Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
August-2024 Volume 28 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2024 Volume 28 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Efficacy and safety of denosumab de‑escalation in giant cell tumor of bone

  • Authors:
    • Eiji Nakata
    • Toshiyuki Kunisada
    • Tomohiro Fujiwara
    • Haruyoshi Katayama
    • Takuto Itano
    • Toshifumi Ozaki
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, Okayama University Hospital, Okayama 700‑8558, Japan
  • Article Number: 387
    |
    Published online on: June 21, 2024
       https://doi.org/10.3892/ol.2024.14520
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Giant cell tumor of bone (GCTB) is a locally aggressive intermediate bone tumor. Denosumab has shown effectiveness in GCTB treatment; however, the benefits of denosumab de‑escalation for unresectable GCTB have not been well discussed. The present study investigated the efficacy and safety of denosumab de‑escalation for GCTB. The medical records of 9 patients with unresectable GCTB or resectable GCTB not eligible for resection, who received de‑escalated denosumab treatment at Okayama University Hospital (Okayama, Japan) between April 2014 and December 2021, were retrospectively reviewed. The denosumab treatment interval was gradually extended to every 8, 12 and 24 weeks. The radiographic changes and clinical symptoms during standard and de‑escalated denosumab therapy were assessed. The denosumab interval was de‑escalated after a median of 12 months of a standard 4‑weekly treatment. Imaging showed that the re‑ossification of osteolytic lesions obtained with the 4‑weekly treatment were sustained with 8‑ and 12‑weekly treatments. The extraskeletal masses reduced significantly with standard treatment, while tumor reduction was sustained during de‑escalated treatment. During the 24‑weekly treatment, 2 patients remained stable, while 2 patients developed local recurrence. The clinical symptoms improved significantly with standard treatment and remained improved during de‑escalated treatment. There were severe adverse events including osteonecrosis of the jaw (2 patients), atypical femoral fracture (1 patient) and malignant transformation of GCTB (1 patient). In conclusion, 12‑weekly de‑escalated denosumab treatment showed clinical benefits as a maintenance treatment in patients with unresectable GCTB, in addition to sustained stable tumor control and improved clinical symptoms with standard treatment. A 24‑weekly treatment can also be administered, with careful attention paid to detecting local recurrence.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

van der Heijden L, Dijkstra S, van de Sande M and Gelderblom H: Current concepts in the treatment of giant cell tumour of bone. Curr Opin Oncol. 32:332–338. 2020. View Article : Google Scholar : PubMed/NCBI

2 

Basu Mallick A and Chawla SP: Giant cell tumor of bone: An update. Curr Oncol Rep. 22:512021. View Article : Google Scholar : PubMed/NCBI

3 

Boriani S, Bandiera S, Casadei R, Boriani L, Donthineni R, Gasbarrini A, Pignotti E, Biagini R and Schwab JH: Giant cell tumor of the mobile spine: A review of 49 cases. Spine (Phila Pa 1976). 37:E37–E45. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Jamshidi K, Bagherifard A, Mirzaei A and Bahrabadi M: giant cell tumor of the sacrum: series of 19 patients and review of the literature. Arch Bone Jt Surg. 5:443–450. 2017.PubMed/NCBI

5 

Tsukamoto S, Mavrogenis AF, Kido A and Errani C: Current concepts in the treatment of giant cell tumors of bone. Cancers (Basel). 13:36472021. View Article : Google Scholar : PubMed/NCBI

6 

Palmerini E, Picci P, Reichardt P and Downey G: Malignancy in giant cell tumor of bone: A review of the literature. Technol Cancer Res Treat. 1:15330338198400002019.PubMed/NCBI

7 

Hosalkar HS, Jones KJ, King JJ and Lackman RD: Serial arterial embolization for large sacral giant-cell tumors: Mid- to long-term results. Spine (Phila Pa 1976). 32:1107–1115. 2007. View Article : Google Scholar : PubMed/NCBI

8 

He SH, Xu W, Sun ZW, Liu WB, Liu YJ, Wei HF and Xiao JR: Selective arterial embolization for the treatment of sacral and pelvic giant cell tumor: A systematic review. Orthop Surg. 9:139–144. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Li H, Gao J, Gao Y, Lin N, Zheng M and Ye Z: Denosumab in giant cell tumor of bone: Current status and pitfalls. Front Oncol. 10:5806052020. View Article : Google Scholar : PubMed/NCBI

10 

Palmerini E, Staals EL, Jones LB, Donati DM, Longhi A and Randall RL: Role of (Neo) adjuvant denosumab for giant cell tumor of bone. Curr Treat Options Oncol. 21:682020. View Article : Google Scholar : PubMed/NCBI

11 

Gupta A, Durocher-Allen L, Popovic S, Tozer R, Yao X and Ghert M: The role of denosumab for surgical outcomes in patients with giant cell tumour of bone: A systematic review. Curr Oncol. 22:1302–1313. 2021. View Article : Google Scholar

12 

van Langevelde K and McCarthy CL: Radiological findings of denosumab treatment for giant cell tumours of bone. Skeletal Radiol. 49:1345–1358. 2020. View Article : Google Scholar : PubMed/NCBI

13 

Thomas D, Henshaw R, Skubitz K, Chawla S, Staddon A, Blay JY, Roudier M, Smith J, Ye Z, Sohn W, et al: Denosumab in patients with giant-cell tumour of bone: An open-label, phase 2 study. Lancet Oncol. 11:275–280. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Chawla S, Henshaw R, Seeger L, Choy E, Blay JY, Ferrari S, Kroep J, Grimer R, Reichardt P, Rutkowski P, et al: Safety and efficacy of denosumab for adults and skeletally mature adolescents with giant cell tumour of bone: Interim analysis of an open-label, parallel-group, phase 2 study. Lancet Oncol. 14:901–908. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Chawla S, Blay JY, Rutkowski P, Le Cesne A, Reichardt P, Gelderblom H, Grimer RJ, Choy E, Skubitz K, Seeger L, et al: Denosumab in patients with giant-cell tumour of bone: A multicentre, open-label, phase 2 study. Lancet Oncol. 20:1719–1729. 2019. View Article : Google Scholar : PubMed/NCBI

16 

Rutkowski P, Ferrari S, Grimer RJ, Stalley PD, Dijkstra SP, Pienkowski A, Vaz G, Wunder JS, Seeger LL, Feng A, et al: Surgical downstaging in an open-label phase II trial of denosumab in patients with giant cell tumor of bone. Ann Surg Oncol. 22:2860–2868. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Alaqaili SI, Abduljabbar AM, Altaho AJ, Khan AA and Alherabi J: A: Malignant sarcomatous transformation of benign giant cell tumor of bone after treatment with denosumab therapy: A literature review of reported cases. Cureus. 28:e37922018.PubMed/NCBI

18 

Palmerini E, Chawla NS, Ferrari S, Sudan M, Picci P, Marchesi E, Leopardi MP, Syed I, Sankhala KK, Parthasarathy P, et al: Denosumab in advanced/unresectable giant-cell tumour of bone (GCTB): For how long? Eur J Cancer. 76:118–124. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Matcuk GR Jr, Patel DB, Schein AJ, White EA and Menendez LR: Giant cell tumor: Rapid recurrence after cessation of long-term denosumab therapy. Skeletal Radiol. 44:1027–1031. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Clemons M, Liu M, Stober C, Pond G, Jemaan Alzahrani M, Ong M, Ernst S, Booth C, Mates M, Abraham Joy A, et al: Two-year results of a randomised trial comparing 4- versus 12-weekly bone-targeted agent use in patients with bone metastases from breast or castration-resistant prostate cancer. J Bone Oncol. 30:1003882021. View Article : Google Scholar : PubMed/NCBI

21 

Liu C, Wang L, Liu L, Zhuang J, Tang S, Zhang T, Zhou C, Feng F, Liu R, Zhang J, et al: Efficacy and safety of de-escalation bone-modifying agents for cancer patients with bone metastases: A systematic review and meta-analysis. Cancer Manag. Res. 10:3809–3823. 2018.

22 

Tanikawa M, Yamada H, Sakata T and Mase M: Dosing interval adjustment of denosumab for the treatment of giant cell tumor of the sphenoid bone: A case report. Surg Neurol Int. 11:3702020. View Article : Google Scholar : PubMed/NCBI

23 

Park A, Cipriano CA, Hill K, Kyriakos M and McDonald DJ: Malignant transformation of a giant cell tumor of bone treated with denosumab: A case report. JBJS Case Connect. 6:e782016. View Article : Google Scholar : PubMed/NCBI

24 

Hamaoka T, Costelloe CM, Madewell JE, Liu P, Berry DA, Islam R, Theriault RL, Hortobagyi GN and Ueno NT: Tumour response interpretation with new tumour response criteria vs the World Health Organisation criteria in patients with bone-only metastatic breast cancer. Br J Cancer. 102:651–657. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Costelloe CM, Chuang HH, Madewell JE and Ueno NT: cancer response criteria and bone metastases: RECIST 1.1, MDA and PERCIST. J Cancer. 1:80–92. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Hayashi N, Costelloe CM, Hamaoka T, Wei C, Niikura N, Theriault RL, Hortobagyi GN, Madewell JE and Ueno NT: A prospective study of bone tumor response assessment in metastatic breast cancer. Clin Breast Cancer. 13:24–30. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Campanacci M, Baldini N, Boriani S and Sudanese A: Giant-cell tumor of bone. J Bone Joint Surg Am. 69:106–114. 1987. View Article : Google Scholar : PubMed/NCBI

28 

Priebe MM and Waring WP: The interobserver reliability of the revised American Spinal Injury Association standards for neurological classification of spinal injury patients. Am J Phys Med Rehabil. 70:268–270. 1991. View Article : Google Scholar : PubMed/NCBI

29 

European Organisation for Research and Treatment of Cancer, . Reduced Dose-density of Denosumab for Unresectable GCTB (REDUCE). ClinicalTrials.gov Identifier: NCT03620149. National Library of Medicine; Bethesda, MD: 2021, https://www.clinicaltrials.gov/ct2/show/NCT03620149January 6–2021

30 

Nakazawa T, Inoue G, Imura T, Miyagi M, Saito W, Namba T, Shirasawa E, Uchida K, Takahira N and Takaso M: Remarkable regression of a giant cell tumor of the cervical spine treated conservatively with denosumab: A case report. Int J Surg Case Rep. 24:22–25. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, et al: New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer. 45:228–247. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Sambri A, Medellin MR, Errani C, Campanacci L, Fujiwara T, Donati D, Parry M and Grimer R: Denosumab in giant cell tumour of bone in the pelvis and sacrum: Long-term therapy or bone resection? J Orthop Sci. 25:513–519. 2020. View Article : Google Scholar : PubMed/NCBI

33 

Bukata SV, Blay JY, Rutkowski P, Skubitz K, Henshaw R, Seeger L, Dai T, Jandial D and Chawla S: Denosumab treatment for giant cell tumor of the spine including the sacrum. Spine(Phila Pa 1976). 46:277–284. 2021. View Article : Google Scholar : PubMed/NCBI

34 

Broehm CJ, Garbrecht EL, Wood J and Bocklage T: Two cases of sarcoma arising in giant cell tumor of bone treated with denosumab. Case Rep. Med. 2015:7671982015.PubMed/NCBI

35 

Raimondi A, Simeone N, Guzzo M, Maniezzo M, Collini P, Morosi C, Greco FG, Frezza AM, Casali PG and Stacchiotti S: Rechallenge of denosumab in jaw osteonecrosis of patients with unresectable giant cell tumour of bone: A case series analysis and literature review. ESMO Open. 5:e0006632020. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Nakata E, Kunisada T, Fujiwara T, Katayama H, Itano T and Ozaki T: Efficacy and safety of denosumab de‑escalation in giant cell tumor of bone. Oncol Lett 28: 387, 2024.
APA
Nakata, E., Kunisada, T., Fujiwara, T., Katayama, H., Itano, T., & Ozaki, T. (2024). Efficacy and safety of denosumab de‑escalation in giant cell tumor of bone. Oncology Letters, 28, 387. https://doi.org/10.3892/ol.2024.14520
MLA
Nakata, E., Kunisada, T., Fujiwara, T., Katayama, H., Itano, T., Ozaki, T."Efficacy and safety of denosumab de‑escalation in giant cell tumor of bone". Oncology Letters 28.2 (2024): 387.
Chicago
Nakata, E., Kunisada, T., Fujiwara, T., Katayama, H., Itano, T., Ozaki, T."Efficacy and safety of denosumab de‑escalation in giant cell tumor of bone". Oncology Letters 28, no. 2 (2024): 387. https://doi.org/10.3892/ol.2024.14520
Copy and paste a formatted citation
x
Spandidos Publications style
Nakata E, Kunisada T, Fujiwara T, Katayama H, Itano T and Ozaki T: Efficacy and safety of denosumab de‑escalation in giant cell tumor of bone. Oncol Lett 28: 387, 2024.
APA
Nakata, E., Kunisada, T., Fujiwara, T., Katayama, H., Itano, T., & Ozaki, T. (2024). Efficacy and safety of denosumab de‑escalation in giant cell tumor of bone. Oncology Letters, 28, 387. https://doi.org/10.3892/ol.2024.14520
MLA
Nakata, E., Kunisada, T., Fujiwara, T., Katayama, H., Itano, T., Ozaki, T."Efficacy and safety of denosumab de‑escalation in giant cell tumor of bone". Oncology Letters 28.2 (2024): 387.
Chicago
Nakata, E., Kunisada, T., Fujiwara, T., Katayama, H., Itano, T., Ozaki, T."Efficacy and safety of denosumab de‑escalation in giant cell tumor of bone". Oncology Letters 28, no. 2 (2024): 387. https://doi.org/10.3892/ol.2024.14520
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team