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Artesunate promotes cervical cancer cell apoptosis by regulating Bcl2 family molecules and reducing the mitochondrial membrane potential

  • Authors:
    • Qianying Zhang
    • Xing Li
    • Caiyi He
    • Rongmiao Zhou
    • Jing Wang
    • Liang Liu
  • View Affiliations / Copyright

    Affiliations: Department of Gynaecological Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Department of Flow Cytometry, Tumour Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Department of Molecular Biology, Tumour Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 315
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    Published online on: May 14, 2024
       https://doi.org/10.3892/ol.2024.14447
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Abstract

Artesunate (ART), an antimalarial drug, has a broad spectrum of antitumour effects in cancer types such as esophageal and gastric cancer. However, evidence demonstrating the role of ART in cervical cancer cells is limited. In the present study, the inhibitory effect of ART on the growth of cervical cancer cells through the modulation of the cell cycle and apoptosis was investigated. The growth‑inhibitory effect of ART on a cervical cancer cell line (SiHa) was detected using a Cell Counting Kit‑8 assay after treatment with ART for 24 h, after which the half‑maximal inhibitory concentration (IC50) was calculated. Using flow cytometry assays, apoptosis, the cell cycle, the levels of reactive oxygen species (ROS) and calcium (Ca2+) ions, as well as the mitochondrial membrane potential were evaluated in SiHa cells following treatment with ART for 24 and 48 h. The mRNA expression levels of Bcl2, Bcl‑xl, (myeloid cell leukaemia 1) Mcl‑1, Bcl2‑like protein 11 (BIM), (Bcl2‑related ovarian killer protein) Bok, Bax and (Bcl2 homologous antagonist/killer) Bak in SiHa cells were detected using reverse transcription‑quantitative PCR. ART inhibited the growth of SiHa cells in a dose‑dependent manner. The IC50 of ART in SiHa cells was 26.32 µg/ml. According to the IC50 value, 15, 30 and 100 µg/ml ART were selected for further experiments, and normal saline (0 µg/ml ART) was used as the control group. The results indicated that treatment with 15, 30 and 100 µg/ml ART for 24 and 48 h induced apoptosis, increased the levels of ROS, the levels of Ca2+ and the mRNA expression levels of BIM, Bok, Bax and Bak, but decreased the cell proliferation indices, the mitochondrial membrane potential and the mRNA expression levels of Bcl2, Bcl‑xl and Mcl‑1 in a dose‑ and time‑dependent manner. In conclusion, ART inhibited the growth of SiHa cells and induced apoptosis via a mechanism associated with the regulation of Bcl2 family member expression, which was associated with the increase of the levels of ROS and Ca2+ and the reduction of the mitochondrial membrane potential.
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View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global Cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Gu XY, Zheng RS, Sun KX, Zhang SW, Zeng HM, Zou XN, Chen WQ and He J: Incidence and mortality of cervical cancer in China, 2014. Zhonghua Zhong Liu Za Zhi. 40:241–246. 2018.(In Chinese). PubMed/NCBI

3 

Kaidar-Person O, Bortnyak-Abdah R, Amit A, Berniger A, Ben-Yosef R and Kuten A: Current principles for radiotherapy in cervical cancer. Med Oncol. 29:2919–2922. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Sharma S, Deep A and Sharma AK: Current treatment for cervical cancer: An update. Anticancer Agents Med Chem. 20:1768–1779. 2020. View Article : Google Scholar : PubMed/NCBI

5 

Diaz-Padilla I, Monk BJ, Mackay HJ and Oaknin A: Treatment of metastatic cervical cancer: Future directions involving targeted agents. Crit Rev Oncol Hematol. 85:303–314. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Lefèvre A and Léonard P: Artesunate and severe malaria in paediatrics. Rev Med Liege. 74:503–507. 2019.PubMed/NCBI

7 

Abanyie F, Acharya SD, Leavy I, Bowe M and Tan KR: Safety and effectiveness of intravenous artesunate for treatment of severe malaria in the united States-April 2019 through december 2020. Clin Infect Dis. 73:1965–1972. 2021. View Article : Google Scholar : PubMed/NCBI

8 

Roussel C, Ndour PA, Kendjo E, Larréché S, Taieb A, Henry B, Lebrun-Vignes B, Chambrion C, Argy N, Houzé S, et al: Intravenous artesunate for the treatment of severe imported malaria: Implementation, efficacy, and safety in 1391 patients. Clin Infect Dis. 73:1795–1804. 2021. View Article : Google Scholar : PubMed/NCBI

9 

Tsuda K, Miyamoto L, Hamano S, Morimoto Y, Kangawa Y, Fukue C, Kagawa Y, Horinouchi Y, Xu W, Ikeda Y, et al: Mechanisms of the pH- and Oxygen-dependent oxidation activities of artesunate. Biol Pharmaceutical Bull. 41:555–563. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Li T, Chen H, Liu XG, Zhou YX and Bai SF: Immunoregulatory effect of artesunate on allergic contact dermatitis and its mechanism. Yao Xue Xue Bao. 47:884–889. 2012.PubMed/NCBI

11 

Meng QF, Zhang XX, Zhang Z, Chen W, Li XL, Wang YJ, Li FF and Li YB: Therapeutic potential of artesunate in experimental autoimmune myasthenia gravis by upregulated T regulatory cells and regulation of Th1/Th2 cytokines. Pharmazie. 73:526–532. 2018.PubMed/NCBI

12 

Wang N, Zeng GZ, Yin JL and Bian ZX: Artesunate activates the ATF4-CHOP-CHAC1 pathway and affects ferroptosis in Burkitt's Lymphoma. Biochem Biophys Res Commun. 519:533–539. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Jiang F, Zhou JY, Zhang D, Liu MH and Chen YG: Artesunate induces apoptosis and autophagy in HCT116 colon cancer cells, and autophagy inhibition enhances the artesunate-induced apoptosis. Int J Mol Med. 42:1295–1304. 2018.PubMed/NCBI

14 

Zhao F, Vakhrusheva O, Markowitsch SD, Slade KS, Tsaur I, Cinatl J Jr, Michaelis M, Efferth T, Haferkamp A and Juengel E: Artesunate impairs growth in cisplatin-resistant bladder cancer cells by cell cycle arrest, apoptosis and autophagy induction. Cells. 9:26432020. View Article : Google Scholar : PubMed/NCBI

15 

Chen S, Gan S, Han L, Li X, Xie X, Zou D and Sun H: Artesunate induces apoptosis and inhibits the proliferation, stemness, and tumorigenesis of leukemia. Ann Transl Med. 8:7672020. View Article : Google Scholar : PubMed/NCBI

16 

Våtsveen TK, Myhre MR, Steen CB, Wälchli S, Lingjærde OC, Bai B, Dillard P, Theodossiou TA, Holien T, Sundan A, et al: Artesunate shows potent anti-tumor activity in B-cell lymphoma. J Hematol Oncol. 11:232018. View Article : Google Scholar : PubMed/NCBI

17 

Yin X, Liu Y, Qin J, Wu Y, Huang J, Zhao Q, Dang T, Tian Y, Yu P and Huang X: Artesunate suppresses the proliferation and development of estrogen receptor-α-Positive endometrial cancer in HAND2-Dependent pathway. Front Cell Dev Biol. 8:6069692020. View Article : Google Scholar : PubMed/NCBI

18 

Mancuso RI, Foglio MA and Olalla Saad ST: Artemisinin-type drugs for the treatment of hematological malignancies. Cancer Chemother Pharmacol. 87:1–22. 2021. View Article : Google Scholar : PubMed/NCBI

19 

Liu L, Zuo LF, Zuo J and Wang J: Artesunate induces apoptosis and inhibits growth of Eca109 and Ec9706 human esophageal cancer cell lines in vitro and in vivo. Mol Med Rep. 12:1465–1472. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Wang L, Liu L, Wang J and Chen Y: Inhibitory effect of artesunate on growth and apoptosis of gastric cancer cells. Arch Med Res. 48:623–630. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Saeed MEM, Cives-Losada C and Efferth T: Biomarker expression profiling in cervix carcinoma biopsies unravels WT1 as a target of artesunate. Cancer Genomics Proteomics. 19:727–739. 2022. View Article : Google Scholar : PubMed/NCBI

22 

Liu L, Ju Y, Wang J and Zhou R: Epigallocatechin-3-gallate promotes apoptosis and reversal of multidrug resistance in esophageal cancer cells. Pathol Res Pract. 213:1242–1250. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Kriváková P, Cervinková Z, Lotková H, Kucera O and Rousar T: Mitochondria and their role in cell metabolism. Acta Medica (Hradec Kralove) Suppl. 48:57–67. 2005.(In Czech). PubMed/NCBI

24 

Estaquier J, Vallette F, Vayssiere JL and Mignotte B: The mitochondrial pathways of apoptosis. Adv Exp Med Biol. 942:157–183. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Lopez J and Tait SW: Mitochondrial apoptosis: Killing cancer using the enemy within. Br J Cancer. 112:957–962. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Jeong SY and Seol DW: The role of mitochondria in apoptosis. BMB Rep. 41:11–22. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Kaloni D, Diepstraten ST, Strasser A and Kelly GL: BCL-2 protein family: Attractive targets for cancer therapy. Apoptosis. 28:20–38. 2023. View Article : Google Scholar : PubMed/NCBI

28 

Kashyap D, Garg VK and Goel N: Intrinsic and extrinsic pathways of apoptosis: Role in cancer development and prognosis. Adv Protein Chem Struct Biol. 125:73–120. 2021. View Article : Google Scholar : PubMed/NCBI

29 

Liu Y, Ju Y, Liu J, Chen Y, Huo X and Liu L: Inhibition of proliferation and migration and induction of apoptosis in glioma cells by silencing TLR4 expression levels via RNA interference. Oncol Lett. 21:132021.PubMed/NCBI

30 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Warren CFA, Wong-Brown MW and Bowden NA: BCL-2 family isoforms in apoptosis and cancer. Cell Death Dis. 10:1772019. View Article : Google Scholar : PubMed/NCBI

32 

Hafezi S and Rahmani M: Targeting BCL-2 in cancer: Advances, challenges, and perspectives. Cancers (Basel). 13:12922021. View Article : Google Scholar : PubMed/NCBI

33 

Wen L, Lv G, Zhao J, Lu S, Gong Y, Li Y, Zheng H, Chen B, Gao H, Tian C and Wang J: In vitro and in vivo effects of artesunate on echinococcus granulosus protoscoleces and metacestodes. Drug Des Devel Ther. 14:4685–4694. 2020. View Article : Google Scholar : PubMed/NCBI

34 

Li Q, Ni W, Deng Z, Liu M, She L and Xie Q: Targeting nasopharyngeal carcinoma by artesunate through inhibiting Akt/mTOR and inducing oxidative stress. Fundam Clin Pharmacol. 31:301–310. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Abate M, Festa A, Falco M, Lombardi A, Luce A, Grimaldi A, Zappavigna S, Sperlongano P, Irace C, Caraglia M and Misso G: Mitochondria as playmakers of apoptosis, autophagy and senescence. Semin Cell Dev Bio. 98:139–153. 2020. View Article : Google Scholar : PubMed/NCBI

36 

Li J, Cui J, Li Z, Fu X, Li J, Li H, Wang S and Zhang M: ORP8 induces apoptosis by releasing cytochrome c from mitochondria in non-small cell lung cancer. Oncol Rep. 43:1516–1524. 2020.PubMed/NCBI

37 

Wang W, Zhu M, Xu Z, Li W, Dong X, Chen Y, Lin B and Li M: Ropivacaine promotes apoptosis of hepatocellular carcinoma cells through damaging mitochondria and activating caspase-3 activity. Biol Res. 52:362019. View Article : Google Scholar : PubMed/NCBI

38 

Zhou X, Chen Y, Wang F, Wu H, Zhang Y, Liu J, Cai Y, Huang S, He N, Hu Z and Jin X: Artesunate induces autophagy dependent apoptosis through upregulating ROS and activating AMPK-mTOR-ULK1 axis in human bladder cancer cells. Chem Biol Interact. 331:1092732020. View Article : Google Scholar : PubMed/NCBI

39 

Ji P, Huang H, Yuan S, Wang L, Wang S, Chen Y, Feng N, Veroniaina H, Wu Z, Wu Z and Qi X: ROS-mediated apoptosis and anticancer effect achieved by artesunate and auxiliary fe(II) released from ferriferous Oxide-Containing recombinant apoferritin. Adv Healthc Mater. 8:e19009112019. View Article : Google Scholar : PubMed/NCBI

40 

Greenshields AL, Fernando W and Hoskin DW: The anti-malarial drug artesunate causes cell cycle arrest and apoptosis of triple-negative MDA-MB-468 and HER2-enriched SK-BR-3 breast cancer cells. Exp Mol Pathol. 107:10–22. 2019. View Article : Google Scholar : PubMed/NCBI

41 

Huang Z, Gan S, Zhuang X, Chen Y, Lu L, Wang Y, Qi X, Feng Q, Huang Q, Du B, et al: Artesunate Inhibits the cell growth in colorectal cancer by promoting ROS-Dependent cell senescence and autophagy. Cells. 11:24722022. View Article : Google Scholar : PubMed/NCBI

42 

Qian S, Wei Z, Yang W, Huang J, Yang Y and Wang J: The role of BCL-2 family proteins in regulating apoptosis and cancer therapy. Front Oncol. 12:9853632022. View Article : Google Scholar : PubMed/NCBI

43 

Holien T, Olsen OE, Misund K, Hella H, Waage A, Rø TB and Sundan A: Lymphoma and myeloma cells are highly sensitive to growth arrest and apoptosis induced by artesunate. Eur J Haematol. 91:339–346. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Cao D, Chen D, Xia JN, Wang WY, Zhu GY, Chen LW, Zhang C, Tan B, Li H and Li YW: Artesunate promoted anti-tumor immunity and overcame EGFR-TKI resistance in non-small-cell lung cancer by enhancing oncogenic TAZ degradation. Biomed Pharmacothe. 155:1137052022. View Article : Google Scholar : PubMed/NCBI

45 

Li ZJ, Dai HQ, Huang XW, Feng J, Deng JH, Wang ZX, Yang XM, Liu YJ, Wu Y, Chen PH, et al: Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma. Acta Pharmacol Sin. 42:301–310. 2021. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Q, Li X, He C, Zhou R, Wang J and Liu L: Artesunate promotes cervical cancer cell apoptosis by regulating Bcl2 family molecules and reducing the mitochondrial membrane potential. Oncol Lett 28: 315, 2024.
APA
Zhang, Q., Li, X., He, C., Zhou, R., Wang, J., & Liu, L. (2024). Artesunate promotes cervical cancer cell apoptosis by regulating Bcl2 family molecules and reducing the mitochondrial membrane potential. Oncology Letters, 28, 315. https://doi.org/10.3892/ol.2024.14447
MLA
Zhang, Q., Li, X., He, C., Zhou, R., Wang, J., Liu, L."Artesunate promotes cervical cancer cell apoptosis by regulating Bcl2 family molecules and reducing the mitochondrial membrane potential". Oncology Letters 28.1 (2024): 315.
Chicago
Zhang, Q., Li, X., He, C., Zhou, R., Wang, J., Liu, L."Artesunate promotes cervical cancer cell apoptosis by regulating Bcl2 family molecules and reducing the mitochondrial membrane potential". Oncology Letters 28, no. 1 (2024): 315. https://doi.org/10.3892/ol.2024.14447
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Q, Li X, He C, Zhou R, Wang J and Liu L: Artesunate promotes cervical cancer cell apoptosis by regulating Bcl2 family molecules and reducing the mitochondrial membrane potential. Oncol Lett 28: 315, 2024.
APA
Zhang, Q., Li, X., He, C., Zhou, R., Wang, J., & Liu, L. (2024). Artesunate promotes cervical cancer cell apoptosis by regulating Bcl2 family molecules and reducing the mitochondrial membrane potential. Oncology Letters, 28, 315. https://doi.org/10.3892/ol.2024.14447
MLA
Zhang, Q., Li, X., He, C., Zhou, R., Wang, J., Liu, L."Artesunate promotes cervical cancer cell apoptosis by regulating Bcl2 family molecules and reducing the mitochondrial membrane potential". Oncology Letters 28.1 (2024): 315.
Chicago
Zhang, Q., Li, X., He, C., Zhou, R., Wang, J., Liu, L."Artesunate promotes cervical cancer cell apoptosis by regulating Bcl2 family molecules and reducing the mitochondrial membrane potential". Oncology Letters 28, no. 1 (2024): 315. https://doi.org/10.3892/ol.2024.14447
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