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Biological effect of ETV4 and the underlying mechanism of its regulatory effect on epithelial‑mesenchymal transition in intrahepatic cholangiocarcinoma cells

  • Authors:
    • Li Liu
    • Yong Feng
    • Xuelian Xiang
    • Mengtao Xu
    • Guodu Tang
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 346
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    Published online on: May 30, 2024
       https://doi.org/10.3892/ol.2024.14479
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Abstract

Intrahepatic cholangiocarcinoma (ICC) is a highly invasive malignant tumor. The prognosis of patients with ICC after radical surgical resection remains poor, due to local infiltration, distant metastasis, a high recurrence rate and lack of effective treatment strategies. E26 transformation‑specific sequence variant 4 (ETV4) is a pro‑carcinogenic factor that is upregulated in several tumors; however, the role of ETV4 in ICC is relatively unknown. The present study aimed to determine the role of ETV4 in the Hccc9810 ICC cell line and to assess how it contributes to epithelial‑mesenchymal transition (EMT) in ICC. Hccc9810 cells were infected with lentiviruses to construct stable ETV4‑overexpressing cells, stable ETV4 knockdown cells and corresponding control groups. The Cell Counting Kit‑8 and Transwell assays were used to quantify cell proliferation, invasion and migration, and the effects on cell cycle progression and apoptosis were detected by flow cytometry. ETV4 was identified as a driver of cell growth, invasion, migration and cell cycle progression, while restraining apoptosis in Hccc9810 cells. Reverse transcription‑quantitative PCR and western blotting revealed that increased ETV4 levels may drive EMT by triggering the TGF‑β1/Smad signaling pathway. This cascade, in turn, may foster tumor cell proliferation, migration, invasion and cell cycle advancement, and hinder apoptosis.
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View References

1 

El-Diwany R, Pawlik TM and Ejaz A: Intrahepatic cholangiocarcinoma. Surg Oncol Clin N Am. 28:587–599. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Lee AJ and Chun YS: Intrahepatic cholangiocarcinoma: The AJCC/UICC 8th edition updates. Chin Clin Oncol. 7:522018. View Article : Google Scholar : PubMed/NCBI

3 

Moris D, Palta M, Kim C, Allen PJ, Morse MA and Lidsky ME: Advances in the treatment of intrahepatic cholangiocarcinoma: An overview of t-he current and future therapeutic landscape for clinicians. CA Cancer J Clin. 73:198–222. 2023. View Article : Google Scholar : PubMed/NCBI

4 

Qi T, Qu Q, Li G, Wang J, Zhu H, Yang Z, Sun Y, Lu Q and Qu J: Function and regulation of the PEA3 subfamily of ETS transcription factors in cancer. Am J Cancer Res. 10:3083–3105. 2020.PubMed/NCBI

5 

Gao X, Jiang M, Chu Y, Han Y, Jin Y, Zhang W, Wang W, Yang S, Li W, Fan A, et al: ETV4 promotes pancreatic ductal adenocarcinoma metastasis through activation of the CXCL13/CXCR5 signaling axis. Cancer Lett. 524:42–56. 2022. View Article : Google Scholar : PubMed/NCBI

6 

Cosi I, Pellecchia A, De Lorenzo E, Torre E, Sica M, Nesi G, Notaro R and De Angioletti M: ETV4 promotes late development of prostatic intraepithelial neoplasia and cell proliferation through direct and p53-mediated downregulation of p21. J Hematol Oncol. 13:1122020. View Article : Google Scholar : PubMed/NCBI

7 

Singsuksawat E, Thuwajit C, Charngkaew K and Thuwajit P: Increased ETV4 expression correlates with estrogen-enhanced proliferation and invasiveness of cholangiocarcinoma cells. Cancer Cell Int. 18:252018. View Article : Google Scholar : PubMed/NCBI

8 

Ang HL, Mohan CD, Shanmugam MK, Leong HC, Makvandi P, Rangappa KS, Bishayee A, Kumar AP and Sethi G: Mechanism of epithelial mesenchymal transition in cancer and its regulation by natural compounds. Med Res Rev. 43:1141–1200. 2023. View Article : Google Scholar : PubMed/NCBI

9 

Derynck R and Weinberg RA: EMT and cancer: More than meets the eye. Dev Cell. 49:313–316. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Navas T, Kinders RJ, Lawrence SM, FerryGalow KV, Borgel S, Hollingshead MG, Srivastava AK, Alcoser SY, Makhlouf HR, Chuaqui R, et al: Clinical evolution of epithelial-mesenchymal transition in human carcinomas. Cancer Res. 80:304–318. 2020. View Article : Google Scholar : PubMed/NCBI

11 

Williams ED, Gao D, Redfern A and Thompson EW: Controversies around epithelial-mesenchymal plasticity in cancer metastasis. Nat Rev Cancer. 19:716–732. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Lim W, Jeon BN, Kim YJ, Kim KH and Ko H: FBI-1 inhibits epithelial-to-mesenchymal transition, migration, and invasion in lung adenocarcinoma A549 cells by downregulating transforming growth factor-β1 signaling pathway. J Cell Biochem. 123:644–656. 2022. View Article : Google Scholar : PubMed/NCBI

13 

Singh A and Settleman J: EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer. Oncogene. 29:4741–4751. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Sawanyawisuth K, Sashida G and Sheng G: Epithelial-mesenchymal transition in liver fluke-induced cholangiocarcinoma. Cancers (Basel). 13:7912021. View Article : Google Scholar : PubMed/NCBI

15 

Vaquero J, Guedj N, Clapéron A, Ho-Bouldoires TH, Paradis V and Fouassier L: Epithelial-mesenchymal transition in cholangiocarcinoma: From clinical evidence to regulatory networks. J Hepatol. 66:424–441. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Clapéron A, Mergey M, Ho-Bouldoires TH, Vignjevic D, Wendum D, Chrétien Y, Merabtene F, Frazao A, Paradis V, Housset C, et al: EGF/EGFR axis contributes to the progression of cholangiocarcinoma through the induction of an epithelial-mesenchymal transition. J Hepatol. 61:325–332. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Chen X, Huang Y, Liu J, Lin W, Chen C, Chen Y, Ding Y, Yang Y, Chen Y, Wang H and Teng L: EXOSC5 promotes proliferation of gastric cancer through regulating AKT/STAT3 signaling pathways. J Cancer. 13:1456–1467. 2022. View Article : Google Scholar : PubMed/NCBI

18 

Xiang C, Sun WH, Ke Y, Yu X and Wang Y: CDCA8 contributes to the development and progression of thyroid cancer through regulating CDK1. J Cancer. 13:2322–2335. 2022. View Article : Google Scholar : PubMed/NCBI

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Xia XL, Xue D, Xiang TH, Xu HY, Song DK, Cheng PG and Wang JQ: Overexpression of long non-coding RNA CRNDE facilitates epithelial-mesenchymal transition and correlates with poor prognosis in intrahepatic cholangiocarcinoma. Oncol Lett. 15:4105–4112. 2018.PubMed/NCBI

21 

Vermani L, Kumar R and Kumar NS: GAPDH and PUM1: Optimal housekeeping genes for quantitative polymerase chain reaction-based analysis of cancer stem cells and epithelial-mesenchymal transition gene expression in rectal tumors. Cureus. 12:e120202020.PubMed/NCBI

22 

Zhang AN, Li N, Chen ZC, Guo YL, Tian CJ, Cheng DJ, Tang XY and Zhang XY: Amygdalin alleviated TGF-β-induced epithelial-mesenchymal transition in bronchial epithelial cells. Chem Biol Interact. 369:1102352023. View Article : Google Scholar : PubMed/NCBI

23 

Zhang H, Huang Y, Wen Q, Li Y, Guo L and Ge N: INHBA gene silencing inhibits proliferation, migration, and invasion of osteosarcoma cells by repressing TGF-β signaling pathway activation. J Orthop Surg Res. 18:8482023. View Article : Google Scholar : PubMed/NCBI

24 

Jiang W, Xu Y, Chen X, Pan S and Zhu X: E26 transformation-specific variant 4 as a tumor promotor in human cancers through specific molecular mechanisms. Mol Ther Oncolytics. 22:518–527. 2021. View Article : Google Scholar : PubMed/NCBI

25 

Zheng C, Liu M, Ge Y, Qian Y and Fan H: HBx increases chromatin accessibility and ETV4 expression to regulate dishevelled-2 and promote HCC progression. Cell Death Dis. 13:1162022. View Article : Google Scholar : PubMed/NCBI

26 

Wang J, Sun C, Li J, Jiang H, Qiu Y and Gong M: Knockdown of ETV4 promotes autophagy-dependent apoptosis in GBM cells by reducing the transcriptional activation of EMP1. Oncol Lett. 23:412022. View Article : Google Scholar : PubMed/NCBI

27 

Tyagi N, Deshmukh SK, Srivastava SK, Azim S, Ahmad A, AlGhadhban A, Singh AP, Carter JE, Wang B and Singh S: ETV4 facilitates cell-cycle progression in pancreatic cells through transcriptional regulation of cyclin D1. Mol Cancer Res. 16:187–196. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Pastushenko I and Blanpain C: EMT transition states during tumor progression and metastasis. Trends Cell Biol. 29:212–226. 2019. View Article : Google Scholar : PubMed/NCBI

29 

Lu W and Kang Y: Epithelial-mesenchymal plasticity in cancer progression and metastasis. Dev Cell. 49:361–374. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Bure IV, Nemtsova MV and Zaletaev DV: Roles of E-cadherin and Noncoding RNAs in the epithelial-mesenchymal transition and progression in gastric cancer. Int J Mol Sci. 20:28702019. View Article : Google Scholar : PubMed/NCBI

31 

Rosso M, Majem B, Devis L, Lapyckyj L, Besso MJ, Llauradó M, Abascal MF, Matos ML, Lanau L, Castellví J, et al: E-cadherin: A determinant molecule associated with ovarian cancer progression, dissemination and aggressiveness. PLoS One. 12:e01844392017. View Article : Google Scholar : PubMed/NCBI

32 

Onder TT, Gupta PB, Mani SA, Yang J, Lander ES and Weinberg RA: Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathwa-ys. Cancer Res. 68:3645–3654. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Ali AN, Ghoneim SM, Ahmed ER, Salam LO and Saleh SM: Cadherin switching in oral squamous cell carcinoma: A clinicopathological study. J Oral Biol Craniofac Res. 13:486–494. 2023. View Article : Google Scholar : PubMed/NCBI

34 

Cao ZQ, Wang Z and Leng P: Aberrant N-cadherin expression in cancer. Biomed Pharmacother. 118:1093202019. View Article : Google Scholar : PubMed/NCBI

35 

Serrano-Gomez SJ, Maziveyi M and Alahari SK: Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications. Mol Cancer. 15:182016. View Article : Google Scholar : PubMed/NCBI

36 

Ridge KM, Eriksson JE, Pekny M and Goldman RD: Roles of vimentin in health and disease. Genes Dev. 36:391–407. 2022. View Article : Google Scholar : PubMed/NCBI

37 

Satelli A and Li S: Vimentin in cancer and its potential as a molecular target for cancer therapy. Cell Mol Life Sci. 68:3033–3046. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Zhou Z, Wu B, Chen J, Shen Y, Wang J, Chen X, Fei F and Li L: ETV4 facilitates proliferation, migration, and invasion of liver cancer by mediating TGF-β signal transduction through activation of B3GNT 3. Genes Genomics. 45:1433–1443. 2023. View Article : Google Scholar : PubMed/NCBI

39 

Yao D, Bao Z, Qian X, Yang Y and Mao Z: ETV4 transcriptionally activates HES1 and promotes Stat3 phosphorylation to promote malignant behaviors of colon adenocarcinoma. Cell Biol Int. 45:2129–2139. 2021. View Article : Google Scholar : PubMed/NCBI

40 

Hao Y, Baker D and Dijke PT: TGF-β-mediated epithelial-mesenchymal transition and cancer metastasis. Int J Mol Sci. 20:27672019. View Article : Google Scholar : PubMed/NCBI

41 

Katsuno Y, Lamouille S and Derynck R: TGF-β signaling and epithelial-mesenchymal transition in cancer progression. Curr Opin Oncol. 25:76–84. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Zhang J, van Dinther M, Thorikay M, Gourabi BM, Kruithof BPT and Ten Dijke P: Opposing USP19 splice variants in TGF-β signaling and TGF-β-induced epithelial-mesenchymal transition of breast cancer cells. Cell Mol Life Sci. 80:432023. View Article : Google Scholar : PubMed/NCBI

43 

Hu HH, Chen DQ, Wang YN, Feng YL, Cao G, Vaziri ND and Zhao YY: New insights into TGF-β/Smad signaling in tissue fibrosis. Chem Biol Interact. 292:76–83. 2018. View Article : Google Scholar : PubMed/NCBI

44 

Zhao M, Mishra L and Deng CX: The role of TGF-β/SMAD4 signaling in cancer. Int J Biol Sci. 14:111–123. 2018. View Article : Google Scholar : PubMed/NCBI

45 

Moon H, Ju HL, Chung SI, Cho KJ, Eun JW, Nam SW, Han KH, Calvisi DF and Ro SW: Transforming growth factor-β promotes liver tumorigenesis in mice via up-regulation of snail. Gastroenterology. 153:1378–1391. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Deckers M, van Dinther M, Buijs J, Que I, Löwik C, van der Pluijm G and ten Dijke P: The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells. Cancer Res. 66:2202–2209. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Thuault S, Valcourt U, Petersen M, Manfioletti G, Heldin CH and Moustakas A: Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition. J Cell Biol. 174:175–183. 2006. View Article : Google Scholar : PubMed/NCBI

48 

Chen HY, Chiang YF, Huang CY, Shieh TM, Kao C, Chang FK, Huang TC, Ali M, Chang HY, Hong YH and Hsia SM: Spirulina phycocyanin extract and its active components suppress epithelial-mesenchymal transition process in endometrial cancer via targeting TGF-beta1/SMAD4 signaling pathway. Biomed Pharmacother. 152:1132192022. View Article : Google Scholar : PubMed/NCBI

49 

David CJ, Huang YH, Chen M, Su J, Zou Y, Bardeesy N, Iacobuzio-Donahue CA and Massagué J: TGF-β tumor suppression through a lethal EMT. Cell. 164:1015–1030. 2016. View Article : Google Scholar : PubMed/NCBI

50 

Yan X, Liao H, Cheng M, Shi X, Lin X, Feng XH and Chen YG: Smad7 protein interacts with receptor-regulated smads (R-Smads) to inhibit transforming growth factor-β (TGF-β)/Smad Signaling. J Biol Chem. 291:382–392. 2016. View Article : Google Scholar : PubMed/NCBI

51 

Wang JY, Gao YB, Zhang N, Zou DW, Wang P, Zhu ZY, Li JY, Zhou SN, Wang SC, Wang YY and Yang JK: miR-21 overexpression enhances TGF-β1-induced epithelial-to-mesenchymal transition by target smad7 and aggravates renal damage in diabetic nephropathy. Mol Cell Endocrinol. 392:163–172. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu L, Feng Y, Xiang X, Xu M and Tang G: Biological effect of ETV4 and the underlying mechanism of its regulatory effect on epithelial‑mesenchymal transition in intrahepatic cholangiocarcinoma cells. Oncol Lett 28: 346, 2024.
APA
Liu, L., Feng, Y., Xiang, X., Xu, M., & Tang, G. (2024). Biological effect of ETV4 and the underlying mechanism of its regulatory effect on epithelial‑mesenchymal transition in intrahepatic cholangiocarcinoma cells. Oncology Letters, 28, 346. https://doi.org/10.3892/ol.2024.14479
MLA
Liu, L., Feng, Y., Xiang, X., Xu, M., Tang, G."Biological effect of ETV4 and the underlying mechanism of its regulatory effect on epithelial‑mesenchymal transition in intrahepatic cholangiocarcinoma cells". Oncology Letters 28.2 (2024): 346.
Chicago
Liu, L., Feng, Y., Xiang, X., Xu, M., Tang, G."Biological effect of ETV4 and the underlying mechanism of its regulatory effect on epithelial‑mesenchymal transition in intrahepatic cholangiocarcinoma cells". Oncology Letters 28, no. 2 (2024): 346. https://doi.org/10.3892/ol.2024.14479
Copy and paste a formatted citation
x
Spandidos Publications style
Liu L, Feng Y, Xiang X, Xu M and Tang G: Biological effect of ETV4 and the underlying mechanism of its regulatory effect on epithelial‑mesenchymal transition in intrahepatic cholangiocarcinoma cells. Oncol Lett 28: 346, 2024.
APA
Liu, L., Feng, Y., Xiang, X., Xu, M., & Tang, G. (2024). Biological effect of ETV4 and the underlying mechanism of its regulatory effect on epithelial‑mesenchymal transition in intrahepatic cholangiocarcinoma cells. Oncology Letters, 28, 346. https://doi.org/10.3892/ol.2024.14479
MLA
Liu, L., Feng, Y., Xiang, X., Xu, M., Tang, G."Biological effect of ETV4 and the underlying mechanism of its regulatory effect on epithelial‑mesenchymal transition in intrahepatic cholangiocarcinoma cells". Oncology Letters 28.2 (2024): 346.
Chicago
Liu, L., Feng, Y., Xiang, X., Xu, M., Tang, G."Biological effect of ETV4 and the underlying mechanism of its regulatory effect on epithelial‑mesenchymal transition in intrahepatic cholangiocarcinoma cells". Oncology Letters 28, no. 2 (2024): 346. https://doi.org/10.3892/ol.2024.14479
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