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ZBTB20 suppresses tumor growth in glioblastoma through activating the TET1/FAS/caspase‑3 pathway

  • Authors:
    • Ping Duan
    • Bo Li
    • Yifan Zhou
    • Huanhuan Cao
    • Shiyue Chen
    • Ying Xing
  • View Affiliations / Copyright

    Affiliations: Department of Physiology and Neurobiology, College of Medicine, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China
    Copyright: © Duan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 358
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    Published online on: June 5, 2024
       https://doi.org/10.3892/ol.2024.14491
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Abstract

Zinc finger and BTB domain containing 20 (ZBTB20) is a key transcription repressor that regulates multiple physiological and pathophysiological processes. Thus far, the role of ZBTB20 in glioblastoma (GBM), a World Health Organization grade IV glioma, remains unclear. In the present study, the expression profile data of ZBTB20 in GBM tissues from public databases was analyzed. It was found that ZBTB20 expression in GBM tissues was significantly lower than that measured in lower grade glioma tissues. Furthermore, patients with GBM with lower ZBTB20 expression were associated with a shorter overall survival time. Gain‑ and loss‑of‑function experiments in GBM cells were also performed. The results demonstrated that ZBTB20 overexpression decreased GBM cell proliferation, while ZBTB20 knockdown significantly enhanced it. Cell cycle analysis showed the ZBTB20 overexpression may have inhibited proliferation through cell cycle arrest at the G2/M phase, while ZBTB20 knockdown increased the percentages of cells in both the S phase and G2/M phase. Ten‑eleven translocation 1 (TET1) is an important tumor suppressor involved in the formation of various types of tumor, and it was upregulated in ZBTB20‑overexpressing GBM cells. It was further demonstrated that ZBTB20 activated the TET1/FAS/caspase‑3 pathway. The results of the present study therefore indicated the potential role of ZBTB20 as a tumor suppressor and therapeutic target for GBM.
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Copy and paste a formatted citation
Spandidos Publications style
Duan P, Li B, Zhou Y, Cao H, Chen S and Xing Y: ZBTB20 suppresses tumor growth in glioblastoma through activating the TET1/FAS/caspase‑3 pathway. Oncol Lett 28: 358, 2024.
APA
Duan, P., Li, B., Zhou, Y., Cao, H., Chen, S., & Xing, Y. (2024). ZBTB20 suppresses tumor growth in glioblastoma through activating the TET1/FAS/caspase‑3 pathway. Oncology Letters, 28, 358. https://doi.org/10.3892/ol.2024.14491
MLA
Duan, P., Li, B., Zhou, Y., Cao, H., Chen, S., Xing, Y."ZBTB20 suppresses tumor growth in glioblastoma through activating the TET1/FAS/caspase‑3 pathway". Oncology Letters 28.2 (2024): 358.
Chicago
Duan, P., Li, B., Zhou, Y., Cao, H., Chen, S., Xing, Y."ZBTB20 suppresses tumor growth in glioblastoma through activating the TET1/FAS/caspase‑3 pathway". Oncology Letters 28, no. 2 (2024): 358. https://doi.org/10.3892/ol.2024.14491
Copy and paste a formatted citation
x
Spandidos Publications style
Duan P, Li B, Zhou Y, Cao H, Chen S and Xing Y: ZBTB20 suppresses tumor growth in glioblastoma through activating the TET1/FAS/caspase‑3 pathway. Oncol Lett 28: 358, 2024.
APA
Duan, P., Li, B., Zhou, Y., Cao, H., Chen, S., & Xing, Y. (2024). ZBTB20 suppresses tumor growth in glioblastoma through activating the TET1/FAS/caspase‑3 pathway. Oncology Letters, 28, 358. https://doi.org/10.3892/ol.2024.14491
MLA
Duan, P., Li, B., Zhou, Y., Cao, H., Chen, S., Xing, Y."ZBTB20 suppresses tumor growth in glioblastoma through activating the TET1/FAS/caspase‑3 pathway". Oncology Letters 28.2 (2024): 358.
Chicago
Duan, P., Li, B., Zhou, Y., Cao, H., Chen, S., Xing, Y."ZBTB20 suppresses tumor growth in glioblastoma through activating the TET1/FAS/caspase‑3 pathway". Oncology Letters 28, no. 2 (2024): 358. https://doi.org/10.3892/ol.2024.14491
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