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Article

Safety evaluation of lenvatinib treatment after atezolizumab plus bevacizumab therapy for patients with unresectable liver cancer: A comparison of lenvatinib as 1st‑ or 2nd‑line treatment

  • Authors:
    • Michio Kimura
    • Shiori Yamada
    • Makiko Go
    • Satoshi Yasuda
    • Hidenori Toyoda
    • Eiseki Usami
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Ogaki Municipal Hospital, Ogaki, Gifu 503‑8502, Japan, Department of Gastroenterology and Hepatology, Ogaki Municipal Hospital, Ogaki, Gifu 503‑8502, Japan
  • Article Number: 330
    |
    Published online on: May 17, 2024
       https://doi.org/10.3892/ol.2024.14464
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Abstract

Atezolizumab plus bevacizumab (Atez/BV) as first‑line therapy and lenvatinib (LEN) as second‑line therapy are the recommended treatments for patients with unresectable hepatocellular carcinoma. Adverse immune events caused by immune checkpoint inhibitors (such as Atez) generally only occur several months after administration; therefore, the potential influence of the first‑line treatment on second‑line treatment is not clear. The present study investigated the safety of second‑line LEN treatment (2nd LEN) by comparing the adverse events (AEs) of 2nd LEN after first‑line Atez/BV treatment for unresectable liver cancer, with those of first‑line LEN treatment (1st LEN). Patients who received Atez/BV as first‑line therapy and 2nd LEN, or those who received 1st LEN at Ogaki Municipal Hospital (Ogaki, Japan) between April 2018 and September 2023 were retrospectively evaluated for treatment duration and AEs. The median treatment duration for patients in the 1st LEN (n=39) and 2nd LEN (n=13) groups was 151.0 days [95% confidence interval (CI) 77‑303 days] and 128.5 days (95% CI 68‑270 days), respectively (P=0.385). A greater proportion of patients showed elevated aspartate aminotransferase/alanine aminotransferase levels in the 2nd LEN group (76.9%) compared with those in the 1st LEN group (46.2%) (P=0.016). Hypothyroidism was more common in those receiving 2nd LEN (46.2%) than 1st LEN (12.8%) (P=0.016). In addition, grade 1 (three patients) and grade 2 (three patients) hypothyroidism was observed in patients receiving 2nd LEN. For these six patients, during first‑line Atez/BV treatment, four patients had grade 0 hypothyroidism and two patients had grade 1 hypothyroidism (P=0.025). In conclusion, patients receiving 2nd LEN after treatment with Atez/BV are at an increased risk of hypothyroidism.
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Copy and paste a formatted citation
Spandidos Publications style
Kimura M, Yamada S, Go M, Yasuda S, Toyoda H and Usami E: Safety evaluation of lenvatinib treatment after atezolizumab plus bevacizumab therapy for patients with unresectable liver cancer: A comparison of lenvatinib as 1st‑ or 2nd‑line treatment. Oncol Lett 28: 330, 2024.
APA
Kimura, M., Yamada, S., Go, M., Yasuda, S., Toyoda, H., & Usami, E. (2024). Safety evaluation of lenvatinib treatment after atezolizumab plus bevacizumab therapy for patients with unresectable liver cancer: A comparison of lenvatinib as 1st‑ or 2nd‑line treatment. Oncology Letters, 28, 330. https://doi.org/10.3892/ol.2024.14464
MLA
Kimura, M., Yamada, S., Go, M., Yasuda, S., Toyoda, H., Usami, E."Safety evaluation of lenvatinib treatment after atezolizumab plus bevacizumab therapy for patients with unresectable liver cancer: A comparison of lenvatinib as 1st‑ or 2nd‑line treatment". Oncology Letters 28.1 (2024): 330.
Chicago
Kimura, M., Yamada, S., Go, M., Yasuda, S., Toyoda, H., Usami, E."Safety evaluation of lenvatinib treatment after atezolizumab plus bevacizumab therapy for patients with unresectable liver cancer: A comparison of lenvatinib as 1st‑ or 2nd‑line treatment". Oncology Letters 28, no. 1 (2024): 330. https://doi.org/10.3892/ol.2024.14464
Copy and paste a formatted citation
x
Spandidos Publications style
Kimura M, Yamada S, Go M, Yasuda S, Toyoda H and Usami E: Safety evaluation of lenvatinib treatment after atezolizumab plus bevacizumab therapy for patients with unresectable liver cancer: A comparison of lenvatinib as 1st‑ or 2nd‑line treatment. Oncol Lett 28: 330, 2024.
APA
Kimura, M., Yamada, S., Go, M., Yasuda, S., Toyoda, H., & Usami, E. (2024). Safety evaluation of lenvatinib treatment after atezolizumab plus bevacizumab therapy for patients with unresectable liver cancer: A comparison of lenvatinib as 1st‑ or 2nd‑line treatment. Oncology Letters, 28, 330. https://doi.org/10.3892/ol.2024.14464
MLA
Kimura, M., Yamada, S., Go, M., Yasuda, S., Toyoda, H., Usami, E."Safety evaluation of lenvatinib treatment after atezolizumab plus bevacizumab therapy for patients with unresectable liver cancer: A comparison of lenvatinib as 1st‑ or 2nd‑line treatment". Oncology Letters 28.1 (2024): 330.
Chicago
Kimura, M., Yamada, S., Go, M., Yasuda, S., Toyoda, H., Usami, E."Safety evaluation of lenvatinib treatment after atezolizumab plus bevacizumab therapy for patients with unresectable liver cancer: A comparison of lenvatinib as 1st‑ or 2nd‑line treatment". Oncology Letters 28, no. 1 (2024): 330. https://doi.org/10.3892/ol.2024.14464
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