Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2024 Volume 28 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2024 Volume 28 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Radiation‑induced pleomorphic liposarcoma after hypofractionated radiotherapy following breast‑conserving surgery: A case report and literature review

  • Authors:
    • Kenta Watanabe
    • Ryoji Tokiya
    • Yujiro Kawata
    • Takeshi Matsuno
    • Ryo Tanaka
    • Naruto Taira
    • Kuniaki Katsui
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Kawasaki Medical School, Kurashiki, Okayama 701‑0192, Japan, Department of Pathology, Kawasaki Medical School, Kurashiki, Okayama 701‑0192, Japan, Department of Dermatology, Kawasaki Medical School, Kurashiki, Okayama 701‑0192, Japan, Department of Breast and Thyroid Surgery, Kawasaki Medical School, Kurashiki, Okayama 701‑0192, Japan
    Copyright: © Watanabe et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 325
    |
    Published online on: May 15, 2024
       https://doi.org/10.3892/ol.2024.14457
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Breast cancer is one of the leading causes of cancer globally. Radiotherapy following breast‑conserving surgery is the standard treatment of breast cancer. Recently, hypofractionated irradiation comprising 42.56 Gy in 16 fractions was selected as a viable radiation therapeutic option. Radiation‑induced sarcoma is the most prevalent secondary malignancy in patients undergoing radiotherapy after breast cancer surgery. Angiosarcomas are the predominant type of radiation‑induced sarcomas, whereas liposarcomas have rarely been reported. The present report details an uncommon instance of radiation‑induced pleomorphic liposarcoma that occurred 8 years after breast‑conserving surgery and hypofractionated radiotherapy. The patient visited the hospital due to hardening of the tissue beneath the skin of the right breast. Ultrasonography revealed a hypoechoic mass in the lower part of the right breast containing internal blood flow. An excisional biopsy revealed that the tumor contained infiltrating spindle‑shaped cells without a capsule containing pleomorphic cells. Lipoblasts were also observed and tended to differentiate into adipose tissue, leading to a diagnosis of pleomorphic liposarcoma. Immunostaining revealed negativity for cytokeratin AE1/AE3, ERG, MDM2 and S‑100 protein; the Ki‑67 index was ~20%. An enlargement resection involving a postoperative bed was performed because of close tumor margins. 18F‑fluorodeoxyglucose positron emission tomography/computed tomography revealed pale accumulation of 18F‑fluorodeoxyglucose in the right chest wall, which was interpreted as a postoperative change owing to the resection biopsy. The tumor was observed in the irradiated field with no distant metastases. Following extensive resection, the patient maintained a recurrence‑free survival period of 3 years and 2 months, during which no adjuvant therapy was administered. Therefore, follow‑up is necessary in patients with breast cancer treated with radiotherapy.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Early Breast Cancer Trialists' Collaborative Group (EBCTCG), . Darby S, McGale P, Correa C, Taylor C, Arriagada R, Clarke M, Cutter D, Davies C, Ewertz M, et al: Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: Meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet. 378:1707–1716. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Whelan TJ, Pignol JP, Levine MN, Julian JA, MacKenzie R, Parpia S, Shelley W, Grimard L, Bowen J, Lukka H, et al: Long-term results of hypofractionated radiation therapy for breast cancer. N Engl J Med. 362:513–520. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Cahan WG, Woodard HQ, Higinbotham NL, Stewart FW and Coley BL: Sarcoma arising in irradiated bone: Report of eleven cases. 1948. Cancer. 82:8–34. 1998. View Article : Google Scholar : PubMed/NCBI

5 

Grantzau T and Overgaard J: Risk of second non-breast cancer among patients treated with and without postoperative radiotherapy for primary breast cancer: A systematic review and meta-analysis of population-based studies including 522,739 patients. Radiother Oncol. 121:402–413. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Kirova YM, Vilcoq JR, Asselain B, Sastre-Garau X and Fourquet A: Radiation-induced sarcomas after radiotherapy for breast carcinoma: A large-scale single-institution review. Cancer. 104:856–863. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Sheth GR, Cranmer LD, Smith BD, Grasso-Lebeau L and Lang JE: Radiation-induced sarcoma of the breast: A systematic review. Oncologist. 17:405–418. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Di Lalla V, Tolba M, Khosrow-Khavar F, Baig A, Freeman C and Panet-Raymond V: Radiation-induced sarcomas of the breast: A review of a 20-year single-center experience. Cureus. 15:e380962023.PubMed/NCBI

9 

Mirjolet C, Diallo I, Bertaut A, Veres C, Sargos P, Helfre S, Sunyach MP, Truc G, Le Pechoux C, Paumier A, et al: Treatment related factors associated with the risk of breast radio-induced-sarcoma. Radiother Oncol. 171:14–21. 2022. View Article : Google Scholar : PubMed/NCBI

10 

Khanna L, Prasad SR, Yedururi S, Parameswaran AM, Marcal LP, Sandrasegaran K, Tirumani SH, Menias CO and Katabathina VS: Second malignancies after radiation therapy: Update on pathogenesis and cross-sectional imaging findings. Radiographics. 41:876–894. 2021. View Article : Google Scholar : PubMed/NCBI

11 

Fletcher CDM; World Health Organization and International Agency for Research on Cancer, : WHO classification of tumours of soft tissue and bone. 4th edition. World Health, Lyon Organization classification of tumoursIARC Press; pp. 4682013

12 

Oliveira AM and Nascimento AG: Pleomorphic liposarcoma. Semin Diagn Pathol. 18:274–285. 2001.PubMed/NCBI

13 

Mariño-Enríquez A, Fletcher CD, Dal Cin P and Hornick JL: Dedifferentiated liposarcoma with ‘homologous’ lipoblastic (pleomorphic liposarcoma-like) differentiation: Clinicopathologic and molecular analysis of a series suggesting revised diagnostic criteria. Am J Surg Pathol. 34:1122–1131. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Anderson WJ and Jo VY: Pleomorphic liposarcoma: Updates and current differential diagnosis. Semin Diagn Pathol. 36:122–128. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Yap J, Chuba PJ, Thomas R, Aref A, Lucas D, Severson RK and Hamre M: Sarcoma as a second malignancy after treatment for breast cancer. Int J Radiat Oncol Biol Phys. 52:1231–1237. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Arbabi L and Warhol MJ: Pleomorphic liposarcoma following radiotherapy for breast carcinoma. Cancer. 49:878–880. 1982. View Article : Google Scholar : PubMed/NCBI

17 

O'Malley S, Weitman D, Olding M and Sekhar L: Multiple neoplasms following craniospinal irradiation for medulloblastoma in a patient with nevoid basal cell carcinoma syndrome. Case report. J Neurosurg. 86:286–288. 1997. View Article : Google Scholar : PubMed/NCBI

18 

Orosz Z, Rohonyi B, Luksander A and Szántó J: Pleomorphic liposarcoma of a young woman following radiotherapy for epithelioid sarcoma. Pathol Oncol Res. 6:287–291. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Yozu M, Symmans P, Dray M, Griffin J, Han C, Ng D, Parry S and Wong K: Muir-Torre syndrome-associated pleomorphic liposarcoma arising in a previous radiation field. Virchows Arch. 462:355–360. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Veiga LHS, Vo JB, Curtis RE, Mille MM, Lee C, Ramin C, Bodelon C, Aiello Bowles EJ, Buist DSM, Weinmann S, et al: Treatment-related thoracic soft tissue sarcomas in US breast cancer survivors: A retrospective cohort study. Lancet Oncol. 23:1451–1464. 2022. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Watanabe K, Tokiya R, Kawata Y, Matsuno T, Tanaka R, Taira N and Katsui K: Radiation‑induced pleomorphic liposarcoma after hypofractionated radiotherapy following breast‑conserving surgery: A case report and literature review. Oncol Lett 28: 325, 2024.
APA
Watanabe, K., Tokiya, R., Kawata, Y., Matsuno, T., Tanaka, R., Taira, N., & Katsui, K. (2024). Radiation‑induced pleomorphic liposarcoma after hypofractionated radiotherapy following breast‑conserving surgery: A case report and literature review. Oncology Letters, 28, 325. https://doi.org/10.3892/ol.2024.14457
MLA
Watanabe, K., Tokiya, R., Kawata, Y., Matsuno, T., Tanaka, R., Taira, N., Katsui, K."Radiation‑induced pleomorphic liposarcoma after hypofractionated radiotherapy following breast‑conserving surgery: A case report and literature review". Oncology Letters 28.1 (2024): 325.
Chicago
Watanabe, K., Tokiya, R., Kawata, Y., Matsuno, T., Tanaka, R., Taira, N., Katsui, K."Radiation‑induced pleomorphic liposarcoma after hypofractionated radiotherapy following breast‑conserving surgery: A case report and literature review". Oncology Letters 28, no. 1 (2024): 325. https://doi.org/10.3892/ol.2024.14457
Copy and paste a formatted citation
x
Spandidos Publications style
Watanabe K, Tokiya R, Kawata Y, Matsuno T, Tanaka R, Taira N and Katsui K: Radiation‑induced pleomorphic liposarcoma after hypofractionated radiotherapy following breast‑conserving surgery: A case report and literature review. Oncol Lett 28: 325, 2024.
APA
Watanabe, K., Tokiya, R., Kawata, Y., Matsuno, T., Tanaka, R., Taira, N., & Katsui, K. (2024). Radiation‑induced pleomorphic liposarcoma after hypofractionated radiotherapy following breast‑conserving surgery: A case report and literature review. Oncology Letters, 28, 325. https://doi.org/10.3892/ol.2024.14457
MLA
Watanabe, K., Tokiya, R., Kawata, Y., Matsuno, T., Tanaka, R., Taira, N., Katsui, K."Radiation‑induced pleomorphic liposarcoma after hypofractionated radiotherapy following breast‑conserving surgery: A case report and literature review". Oncology Letters 28.1 (2024): 325.
Chicago
Watanabe, K., Tokiya, R., Kawata, Y., Matsuno, T., Tanaka, R., Taira, N., Katsui, K."Radiation‑induced pleomorphic liposarcoma after hypofractionated radiotherapy following breast‑conserving surgery: A case report and literature review". Oncology Letters 28, no. 1 (2024): 325. https://doi.org/10.3892/ol.2024.14457
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team