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Case Report Open Access

Lymph node myeloid sarcoma with TP53‑associated myelodysplastic syndrome: A case report 

  • Authors:
    • Mengke Mao
    • Shu Deng
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang 310006, P.R. China
    Copyright: © Mao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 324
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    Published online on: May 15, 2024
       https://doi.org/10.3892/ol.2024.14458
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Abstract

Myeloid sarcoma (MS) is a rare extramedullary tumor mass that carries a high risk of progression to acute myeloid leukemia (AML), and patients with MS are commonly treated with the AML regimen. However, MS is frequently misdiagnosed due to its lack of clinical specificity. Patients with MS who harbor tumor protein p53 (TP53) mutations and complex karyotypes are considered to have a poorer prognosis. The present study reports a case of lymph node MS with TP53 (V173G)‑related myelodysplastic syndrome (MDS). The mass was first considered to be a lymphoma and treated as such. However, following immunohistochemical analysis, which revealed cells positive for CD43, myeloperoxidase and CD117, the patient was later diagnosed with MS combined with MDS. The patient went into complete remission after the first cycle of chemotherapy, and showed a decrease in platelet, red blood cell and white blood cell counts following the second cycle of chemotherapy. After the third chemotherapy, agranulocytosis occurred, leading to refractory pneumonia and eventually death due to respiratory failure. MS with TP53‑related MDS has a low incidence rate, a poor prognosis and a short survival time. The clinical manifestations of MS are non‑specific and easy to misdiagnose, leading to delayed diagnosis and treatment, and ultimately worsening the prognosis of the patients. Therefore, a lymph node biopsy should be performed as soon as possible for patients with lymph node enlargement, and early treatment should be carried out to prolong the survival period.
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Copy and paste a formatted citation
Spandidos Publications style
Mao M and Deng S: Lymph node myeloid sarcoma with TP53‑associated myelodysplastic syndrome: A case report . Oncol Lett 28: 324, 2024.
APA
Mao, M., & Deng, S. (2024). Lymph node myeloid sarcoma with TP53‑associated myelodysplastic syndrome: A case report . Oncology Letters, 28, 324. https://doi.org/10.3892/ol.2024.14458
MLA
Mao, M., Deng, S."Lymph node myeloid sarcoma with TP53‑associated myelodysplastic syndrome: A case report ". Oncology Letters 28.1 (2024): 324.
Chicago
Mao, M., Deng, S."Lymph node myeloid sarcoma with TP53‑associated myelodysplastic syndrome: A case report ". Oncology Letters 28, no. 1 (2024): 324. https://doi.org/10.3892/ol.2024.14458
Copy and paste a formatted citation
x
Spandidos Publications style
Mao M and Deng S: Lymph node myeloid sarcoma with TP53‑associated myelodysplastic syndrome: A case report . Oncol Lett 28: 324, 2024.
APA
Mao, M., & Deng, S. (2024). Lymph node myeloid sarcoma with TP53‑associated myelodysplastic syndrome: A case report . Oncology Letters, 28, 324. https://doi.org/10.3892/ol.2024.14458
MLA
Mao, M., Deng, S."Lymph node myeloid sarcoma with TP53‑associated myelodysplastic syndrome: A case report ". Oncology Letters 28.1 (2024): 324.
Chicago
Mao, M., Deng, S."Lymph node myeloid sarcoma with TP53‑associated myelodysplastic syndrome: A case report ". Oncology Letters 28, no. 1 (2024): 324. https://doi.org/10.3892/ol.2024.14458
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