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MIS18A upregulation promotes cell viability, migration and tumor immune evasion in lung adenocarcinoma

  • Authors:
    • Yongjie Zhu
    • Zihao Li
    • Zuotao Wu
    • Ting Zhuo
    • Lei Dai
    • Guanbiao Liang
    • Huajian Peng
    • Honglin Lu
    • Yongyong Wang
  • View Affiliations / Copyright

    Affiliations: Department of Cardio‑Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China, Department of Thoracic Surgery, Liuzhou People's Hospital Affiliated to Guangxi Medical University, Liuzhou, Guangxi Zhuang Autonomous Region 545026, P.R. China, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 376
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    Published online on: June 13, 2024
       https://doi.org/10.3892/ol.2024.14509
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Abstract

Lung adenocarcinoma (LUAD) presents a significant global health challenge owing to its poor prognosis and high mortality rates. Despite its involvement in the initiation and progression of a number of cancer types, the understanding of the precise impact of MIS18 kinetochore protein A (MIS18A) on LUAD remains incomplete. In the present study, the role of MIS18A in LUAD was investigated by analyzing the genomic and clinical data from multiple public datasets. The expression of MIS18A was validated using reverse transcription‑quantitative polymerase chain reaction, and in vitro experiments involving small interfering RNA‑induced downregulation of MIS18A in lung cancer cells were conducted to further explore its impact. These findings revealed that elevated MIS18A expression in LUAD was associated with advanced clinical features and poor prognosis. Functional analysis also revealed the role of MIS18A in regulating the cell cycle and immune‑related pathways. Moreover, MIS18A altered the immune microenvironment in LUAD, influencing its response to immunotherapy and drug sensitivity. The results of the in vitro experiments indicated that suppression of MIS18A expression reduced the proliferative and migratory capacities of LUAD cells. In summary, MIS18A possesses potential as a biomarker and may serve as a possible therapeutic target for LUAD, with significant implications for tumor progression by influencing both cell cycle dynamics and immune infiltration.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu Y, Li Z, Wu Z, Zhuo T, Dai L, Liang G, Peng H, Lu H and Wang Y: MIS18A upregulation promotes cell viability, migration and tumor immune evasion in lung adenocarcinoma. Oncol Lett 28: 376, 2024.
APA
Zhu, Y., Li, Z., Wu, Z., Zhuo, T., Dai, L., Liang, G. ... Wang, Y. (2024). MIS18A upregulation promotes cell viability, migration and tumor immune evasion in lung adenocarcinoma. Oncology Letters, 28, 376. https://doi.org/10.3892/ol.2024.14509
MLA
Zhu, Y., Li, Z., Wu, Z., Zhuo, T., Dai, L., Liang, G., Peng, H., Lu, H., Wang, Y."MIS18A upregulation promotes cell viability, migration and tumor immune evasion in lung adenocarcinoma". Oncology Letters 28.2 (2024): 376.
Chicago
Zhu, Y., Li, Z., Wu, Z., Zhuo, T., Dai, L., Liang, G., Peng, H., Lu, H., Wang, Y."MIS18A upregulation promotes cell viability, migration and tumor immune evasion in lung adenocarcinoma". Oncology Letters 28, no. 2 (2024): 376. https://doi.org/10.3892/ol.2024.14509
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu Y, Li Z, Wu Z, Zhuo T, Dai L, Liang G, Peng H, Lu H and Wang Y: MIS18A upregulation promotes cell viability, migration and tumor immune evasion in lung adenocarcinoma. Oncol Lett 28: 376, 2024.
APA
Zhu, Y., Li, Z., Wu, Z., Zhuo, T., Dai, L., Liang, G. ... Wang, Y. (2024). MIS18A upregulation promotes cell viability, migration and tumor immune evasion in lung adenocarcinoma. Oncology Letters, 28, 376. https://doi.org/10.3892/ol.2024.14509
MLA
Zhu, Y., Li, Z., Wu, Z., Zhuo, T., Dai, L., Liang, G., Peng, H., Lu, H., Wang, Y."MIS18A upregulation promotes cell viability, migration and tumor immune evasion in lung adenocarcinoma". Oncology Letters 28.2 (2024): 376.
Chicago
Zhu, Y., Li, Z., Wu, Z., Zhuo, T., Dai, L., Liang, G., Peng, H., Lu, H., Wang, Y."MIS18A upregulation promotes cell viability, migration and tumor immune evasion in lung adenocarcinoma". Oncology Letters 28, no. 2 (2024): 376. https://doi.org/10.3892/ol.2024.14509
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