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Consistent efficacy of hepatic artery infusion chemotherapy irrespective of PD‑L1 positivity in unresectable hepatocellular carcinoma

  • Authors:
    • Ji Hoon Kim
    • Young Hoon Kim
    • Hee-Chul Nam
    • Chang-Wook Kim
    • Jae-Sung Yoo
    • Ji Won Han
    • Jeong Won Jang
    • Jong Young Choi
    • Seung Kew Yoon
    • Ho Jong Chun
    • Jung Suk Oh
    • Suho Kim
    • Sung Hak Lee
    • Pil Soo Sung
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology and Hepatology, Uijeongbu St. Mary's Hospital, The Catholic University of Korea, Uijeongbu, Gyeonggi 11765, Republic of Korea, Department of Pathology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Republic of Korea, Department of Gastroenterology and Hepatology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Republic of Korea, Department of Radiology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Republic of Korea
    Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 388
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    Published online on: June 21, 2024
       https://doi.org/10.3892/ol.2024.14521
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Abstract

Atezolizumab/bevacizumab is the first line of treatment for unresectable hepatocellular carcinoma (HCC), combining immune checkpoint inhibitor and anti‑VEGF monoclonal antibodies. Hepatic arterial infusion chemotherapy (HAIC) is administered when the above‑described combination fails to confer sufficient clinical benefit. The present study aimed to explore the association between tumor programmed cell death‑ligand 1 (PD‑L1) positivity and HAIC response. A total of 40 patients with HCC who had undergone HAIC with available biopsy samples obtained between January 2020 and May 2023 were retrospectively enrolled. Tumor response, progression‑free survival (PFS), disease control rate (DCR) and overall survival (OS) were evaluated. PD‑L1 expression in tumor samples was assessed using a combined positivity score. The response rates of HAIC‑treated patients with advanced HCC after failure of atezolizumab/bevacizumab combination therapy were recorded. OS (P=0.9717) and PFS (P=0.4194) did not differ between patients with and without PD‑L1 positivity. The objective response rate (P=0.7830) and DCR (P=0.7020) also did not differ based on PD‑L1 status. In conclusion, the current findings highlight the consistent efficacy of HAIC, regardless of PD‑L1 positivity.
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Copy and paste a formatted citation
Spandidos Publications style
Kim JH, Kim YH, Nam H, Kim C, Yoo J, Han JW, Jang JW, Choi JY, Yoon SK, Chun H, Chun H, et al: Consistent efficacy of hepatic artery infusion chemotherapy irrespective of PD‑L1 positivity in unresectable hepatocellular carcinoma. Oncol Lett 28: 388, 2024.
APA
Kim, J.H., Kim, Y.H., Nam, H., Kim, C., Yoo, J., Han, J.W. ... Sung, P.S. (2024). Consistent efficacy of hepatic artery infusion chemotherapy irrespective of PD‑L1 positivity in unresectable hepatocellular carcinoma. Oncology Letters, 28, 388. https://doi.org/10.3892/ol.2024.14521
MLA
Kim, J. H., Kim, Y. H., Nam, H., Kim, C., Yoo, J., Han, J. W., Jang, J. W., Choi, J. Y., Yoon, S. K., Chun, H., Oh, J. S., Kim, S., Lee, S. H., Sung, P. S."Consistent efficacy of hepatic artery infusion chemotherapy irrespective of PD‑L1 positivity in unresectable hepatocellular carcinoma". Oncology Letters 28.2 (2024): 388.
Chicago
Kim, J. H., Kim, Y. H., Nam, H., Kim, C., Yoo, J., Han, J. W., Jang, J. W., Choi, J. Y., Yoon, S. K., Chun, H., Oh, J. S., Kim, S., Lee, S. H., Sung, P. S."Consistent efficacy of hepatic artery infusion chemotherapy irrespective of PD‑L1 positivity in unresectable hepatocellular carcinoma". Oncology Letters 28, no. 2 (2024): 388. https://doi.org/10.3892/ol.2024.14521
Copy and paste a formatted citation
x
Spandidos Publications style
Kim JH, Kim YH, Nam H, Kim C, Yoo J, Han JW, Jang JW, Choi JY, Yoon SK, Chun H, Chun H, et al: Consistent efficacy of hepatic artery infusion chemotherapy irrespective of PD‑L1 positivity in unresectable hepatocellular carcinoma. Oncol Lett 28: 388, 2024.
APA
Kim, J.H., Kim, Y.H., Nam, H., Kim, C., Yoo, J., Han, J.W. ... Sung, P.S. (2024). Consistent efficacy of hepatic artery infusion chemotherapy irrespective of PD‑L1 positivity in unresectable hepatocellular carcinoma. Oncology Letters, 28, 388. https://doi.org/10.3892/ol.2024.14521
MLA
Kim, J. H., Kim, Y. H., Nam, H., Kim, C., Yoo, J., Han, J. W., Jang, J. W., Choi, J. Y., Yoon, S. K., Chun, H., Oh, J. S., Kim, S., Lee, S. H., Sung, P. S."Consistent efficacy of hepatic artery infusion chemotherapy irrespective of PD‑L1 positivity in unresectable hepatocellular carcinoma". Oncology Letters 28.2 (2024): 388.
Chicago
Kim, J. H., Kim, Y. H., Nam, H., Kim, C., Yoo, J., Han, J. W., Jang, J. W., Choi, J. Y., Yoon, S. K., Chun, H., Oh, J. S., Kim, S., Lee, S. H., Sung, P. S."Consistent efficacy of hepatic artery infusion chemotherapy irrespective of PD‑L1 positivity in unresectable hepatocellular carcinoma". Oncology Letters 28, no. 2 (2024): 388. https://doi.org/10.3892/ol.2024.14521
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