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Comprehensive pan‑cancer analysis of MTDH for human tumor prognosis and as an immunological biomarker including breast and kidney cancer

  • Authors:
    • Lixian Yang
    • Mingqiang Han
    • Xiaoling Zhao
    • Lei Zheng
    • Fanting Kong
    • Shiyu Zhang
    • Lining Jia
    • Xiaowei Li
    • Meng Wang
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, Xingtai People's Hospital, Xingtai, Hebei 054001, P.R. China, Department of Thyroid Surgery, Xingtai People's Hospital, Xingtai, Hebei 054001, P.R. China, Oncology Laboratory, Xingtai People's Hospital, Xingtai, Hebei 054001, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 349
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    Published online on: June 3, 2024
       https://doi.org/10.3892/ol.2024.14482
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Abstract

Metadherin (MTDH), initially discovered in primary astrocytes of the human fetus through rapid subtraction hybridization and labeled as astrocyte elevated gene‑1, represents a widely recognized oncogene present in multiple types of cancers. However, the role of MTDH in different types of cancer remains unclear. To address this, a comprehensive analysis of MTDH across various types of cancers was conducted by utilizing multiple databases such as The Cancer Genome Atlas. The present analysis discovered that MTDH exhibits differential expression in different types of cancer and is associated with important factors including tumor mutational burden and microsatellite instability. These findings highlighted the significance of MTDH in the tumor microenvironment and its involvement in the development of immune cells in specific cancers. Furthermore, the results of the present study indicated that the expression of MTDH is strongly correlated with clinical prognosis, mutations and immune cell infiltration. MTDH could serve as a potential indicator of patient prognosis and potentially play a role in modulating the immune system. Given its potential as a novel immunological checkpoint, MTDH may be a viable target for tumor immunotherapy.
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1 

Arnold M, Rutherford MJ, Bardot A, Ferlay J, Andersson TM, Myklebust TÅ, Tervonen H, Thursfield V, Ransom D, Shack L, et al: Progress in cancer survival, mortality, and incidence in seven high-income countries 1995–2014 (ICBP SURVMARK-2): A population-based study. Lancet Oncol. 20:1493–1505. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Bindea G, Mlecnik B, Tosolini M, Kirilovsky A, Waldner M, Obenauf AC, Angell H, Fredriksen T, Lafontaine L, Berger A, et al: Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity. 39:782–795. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Schumacher TN and Schreiber RD: Neoantigens in cancer immunotherapy. Science. 348:69–74. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Topalian SL, Drake CG and Pardoll DM: Immune checkpoint blockade: A common denominator approach to cancer therapy. Cancer Cell. 27:450–461. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Becht E, Giraldo NA, Dieu-Nosjean MC, Sautès-Fridman C and Fridman WH: Cancer immune contexture and immunotherapy. Curr Opin Immunol. 39:7–13. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Su ZZ, Kang DC, Chen Y, Pekarskaya O, Chao W, Volsky DJ and Fisher PB: Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, RaSH. Oncogene. 21:3592–3602. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Blanco MA, Alečković M, Hua Y, Li T, Wei Y, Xu Z, Cristea IM and Kang Y: Identification of staphylococcal nuclease domain-containing 1 (SND1) as a Metadherin-interacting protein with metastasis-promoting functions. J Biol Chem. 286:19982–19992. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Kang DC, Su ZZ, Sarkar D, Emdad L, Volsky DJ and Fisher PB: Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. Gene. 353:8–15. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Lee SG, Kang DC, DeSalle R, Sarkar D and Fisher PB: AEG-1/MTDH/LYRIC, the beginning: Initial cloning, structure, expression profile, and regulation of expression. Adv Cancer Res. 120:1–38. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Yoo BK, Emdad L, Lee SG, Su ZZ, Santhekadur P, Chen D, Gredler R, Fisher PB and Sarkar D: Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology. Pharmacol Ther. 130:1–8. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Liu HY, Liu CX, Han B, Zhang XY and Sun RP: AEG-1 is associated with clinical outcome in neuroblastoma patients. Cancer Biomark. 11:115–121. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Subramanian A, Kuehn H, Gould J, Tamayo P and Mesirov JP: GSEA-P: A desktop application for gene set enrichment analysis. Bioinformatics. 23:3251–3253. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Tokunaga E, Nakashima Y, Yamashita N, Hisamatsu Y, Okada S, Akiyoshi S, Aishima S, Kitao H, Morita M and Maehara Y: Overexpression of metadherin/MTDH is associated with an aggressive phenotype and a poor prognosis in invasive breast cancer. Breast Cancer. 21:341–349. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Meng X, Brachova P, Yang S, Xiong Z, Zhang Y, Thiel KW and Leslie KK: Knockdown of MTDH sensitizes endometrial cancer cells to cell death induction by death receptor ligand TRAIL and HDAC inhibitor LBH589 co-treatment. PLoS One. 6:e209202011. View Article : Google Scholar : PubMed/NCBI

15 

Meng X, Thiel KW and Leslie KK: Drug resistance mediated by AEG-1/MTDH/LYRIC. Adv Cancer Res. 120:135–157. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Heo J, Lim CK, Whang DR, Shin J, Jeong SY, Park SY, Kwon IC and Kim S: Self-deprotonation and colorization of 1,3-bis(dicyanomethylidene)indan in polar media: A facile route to a minimal polymethine dye for NIR fluorescence imaging. Chemistry. 18:8699–8704. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Yoshihara K, Shahmoradgoli M, Martínez E, Vegesna R, Kim H, Torres-Garcia W, Treviño V, Shen H, Laird PW, Levine DA, et al: Inferring tumour purity and stromal and immune cell admixture from expression data. Nat Commun. 4:26122013. View Article : Google Scholar : PubMed/NCBI

18 

Emdad L, Das SK, Dasgupta S, Hu B, Sarkar D and Fisher PB: AEG-1/MTDH/LYRIC: signaling pathways, downstream genes, interacting proteins, and regulation of tumor angiogenesis. Adv Cancer Res. 120:75–111. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Goldman M, Craft B, Hastie M, Repečka K, McDade F, Kamath A, Banerjee A, Luo Y, Rogers D, Brooks AN, et al: The UCSC Xena platform for public and private cancer genomics data visualization and interpretation. bioRxiv. 3264702019.

20 

Li T, Fu J, Zeng Z, Cohen D, Li J, Chen Q, Li B and Liu XS: TIMER2.0 for analysis of tumor-infiltrating immune cells. Nucleic Acids Res. 48((W1)): W509–W514. 2020. View Article : Google Scholar : PubMed/NCBI

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Szklarczyk D, Gable AL, Nastou KC, Lyon D, Kirsch R, Pyysalo S, Doncheva NT, Legeay M, Fang T, Bork P, et al: The STRING database in 2021: Customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets. Nucleic Acids Res. 49((D1)): D605–D612. 2021. View Article : Google Scholar : PubMed/NCBI

23 

Liao Y, Wang J, Jaehnig EJ, Shi Z and Zhang B: WebGestalt 2019: Gene set analysis toolkit with revamped UIs and APIs. Nucleic Acids Res. 47((W1)): W199–W205. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Ogłuszka M, Orzechowska M, Jędroszka D, Witas P and Bednarek AK: Evaluate Cutpoints: Adaptable continuous data distribution system for determining survival in Kaplan-Meier estimator. Comput Methods Programs Biomed. 177:133–139. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Zeng D, Ye Z, Shen R, Yu G, Wu J, Xiong Y, Zhou R, Qiu W, Huang N, Sun L, et al: IOBR: multi-omics immuno-oncology biological research to decode tumor microenvironment and signatures. Front Immunol. 12:6879752021. View Article : Google Scholar : PubMed/NCBI

26 

He J, Ding H, Li H, Pan Z and Chen Q: Intra-tumoral expression of SLC7A11 is associated with immune microenvironment, drug resistance, and prognosis in cancers: A pan-cancer analysis. Front Genet. 12:7708572021. View Article : Google Scholar : PubMed/NCBI

27 

Li L, Yao W, Yan S, Dong X, Lv Z, Jing Q, Wang Q, Ma B, Hao C, Xue D and Wang D: Pan-cancer analysis of prognostic and immune infiltrates for CXCs. Cancers (Basel. 13:41532021. View Article : Google Scholar : PubMed/NCBI

28 

Stenström J, Hedenfalk I and Hagerling C: Regulatory T lymphocyte infiltration in metastatic breast cancer-an independent prognostic factor that changes with tumor progression. Breast Cancer Res. 23:272021. View Article : Google Scholar : PubMed/NCBI

29 

Ren L, Yi J, Yang Y, Li W, Zheng X, Liu J, Li S, Yang H, Zhang Y, Ge B, et al: Systematic pan-cancer analysis identifies APOC1 as an immunological biomarker which regulates macrophage polarization and promotes tumor metastasis. Pharmacol Res. 183:1063762022. View Article : Google Scholar : PubMed/NCBI

30 

Shan L, Lu Y, Song Y, Zhu X, Xiang CC, Zuo ED and Cheng X: Identification of nine M6A-related long noncoding RNAs as prognostic signatures associated with oxidative stress in oral cancer based on data from the cancer genome atlas. Oxid Med Cell Longev. 2022:95298142022. View Article : Google Scholar : PubMed/NCBI

31 

Niwa N, Tanaka N, Hongo H, Miyazaki Y, Takamatsu K, Mizuno R, Kikuchi E, Mikami S, Kosaka T and Oya M: TNFAIP2 expression induces epithelial-to-mesenchymal transition and confers platinum resistance in urothelial cancer cells. Lab Invest. 99:1702–1713. 2019. View Article : Google Scholar : PubMed/NCBI

32 

Jiao Y, Yang H, Qian J, Gong Y, Liu H, Wu S, Cao L and Tang L: miR-3664-5P suppresses the proliferation and metastasis of gastric cancer by attenuating the NF-κB signaling pathway through targeting MTDH. Int J Oncol. 54:845–858. 2019.PubMed/NCBI

33 

Luo L, Tang H, Ling L, Li N, Jia X, Zhang Z, Wang X, Shi L, Yin J, Qiu N, et al: LINC01638 lncRNA activates MTDH-Twist1 signaling by preventing SPOP-mediated c-Myc degradation in triple-negative breast cancer. Oncogene. 37:6166–6179. 2018. View Article : Google Scholar : PubMed/NCBI

34 

Qin Y, Wang J, Zhu G, Li G, Tan H, Chen C, Pi L, She L, Chen X, Wei M, et al: CCL18 promotes the metastasis of squamous cell carcinoma of the head and neck through MTDH-NF-κB signalling pathway. J Cell Mol Med. 23:2689–2701. 2019. View Article : Google Scholar : PubMed/NCBI

35 

Yin Q, Han Y, Zhu D, Li Z, Shan S, Jin W, Lu Q and Ren T: miR-145 and miR-497 suppress TGF-β-induced epithelial-mesenchymal transition of non-small cell lung cancer by targeting MTDH. Cancer Cell Int. 18:1052018. View Article : Google Scholar : PubMed/NCBI

36 

Yu C, Liu Y and Qin Z: Metadherin contributes to epithelial-mesenchymal transition and paclitaxel resistance induced by acidic extracellular pH in nasopharyngeal carcinoma. Oncol Lett. 15:3858–3863. 2018.PubMed/NCBI

37 

Li J, Li C, Li H, Zhang T, Hao X, Chang J and Xu Y: MicroRNA-30a-5p suppresses tumor cell proliferation of human renal cancer via the MTDH/PTEN/AKT pathway. Int J Mol Med. 41:1021–1029. 2018.PubMed/NCBI

38 

Zhang F, Huang H, Qin Y, Chen C, She L, Wang J, Huang D, Tang Q, Liu Y, Zhu G and Zhang X: MTDH associates with m6A RNA methylation and predicts cancer response for immune checkpoint treatment. iScience. 24:1031022021. View Article : Google Scholar : PubMed/NCBI

39 

Zhang H, Dai Z, Wu W, Wang Z, Zhang N, Zhang L, Zeng WJ, Liu Z and Cheng Q: Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer. J Exp Clin Cancer Res. 40:1842021. View Article : Google Scholar : PubMed/NCBI

40 

Esfahani K, Roudaia L, Buhlaiga N, Del Rincon SV, Papneja N and Miller WH Jr: A review of cancer immunotherapy: From the past, to the present, to the future. Curr Oncol. 27 (Suppl 2):S87–S97. 2020. View Article : Google Scholar : PubMed/NCBI

41 

Zhang H, Luo YB, Wu W, Zhang L, Wang Z, Dai Z, Feng S, Cao H, Cheng Q and Liu Z: The molecular feature of macrophages in tumor immune microenvironment of glioma patients. Comput Struct Biotechnol J. 19:4603–4618. 2021. View Article : Google Scholar : PubMed/NCBI

42 

Zhang H, Wang Z, Dai Z, Wu W, Cao H, Li S, Zhang N and Cheng Q: Novel Immune Infiltrating cell signature based on cell pair algorithm is a prognostic marker in cancer. Front Immunol. 12:6944902021. View Article : Google Scholar : PubMed/NCBI

43 

Hiam-Galvez KJ, Allen BM and Spitzer MH: Systemic immunity in cancer. Nat Rev Cancer. 21:345–359. 2021. View Article : Google Scholar : PubMed/NCBI

44 

Josefowicz SZ, Lu LF and Rudensky AY: Regulatory T cells: Mechanisms of differentiation and function. Annu Rev Immunol. 30:531–564. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Li C, Jiang P, Wei S, Xu X and Wang J: Regulatory T cells in tumor microenvironment: New mechanisms, potential therapeutic strategies and future prospects. Mol Cancer. 19:1162020. View Article : Google Scholar : PubMed/NCBI

46 

Chen Y, Song Y, Du W, Gong L, Chang H and Zou Z: Tumor-associated macrophages: An accomplice in solid tumor progression. J Biomed Sci. 26:782019. View Article : Google Scholar : PubMed/NCBI

47 

Duan Z and Luo Y: Targeting macrophages in cancer immunotherapy. Signal Transduct Target Ther. 6:1272021. View Article : Google Scholar : PubMed/NCBI

48 

Yin M, Li X, Tan S, Zhou HJ, Ji W, Bellone S, Xu X, Zhang H, Santin AD, Lou G and Min W: Tumor-associated macrophages drive spheroid formation during early transcoelomic metastasis of ovarian cancer. J Clin Invest. 126:4157–4173. 2016. View Article : Google Scholar : PubMed/NCBI

49 

Mantovani A, Marchesi F, Malesci A, Laghi L and Allavena P: Tumour-associated macrophages as treatment targets in oncology. Nat Rev Clin Oncol. 14:399–416. 2017. View Article : Google Scholar : PubMed/NCBI

50 

Galli F, Aguilera JV, Palermo B, Markovic SN, Nisticò P and Signore A: Relevance of immune cell and tumor microenvironment imaging in the new era of immunotherapy. J Exp Clin Cancer Res. 39:892020. View Article : Google Scholar : PubMed/NCBI

51 

Manna D and Sarkar D: Multifunctional role of astrocyte elevated gene-1 (AEG-1) in cancer: Focus on drug resistance. Cancers (Basel). 13:17922021. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang L, Han M, Zhao X, Zheng L, Kong F, Zhang S, Jia L, Li X and Wang M: Comprehensive pan‑cancer analysis of MTDH for human tumor prognosis and as an immunological biomarker including breast and kidney cancer. Oncol Lett 28: 349, 2024.
APA
Yang, L., Han, M., Zhao, X., Zheng, L., Kong, F., Zhang, S. ... Wang, M. (2024). Comprehensive pan‑cancer analysis of MTDH for human tumor prognosis and as an immunological biomarker including breast and kidney cancer. Oncology Letters, 28, 349. https://doi.org/10.3892/ol.2024.14482
MLA
Yang, L., Han, M., Zhao, X., Zheng, L., Kong, F., Zhang, S., Jia, L., Li, X., Wang, M."Comprehensive pan‑cancer analysis of MTDH for human tumor prognosis and as an immunological biomarker including breast and kidney cancer". Oncology Letters 28.2 (2024): 349.
Chicago
Yang, L., Han, M., Zhao, X., Zheng, L., Kong, F., Zhang, S., Jia, L., Li, X., Wang, M."Comprehensive pan‑cancer analysis of MTDH for human tumor prognosis and as an immunological biomarker including breast and kidney cancer". Oncology Letters 28, no. 2 (2024): 349. https://doi.org/10.3892/ol.2024.14482
Copy and paste a formatted citation
x
Spandidos Publications style
Yang L, Han M, Zhao X, Zheng L, Kong F, Zhang S, Jia L, Li X and Wang M: Comprehensive pan‑cancer analysis of MTDH for human tumor prognosis and as an immunological biomarker including breast and kidney cancer. Oncol Lett 28: 349, 2024.
APA
Yang, L., Han, M., Zhao, X., Zheng, L., Kong, F., Zhang, S. ... Wang, M. (2024). Comprehensive pan‑cancer analysis of MTDH for human tumor prognosis and as an immunological biomarker including breast and kidney cancer. Oncology Letters, 28, 349. https://doi.org/10.3892/ol.2024.14482
MLA
Yang, L., Han, M., Zhao, X., Zheng, L., Kong, F., Zhang, S., Jia, L., Li, X., Wang, M."Comprehensive pan‑cancer analysis of MTDH for human tumor prognosis and as an immunological biomarker including breast and kidney cancer". Oncology Letters 28.2 (2024): 349.
Chicago
Yang, L., Han, M., Zhao, X., Zheng, L., Kong, F., Zhang, S., Jia, L., Li, X., Wang, M."Comprehensive pan‑cancer analysis of MTDH for human tumor prognosis and as an immunological biomarker including breast and kidney cancer". Oncology Letters 28, no. 2 (2024): 349. https://doi.org/10.3892/ol.2024.14482
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