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August-2024 Volume 28 Issue 2

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Case Report Open Access

Tumor lysis syndrome in a patient with advanced lung squamous cell carcinoma undergoing combined therapy with a programmed cell death protein 1 inhibitor and first‑line chemotherapy: A case report

  • Authors:
    • Li Cao
    • Wei Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The Second People's Hospital of Guiyang, Guiyang, Guizhou 550081, P.R. China, Department of Oncology, Guizhou Hospital of the First Affiliated Hospital of Sun Yat‑sen University, Guiyang, Guizhou 550003, P.R. China
    Copyright: © Cao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 380
    |
    Published online on: June 17, 2024
       https://doi.org/10.3892/ol.2024.14513
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Abstract

Tumor lysis syndrome (TLS) is a rare but serious complication in patients with solid tumors. It is characterized by a complex array of metabolic disturbances and clinical symptoms, resulting from the release of cellular contents into the bloodstream after tumor cell lysis. The present study reports the case of a patient with advanced lung squamous cell carcinoma (SCC) who developed TLS following combined treatment with PD‑1 inhibitors and first‑line chemotherapy. The treatment strategy included intravenous fluid replacement, urine alkalinization, uric acid reduction, renal protection and electrolyte stabilization, leading to the normalization of laboratory values. After one cycle of the combined therapy, the patient achieved a partial response, classified using the Response Evaluation Criteria in Solid Tumours 1.1 criteria. To the best of our knowledge, this is the first reported case of TLS in a patient with advanced lung SCC receiving concurrent PD‑1 inhibitor and chemotherapy treatment. Given the increasing use of PD‑1 inhibitors, it is essential to remain vigilant about the potential for TLS in solid tumors. Prompt intervention in high‑risk patients, ongoing monitoring after treatment, and early detection of TLS are vital to improve patient adherence, ensure continuity of care and enhance outcomes.
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Copy and paste a formatted citation
Spandidos Publications style
Cao L and Zhang W: Tumor lysis syndrome in a patient with advanced lung squamous cell carcinoma undergoing combined therapy with a programmed cell death protein 1 inhibitor and first‑line chemotherapy: A case report. Oncol Lett 28: 380, 2024.
APA
Cao, L., & Zhang, W. (2024). Tumor lysis syndrome in a patient with advanced lung squamous cell carcinoma undergoing combined therapy with a programmed cell death protein 1 inhibitor and first‑line chemotherapy: A case report. Oncology Letters, 28, 380. https://doi.org/10.3892/ol.2024.14513
MLA
Cao, L., Zhang, W."Tumor lysis syndrome in a patient with advanced lung squamous cell carcinoma undergoing combined therapy with a programmed cell death protein 1 inhibitor and first‑line chemotherapy: A case report". Oncology Letters 28.2 (2024): 380.
Chicago
Cao, L., Zhang, W."Tumor lysis syndrome in a patient with advanced lung squamous cell carcinoma undergoing combined therapy with a programmed cell death protein 1 inhibitor and first‑line chemotherapy: A case report". Oncology Letters 28, no. 2 (2024): 380. https://doi.org/10.3892/ol.2024.14513
Copy and paste a formatted citation
x
Spandidos Publications style
Cao L and Zhang W: Tumor lysis syndrome in a patient with advanced lung squamous cell carcinoma undergoing combined therapy with a programmed cell death protein 1 inhibitor and first‑line chemotherapy: A case report. Oncol Lett 28: 380, 2024.
APA
Cao, L., & Zhang, W. (2024). Tumor lysis syndrome in a patient with advanced lung squamous cell carcinoma undergoing combined therapy with a programmed cell death protein 1 inhibitor and first‑line chemotherapy: A case report. Oncology Letters, 28, 380. https://doi.org/10.3892/ol.2024.14513
MLA
Cao, L., Zhang, W."Tumor lysis syndrome in a patient with advanced lung squamous cell carcinoma undergoing combined therapy with a programmed cell death protein 1 inhibitor and first‑line chemotherapy: A case report". Oncology Letters 28.2 (2024): 380.
Chicago
Cao, L., Zhang, W."Tumor lysis syndrome in a patient with advanced lung squamous cell carcinoma undergoing combined therapy with a programmed cell death protein 1 inhibitor and first‑line chemotherapy: A case report". Oncology Letters 28, no. 2 (2024): 380. https://doi.org/10.3892/ol.2024.14513
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