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First‑line programmed cell death 1 inhibitor plus chemotherapy vs. standard treatment in patients with recurrent or metastatic oral squamous cell carcinoma: A retrospective cohort study

  • Authors:
    • Lei Cheng
    • Congna Chai
    • Yingqi Liu
    • Jianjun Jiao
  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, Handan Central Hospital, Handan, Hebei 056001, P.R. China, Department of Oral and Maxillofacial Surgery, Handan Central Hospital, Handan, Hebei 056001, P.R. China
    Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 352
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    Published online on: June 3, 2024
       https://doi.org/10.3892/ol.2024.14486
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Abstract

Programmed cell death 1 (PD‑1) inhibitor revives the killing effect of immune cells to prevent tumor progression. The present study aimed to evaluate the efficacy and safety of first‑line PD‑1 inhibitor + chemotherapy vs. standard treatment in recurrent or metastatic (R/M) oral squamous cell carcinoma (OSCC). A total of 51 patients with R/M OSCC were reviewed and divided into the PD‑1 inhibitor + ​chemotherapy (n=21) and standard treatment (n=30) groups based on their actual treatments. The results of the present study demonstrated that the objective response rate (52.4 vs. 36.7%, P=0.265) and disease control rate (81.0 vs. 70.0%, P=0.377) were numerically elevated in the PD‑1 inhibitor + ​chemotherapy group compared with those in the standard treatment group; however, the results did not reach statistical significance. The progression‑free survival (PFS) was numerically increased (without statistical significance) in the PD‑1 inhibitor + chemotherapy group compared with that of the standard treatment group (P=0.057). Specifically, the PD‑1 inhibitor + chemotherapy group and the standard treatment group exhibited a median [95% confidence interval (CI)] PFS duration of 6.7 (1.6‑11.8) and 5.2 (3.4‑7.0) months, respectively. In addition, the PD‑1 inhibitor + chemotherapy group demonstrated increased overall survival (OS) compared with that of the standard treatment group (P=0.032). Specifically, the PD‑1 inhibitor + chemotherapy group and the standard treatment group exhibited a median (95% CI) OS duration of 18.3 (11.9‑24.7) and 10.3 (7.9‑12.7) months, respectively. Furthermore, multivariate Cox regression analysis indicated that PD‑1 inhibitor + chemotherapy was independently associated with improved PFS [hazard ratio (HR)=0.308, P=0.002] and OS (HR=0.252, P=0.003). In addition, the incidence of grade 3‑5 adverse events (AEs) was relatively low in both groups and the incidence of any grade of each AE was not significantly different between groups (all P>0.050). In conclusion, the first‑line PD‑1 inhibitor + chemotherapy group had improved efficacy and comparable safety compared with those of the standard treatment in patients with R/M OSCC.
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Copy and paste a formatted citation
Spandidos Publications style
Cheng L, Chai C, Liu Y and Jiao J: First‑line programmed cell death 1 inhibitor plus chemotherapy vs. standard treatment in patients with recurrent or metastatic oral squamous cell carcinoma: A retrospective cohort study. Oncol Lett 28: 352, 2024.
APA
Cheng, L., Chai, C., Liu, Y., & Jiao, J. (2024). First‑line programmed cell death 1 inhibitor plus chemotherapy vs. standard treatment in patients with recurrent or metastatic oral squamous cell carcinoma: A retrospective cohort study. Oncology Letters, 28, 352. https://doi.org/10.3892/ol.2024.14486
MLA
Cheng, L., Chai, C., Liu, Y., Jiao, J."First‑line programmed cell death 1 inhibitor plus chemotherapy vs. standard treatment in patients with recurrent or metastatic oral squamous cell carcinoma: A retrospective cohort study". Oncology Letters 28.2 (2024): 352.
Chicago
Cheng, L., Chai, C., Liu, Y., Jiao, J."First‑line programmed cell death 1 inhibitor plus chemotherapy vs. standard treatment in patients with recurrent or metastatic oral squamous cell carcinoma: A retrospective cohort study". Oncology Letters 28, no. 2 (2024): 352. https://doi.org/10.3892/ol.2024.14486
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng L, Chai C, Liu Y and Jiao J: First‑line programmed cell death 1 inhibitor plus chemotherapy vs. standard treatment in patients with recurrent or metastatic oral squamous cell carcinoma: A retrospective cohort study. Oncol Lett 28: 352, 2024.
APA
Cheng, L., Chai, C., Liu, Y., & Jiao, J. (2024). First‑line programmed cell death 1 inhibitor plus chemotherapy vs. standard treatment in patients with recurrent or metastatic oral squamous cell carcinoma: A retrospective cohort study. Oncology Letters, 28, 352. https://doi.org/10.3892/ol.2024.14486
MLA
Cheng, L., Chai, C., Liu, Y., Jiao, J."First‑line programmed cell death 1 inhibitor plus chemotherapy vs. standard treatment in patients with recurrent or metastatic oral squamous cell carcinoma: A retrospective cohort study". Oncology Letters 28.2 (2024): 352.
Chicago
Cheng, L., Chai, C., Liu, Y., Jiao, J."First‑line programmed cell death 1 inhibitor plus chemotherapy vs. standard treatment in patients with recurrent or metastatic oral squamous cell carcinoma: A retrospective cohort study". Oncology Letters 28, no. 2 (2024): 352. https://doi.org/10.3892/ol.2024.14486
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