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Panoramic RNA expression of fibroblast growth factors in human glioblastoma tissues and the impact on the survival of patients

  • Authors:
    • Kun Zhao
    • Jiakun Xu
    • Beichuan Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The First Affiliated Hospital of Sun Yat‑sen University, Guangzhou, Guangdong 510080, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 317
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    Published online on: May 14, 2024
       https://doi.org/10.3892/ol.2024.14450
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Abstract

Fibroblast growth factors (FGFs) have a key role in various critical steps of tumor growth and progression through effects on angiogenesis, inflammation and the growth and invasion of malignant cells. Nevertheless, the role of the FGF family in human glioblastoma (GBM) has been rarely studied. The objective of the present study was to assess the RNA expression of all FGF family members in tissues obtained from patients with GBM and to analyze the association between FGF expression and the survival of these patients. For this, the RNA expression of FGF family members in the malignant and proximal tissues of 12 patients with GBM was determined by analyzing high‑throughput RNA transcriptome sequencing data uploaded to the National Center for Biotechnology Information database. The relationship between FGF genes and the survival of patients with GBM and glioma was also respectively studied by analyzing data from The Cancer Genome Atlas database using the Gene Expression Profiling Interactive Analysis tool. The results showed that the expression of FGF1, FGF17, FGF20 and FGF22 in GBM tissues was lower than that in adjacent tissues, with a difference of >2 times. Analysis of the overall survival of patients with GBM indicated there were no significant relationships between the expression of FGF1, FGF17, FGF20, FGF22 and overall survival. Analysis of the overall survival of patients with glioma showed that glioma patients with low FGF1 expression achieved a longer survival time than patients with high FGF1 expression; however, high expression of FGF17 and FGF22 indicated a longer survival time. In summary, the results of the present study demonstrated the panoramic expression of FGF family members in patients with GBM, and indicated that FGF1, FGF17 and FGF22 did not affect the survival of patients with GBM, but had a notable influence on the survival of patients with glioma.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao K, Xu J and Zhao B: Panoramic RNA expression of fibroblast growth factors in human glioblastoma tissues and the impact on the survival of patients. Oncol Lett 28: 317, 2024.
APA
Zhao, K., Xu, J., & Zhao, B. (2024). Panoramic RNA expression of fibroblast growth factors in human glioblastoma tissues and the impact on the survival of patients. Oncology Letters, 28, 317. https://doi.org/10.3892/ol.2024.14450
MLA
Zhao, K., Xu, J., Zhao, B."Panoramic RNA expression of fibroblast growth factors in human glioblastoma tissues and the impact on the survival of patients". Oncology Letters 28.1 (2024): 317.
Chicago
Zhao, K., Xu, J., Zhao, B."Panoramic RNA expression of fibroblast growth factors in human glioblastoma tissues and the impact on the survival of patients". Oncology Letters 28, no. 1 (2024): 317. https://doi.org/10.3892/ol.2024.14450
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao K, Xu J and Zhao B: Panoramic RNA expression of fibroblast growth factors in human glioblastoma tissues and the impact on the survival of patients. Oncol Lett 28: 317, 2024.
APA
Zhao, K., Xu, J., & Zhao, B. (2024). Panoramic RNA expression of fibroblast growth factors in human glioblastoma tissues and the impact on the survival of patients. Oncology Letters, 28, 317. https://doi.org/10.3892/ol.2024.14450
MLA
Zhao, K., Xu, J., Zhao, B."Panoramic RNA expression of fibroblast growth factors in human glioblastoma tissues and the impact on the survival of patients". Oncology Letters 28.1 (2024): 317.
Chicago
Zhao, K., Xu, J., Zhao, B."Panoramic RNA expression of fibroblast growth factors in human glioblastoma tissues and the impact on the survival of patients". Oncology Letters 28, no. 1 (2024): 317. https://doi.org/10.3892/ol.2024.14450
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