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Article Open Access

Comprehensive analysis of signaling lymphocyte activation molecule family as a prognostic biomarker and correlation with immune infiltration in clear cell renal cell carcinoma

  • Authors:
    • Na Song
    • Ziwei Wang
    • Pingyu Shi
    • Kai Cui
    • Yanwu Fan
    • Liqun Zeng
    • Wenyu Di
    • Jinsong Li
    • Wei Su
    • Haijun Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Xinxiang Key Laboratory of Tumor Precision Medicine, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100, P.R. China, Department of Pathology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453000, P.R. China
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 354
    |
    Published online on: June 3, 2024
       https://doi.org/10.3892/ol.2024.14487
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Abstract

Clear cell renal cell carcinoma (ccRCC) is a common type of kidney cancer and accounts for 2‑3% of all cancer cases. Furthermore, a growing number of immunotherapy approaches are being used in antitumor treatment. Signaling lymphocyte activation molecule family (SLAMF) members have been well studied in several cancers, whereas their roles in ccRCC have not been investigated. The present study comprehensively assessed the molecular mechanisms of SLAMF members in ccRCC, performed using The Cancer Genome Atlas database, with analysis of gene transcription, prognosis, biological function, clinical features, tumor‑associated immune cells and the correlation with programmed cell death protein 1/programmed death‑ligand 1 immune checkpoints. Simultaneously, the Tumor Immune Dysfunction and Exclusion algorithm was used to predict the efficacy of immune checkpoint blockade (ICB) therapy in patients with high and low SLAMF expression levels. The results demonstrated that all SLAMF members were highly expressed in ccRCC, and patients with high expression levels of SLAMF1, 4, 7 and 8 had a worse prognosis that those with low expression. SLAMF members were not only highly associated with immune activation but also with immunosuppressive agents. The level of immune cell infiltration was associated with the prognosis of patients with ccRCC with high SLAMF expression. Moreover, high ICB response rates were observed in patients with high expression levels of SMALF1 and 4. In summary, SLAMF members may serve as future potential biomarkers for predicting the prognosis of ccRCC and emerge as a novel immunotherapy target.
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Copy and paste a formatted citation
Spandidos Publications style
Song N, Wang Z, Shi P, Cui K, Fan Y, Zeng L, Di W, Li J, Su W, Wang H, Wang H, et al: Comprehensive analysis of signaling lymphocyte activation molecule family as a prognostic biomarker and correlation with immune infiltration in clear cell renal cell carcinoma. Oncol Lett 28: 354, 2024.
APA
Song, N., Wang, Z., Shi, P., Cui, K., Fan, Y., Zeng, L. ... Wang, H. (2024). Comprehensive analysis of signaling lymphocyte activation molecule family as a prognostic biomarker and correlation with immune infiltration in clear cell renal cell carcinoma. Oncology Letters, 28, 354. https://doi.org/10.3892/ol.2024.14487
MLA
Song, N., Wang, Z., Shi, P., Cui, K., Fan, Y., Zeng, L., Di, W., Li, J., Su, W., Wang, H."Comprehensive analysis of signaling lymphocyte activation molecule family as a prognostic biomarker and correlation with immune infiltration in clear cell renal cell carcinoma". Oncology Letters 28.2 (2024): 354.
Chicago
Song, N., Wang, Z., Shi, P., Cui, K., Fan, Y., Zeng, L., Di, W., Li, J., Su, W., Wang, H."Comprehensive analysis of signaling lymphocyte activation molecule family as a prognostic biomarker and correlation with immune infiltration in clear cell renal cell carcinoma". Oncology Letters 28, no. 2 (2024): 354. https://doi.org/10.3892/ol.2024.14487
Copy and paste a formatted citation
x
Spandidos Publications style
Song N, Wang Z, Shi P, Cui K, Fan Y, Zeng L, Di W, Li J, Su W, Wang H, Wang H, et al: Comprehensive analysis of signaling lymphocyte activation molecule family as a prognostic biomarker and correlation with immune infiltration in clear cell renal cell carcinoma. Oncol Lett 28: 354, 2024.
APA
Song, N., Wang, Z., Shi, P., Cui, K., Fan, Y., Zeng, L. ... Wang, H. (2024). Comprehensive analysis of signaling lymphocyte activation molecule family as a prognostic biomarker and correlation with immune infiltration in clear cell renal cell carcinoma. Oncology Letters, 28, 354. https://doi.org/10.3892/ol.2024.14487
MLA
Song, N., Wang, Z., Shi, P., Cui, K., Fan, Y., Zeng, L., Di, W., Li, J., Su, W., Wang, H."Comprehensive analysis of signaling lymphocyte activation molecule family as a prognostic biomarker and correlation with immune infiltration in clear cell renal cell carcinoma". Oncology Letters 28.2 (2024): 354.
Chicago
Song, N., Wang, Z., Shi, P., Cui, K., Fan, Y., Zeng, L., Di, W., Li, J., Su, W., Wang, H."Comprehensive analysis of signaling lymphocyte activation molecule family as a prognostic biomarker and correlation with immune infiltration in clear cell renal cell carcinoma". Oncology Letters 28, no. 2 (2024): 354. https://doi.org/10.3892/ol.2024.14487
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