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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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July-2024 Volume 28 Issue 1

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Case Report Open Access

Complete response to tremelimumab plus durvalumab treatment in hepatocellular carcinoma with a bile duct tumor thrombus: 
A case report

  • Authors:
    • Nobuaki Ishihara
    • Shohei Komatsu
    • Masahiro Kido
    • Hidetoshi Gon
    • Kenji Fukushima
    • Takeshi Urade
    • Toshihiko Yoshida
    • Keisuke Arai
    • Hiroaki Yanagimoto
    • Hirochika Toyama
    • Takumi Fukumoto
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Division of Hepato‑Biliary‑Pancreatic Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo 650‑0017, Japan
    Copyright: © Ishihara et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 332
    |
    Published online on: May 17, 2024
       https://doi.org/10.3892/ol.2024.14465
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Abstract

Tremelimumab plus durvalumab (Dur/Tre) is the first‑line treatment for advanced hepatocellular carcinoma (HCC) worldwide. The present report describes the case of a 68‑year‑old man diagnosed with advanced HCC and a bile duct tumor thrombus (BDTT) who achieved a complete response to Dur/Tre therapy. The BDTT progressed to the bifurcation of the left and right hepatic ducts. Over time, both the tumors and BDTT progressively decreased in size, and a complete response was confirmed using the Response Evaluation Criteria in Solid Tumors (version 1.1.) 6 months after treatment administration. Subsequently, immune‑related adverse events, including type 1 diabetes mellitus and diabetic ketoacidosis, emerged, leading to treatment discontinuation. The patient was undergoing outpatient follow‑up in a drug‑free state with no signs of recurrence 290 days after the initial administration of Dur/Tre. Although long‑term and meticulous observations are required, the present findings could influence the choice of systemic chemotherapy for advanced HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Ishihara N, Komatsu S, Kido M, Gon H, Fukushima K, Urade T, Yoshida T, Arai K, Yanagimoto H, Toyama H, Toyama H, et al: Complete response to tremelimumab plus durvalumab treatment in hepatocellular carcinoma with a bile duct tumor thrombus:&nbsp;<br />A case report. Oncol Lett 28: 332, 2024.
APA
Ishihara, N., Komatsu, S., Kido, M., Gon, H., Fukushima, K., Urade, T. ... Fukumoto, T. (2024). Complete response to tremelimumab plus durvalumab treatment in hepatocellular carcinoma with a bile duct tumor thrombus:&nbsp;<br />A case report. Oncology Letters, 28, 332. https://doi.org/10.3892/ol.2024.14465
MLA
Ishihara, N., Komatsu, S., Kido, M., Gon, H., Fukushima, K., Urade, T., Yoshida, T., Arai, K., Yanagimoto, H., Toyama, H., Fukumoto, T."Complete response to tremelimumab plus durvalumab treatment in hepatocellular carcinoma with a bile duct tumor thrombus:&nbsp;<br />A case report". Oncology Letters 28.1 (2024): 332.
Chicago
Ishihara, N., Komatsu, S., Kido, M., Gon, H., Fukushima, K., Urade, T., Yoshida, T., Arai, K., Yanagimoto, H., Toyama, H., Fukumoto, T."Complete response to tremelimumab plus durvalumab treatment in hepatocellular carcinoma with a bile duct tumor thrombus:&nbsp;<br />A case report". Oncology Letters 28, no. 1 (2024): 332. https://doi.org/10.3892/ol.2024.14465
Copy and paste a formatted citation
x
Spandidos Publications style
Ishihara N, Komatsu S, Kido M, Gon H, Fukushima K, Urade T, Yoshida T, Arai K, Yanagimoto H, Toyama H, Toyama H, et al: Complete response to tremelimumab plus durvalumab treatment in hepatocellular carcinoma with a bile duct tumor thrombus:&nbsp;<br />A case report. Oncol Lett 28: 332, 2024.
APA
Ishihara, N., Komatsu, S., Kido, M., Gon, H., Fukushima, K., Urade, T. ... Fukumoto, T. (2024). Complete response to tremelimumab plus durvalumab treatment in hepatocellular carcinoma with a bile duct tumor thrombus:&nbsp;<br />A case report. Oncology Letters, 28, 332. https://doi.org/10.3892/ol.2024.14465
MLA
Ishihara, N., Komatsu, S., Kido, M., Gon, H., Fukushima, K., Urade, T., Yoshida, T., Arai, K., Yanagimoto, H., Toyama, H., Fukumoto, T."Complete response to tremelimumab plus durvalumab treatment in hepatocellular carcinoma with a bile duct tumor thrombus:&nbsp;<br />A case report". Oncology Letters 28.1 (2024): 332.
Chicago
Ishihara, N., Komatsu, S., Kido, M., Gon, H., Fukushima, K., Urade, T., Yoshida, T., Arai, K., Yanagimoto, H., Toyama, H., Fukumoto, T."Complete response to tremelimumab plus durvalumab treatment in hepatocellular carcinoma with a bile duct tumor thrombus:&nbsp;<br />A case report". Oncology Letters 28, no. 1 (2024): 332. https://doi.org/10.3892/ol.2024.14465
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