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Prognostic value and drug sensitivity of F‑box and leucine‑rich repeat protein 6 in glioma

  • Authors:
    • Qingyuan Lin
    • Jinchao Zhu
    • Weiyao Zhu
    • Honglin Zhu
    • Meijun Li
    • Jiaqi Zhao
    • Shouqiang Jia
    • Shengdong Nie
  • View Affiliations / Copyright

    Affiliations: School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, P.R. China, Department of Pathology, The Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China, Department of Ultrasound, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200000, P.R. China, Department of Imaging, Jinan People's Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250102, P.R. China
    Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 320
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    Published online on: May 14, 2024
       https://doi.org/10.3892/ol.2024.14453
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Abstract

Gliomas are highly malignant and invasive tumors lacking clear boundaries. Previous bioinformatics and experimental analyses have indicated that F‑box and leucine‑rich repeat protein 6 (FBXL6), a protein crucial for the cell cycle and tumorigenesis, is highly expressed in certain types of tumors. The high expression level of FBXL6 is reported to promote tumor growth and adversely affect patient survival. However, the molecular mechanism, prognostic value and drug sensitivity of FBXL6 in glioma remain unclear. To address this, the present study analyzed FBXL6 expression in gliomas, utilizing data from The Cancer Genome Atlas and Chinese Glioma Genome Atlas databases. Analysis of FBXL6 mRNA expression levels, combined with patient factors such as age, sex and tumor grade using Kaplan‑Meier plots and nomograms, demonstrated a strong correlation between FBXL6 expression and glioma progression. Co‑expression networks provided further insights into the biological function of FBXL6. Additionally, using CIBERSORT and TISDB tools, the correlation between FBXL6 expression correlation tumor‑infiltrating immune cells and immune genes was demonstrated to be statistically significant. These findings were validated by examining FBXL6 mRNA and protein levels in glioma tissues using various techniques, including western blot, reverse transcription‑quantitative PCR and immunohistochemistry. These assays demonstrated the role of FBXL6 in glioma progression. Furthermore, drug sensitivity analysis demonstrated a strong correlation between FBXL6 expression and various drugs, which indicated that FBXL6 may potentially act as a future promising therapeutic target in glioma treatment. Therefore, the present study identified FBXL6 as a diagnostic and prognostic marker in patients with gliomas and highlighted its potential role in glioma progression.
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View References

1 

Ostrom QT, Bauchet L, Davis FG, Deltour I, Fisher JL, Langer CE, Pekmezci M, Schwartzbaum JA, Turner MC, Walsh KM, et al: The epidemiology of glioma in adults: A ‘state of the science’ review. Neuro Oncol. 16:896–913. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Molinaro AM, Taylor JW, Wiencke JK and Wrensch MR: Genetic and molecular epidemiology of adult diffuse glioma. Nat Rev Neurol. 15:405–417. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Cancer Genome Atlas Research Network, . Brat DJ, Verhaak RG, Aldape KD, Yung WK, Salama SR, Cooper LA, Rheinbay E, Miller CR, Vitucci M, et al: Comprehensive, integrative genomic analysis of diffuse lower-grade gliomas. N Engl J Med. 372:2481–2498. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW and Kleihues P: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 114:97–109. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Yuan B, Wang G, Tang X, Tong A and Zhou L: Immunotherapy of glioblastoma: Recent advances and future prospects. Hum Vaccin Immunother. 18:20554172022. View Article : Google Scholar : PubMed/NCBI

6 

Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, et al: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 352:987–996. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Roukens MG, Alloul-Ramdhani M, Moghadasi S, Op den Brouw M and Baker DA: Downregulation of vertebrate Tel (ETV6) and Drosophila Yan is facilitated by an evolutionarily conserved mechanism of F-box-mediated ubiquitination. Mol Cell Biol. 28:4394–4406. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Bonacci T and Emanuele MJ: Dissenting degradation: Deubiquitinases in cell cycle and cancer. Semin Cancer Biol. 67:145–158. 2020. View Article : Google Scholar : PubMed/NCBI

9 

Abbas R and Larisch S: Killing by degradation: Regulation of apoptosis by the ubiquitin-proteasome-system. Cells. 10:34652021. View Article : Google Scholar : PubMed/NCBI

10 

Daulny A and Tansey WP: Damage control: DNA repair, transcription, and the ubiquitin-proteasome system. DNA Repair (Amst). 8:444–448. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Bendotti C, Marino M, Cheroni C, Fontana E, Crippa V, Poletti A and De Biasi S: Dysfunction of constitutive and inducible ubiquitin-proteasome system in amyotrophic lateral sclerosis: Implication for protein aggregation and immune response. Prog Neurobiol. 97:101–126. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Han D, Wang L, Jiang S and Yang Q: The ubiquitin-proteasome system in breast cancer. Trends Mol Med. 29:599–621. 2023. View Article : Google Scholar : PubMed/NCBI

13 

Reinstein E and Ciechanover A: Narrative review: Protein degradation and human diseases: The ubiquitin connection. Ann Intern Med. 145:676–684. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Dang F, Nie L and Wei W: Ubiquitin signaling in cell cycle control and tumorigenesis. Cell Death Differ. 28:427–438. 2021. View Article : Google Scholar : PubMed/NCBI

15 

Ciechanover A: The unravelling of the ubiquitin system. Nat Rev Mol Cell Biol. 16:322–324. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KK, Flores LG, Shao Y, et al: The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis. Cell. 149:1098–1111. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Meng X, Liu X, Guo X, Jiang S, Chen T, Hu Z, Liu H, Bai Y, Xue M, Hu R, et al: FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells. Nature. 564:130–135. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Wang Z, Liu P, Inuzuka H and Wei W: Roles of F-box proteins in cancer. Nat Rev Cancer. 14:233–247. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Wu J, Zhang X, Zhang L, Wu CY, Rezaeian AH, Chan CH, Li JM, Wang J, Gao Y, Han F, et al: Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1. Mol Cell. 46:351–361. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Nelson DE, Randle SJ and Laman H: Beyond ubiquitination: The atypical functions of Fbxo7 and other F-box proteins. Open Biol. 3:1301312013. View Article : Google Scholar : PubMed/NCBI

21 

Chen D, Liu X, Xia T, Tekcham DS, Wang W, Chen H, Li T, Lu C, Ning Z, Liu X, et al: A multidimensional characterization of E3 ubiquitin ligase and substrate interaction network. iScience. 16:177–191. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Li Y, Cui K, Zhang Q, Li X, Lin X, Tang Y, Prochownik EV and Li Y: FBXL6 degrades phosphorylated p53 to promote tumor growth. Cell Death Differ. 28:2112–2125. 2021. View Article : Google Scholar : PubMed/NCBI

23 

Yu Y, Yao W, Wang T, Xue W, Meng Y, Cai L, Jian W, Yu Y and Zhang C: FBXL6 depletion restrains clear cell renal cell carcinoma progression. Transl Oncol. 26:1015502022. View Article : Google Scholar : PubMed/NCBI

24 

Shi W, Feng L, Dong S, Ning Z, Hua Y, Liu L, Chen Z and Meng Z: FBXL6 governs c-MYC to promote hepatocellular carcinoma through ubiquitination and stabilization of HSP90AA1. Cell Commun Signal. 18:1002020. View Article : Google Scholar : PubMed/NCBI

25 

Schiff D: Low-grade gliomas. Continuum (Minneap Minn). 23:1564–1579. 2017.PubMed/NCBI

26 

Russell B, Collins A, Dally M, Dowling A, Gold M, Murphy M and Philip J: Living longer with adult high-grade glioma: Setting a research agenda for patients and their caregivers. J Neurooncol. 120:1–10. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Ding H, Zhao J, Zhang Y, Yu J, Liu M, Li X, Xu L, Lin M, Liu C, He Z, et al: Systematic analysis of drug vulnerabilities conferred by tumor suppressor loss. Cell Rep. 27:3331–3344.e6. 2019. View Article : Google Scholar : PubMed/NCBI

28 

Dai Z, Wu J, Chen F, Cheng Q, Zhang M, Wang Y, Guo Y and Song T: CXCL5 promotes the proliferation and migration of glioma cells in autocrine- and paracrine-dependent manners. Oncol Rep. 36:3303–3310. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Zhang J, Lin XT, Yu HQ, Fang L, Wu D, Luo YD, Zhang YJ and Xie CM: Elevated FBXL6 expression in hepatocytes activates VRK2-transketolase-ROS-mTOR-mediated immune evasion and liver cancer metastasis in mice. Exp Mol Med. 55:2162–2176. 2023. View Article : Google Scholar : PubMed/NCBI

31 

Wu W, Klockow JL, Zhang M, Lafortune F, Chang E, Jin L, Wu Y and Daldrup-Link HE: Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance. Pharmacol Res. 171:1057802021. View Article : Google Scholar : PubMed/NCBI

32 

Chinot OL, Wick W, Mason W, Henriksson R, Saran F, Nishikawa R, Carpentier AF, Hoang-Xuan K, Kavan P, Cernea D, et al: Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma. N Engl J Med. 370:709–722. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Chen J, McKay RM and Parada LF: Malignant glioma: Lessons from genomics, mouse models, and stem cells. Cell. 149:36–47. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Liu LY, Ji MS, Nguyen NT, Chow FE, Molaie DM, Pianka ST, Green RM, Liau LM, Ellingson BM, Nghiemphu PL, et al: Patterns of long-term survivorship following bevacizumab treatment for recurrent glioma: A case series. CNS Oncol. 8:CNS352019. View Article : Google Scholar : PubMed/NCBI

35 

Ghorbani A, Avery LM, Sohaei D, Soosaipillai A, Richer M, Horbinski C, McCortney K, Xu W, Diamandis EP and Prassas I: Discovery of novel glioma serum biomarkers by proximity extension assay. Clin Proteomics. 20:122023. View Article : Google Scholar : PubMed/NCBI

36 

Cheng J, Guo J, Wang Z, North BJ, Tao K, Dai X and Wei W: Functional analysis of Cullin 3 E3 ligases in tumorigenesis. Biochim Biophys Acta Rev Cancer. 1869:11–28. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Naseem Y, Zhang C, Zhou X, Dong J, Xie J, Zhang H, Agboyibor C, Bi Y and Liu H: Inhibitors targeting the F-BOX proteins. Cell Biochem Biophys. 81:577–597. 2023. View Article : Google Scholar : PubMed/NCBI

38 

D'Angiolella V, Donato V, Vijayakumar S, Saraf A, Florens L, Washburn MP, Dynlacht B and Pagano M: SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. Nature. 466:138–142. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Rye MS, Wiertsema SP, Scaman ES, Oommen J, Sun W, Francis RW, Ang W, Pennell CE, Burgner D, Richmond P, et al: FBXO11, a regulator of the TGFβ pathway, is associated with severe otitis media in Western Australian children. Genes Immun. 12:352–359. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Duan S, Cermak L, Pagan JK, Rossi M, Martinengo C, di Celle PF, Chapuy B, Shipp M, Chiarle R and Pagano M: FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas. Nature. 481:90–93. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Santra MK, Wajapeyee N and Green MR: F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage. Nature. 459:722–725. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Yoshida Y, Tokunaga F, Chiba T, Iwai K, Tanaka K and Tai T: Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains. J Biol Chem. 278:43877–43884. 2003. View Article : Google Scholar : PubMed/NCBI

43 

Yoshida Y, Chiba T, Tokunaga F, Kawasaki H, Iwai K, Suzuki T, Ito Y, Matsuoka K, Yoshida M, Tanaka K and Tai T: E3 ubiquitin ligase that recognizes sugar chains. Nature. 418:438–442. 2002. View Article : Google Scholar : PubMed/NCBI

44 

Frescas D and Pagano M: Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: Tipping the scales of cancer. Nat Rev Cancer. 8:438–449. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Nakayama KI and Nakayama K: Regulation of the cell cycle by SCF-type ubiquitin ligases. Semin Cell Dev Biol. 16:323–333. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Maser RS, Choudhury B, Campbell PJ, Feng B, Wong KK, Protopopov A, O'Neil J, Gutierrez A, Ivanova E, Perna I, et al: Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature. 447:966–971. 2007. View Article : Google Scholar : PubMed/NCBI

47 

Menyhárt O and Győrffy B: Multi-omics approaches in cancer research with applications in tumor subtyping, prognosis, and diagnosis. Comput Struct Biotechnol J. 19:949–960. 2021. View Article : Google Scholar : PubMed/NCBI

48 

Liu K, Zhang Q, Lan H, Wang L, Mou P, Shao W, Liu D, Yang W, Lin Z, Lin Q and Ji T: GCN5 Potentiates glioma proliferation and invasion via STAT3 and AKT signaling pathways. Int J Mol Sci. 16:21897–21910. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Ouyang C, Mu J, Lu Q, Li J, Zhu H, Wang Q, Zou MH and Xie Z: Autophagic degradation of KAT2A/GCN5 promotes directional migration of vascular smooth muscle cells by reducing TUBA/α-tubulin acetylation. Autophagy. 16:1753–1770. 2020. View Article : Google Scholar : PubMed/NCBI

50 

Zhang S, Zhang H and Yu L: HMGA2 promotes glioma invasion and poor prognosis via a long-range chromatin interaction. Cancer Med. 7:3226–3239. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lin Q, Zhu J, Zhu W, Zhu H, Li M, Zhao J, Jia S and Nie S: Prognostic value and drug sensitivity of F‑box and leucine‑rich repeat protein 6 in glioma. Oncol Lett 28: 320, 2024.
APA
Lin, Q., Zhu, J., Zhu, W., Zhu, H., Li, M., Zhao, J. ... Nie, S. (2024). Prognostic value and drug sensitivity of F‑box and leucine‑rich repeat protein 6 in glioma. Oncology Letters, 28, 320. https://doi.org/10.3892/ol.2024.14453
MLA
Lin, Q., Zhu, J., Zhu, W., Zhu, H., Li, M., Zhao, J., Jia, S., Nie, S."Prognostic value and drug sensitivity of F‑box and leucine‑rich repeat protein 6 in glioma". Oncology Letters 28.1 (2024): 320.
Chicago
Lin, Q., Zhu, J., Zhu, W., Zhu, H., Li, M., Zhao, J., Jia, S., Nie, S."Prognostic value and drug sensitivity of F‑box and leucine‑rich repeat protein 6 in glioma". Oncology Letters 28, no. 1 (2024): 320. https://doi.org/10.3892/ol.2024.14453
Copy and paste a formatted citation
x
Spandidos Publications style
Lin Q, Zhu J, Zhu W, Zhu H, Li M, Zhao J, Jia S and Nie S: Prognostic value and drug sensitivity of F‑box and leucine‑rich repeat protein 6 in glioma. Oncol Lett 28: 320, 2024.
APA
Lin, Q., Zhu, J., Zhu, W., Zhu, H., Li, M., Zhao, J. ... Nie, S. (2024). Prognostic value and drug sensitivity of F‑box and leucine‑rich repeat protein 6 in glioma. Oncology Letters, 28, 320. https://doi.org/10.3892/ol.2024.14453
MLA
Lin, Q., Zhu, J., Zhu, W., Zhu, H., Li, M., Zhao, J., Jia, S., Nie, S."Prognostic value and drug sensitivity of F‑box and leucine‑rich repeat protein 6 in glioma". Oncology Letters 28.1 (2024): 320.
Chicago
Lin, Q., Zhu, J., Zhu, W., Zhu, H., Li, M., Zhao, J., Jia, S., Nie, S."Prognostic value and drug sensitivity of F‑box and leucine‑rich repeat protein 6 in glioma". Oncology Letters 28, no. 1 (2024): 320. https://doi.org/10.3892/ol.2024.14453
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