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Case Report Open Access

Synchronous small cell neuroendocrine carcinoma of the cervix and immature ovarian teratoma: A case report and literature review

  • Authors:
    • Mingyu Xie
    • Yongsen Li
    • Hui Chen
    • Qingping Jiang
    • Hanzhen Xiong
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. China, Department of Pathology, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. China
    Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 313
    |
    Published online on: May 14, 2024
       https://doi.org/10.3892/ol.2024.14446
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Abstract

The onset of two synchronous primary malignancies of the female genital tract is uncommon; therefore, the simultaneous occurrence of cervical small cell neuroendocrine carcinoma and ovarian immature teratoma is rare. The present study describes the case of a woman with cervical small cell neuroendocrine carcinoma complicated by ovarian immature teratoma. The clinical manifestations, and the histopathological and immunophenotypic features of the patient are recorded. Furthermore, all PubMed‑indexed cases of synchronous primary malignancies in both the cervix and ovary have been briefly summarized.
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1 

Tong SY, Lee YS, Park JS, Bae SN, Lee JM and Namkoong SE: Clinical analysis of synchronous primary neoplasms of the female reproductive tract. Eur J Obstet Gynecol Reprod Biol. 136:78–82. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Coyte A, Morrison DS and McLoone P: Second primary cancer risk-the impact of applying different definitions of multiple primaries: Results from a retrospective population-based cancer registry study. BMC Cancer. 14:2722014. View Article : Google Scholar : PubMed/NCBI

3 

Meeks MW, Grace S, Chen Y, Petterchak J, Bolesta E, Zhou Y and Lai JP: Synchronous quadruple primary neoplasms: Colon adenocarcinoma, collision tumor of neuroendocrine tumor and schwann cell hamartoma and sessile serrated adenoma of the appendix. Anticancer Res. 36:4307–4311. 2016.PubMed/NCBI

4 

Saatli B, Yildirim N, Ozay AC, Koyuncuoglu M, Demirkan B and Saygili U: Synchronous tumors of the female genital tract: A 20-year experience in a single center. Ginekol Pol. 85:441–445. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Vogt A, Schmid S, Heinimann K, Frick H, Herrmann C, Cerny T and Omlin A: Multiple primary tumours: Challenges and approaches, a review. ESMO Open. 2:e0001722017. View Article : Google Scholar : PubMed/NCBI

6 

Biller LH, Syngal S and Yurgelun MB: Recent advances in Lynch syndrome. Fam Cancer. 18:211–219. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Tjalma WAA, Trinh XB, Rosenlund M, Makar AP, Kridelka F, Rosillon D, Van Dam PA, Collas De Souza S, Holl K, Simon P and Jenkins D: A cross-sectional, multicentre, epidemiological study on human papillomavirus (HPV) type distribution in adult women diagnosed with invasive cervical cancer in Belgium. Facts Views Vis Obgyn. 7:101–108. 2015.PubMed/NCBI

8 

Atienza-Amores M, Guerini-Rocco E, Soslow RA, Park KJ and Weigelt B: Small cell carcinoma of the gynecologic tract: A multifaceted spectrum of lesions. Gynecol Oncol. 134:410–418. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Huang YD, Hung YC, Yeh LS, Chiang IP, Zeng GC and Chang WC: Synchronous ovarian endometrioid adenocarcinoma and endocervical mucinous adenocarcinoma. Taiwan J Obstet Gynecol. 45:264–267. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Phupong V, Khemapech N and Triratanachat S: Triple synchronous primary cervical, endometrial and ovarian cancer with four different histologic patterns. Arch Gynecol Obstet. 276:655–658. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Pekin T, Yoruk P, Yildizhan R, Yildizhan B and Ramadan S: Three synchronized neoplasms of the female genital tract: An extraordinary presentation. Arch Gynecol Obstet. 276:541–545. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Kilciksiz S, Gokce T, Somali I, Uysal D, Baloglu A and Yigit S: A case with three different synchronous primaries of the female genital system and their treatment. J BUON. 12:291–293. 2007.PubMed/NCBI

13 

Saglam A, Bozdag G, Kuzey GM, Kucukali T and Ayhan A: Four synchronous female genital malignancies: The ovary, cervix, endometrium and fallopian tube. Arch Gynecol Obstet. 277:557–562. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Hale CS, Lee L and Mittal K: Triple synchronous primary gynecologic carcinomas: A case report and review of the literature. Int J Surg Pathol. 19:552–555. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Takatori E, Shoji T, Miura Y, Takeuchi S, Uesugi N and Sugiyama T: Triple simultaneous primary invasive gynecological malignancies: A case report. J Obstet Gynaecol Res. 40:627–631. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Chiofalo B, Di Giuseppe J, Alessandrini L, Perin T, Giorda G, Canzonieri V and Sopracordevole F: Triple synchronous invasive malignancies of the female genital tract in a patient with a history of leukemia: A case report and review of the literature. Pathol Res Pract. 212:573–577. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Abu-Zaid A, Alsabban M, Abuzaid M, Alomar O, Salem H and Al-Badawi IA: Triple synchronous primary neoplasms of the cervix, endometrium, and ovary: A rare case report and summary of all the english pubmed-indexed literature. Case Rep Obstet Gynecol. 2017:97050782017.PubMed/NCBI

18 

Wang DD and Yang Q: Synchronous quadruple primary malignancies of the cervix, endometrium, ovary, and stomach in a single patient: A case report and review of literature. World J Clin Cases. 7:3364–3371. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Bacalbasa N, Balescu IC, Diaconu C, Dima S, Iliescu L, Vilcu M, Filipescu A, Halmaciu I, Cretoiu D and Brezean I: Synchronous cervical adenocarcinoma and ovarian serous adenocarcinoma-a case report and literature review. Medicina (Kaunas). 56:1522020. View Article : Google Scholar : PubMed/NCBI

20 

Mishra P, Sasmal PK, Jena SK, Senapati S and Patra S: Pure primary ovarian carcinoid tumor with carcinoid syndrome and cervical carcinoma: A rare concoction of dual primary malignancies. Indian J Pathol Microbiol. 64:563–567. 2021. View Article : Google Scholar : PubMed/NCBI

21 

Kuriakose S, Umadevi N, Mathew S, Supriya N, Aravindan K, Smitha D and Amritha Malini G: Neuroendocrine carcinoma of the cervix presenting as intractable hyponatremic seizures due to paraneoplastic SIADH-a rare case report and brief review of the literature. Ecancermedicalscience. 8:4502014.PubMed/NCBI

22 

Wang M, Vasey Q, Varikatt W and Mclean M: Ectopic insulin secretion by a large-cell neuroendocrine carcinoma of the cervix. Clin Case Rep. 9:482–486. 2020. View Article : Google Scholar : PubMed/NCBI

23 

Singh R, Bibbo M, Cunnane MF, Carlson JA and de Papp AE: Metastatic cervical carcinoma with ectopic calcitonin production presenting as a thyroid mass. Endocr Pract. 8:50–53. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Hausken J, Haave EM, Haugaa H, Løberg EM and Kongsgaard UE: A patient with solid gynecologic cancer causing lactic acidosis, severe hypercalcemia, and hypoglycemia. Clin Case Rep. 7:64–70. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Boussios S, Attygalle A, Hazell S, Moschetta M, McLachlan J, Okines A and Banerjee S: Malignant ovarian germ cell tumors in postmenopausal patients: The royal marsden experience and literature review. Anticancer Res. 35:6713–6722. 2015.PubMed/NCBI

26 

Parrington JM, West LF and Povey S: The origin of ovarian teratomas. J Med Genet. 21:4–12. 1984. View Article : Google Scholar : PubMed/NCBI

27 

Snir OL, DeJoseph M, Wong S, Buza N and Hui P: Frequent homozygosity in both mature and immature ovarian teratomas: A shared genetic basis of tumorigenesis. Mod Pathol. 30:1467–1475. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Abu-Rustum NR, Yashar CM, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Crispens MA, et al: NCCN guidelines® insights: Cervical cancer, version 1.2024. J Natl Compr Canc Netw. 21:1224–1233. 2023. View Article : Google Scholar : PubMed/NCBI

29 

Cohen JG, Kapp DS, Shin JY, Urban R, Sherman AE, Chen LM, Osann K and Chan JK: Small cell carcinoma of the cervix: Treatment and survival outcomes of 188 patients. Am J Obstet Gynecol. 203:341–347.e1-e6. 2010. View Article : Google Scholar

30 

Li P, Ma J, Zhang X, Guo Y, Liu Y, Li X, Zhao D and Wang Z: Cervical small cell carcinoma frequently presented in multiple high risk HPV infection and often associated with other type of epithelial tumors. Diagn Pathol. 13:312018. View Article : Google Scholar : PubMed/NCBI

31 

Linder D, McCaw BK and Hecht F: Parthenogenic origin of benign ovarian teratomas. N Engl J Med. 292:63–66. 1975. View Article : Google Scholar : PubMed/NCBI

32 

Nomura K, Ohama K, Okamoto E and Fujiwara A: Cytogenetic studies of multiple ovarian dermoid cysts in a single host. Nihon Sanka Fujinka Gakkai Zasshi. 35:1938–1944. 1983.(In Japanese). PubMed/NCBI

33 

Wang WC and Lai YC: Genetic analysis results of mature cystic teratomas of the ovary in Taiwan disagree with the previous origin theory of this tumor. Hum Pathol. 52:128–135. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Poulos C, Cheng L, Zhang S, Gersell DJ and Ulbright TM: Analysis of ovarian teratomas for isochromosome 12p: Evidence supporting a dual histogenetic pathway for teratomatous elements. Mod Pathol. 19:766–771. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Kraggerud SM, Hoei-Hansen CE, Alagaratnam S, Skotheim RI, Abeler VM, Rajpert-De Meyts E and Lothe RA: Molecular characteristics of malignant ovarian germ cell tumors and comparison with testicular counterparts: Implications for pathogenesis. Endocr Rev. 34:339–376. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Faure-Conter C and Pashankar F: Immature ovarian teratoma: When to give adjuvant therapy? J Pediatr Hematol Oncol. 39:487–489. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xie M, Li Y, Chen H, Jiang Q and Xiong H: Synchronous small cell neuroendocrine carcinoma of the cervix and immature ovarian teratoma: A case report and literature review. Oncol Lett 28: 313, 2024.
APA
Xie, M., Li, Y., Chen, H., Jiang, Q., & Xiong, H. (2024). Synchronous small cell neuroendocrine carcinoma of the cervix and immature ovarian teratoma: A case report and literature review. Oncology Letters, 28, 313. https://doi.org/10.3892/ol.2024.14446
MLA
Xie, M., Li, Y., Chen, H., Jiang, Q., Xiong, H."Synchronous small cell neuroendocrine carcinoma of the cervix and immature ovarian teratoma: A case report and literature review". Oncology Letters 28.1 (2024): 313.
Chicago
Xie, M., Li, Y., Chen, H., Jiang, Q., Xiong, H."Synchronous small cell neuroendocrine carcinoma of the cervix and immature ovarian teratoma: A case report and literature review". Oncology Letters 28, no. 1 (2024): 313. https://doi.org/10.3892/ol.2024.14446
Copy and paste a formatted citation
x
Spandidos Publications style
Xie M, Li Y, Chen H, Jiang Q and Xiong H: Synchronous small cell neuroendocrine carcinoma of the cervix and immature ovarian teratoma: A case report and literature review. Oncol Lett 28: 313, 2024.
APA
Xie, M., Li, Y., Chen, H., Jiang, Q., & Xiong, H. (2024). Synchronous small cell neuroendocrine carcinoma of the cervix and immature ovarian teratoma: A case report and literature review. Oncology Letters, 28, 313. https://doi.org/10.3892/ol.2024.14446
MLA
Xie, M., Li, Y., Chen, H., Jiang, Q., Xiong, H."Synchronous small cell neuroendocrine carcinoma of the cervix and immature ovarian teratoma: A case report and literature review". Oncology Letters 28.1 (2024): 313.
Chicago
Xie, M., Li, Y., Chen, H., Jiang, Q., Xiong, H."Synchronous small cell neuroendocrine carcinoma of the cervix and immature ovarian teratoma: A case report and literature review". Oncology Letters 28, no. 1 (2024): 313. https://doi.org/10.3892/ol.2024.14446
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