Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
August-2024 Volume 28 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2024 Volume 28 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

KIF2A correlates with lymphovascular invasion and higher tumor stage, and can be used to predict worse prognosis in patients with endometrial carcinoma

  • Authors:
    • Yuanyuan Shi
    • Liyang Yin
    • Yajing Hao
    • Jurong Wang
    • Weiyue Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Gynaecology, Handan Central Hospital, Handan, Hebei 056000, P.R. China, Department of General Surgery, Handan Central Hospital, Handan, Hebei 056000, P.R. China, Department of Emergency Surgery, Handan Central Hospital, Handan, Hebei 056000, P.R. China, Department of Gynaecology, Handan Central Hospital, Handan, Hebei 056000, P.R. China
    Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 396
    |
    Published online on: June 25, 2024
       https://doi.org/10.3892/ol.2024.14529
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Kinesin family protein 2A (KIF2A) is a microtubule depolymerase that participates in the progression of various cancers; however, its clinical utility in endometrial carcinoma (EC) remains unclear. The aim of the present study was to assess KIF2A expression and its relationship with prognosis in patients with EC. Data from 230 patients with EC who underwent tumor resection were reviewed in the current, retrospective study. KIF2A expression was measured in 230 formalin‑fixed paraffin‑embedded (FFPE) specimens of tumor tissue and 50 FFPE specimens of non‑tumor tissue using immunohistochemistry (IHC). KIF2A expression was elevated in EC tumor tissue vs. non‑tumor tissue (P<0.001). Furthermore, tumor KIF2A expression was linked with lymphovascular invasion (P=0.004) and higher International Federation of Gynecology and Obstetrics (FIGO) stage (P=0.001). High tumor KIF2A expression (IHC score>3) was correlated with shorter disease‑free survival (DFS; P=0.014) and overall survival (OS; P=0.012). Moreover, the time‑dependent receiver operating characteristic curves revealed that tumor KIF2A expression had an acceptable use for estimating the relapse and death risks at each timepoint within 6 years, with each area under the curve remaining stable at ≥0.7. Notably, tumor KIF2A expression (high vs. low) independently forecast shorter DFS (hazard ratio, 2.506; P=0.013), but not OS (P>0.05). Furthermore, information from The Human Protein Atlas database indicated that high tumor KIF2A expression was associated with worse OS in patients with EC (P=0.027). Tumor KIF2A is not only associated with lymphovascular invasion and higher FIGO stage, but also reflects unfavorable survival in patients with EC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Koskas M, Amant F, Mirza MR and Creutzberg CL: Cancer of the corpus uteri: 2021 update. Int J Gynaecol Obstet. 155 (Suppl 1):S45–S60. 2021. View Article : Google Scholar

2 

Concin N, Matias-Guiu X, Vergote I, Cibula D, Mirza MR, Marnitz S, Ledermann J, Bosse T, Chargari C, Fagotti A, et al: ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma. Int J Gynecol Cancer. 31:12–39. 2021. View Article : Google Scholar : PubMed/NCBI

3 

Yang Z, Yang X, Liu X, Ma K, Meng YT, Yin HF, Wen J, Yang JH, Zhen Z, Feng ZH and Liao QP: Clinical characteristics and prognostic characterization of endometrial carcinoma: A comparative analysis of molecular typing protocols. BMC Cancer. 23:2432023. View Article : Google Scholar : PubMed/NCBI

4 

Zhang SZ, Zhang L and Xie L: Cancer Burden in China during 1990–2019: Analysis of the global burden of disease. Biomed Res Int. 2022:39180452022.PubMed/NCBI

5 

Kovacevic N: Surgical treatment and fertility perservation in endometrial cancer. Radiol Oncol. 55:144–149. 2021. View Article : Google Scholar : PubMed/NCBI

6 

van den Heerik ASVM, Horeweg N, de Boer SM, Bosse T and Creutzberg CL: Adjuvant therapy for endometrial cancer in the era of molecular classification: Radiotherapy, chemoradiation and novel targets for therapy. Int J Gynecol Cancer. 31:594–604. 2021. View Article : Google Scholar : PubMed/NCBI

7 

Tung HJ, Huang HJ and Lai CH: Adjuvant and post-surgical treatment in endometrial cancer. Best Pract Res Clin Obstet Gynaecol. 78:52–63. 2022. View Article : Google Scholar : PubMed/NCBI

8 

Crosbie EJ, Kitson SJ, McAlpine JN, Mukhopadhyay A, Powell ME and Singh N: Endometrial cancer. Lancet. 399:1412–1428. 2022. View Article : Google Scholar : PubMed/NCBI

9 

Lee YC, Lheureux S and Oza AM: Treatment strategies for endometrial cancer: Current practice and perspective. Curr Opin Obstet Gynecol. 29:47–58. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Kasius JC, Pijnenborg JMA, Lindemann K, Forsse D, van Zwol J, Kristensen GB, Krakstad C, Werner HMJ and Amant F: Risk stratification of endometrial cancer patients: FIGO stage, biomarkers and molecular classification. Cancers (Basel). 13:58482021. View Article : Google Scholar : PubMed/NCBI

11 

McAlpine J, Leon-Castillo A and Bosse T: The rise of a novel classification system for endometrial carcinoma; integration of molecular subclasses. J Pathol. 244:538–549. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Wang N, Zhang J, Fan X and Ma J, He J, Kang S, Cheng J and Ma J: Identification of risk factors for the prognosis of Chinese patients with endometrial carcinoma. Medicine (Baltimore). 100:e273052021. View Article : Google Scholar : PubMed/NCBI

13 

Liang S and Zhang Y: Clinical pathological characteristics and survival of high-grade endometrioid carcinoma. J Obstet Gynaecol Res. 47:3644–3651. 2021. View Article : Google Scholar : PubMed/NCBI

14 

Wang Y, Wang J, Zhao A, Huang X and Zhang X: HPV16 E6E7 up-regulates KIF2A expression by activating JNK/c-Jun signal, is beneficial to migration and invasion of cervical cancer cells. Open Med (Wars). 17:1780–1787. 2022. View Article : Google Scholar : PubMed/NCBI

15 

Xu Y, Wang W, Chen J, Mao H, Liu Y, Gu S, Liu Q, Xi Q and Shi W: High neuropilin and tolloid-like 1 expression associated with metastasis and poor survival in epithelial ovarian cancer via regulation of actin cytoskeleton. J Cell Mol Med. 24:9114–9124. 2020. View Article : Google Scholar : PubMed/NCBI

16 

Zhao P, Lan F, Zhang H, Zeng G and Liu D: Down-regulation of KIF2A inhibits gastric cancer cell invasion via suppressing MT1-MMP. Clin Exp Pharmacol Physiol. 45:1010–1018. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Wang K, Lin C, Wang C, Shao Q, Gao W, Song B, Wang L, Song X, Qu X and Wei F: Silencing Kif2a induces apoptosis in squamous cell carcinoma of the oral tongue through inhibition of the PI3K/Akt signaling pathway. Mol Med Rep. 9:273–278. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Wang D, Zhu H, Ye Q, Wang C and Xu Y: Prognostic Value of KIF2A and HER2-Neu overexpression in patients with epithelial ovarian cancer. Medicine (Baltimore). 95:e28032016. View Article : Google Scholar : PubMed/NCBI

19 

Lei G, Xin X and Hu X: Clinical significance of kinesin family member 2A as a facilitating biomarker of disease surveillance and prognostication in cervical cancer patients. Ir J Med Sci. 191:665–670. 2022. View Article : Google Scholar : PubMed/NCBI

20 

Tian Y, Zhao K, Yuan L, Li J, Feng S, Feng Y, Fang Z, Li H and Deng R: EIF3B correlates with advanced disease stages and poor prognosis, and it promotes proliferation and inhibits apoptosis in non-small cell lung cancer. Cancer Biomark. 23:291–300. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Wei DC, Yeh YC, Hung JJ, Chou TY, Wu YC, Lu PJ, Cheng HC, Hsu YL, Kuo YL, Chen KY, et al: Overexpression of T-LAK cell-originated protein kinase predicts poor prognosis in patients with stage I lung adenocarcinoma. Cancer Sci. 103:731–738. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Neven P, Van Calster B, Van den Bempt I, Van Huffel S, Van Belle V, Hendrickx W, Decock J, Wildiers H, Paridaens R, Amant F, et al: Age interacts with the expression of steroid and HER-2 receptors in operable invasive breast cancer. Breast Cancer Res Treat. 110:153–159. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Amant F, Mirza MR, Koskas M and Creutzberg CL: Cancer of the corpus uteri. Int J Gynaecol Obstet. 143 (Suppl 2):S37–S50. 2018. View Article : Google Scholar

24 

Yang H and Liu Y: Kinesin family member 2A serves as a potential biomarker reflecting more frequent lymph node metastasis and tumor recurrence risk in basal-like breast cancer patients. Front Surg. 9:8892942022. View Article : Google Scholar : PubMed/NCBI

25 

Sheng N, Xu YZ, Xi QH, Jiang HY, Wang CY, Zhang Y and Ye Q: Overexpression of KIF2A is Suppressed by miR-206 and associated with poor prognosis in ovarian cancer. Cell Physiol Biochem. 50:810–822. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Wang ZX, Ren SC, Chang ZS and Ren J: Identification of kinesin family member 2A (KIF2A) as a promising therapeutic target for osteosarcoma. Biomed Res Int. 2020:71027572020.PubMed/NCBI

27 

Wang C, Xie X, Li W and Jiang D: Expression of KIF2A, NDC80, CDK1, and CCNB1 in breast cancer patients: Their interaction and linkage with tumor features and prognosis. J Clin Lab Anal. 36:e246472022. View Article : Google Scholar : PubMed/NCBI

28 

Bai F, He Z, Zhou H and Gan W: Kinesin family member 2A links with advanced tumor stage, reduced chemosensitivity and worse prognosis in gastric cancer. J Clin Lab Anal. 36:e243132022. View Article : Google Scholar : PubMed/NCBI

29 

Zaganjor E, Osborne JK, Weil LM, Diaz-Martinez LA, Gonzales JX, Singel SM, Larsen JE, Girard L, Minna JD and Cobb MH: Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells. Oncogene. 33:5457–5466. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Schimizzi GV, Currie JD and Rogers SL: Expression levels of a kinesin-13 microtubule depolymerase modulates the effectiveness of anti-microtubule agents. PLoS One. 5:e113812010. View Article : Google Scholar : PubMed/NCBI

31 

Xu L, Zhang X, Wang Z, Zhao X, Zhao L and Hu Y: Kinesin family member 2A promotes cancer cell viability, mobility, stemness, and chemoresistance to cisplatin by activating the PI3K/AKT/VEGF signaling pathway in non-small cell lung cancer. Am J Transl Res. 13:2060–2076. 2021.PubMed/NCBI

32 

Gou R, Zheng M, Hu Y, Gao L, Wang S, Liu O, Li X, Zhu L, Liu J and Lin B: Identification and clinical validation of NUSAP1 as a novel prognostic biomarker in ovarian cancer. BMC Cancer. 22:6902022. View Article : Google Scholar : PubMed/NCBI

33 

Chang H, Wang J, Tian Y, Xu J, Gou X and Cheng J: The TPX2 gene is a promising diagnostic and therapeutic target for cervical cancer. Oncol Rep. 27:1353–1359. 2012.PubMed/NCBI

34 

Liu W, Xu C, Meng Q and Kang P: The clinical value of kinesin superfamily protein 2A in hepatocellular carcinoma. Clin Res Hepatol Gastroenterol. 45:1015272021. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Shi Y, Yin L, Hao Y, Wang J and Zhou W: KIF2A correlates with lymphovascular invasion and higher tumor stage, and can be used to predict worse prognosis in patients with endometrial carcinoma. Oncol Lett 28: 396, 2024.
APA
Shi, Y., Yin, L., Hao, Y., Wang, J., & Zhou, W. (2024). KIF2A correlates with lymphovascular invasion and higher tumor stage, and can be used to predict worse prognosis in patients with endometrial carcinoma. Oncology Letters, 28, 396. https://doi.org/10.3892/ol.2024.14529
MLA
Shi, Y., Yin, L., Hao, Y., Wang, J., Zhou, W."KIF2A correlates with lymphovascular invasion and higher tumor stage, and can be used to predict worse prognosis in patients with endometrial carcinoma". Oncology Letters 28.2 (2024): 396.
Chicago
Shi, Y., Yin, L., Hao, Y., Wang, J., Zhou, W."KIF2A correlates with lymphovascular invasion and higher tumor stage, and can be used to predict worse prognosis in patients with endometrial carcinoma". Oncology Letters 28, no. 2 (2024): 396. https://doi.org/10.3892/ol.2024.14529
Copy and paste a formatted citation
x
Spandidos Publications style
Shi Y, Yin L, Hao Y, Wang J and Zhou W: KIF2A correlates with lymphovascular invasion and higher tumor stage, and can be used to predict worse prognosis in patients with endometrial carcinoma. Oncol Lett 28: 396, 2024.
APA
Shi, Y., Yin, L., Hao, Y., Wang, J., & Zhou, W. (2024). KIF2A correlates with lymphovascular invasion and higher tumor stage, and can be used to predict worse prognosis in patients with endometrial carcinoma. Oncology Letters, 28, 396. https://doi.org/10.3892/ol.2024.14529
MLA
Shi, Y., Yin, L., Hao, Y., Wang, J., Zhou, W."KIF2A correlates with lymphovascular invasion and higher tumor stage, and can be used to predict worse prognosis in patients with endometrial carcinoma". Oncology Letters 28.2 (2024): 396.
Chicago
Shi, Y., Yin, L., Hao, Y., Wang, J., Zhou, W."KIF2A correlates with lymphovascular invasion and higher tumor stage, and can be used to predict worse prognosis in patients with endometrial carcinoma". Oncology Letters 28, no. 2 (2024): 396. https://doi.org/10.3892/ol.2024.14529
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team