Open Access

Increased CD56 expression after photodynamic therapy indicates an increased natural killer cell count following early photodynamic therapy for cutaneous squamous cell carcinoma

  • Authors:
    • Hongqing Zhao
    • Yuan Ren
    • Huiling Kou
    • Junbo Zhang
    • Xingcun Zhang
  • View Affiliations

  • Published online on: June 13, 2024     https://doi.org/10.3892/ol.2024.14505
  • Article Number: 372
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cutaneous squamous cell carcinoma (cSCC) is the second most common type of skin cancer. Photodynamic therapy (PDT) is a promising therapeutic method for managing cSCC due to its proven ability to target specific areas over time and its low risk of side effects. PDT may cause tissue damage and vascular shutdown, and may regulate local immunological responses. The present study aimed to investigate and compare the early lymphocyte modifications before and after PDT for SCC. A total of 10 patients with SCC were identified by pathological investigation. Initially, all wounds were treated with 20% aminolevulinic acid (ALA)‑PDT as the initial stage in the therapeutic procedure. The wounds were treated by exposing them to red LED light with a wavelength of 635 nm, an energy density of 100 J/cm2 and an intensity of 80 mW/cm2. The tumor tissue was surgically removed 24 h later, and another round of PDT therapy was administered. Immunohistochemistry for CD3 and CD56 was conducted on the wound tissue post‑surgery. If the wound showed granulation, necrosis or secretion, debridement was added to the therapy. All patients were monitored for 0.6‑1.0 year post‑treatment. ALA‑PDT combination surgery fully controlled the tumor tissue in all 10 patients. The immunohistochemical analysis of the wound tissues showed that the expression of CD56 increased, while the expression of CD3 was not different after photodynamic therapy. These results also indirectly indicated that the overall count of NK cells in the 10 patients increased, nevertheless, there was no alteration in the T lymphocyte count. In conclusion, the ALA‑PDT combination surgical therapy for cSCC demonstrates favorable results. An increase in CD56 expression may be a mechanism for the effective treatment of cSCC with PDT.
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August-2024
Volume 28 Issue 2

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Spandidos Publications style
Zhao H, Ren Y, Kou H, Zhang J and Zhang X: Increased CD56 expression after photodynamic therapy indicates an increased natural killer cell count following early photodynamic therapy for cutaneous squamous cell carcinoma. Oncol Lett 28: 372, 2024.
APA
Zhao, H., Ren, Y., Kou, H., Zhang, J., & Zhang, X. (2024). Increased CD56 expression after photodynamic therapy indicates an increased natural killer cell count following early photodynamic therapy for cutaneous squamous cell carcinoma. Oncology Letters, 28, 372. https://doi.org/10.3892/ol.2024.14505
MLA
Zhao, H., Ren, Y., Kou, H., Zhang, J., Zhang, X."Increased CD56 expression after photodynamic therapy indicates an increased natural killer cell count following early photodynamic therapy for cutaneous squamous cell carcinoma". Oncology Letters 28.2 (2024): 372.
Chicago
Zhao, H., Ren, Y., Kou, H., Zhang, J., Zhang, X."Increased CD56 expression after photodynamic therapy indicates an increased natural killer cell count following early photodynamic therapy for cutaneous squamous cell carcinoma". Oncology Letters 28, no. 2 (2024): 372. https://doi.org/10.3892/ol.2024.14505