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Association between CD4+ T cells ATP levels and disease progression in patients with non‑small cell lung cancer

  • Authors:
    • Weipeng Ye
    • Kailian Hou
    • Na Tao
    • Weiyi Li
    • Zhiqiong Tan
    • Qunfeng Huang
    • Dongheng Yang
    • Haoxin Lin
    • Zihao Deng
    • Yuanyuan Xia
    • Guifang Yu
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The Fifth Affiliated Hospital of Guangzhou Medical University, Huangpu, Guangzhou 510700, P.R. China
    Copyright: © Ye et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 369
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    Published online on: June 12, 2024
       https://doi.org/10.3892/ol.2024.14502
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Abstract

Introducing the exploration of stimulated CD4+ cells adenosine triphosphate (sATPCD4) levels for immune monitoring post non‑small cell lung cancer (NSCLC) chemotherapy, the present study aimed to investigate its efficacy in gauging the potential risk of disease progression (PD) in patients with NSCLC. Therefore, a total of 89 patients with advanced NSCLC, who underwent chemotherapy between August 15 2022 and August 30 2023 at the Fifth Affiliated Hospital of Guangzhou Medical University (Guangzhou, China), were retrospectively studied. Patients were divided into the PD (n=21) and disease stability (non‑PD; n=68) groups and their clinical data were compared. The thresholds for predicting PD were identified using receiver operating characteristics (ROC) curves. Multivariate logistic regression analysis was carried out to assess the association between peripheral blood markers and the incidence of PD. Therefore, post‑chemotherapy, significant differences in white blood cell count, non‑stimulated CD4+ cells ATP and sATPCD4 levels were obtained between patients in the PD and non‑PD groups (P<0.05). In addition, sATPCD4 levels were notably decreased in the PD group compared with the non‑PD group. Furthermore, ROC analysis revealed that the predictive threshold for PD was 224.5 ng/ml [area under the curve=0.887; 95% confidence interval, 0.811‑0.963]. Additionally, patients with low immunity (ATP <224.5 ng/ml) exhibited a higher risk of PD compared with the high‑immunity group (ATP >224.5 ng/ml; P<0.0001). Finally, multivariate logistic regression analysis suggested that sATPCD4 could serve as an independent factor for predicting NSCLC progression. Overall, the current study predicted that immune function could be possibly associated with the risk of PD in patients with NSCLC.
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View References

1 

Siegel RL, Miller KD, Wagle NS and Jemal A: Cancer statistics, 2023. CA Cancer J Clin. 73:17–48. 2023. View Article : Google Scholar : PubMed/NCBI

2 

Xia C, Dong X, Li H, Cao M, Sun D, He S, Yang F, Yan X, Zhang S, Li N and Chen W: Cancer statistics in China and United States, 2022: Profiles, trends, and determinants. Chin Med J (Engl). 135:584–590. 2022. View Article : Google Scholar : PubMed/NCBI

3 

Chen X, Liu Y, Røe OD, Qian Y, Guo R, Zhu L, Yin Y and Shu Y: Gefitinib or erlotinib as maintenance therapy in patients with advanced stage non-small cell lung cancer: A systematic review. PLoS One. 8:e593142013. View Article : Google Scholar : PubMed/NCBI

4 

Li K, Zhang Q, Zhang Y, Yang J and Zheng J: T-cell-associated cellular immunotherapy for lung cancer. J Cancer Res Clin Oncol. 141:1249–1258. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Carlisle JW, Steuer CE, Owonikoko TK and Saba NF: An update on the immune landscape in lung and head and neck cancers. CA Cancer J Clin. 70:505–517. 2020. View Article : Google Scholar : PubMed/NCBI

6 

Mazzaschi G, Facchinetti F, Missale G, Canetti D, Madeddu D, Zecca A, Veneziani M, Gelsomino F, Goldoni M, Buti S, et al: The circulating pool of functionally competent NK and CD8+ cells predicts the outcome of anti-PD1 treatment in advanced NSCLC. Lung Cancer. 127:153–163. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Kotsakis A, Koinis F, Katsarou A, Gioulbasani M, Aggouraki D, Kentepozidis N, Georgoulias V and Vetsika EK: Prognostic value of circulating regulatory T cell subsets in untreated non-small cell lung cancer patients. Sci Rep. 6:392472016. View Article : Google Scholar : PubMed/NCBI

8 

Yan Y, Wang X, Liu C and Jia J: Association of lymphocyte subsets with efficacy and prognosis of immune checkpoint inhibitor therapy in advanced non-small cell lung carcinoma: A retrospective study. BMC Pulm Med. 22:1662022. View Article : Google Scholar : PubMed/NCBI

9 

Robaire B and Hales BF: Mechanisms of action of cyclophosphamide as a male-mediated developmental toxicant. Adv Exp Med Biol. 518:169–180. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Vollmer T, Stewart T and Baxter N: Mitoxantrone and cytotoxic drugs' mechanisms of action. Neurology. 74:S41–S46. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Hodge JW, Garnett CT, Farsaci B, Palena C, Tsang KY, Ferrone S and Gameiro SR: Chemotherapy-induced immunogenic modulation of tumor cells enhances killing by cytotoxic T lymphocytes and is distinct from immunogenic cell death. Int J Cancer. 133:624–636. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Locher C, Conforti R, Aymeric L, Ma Y, Yamazaki T, Rusakiewicz S, Tesniere A, Ghiringhelli F, Apetoh L, Morel Y, et al: Desirable cell death during anticancer chemotherapy. Ann N Y Acad Sci. 1209:99–108. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Xue F, Gao W, Qin T, Wu C, Luo Y, Chen J, Zhou T, Feng M, Qiu B, Zhu J, et al: Immune cell function assays in the diagnosis of infection in pediatric liver transplantation: An open-labeled, two center prospective cohort study. Transl Pediatr. 10:333–343. 2021. View Article : Google Scholar : PubMed/NCBI

14 

Liu W, Wang K, Zhao YH, Song GP, Gao W and Li DH: Clinical relevance of a CD4+ T cell immune function assay in the diagnosis of infection in pediatric living-donor liver transplantation. Exp Ther Med. 18:3823–3828. 2019.PubMed/NCBI

15 

Maidman SD, Gidea C, Reyentovich A, Rao S, Saraon T, Kadosh BS, Narula N, Carillo J, Smith D, Moazami N, et al: Pre-transplant immune cell function assay as a predictor of early cardiac allograft rejection. Clin Transplant. 36:e147452022. View Article : Google Scholar : PubMed/NCBI

16 

Serban G, Whittaker V, Fan J, Liu Z, Manga K, Khan M, Kontogianni K, Padmanabhan A, Cohen D, Suciu-Foca N, et al: Significance of immune cell function monitoring in renal transplantation after Thymoglobulin induction therapy. Hum Immunol. 70:882–890. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Xian Y, Zhang KX, Bi XG, Zheng CL and Xie D: Value of adenosine triphosphate in CD4+ T lymphocytes to the prediction of prognosis of septic patients. Chin Pract Diagn Ther. 37:1216–1221. 2023.(In Chinese).

18 

Cheng JW, Shi YH, Fan J, Huang XW, Qiu SJ, Xiao YS, Wang Z, Dai Z, Tang ZY and Zhou J: An immune function assay predicts post-transplant recurrence in patients with hepatocellular carcinoma. J Cancer Res Clin Oncol. 137:1445–1453. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Uemura T, Riley TR, Khan A, Hollenbeak C, Schreibman I, Ghahramani N, Reeves B, Domen RE, Zander DS and Kadry Z: Immune functional assay for immunosuppressive management in post-transplant malignancy. Clin Transplant. 25:E32–E37. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Chen DS and Mellman I: Oncology meets immunology: The cancer-immunity cycle. Immunity. 39:1–10. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Gridelli C, Ardizzoni A, Le Chevalier T, Manegold C, Perrone F, Thatcher N, Van Zandwijk N, Di Maio M, Martelli O and De Marinis F: Treatment of advanced non-small-cell lung cancer patients with ECOG performance status 2: Results of an European experts panel. Ann Oncol. 15:419–426. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Detterbeck FC, Chansky K, Groome P, Bolejack V, Crowley J, Shemanski L, Kennedy C, Krasnik M, Peake M and Rami-Porta R: IASLC Staging and Prognostic Factors Committee, Advisory Boards, and Participating Institutions: The IASLC lung cancer staging project: Methodology and validation used in the development of proposals for revision of the stage classification of NSCLC in the forthcoming (eighth) edition of the TNM classification of lung cancer. J Thorac Oncol. 11:1433–1446. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Seymour L, Bogaerts J, Perrone A, Ford R, Schwartz LH, Mandrekar S, Lin NU, Litière S, Dancey J, Chen A, et al: iRECIST: Guidelines for response criteria for use in trials testing immunotherapeutics. Lancet Oncol. 18:e143–e152. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Hou K, Ye W, Huang Q, Li W, Tan Z, Tao N, Yang D, Lin H, Deng Z, Xia Y and Yu G: The predictive value of peripheral blood CD4 cells ATP concentration for immune-related adverse events in advanced non-small cell lung cancer patients. BMC Immunol. 25:32024. View Article : Google Scholar : PubMed/NCBI

25 

Wang L, Zhang M, Pan X, Zhao M, Huang L, Hu X, Wang X, Qiao L, Guo Q, Xu W, et al: Integrative serum metabolic fingerprints based multi-modal platforms for lung adenocarcinoma early detection and pulmonary nodule classification. Adv Sci (Weinh). 9:e22037862022. View Article : Google Scholar : PubMed/NCBI

26 

Griesinger F, Korol EE, Kayaniyil S, Varol N, Ebner T and Goring SM: Efficacy and safety of first-line carboplatin-versus cisplatin-based chemotherapy for non-small cell lung cancer: A meta-analysis. Lung Cancer. 135:196–204. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Chalabi M, Cardona A, Nagarkar D, Scala AD, Gandara D, Rittmeyer A, Albert M, Powles T, Kok M and Herrera FG; imCORE working group of early career investigators, : Efficacy of chemotherapy and atezolizumab in patients with non-small-cell lung cancer receiving antibiotics and proton pump inhibitors: Pooled post hoc analyses of the OAK and POPLAR trials. Ann Oncol. 31:525–531. 2020. View Article : Google Scholar : PubMed/NCBI

28 

Ding Z, Liu Y, Huang Q, Cheng C, Song L, Zhang C, Cui X, Wang Y, Han Y and Zhang H: m6A-and immune-related lncRNA signature confers robust predictive power for immune efficacy in lung squamous cell carcinoma. View. 4:202200832023. View Article : Google Scholar

29 

Hanoteau A, Newton JM, Krupar R, Huang C, Liu HC, Gaspero A, Gartrell RD, Saenger YM, Hart TD, Santegoets SJ, et al: Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy. J Immunother Cancer. 7:102019. View Article : Google Scholar : PubMed/NCBI

30 

Xu L, Zou C, Zhang S, Chu TSM, Zhang Y, Chen W, Zhao C, Yang L, Xu Z, Dong S, et al: Reshaping the systemic tumor immune environment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacy in solid tumors. J Hematol Oncol. 15:872022. View Article : Google Scholar : PubMed/NCBI

31 

Salem ML, Atia I and Elmashad NM: Higher cytotoxic activities of CD8+ T cells and natural killer cells from peripheral blood of early diagnosed lung cancer patients. BMC Immunology. 24:242023. View Article : Google Scholar : PubMed/NCBI

32 

Kang DH, Choi SW, Sun P, Chung C, Park D, Lee SI, Koh JS, Kim Y and Lee JE: The rest period between chemotherapy and immunotherapy influences the efficacy of immune checkpoint inhibitors in lung cancer. Thoracic Cancer. 13:2346–2354. 2022. View Article : Google Scholar : PubMed/NCBI

33 

Bonora M, Patergnani S, Rimessi A, De Marchi E, Suski JM, Bononi A, Giorgi C, Marchi S, Missiroli S, Poletti F, et al: ATP synthesis and storage. Purinergic Signal. 8:343–357. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Kowalski R, Post D, Schneider MC, Britz J, Thomas J, Deierhoi M, Lobashevsky A, Redfield R, Schweitzer E, Heredia A, et al: Immune cell function testing: An adjunct to therapeutic drug monitoring in transplant patient management. Clin Transplant. 17:77–88. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Rodrigo E, López-Hoyos M, Corral M, Fábrega E, Fernández-Fresnedo G, Segundo DS, Piñera C and Arias M: ImmuKnow as a diagnostic tool for predicting infection and acute rejection in adult liver transplant recipients: A systematic review and meta-analysis. Liver Transpl. 18:1244–1252. 2012. View Article : Google Scholar

36 

Lawrence KL, White PH, Morris GP, Jennemann J, Phelan DL, Hotchkiss RS and Kollef MH: CD4+ lymphocyte adenosine triphosphate determination in sepsis: A cohort study. Crit Care. 14:R1102010. View Article : Google Scholar : PubMed/NCBI

37 

Kagamu H, Kitano S, Yamaguchi O, Yoshimura K, Horimoto K, Kitazawa M, Fukui K, Shiono A, Mouri A, Nishihara F, et al: CD4+ T-cell immunity in the peripheral blood correlates with response to anti-PD-1 therapy. Cancer Immunol Res. 8:334–344. 2020. View Article : Google Scholar : PubMed/NCBI

38 

Xue F, Zhang J, Han L, Li Q, Xu N, Zhou T, Xi Z, Wu Y and Xia Q: Immune cell functional assay in monitoring of adult liver transplantation recipients with infection. Transplantation. 89:620–626. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Sun B and Zhang Y: Overview of orchestration of CD4+ T cell subsets in immune responses. Adv Exp Med Biol. 84:1–13. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Vonderheide RH and Bayne LJ: Inflammatory networks and immune surveillance of pancreatic carcinoma. Curr Opin Immunol. 25:200–205. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Zhang BB, Zhu W, Tao J, Li Y, Du CC, Chen YX and Liu YD: Short-term efficacy of different first-line chemotherapy regimens for advanced non-small cell lung cancer: A network meta-analysis. Clin Trans Sci. 13:589–598. 2020. View Article : Google Scholar

42 

Xu J, Xiong Y, Xu Z, Xing H, Zhou L and Zhang X: From targeted therapy to a novel way: Immunogenic cell death in lung cancer. Front Med (Lausanne). 9:11025502022. View Article : Google Scholar : PubMed/NCBI

43 

Hamarsheh SA, Groß O, Brummer T and Zeiser R: Immune modulatory effects of oncogenic KRAS in cancer. Nat Commun. 11:54392020. View Article : Google Scholar : PubMed/NCBI

44 

Ravaioli M, Neri F, Lazzarotto T, Bertuzzo VR, Di Gioia P, Stacchini G, Morelli MC, Ercolani G, Cescon M, Chiereghin A, et al: Immunosuppression modifications based on an immune response assay: Results of a randomized, controlled trial. Transplantation. 99:1625–1632. 2015. View Article : Google Scholar : PubMed/NCBI

45 

Petroni G, Buqué A, Zitvogel L, Kroemer G and Galluzzi L: Immunomodulation by targeted anticancer agents. Cancer Cell. 39:310–345. 2021. View Article : Google Scholar : PubMed/NCBI

46 

Kelly B and O'Neill LA: Metabolic reprogramming in macrophages and dendritic cells in innate immunity. Cell Res. 25:771–784. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Zhang Y, Fang W, Yan Y, Wang M, Kang S, Sheng J, Zhan J, Chen N, Hong S, Yang Y, et al: The efficacy of first-line chemotherapy is associated with KRAS mutation status in patients with advanced non-small cell lung cancer: A meta-analysis. Med Oncol. 32:612015. View Article : Google Scholar : PubMed/NCBI

48 

Dy GK, Govindan R, Velcheti V, Falchook GS, Italiano A, Wolf J, Sacher AG, Takahashi T, Ramalingam SS, Dooms C, et al: Long-term outcomes and molecular correlates of sotorasib efficacy in patients with pretreated KRAS G12C-mutated non-small-cell lung cancer: 2-year analysis of CodeBreaK 100. J Clin Oncol. 41:3311–3317. 2023. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ye W, Hou K, Tao N, Li W, Tan Z, Huang Q, Yang D, Lin H, Deng Z, Xia Y, Xia Y, et al: Association between CD4<sup>+</sup> T cells ATP levels and disease progression in patients with non‑small cell lung cancer. Oncol Lett 28: 369, 2024.
APA
Ye, W., Hou, K., Tao, N., Li, W., Tan, Z., Huang, Q. ... Yu, G. (2024). Association between CD4<sup>+</sup> T cells ATP levels and disease progression in patients with non‑small cell lung cancer. Oncology Letters, 28, 369. https://doi.org/10.3892/ol.2024.14502
MLA
Ye, W., Hou, K., Tao, N., Li, W., Tan, Z., Huang, Q., Yang, D., Lin, H., Deng, Z., Xia, Y., Yu, G."Association between CD4<sup>+</sup> T cells ATP levels and disease progression in patients with non‑small cell lung cancer". Oncology Letters 28.2 (2024): 369.
Chicago
Ye, W., Hou, K., Tao, N., Li, W., Tan, Z., Huang, Q., Yang, D., Lin, H., Deng, Z., Xia, Y., Yu, G."Association between CD4<sup>+</sup> T cells ATP levels and disease progression in patients with non‑small cell lung cancer". Oncology Letters 28, no. 2 (2024): 369. https://doi.org/10.3892/ol.2024.14502
Copy and paste a formatted citation
x
Spandidos Publications style
Ye W, Hou K, Tao N, Li W, Tan Z, Huang Q, Yang D, Lin H, Deng Z, Xia Y, Xia Y, et al: Association between CD4<sup>+</sup> T cells ATP levels and disease progression in patients with non‑small cell lung cancer. Oncol Lett 28: 369, 2024.
APA
Ye, W., Hou, K., Tao, N., Li, W., Tan, Z., Huang, Q. ... Yu, G. (2024). Association between CD4<sup>+</sup> T cells ATP levels and disease progression in patients with non‑small cell lung cancer. Oncology Letters, 28, 369. https://doi.org/10.3892/ol.2024.14502
MLA
Ye, W., Hou, K., Tao, N., Li, W., Tan, Z., Huang, Q., Yang, D., Lin, H., Deng, Z., Xia, Y., Yu, G."Association between CD4<sup>+</sup> T cells ATP levels and disease progression in patients with non‑small cell lung cancer". Oncology Letters 28.2 (2024): 369.
Chicago
Ye, W., Hou, K., Tao, N., Li, W., Tan, Z., Huang, Q., Yang, D., Lin, H., Deng, Z., Xia, Y., Yu, G."Association between CD4<sup>+</sup> T cells ATP levels and disease progression in patients with non‑small cell lung cancer". Oncology Letters 28, no. 2 (2024): 369. https://doi.org/10.3892/ol.2024.14502
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