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Systematic analysis of the expression profiles and prognostic significance of the MED gene family in renal clear cell carcinoma

  • Authors:
    • Min Wang
    • Min Min
    • Jia Mai
    • Xiaojuan Liu
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Outpatient Department, The Air Force Hospital of Western Theater, People's Liberation Army, Chengdu, Sichuan 500643, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 398
    |
    Published online on: June 26, 2024
       https://doi.org/10.3892/ol.2024.14531
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Abstract

The mediator complex (MED) family is a contributing factor in the regulation of transcription and proliferation of cells, and is closely associated with the development of various types of cancer. However, the significance of the expression levels and prognostic value of MED genes in kidney renal clear cell carcinoma (KIRC) have rarely been reported. The present study analyzed the expression and prognostic potential of MED genes in KIRC. The Search Tool for the Retrieval of Interacting Genes/Proteins was used to construct the protein‑protein interaction network (PPI), the Assistant for Clinical Bioinformatics database was used to perform correlation analysis, GEPIA 2 was utilized to draw the Kaplan‑Meier plot and analyze prognostic significance and the Tumor Immune Estimation Resource was used to assess the association of MED genes with the infiltration of immune cells in patients with KIRC. A total of 30 MED genes were identified, and among these genes, 11 were selected for the creation of a prognostic gene signature based on the results of a LASSO Cox regression analysis. Furthermore, according to univariate and multivariate analyses, MED7, MED16, MED21, MED25 and MED29 may be valuable independent predictive biomarkers for the prognosis of individuals with KIRC. Furthermore, there were significant differences in the expression levels of MED7, MED21 and MED25 in KIRC among different tumor grades. Additionally, patients with KIRC with high transcription levels of MED7, MED21 and MED29 had considerably longer overall survival times. The expression levels of MED genes were also linked to the infiltration of several immune cells. Overall, MED genes may have potential significance in predicting the prognosis of patients with KIRC.
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Copy and paste a formatted citation
Spandidos Publications style
Wang M, Min M, Mai J and Liu X: Systematic analysis of the expression profiles and prognostic significance of the MED gene family in renal clear cell carcinoma. Oncol Lett 28: 398, 2024.
APA
Wang, M., Min, M., Mai, J., & Liu, X. (2024). Systematic analysis of the expression profiles and prognostic significance of the MED gene family in renal clear cell carcinoma. Oncology Letters, 28, 398. https://doi.org/10.3892/ol.2024.14531
MLA
Wang, M., Min, M., Mai, J., Liu, X."Systematic analysis of the expression profiles and prognostic significance of the MED gene family in renal clear cell carcinoma". Oncology Letters 28.2 (2024): 398.
Chicago
Wang, M., Min, M., Mai, J., Liu, X."Systematic analysis of the expression profiles and prognostic significance of the MED gene family in renal clear cell carcinoma". Oncology Letters 28, no. 2 (2024): 398. https://doi.org/10.3892/ol.2024.14531
Copy and paste a formatted citation
x
Spandidos Publications style
Wang M, Min M, Mai J and Liu X: Systematic analysis of the expression profiles and prognostic significance of the MED gene family in renal clear cell carcinoma. Oncol Lett 28: 398, 2024.
APA
Wang, M., Min, M., Mai, J., & Liu, X. (2024). Systematic analysis of the expression profiles and prognostic significance of the MED gene family in renal clear cell carcinoma. Oncology Letters, 28, 398. https://doi.org/10.3892/ol.2024.14531
MLA
Wang, M., Min, M., Mai, J., Liu, X."Systematic analysis of the expression profiles and prognostic significance of the MED gene family in renal clear cell carcinoma". Oncology Letters 28.2 (2024): 398.
Chicago
Wang, M., Min, M., Mai, J., Liu, X."Systematic analysis of the expression profiles and prognostic significance of the MED gene family in renal clear cell carcinoma". Oncology Letters 28, no. 2 (2024): 398. https://doi.org/10.3892/ol.2024.14531
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