Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2024 Volume 28 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2024 Volume 28 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Oncogenic role of RNA-binding protein GNL2 in glioma: Promotion of tumor development through enhancing protein synthesis

  • Authors:
    • Xudong Yang
    • Xiangdong Li
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu 215008, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 307
    |
    Published online on: May 9, 2024
       https://doi.org/10.3892/ol.2024.14440
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

RNA‑binding proteins (RBPs) are aberrantly expressed in various diseases, including glioma. In the present study, the role and mechanism of RBPs in glioma were investigated. Differentially expressed genes (DEGs) in glioma were screened from public databases and overlapping genes between DEGs and RBPs were selected in a bioinformatics analysis to identify the hub gene. Next, evaluation of expression, survival analysis and cell experiments were performed to examine the impact of the hub gene on glioma. Through bioinformatics analysis, G protein nucleolar 2 (GNL2), programmed cell death 11 (PDCD11) and ribosomal protein S6 (RPS6) were identified as potential biomarkers in glioma prognosis and GNL2 was chosen as the hub gene for further investigation. GNL2 was increased in glioma tissues and related to poor survival outcomes. Cell experiments revealed that GNL2 knockdown inhibited glioma cell growth, migration and invasion. In addition, GNL2 was found to affect the overall protein synthesis of ribosomal protein L11 in glioma cells. In conclusion, GNL2, PDCD11 and RPS6 may serve as potential biomarkers in glioma prognosis. Importantly, GNL2 acts as an oncogene in glioma and it enhances protein synthesis to promote the development of brain glioma.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Elia-Pasquet S, Provost D, Jaffré A, Loiseau H, Vital A, Kantor G, Maire JP, Dautheribes M, Darrouzet V, Dartigues JF, et al: Incidence of central nervous system tumors in Gironde, France. Neuroepidemiology. 23:110–117. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Persano L, Rampazzo E, Basso G and Viola G: Glioblastoma cancer stem cells: Role of the microenvironment and therapeutic targeting. Biochem Pharmacol. 85:612–622. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Reddy AT and Wellons JC III: Pediatric high-grade gliomas. Cancer J. 9:107–112. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Perkins SM, Rubin JB, Leonard JR, Smyth MD, El Naqa I, Michalski JM, Simpson JR, Limbrick DL, Park TS and Mansur DB: Glioblastoma in children: A single-institution experience. Int J Radiat Oncol Biol Phys. 80:1117–1121. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Bălașa A, Șerban G, Chinezu R, Hurghiș C, Tămaș F and Manu D: The involvement of exosomes in glioblastoma development, diagnosis, prognosis, and treatment. Brain Sci. 10:5532020. View Article : Google Scholar : PubMed/NCBI

6 

Seymour T, Nowak A and Kakulas F: Targeting aggressive cancer stem cells in glioblastoma. Front Oncol. 5:1592015. View Article : Google Scholar : PubMed/NCBI

7 

Anji A and Kumari M: Guardian of genetic messenger-RNA-binding proteins. Biomolecules. 6:42016. View Article : Google Scholar : PubMed/NCBI

8 

Hentze MW, Castello A, Schwarzl T and Preiss T: A brave new world of RNA-binding proteins. Nat Rev Mol Cell Biol. 19:327–341. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Muleya V and Marondedze C: Functional roles of RNA-Binding Proteins in plant signaling. Life. 10:2882020. View Article : Google Scholar : PubMed/NCBI

10 

Idler RK and Yan W: Control of messenger RNA fate by RNA-binding proteins: An emphasis on mammalian spermatogenesis. J Androl. 33:309–337. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Li X, Zhang F, Ma J, Ruan X, Liu X, Zheng J, Liu Y, Cao S, Shen S, Shao L, et al: NCBP3/SNHG6 inhibits GBX2 transcription in a histone modification manner to facilitate the malignant biological behaviour of glioma cells. RNA Biol. 18:47–63. 2021. View Article : Google Scholar : PubMed/NCBI

12 

Gerstberger S, Hafner M and Tuschl T: A census of human RNA-binding proteins. Nat Rev Genet. 15:829–845. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 3:1101–1108. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Tailler M, Lindqvist LM, Gibson L and Adams JM: By reducing global mRNA translation in several ways, 2-deoxyglucose lowers MCL-1 protein and sensitizes hemopoietic tumor cells to BH3 mimetic ABT737. Cell Death Differ. 26:1766–1781. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Okuwaki M, Saito S, Hirawake-Mogi H and Nagata K: The interaction between nucleophosmin/NPM1 and the large ribosomal subunit precursors contribute to maintaining the nucleolar structure. Biochim Biophys Acta Mol Cell Res. 1868:1188792021. View Article : Google Scholar : PubMed/NCBI

16 

Yelland JN, Bravo JPK, Black JJ, Taylor DW and Johnson AW: A single 2′-O-methylation of ribosomal RNA gates assembly of a functional ribosome. Nat Struct Mol Biol. 30:91–98. 2023. View Article : Google Scholar : PubMed/NCBI

17 

Nakamura K, Reid BM, Chen A, Chen Z, Goode EL, Permuth JB, Teer JK, Tyrer J, Yu X, Kanetsky PA, et al: Functional analysis of the 1p34.3 risk locus implicates GNL2 in high-grade serous ovarian cancer. Am J Hum Genet. 109:116–135. 2022. View Article : Google Scholar : PubMed/NCBI

18 

Ostrom QT, Bauchet L, Davis FG, Deltour I, Fisher JL, Langer CE, Pekmezci M, Schwartzbaum JA, Turner MC, Walsh KM, et al: The epidemiology of glioma in adults: a ‘state of the science’ review. Neuro Oncol. 16:896–913. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Xiao H, Ding N, Liao H, Yao Z, Cheng X, Zhang J and Zhao M: Prediction of relapse and prognosis by expression levels of long noncoding RNA PEG10 in glioma patients. Medicine (Baltimore). 98:e175832019. View Article : Google Scholar : PubMed/NCBI

20 

Delgado-López P and Corrales-García E: Survival in glioblastoma: A review on the impact of treatment modalities. Clin Transl Oncol. 18:1062–1071. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Van Meir EG, Hadjipanayis CG, Norden AD, Shu HK, Wen PY and Olson JJ: Exciting new advances in neuro-oncology: The avenue to a cure for malignant glioma. CA Cancer J Clin. 60:166–193. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Wohlfart S, Khalansky AS, Gelperina S, Maksimenko O, Bernreuther C, Glatzel M and Kreuter J: Efficient chemotherapy of rat glioblastoma using doxorubicin-loaded PLGA nanoparticles with different stabilizers. PLoS One. 6:e191212011. View Article : Google Scholar : PubMed/NCBI

23 

Chow AKM, Yau SWL and Ng L: Novel molecular targets in hepatocellular carcinoma. World J Clin Oncol. 11:589–605. 2020. View Article : Google Scholar : PubMed/NCBI

24 

Chaillou T, Kirby TJ and McCarthy JJ: Ribosome biogenesis: Emerging evidence for a central role in the regulation of skeletal muscle mass. J Cell Physiol. 229:1584–1594. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Henras AK, Plisson-Chastang C, O'Donohue MF, Chakraborty A and Gleizes PE: An overview of pre-ribosomal RNA processing in eukaryotes. Wiley Interdiscip Rev RNA. 6:225–242. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Yoshida Y, Wang H, Hiwasa T, Machida T, Kobayashi E, Mine S, Tomiyoshi G, Nakamura R, Shinmen N, Kuroda H, et al: Elevation of autoantibody level against PDCD11 in patients with transient ischemic attack. Oncotarget. 9:8836–8848. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Eid W, Hess D, König C, Gentili C and Ferrari S: The human exonuclease-1 interactome and phosphorylation sites. Biochem Biophys Res Commun. 514:567–573. 2019. View Article : Google Scholar : PubMed/NCBI

28 

Xing Z, Wang R and Wang X, Liu J, Zhang M, Feng K and Wang X: CircRNA circ-PDCD11 promotes triple-negative breast cancer progression via enhancing aerobic glycolysis. Cell Death Discov. 7:2182021. View Article : Google Scholar : PubMed/NCBI

29 

Williams AJ, Werner-Fraczek J, Chang IF and Bailey-Serres J: Regulated phosphorylation of 40S ribosomal protein S6 in root tips of maize. Plant Physiol. 132:2086–2097. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Cuperjani F, Gashi L, Kurshumliu F, Dreshaj S and Selimi F: Relationship between ribosomal protein S6-pS240 expression and other prognostic factors in non-special type invasive breast cancer. Breast Care (Basel). 14:171–175. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Shirakawa Y, Ohta K, Miyake S, Kanemaru A, Kuwano A, Yonemaru K, Uchino S, Yamaoka M, Ito Y, Ito N, et al: Glioma cells acquire stem-like characters by extrinsic ribosome stimuli. Cells. 10:29702021. View Article : Google Scholar : PubMed/NCBI

32 

Mahmoud AB, Ajina R, Aref S, Darwish M, Alsayb M, Taher M, AlSharif SA, Hashem AM and Alkayyal AA: Advances in immunotherapy for glioblastoma multiforme. Front Immunol. 13:9444522022. View Article : Google Scholar : PubMed/NCBI

33 

Liau LM, Ashkan K, Brem S, Campian JL, Trusheim JE, Iwamoto FM, Tran DD, Ansstas G, Cobbs CS, Heth JA, et al: Association of autologous tumor lysate-loaded dendritic cell vaccination with extension of survival among patients with newly diagnosed and recurrent glioblastoma: A phase 3 prospective externally controlled cohort trial. JAMA Oncol. 9:112–121. 2023. View Article : Google Scholar : PubMed/NCBI

34 

Todo T, Ito H, Ino Y, Ohtsu H, Ota Y, Shibahara J and Tanaka M: Intratumoral oncolytic herpes virus G47 for residual or recurrent glioblastoma: A phase 2 trial. Nat Med. 28:1630–1639. 2022. View Article : Google Scholar : PubMed/NCBI

35 

Chen R, Smith-Cohn M, Cohen AL and Colman H: Glioma subclassifications and their clinical significance. Neurotherapeutics. 14:284–297. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Quiroga-Artigas G, de Jong D and Schnitzler CE: GNL3 is an evolutionarily-conserved stem cell gene influencing cell proliferation, animal growth, and regeneration in the hydrozoan Hydractinia. Open Biol. 12:2201202022. View Article : Google Scholar : PubMed/NCBI

37 

Dong Y, Cai Q, Fu L, Liu H, Ma M and Wu X: Study of the G protein nucleolar 2 value in liver hepatocellular carcinoma treatment and prognosis. Biomed Res Int. 2021:48736782021. View Article : Google Scholar : PubMed/NCBI

38 

Kang J, Brajanovski N, Chan KT, Xuan J, Pearson RB and Sanij E: Ribosomal proteins and human diseases: Molecular mechanisms and targeted therapy. Signal Transduct Target Ther. 6:3232021. View Article : Google Scholar : PubMed/NCBI

39 

Guo P, Wang Y, Dai C, Tao C, Wu F, Xie X, Yu H, Zhu Q, Li J, Ye L, et al: Ribosomal protein S15a promotes tumor angiogenesis via enhancing Wnt/β-catenin-induced FGF18 expression in hepatocellular carcinoma. Oncogene. 37:1220–1236. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Elhamamsy AR, Metge BJ, Alsheikh HA, Shevde LA and Samant RS: Ribosome biogenesis: A central player in cancer metastasis and therapeutic resistance. Cancer Res. 82:2344–2353. 2022. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang X and Li X: Oncogenic role of RNA-binding protein GNL2 in glioma: Promotion of tumor development through enhancing protein synthesis. Oncol Lett 28: 307, 2024.
APA
Yang, X., & Li, X. (2024). Oncogenic role of RNA-binding protein GNL2 in glioma: Promotion of tumor development through enhancing protein synthesis. Oncology Letters, 28, 307. https://doi.org/10.3892/ol.2024.14440
MLA
Yang, X., Li, X."Oncogenic role of RNA-binding protein GNL2 in glioma: Promotion of tumor development through enhancing protein synthesis". Oncology Letters 28.1 (2024): 307.
Chicago
Yang, X., Li, X."Oncogenic role of RNA-binding protein GNL2 in glioma: Promotion of tumor development through enhancing protein synthesis". Oncology Letters 28, no. 1 (2024): 307. https://doi.org/10.3892/ol.2024.14440
Copy and paste a formatted citation
x
Spandidos Publications style
Yang X and Li X: Oncogenic role of RNA-binding protein GNL2 in glioma: Promotion of tumor development through enhancing protein synthesis. Oncol Lett 28: 307, 2024.
APA
Yang, X., & Li, X. (2024). Oncogenic role of RNA-binding protein GNL2 in glioma: Promotion of tumor development through enhancing protein synthesis. Oncology Letters, 28, 307. https://doi.org/10.3892/ol.2024.14440
MLA
Yang, X., Li, X."Oncogenic role of RNA-binding protein GNL2 in glioma: Promotion of tumor development through enhancing protein synthesis". Oncology Letters 28.1 (2024): 307.
Chicago
Yang, X., Li, X."Oncogenic role of RNA-binding protein GNL2 in glioma: Promotion of tumor development through enhancing protein synthesis". Oncology Letters 28, no. 1 (2024): 307. https://doi.org/10.3892/ol.2024.14440
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team