohei Nishikawa
    • Naoki Kawahara
    • Yuki Yamada
    • Fuminori Kimura
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Nara Medical University, Shijo, Kashihara, Nara 634‑8522, Japan
    Copyright: © Maehana et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 302
    |
    Published online on: May 8, 2024
       https://doi.org/10.3892/ol.2024.14435
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Abstract

Tissue factor pathway inhibitor‑2 (TFPI2) is a tumor marker for diagnosing ovarian cancer and ovarian clear cell carcinoma (OCCC); however, its effectiveness as a prognostic marker remains unclear. The present study aimed to investigate the utility of TFPI2 as a prognostic marker for ovarian cancer. A total of 256 cases of ovarian cancer was collected at Nara Medical University (Kashihara, Japan) from January 2008 to January 2022. The majority of cases were serous carcinoma (109, 42.6%), followed by OCCC (66, 25.8%), mucinous carcinoma (40, 15.6%), endometrial carcinoma (15, 5.9%), and other (26, 10.2%). The median preoperative serum TFPI2 for ovarian cancer was 219.0 (82.5‑5, 824.2) pg/ml. Overall survival (OS) of patients with non‑OCCC and OCCC was calculated using the cut‑off value determined obtained through receiver operating characteristic curve analysis. Cut‑off values of TFPI2 for OS were 201 for non‑OCCC and 255 pg/ml for OCCC. In univariate analysis, OS was significantly elevated in patients with non‑OCCC and OCCC who had TFPI2 levels ≥201 pg/ml (P<0.001) and ≥255 pg/ml (P=0.036), respectively. Progression‑free survival (PFS) was significantly elevated in patients with non‑OCCC and OCCC who had TFPI2 levels ≥201 and ≥255 pg/ml (both P<0.001), respectively. Multivariate analysis revealed that OS was significantly higher in patients with non‑OCCC who had TFPI2 levels ≥201 pg/ml (P=0.021), while PFS was significantly higher in patients with OCCC who had TFPI2 levels ≥255 pg/ml (P=0.020). These findings suggest that TFPI2 is a potential prognostic marker for ovarian carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Maehana T, Kawaguchi R, Nishikawa K, Kawahara N, Yamada Y and Kimura F: Investigating the efficacy of tissue factor pathway inhibitor‑2 as a promising prognostic marker for ovarian cancer Corrigendum in /10.3892/ol.2025.14978. Oncol Lett 28: 302, 2024.
APA
Maehana, T., Kawaguchi, R., Nishikawa, K., Kawahara, N., Yamada, Y., & Kimura, F. (2024). Investigating the efficacy of tissue factor pathway inhibitor‑2 as a promising prognostic marker for ovarian cancer Corrigendum in /10.3892/ol.2025.14978. Oncology Letters, 28, 302. https://doi.org/10.3892/ol.2024.14435
MLA
Maehana, T., Kawaguchi, R., Nishikawa, K., Kawahara, N., Yamada, Y., Kimura, F."Investigating the efficacy of tissue factor pathway inhibitor‑2 as a promising prognostic marker for ovarian cancer Corrigendum in /10.3892/ol.2025.14978". Oncology Letters 28.1 (2024): 302.
Chicago
Maehana, T., Kawaguchi, R., Nishikawa, K., Kawahara, N., Yamada, Y., Kimura, F."Investigating the efficacy of tissue factor pathway inhibitor‑2 as a promising prognostic marker for ovarian cancer Corrigendum in /10.3892/ol.2025.14978". Oncology Letters 28, no. 1 (2024): 302. https://doi.org/10.3892/ol.2024.14435
Copy and paste a formatted citation
x
Spandidos Publications style
Maehana T, Kawaguchi R, Nishikawa K, Kawahara N, Yamada Y and Kimura F: Investigating the efficacy of tissue factor pathway inhibitor‑2 as a promising prognostic marker for ovarian cancer Corrigendum in /10.3892/ol.2025.14978. Oncol Lett 28: 302, 2024.
APA
Maehana, T., Kawaguchi, R., Nishikawa, K., Kawahara, N., Yamada, Y., & Kimura, F. (2024). Investigating the efficacy of tissue factor pathway inhibitor‑2 as a promising prognostic marker for ovarian cancer Corrigendum in /10.3892/ol.2025.14978. Oncology Letters, 28, 302. https://doi.org/10.3892/ol.2024.14435
MLA
Maehana, T., Kawaguchi, R., Nishikawa, K., Kawahara, N., Yamada, Y., Kimura, F."Investigating the efficacy of tissue factor pathway inhibitor‑2 as a promising prognostic marker for ovarian cancer Corrigendum in /10.3892/ol.2025.14978". Oncology Letters 28.1 (2024): 302.
Chicago
Maehana, T., Kawaguchi, R., Nishikawa, K., Kawahara, N., Yamada, Y., Kimura, F."Investigating the efficacy of tissue factor pathway inhibitor‑2 as a promising prognostic marker for ovarian cancer Corrigendum in /10.3892/ol.2025.14978". Oncology Letters 28, no. 1 (2024): 302. https://doi.org/10.3892/ol.2024.14435
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