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Plasma von Willebrand factor levels in patients with cancer: A meta‑analysis

  • Authors:
    • Xitan Wang
    • Xiaoyu Zhang
    • Chaonan Zhang
    • Li Qi
    • Ju Liu
  • View Affiliations / Copyright

    Affiliations: School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong 261053, P.R. China, Department of Medical Physiology, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, Shandong 261053, P.R. China, Department of Infectious Diseases, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong 261053, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 399
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    Published online on: June 26, 2024
       https://doi.org/10.3892/ol.2024.14532
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Abstract

von Willebrand Factor (VWF) is well recognized for being dysregulated in various malignancies and has emerged as a potential biomarker for cancer detection. The present meta‑analysis aimed to elucidate the association between plasma VWF and the incidence and metastasis of cancer. For this purpose, a comprehensive search was conducted across multiple databases from their inception until March 3, 2023. This culminated in the selection of 15 original studies on various types of cancer, including a collective sample of 1,403 individuals. The standardized mean difference (SMD) and 95% confidence intervals (CIs) were employed as statistical parameters to determine the association between plasma VWF and the incidence and metastasis of cancer. These were estimated using a random‑effects model. The pooled data revealed that the plasma VWF levels of patients with cancer were significantly elevated compared with those of healthy controls (SMD, 0.98; 95% CI, 0.59‑1.36), and a significant association was observed between plasma VWF levels and cancer metastasis (SMD, 0.69; 95% CI, 0.33‑1.06). The symmetry of the Begg's funnel plots indicated that no significant bias was present in the analyses of VWF in cancer and its metastasis. In summary, the results of the present meta‑analysis support the hypothesis that increased plasma VWF levels may serve as a biomarker for cancer and metastatic progression.
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View References

1 

Sharda AV, Barr AM, Harrison JA, Wilkie AR, Fang C, Mendez LM, Ghiran IC, Italiano JE and Flaumenhaft R: VWF maturation and release are controlled by 2 regulators of Weibel-Palade body biogenesis: exocyst and BLOC-2. Blood. 136:2824–2837. 2020. View Article : Google Scholar : PubMed/NCBI

2 

Zhang Z and Li W: Formation and function of Weibel-Palade bodies. Yi Chuan. 31:882–888. 2009.(In Chinese). View Article : Google Scholar : PubMed/NCBI

3 

Holthenrich A and Gerke V: Regulation of von-willebrand factor secretion from endothelial cells by the annexin A2-S100A10 complex. Int J Mol Sci. 19:17522018. View Article : Google Scholar : PubMed/NCBI

4 

Sadler JE: von Willebrand factor assembly and secretion. J Thromb Haemost. 7 (Suppl 1):S24–S27. 2009. View Article : Google Scholar

5 

Kanaji S, Fahs SA, Shi Q, Haberichter SL and Montgomery RR: Contribution of platelet vs endothelial VWF to platelet adhesion and hemostasis. J Thromb Haemost. 10:1646–1652. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Mourik M and Eikenboom J: Lifecycle of Weibel-Palade bodies. Hamostaseologie. 37:13–24. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Naß J, Terglane J and Gerke V: Weibel Palade bodies: Unique secretory organelles of endothelial cells that control blood vessel homeostasis. Front Cell Dev Biol. 9:8139952021. View Article : Google Scholar : PubMed/NCBI

8 

Prasannan N and Scully M: Novel antiplatelet strategies targeting VWF and GPIb. Platelets. 32:42–46. 2021. View Article : Google Scholar : PubMed/NCBI

9 

Pierre-Louis O, Resiere D, Alphonsine C, Dantin F, Banydeen R, Dubois MD, Mehdaoui H and Neviere R: Increased binding of von willebrand factor to sub-endothelial collagen may facilitate thrombotic events complicating bothrops lanceolatus envenomation in humans. Toxins (Basel). 15:4412023. View Article : Google Scholar : PubMed/NCBI

10 

Thompson AR: Structure and function of the factor VIII gene and protein. Semin Thromb Hemost. 29:11–22. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Lenting PJ, Casari C, Christophe OD and Denis CV: von Willebrand factor: The old, the new and the unknown. J Thromb Haemost. 10:2428–2437. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Schwameis M, Schörgenhofer C, Assinger A, Steiner MM and Jilma B: VWF excess and ADAMTS13 deficiency: A unifying pathomechanism linking inflammation to thrombosis in DIC, malaria, and TTP. Thromb Haemost. 113:708–718. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Ishihara J, Ishihara A, Starke RD, Peghaire CR, Smith KE, McKinnon TAJ, Tabata Y, Sasaki K, White MJV, Fukunaga K, et al: The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing. Blood. 133:2559–2569. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Mochizuki S, Soejima K, Shimoda M, Abe H, Sasaki A, Okano HJ, Okano H and Okada Y: Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand factor. J Natl Cancer Inst. 104:906–922. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Desch A, Strozyk EA, Bauer AT, Huck V, Niemeyer V, Wieland T and Schneider SW: Highly invasive melanoma cells activate the vascular endothelium via an MMP-2/integrin αvβ5-induced secretion of VEGF-A. Am J Pathol. 181:693–705. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Goerge T, Barg A, Schnaeker EM, Poppelmann B, Shpacovitch V, Rattenholl A, Maaser C, Luger TA, Steinhoff M and Schneider SW: Tumor-derived matrix metalloproteinase-1 targets endothelial proteinase-activated receptor 1 promoting endothelial cell activation. Cancer Res. 66:7766–7774. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Goertz L, Schneider SW, Desch A, Mayer FT, Koett J, Nowak K, Karampinis I, Bohlmann MK, Umansky V and Bauer AT: Heparins that block VEGF-A-mediated von Willebrand factor fiber generation are potent inhibitors of hematogenous but not lymphatic metastasis. Oncotarget. 7:68527–68545. 2016. View Article : Google Scholar : PubMed/NCBI

18 

John A, Robador JR, Vidal-Y-Sy S, Houdek P, Wladykowski E, Günes C, Bolenz C, Schneider SW, Bauer AT and Gorzelanny C: Urothelial carcinoma of the bladder induces endothelial cell activation and hypercoagulation. Mol Cancer Res. 18:1099–1109. 2020. View Article : Google Scholar : PubMed/NCBI

19 

Zhang P, Goodrich C, Fu C and Dong C: Melanoma upregulates ICAM-1 expression on endothelial cells through engagement of tumor CD44 with endothelial E-selectin and activation of a PKCα-p38-SP-1 pathway. FASEB J. 28:4591–4609. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Bauer AT, Suckau J, Frank K, Desch A, Goertz L, Wagner AH, Hecker M, Goerge T, Umansky L, Beckhove P, et al: von Willebrand factor fibers promote cancer-associated platelet aggregation in malignant melanoma of mice and humans. Blood. 125:3153–3163. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Goerge T, Kleinerüschkamp F, Barg A, Schnaeker EM, Huck V, Schneider MF, Steinhoff M and Schneider SW: Microfluidic reveals generation of platelet-strings on tumor-activated endothelium. Thromb Haemost. 98:283–286. 2007. View Article : Google Scholar : PubMed/NCBI

22 

McCarty OJ, Mousa SA, Bray PF and Konstantopoulos K: Immobilized platelets support human colon carcinoma cell tethering, rolling, and firm adhesion under dynamic flow conditions. Blood. 96:1789–1797. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Morganti M, Carpi A, Amo-Takyi B, Sagripanti A, Nicolini A, Giardino R and Mittermayer C: Von Willebrand's factor mediates the adherence of human tumoral cells to human endothelial cells and ticlopidine interferes with this effect. Biomed Pharmacother. 54:431–436. 2000. View Article : Google Scholar : PubMed/NCBI

24 

Feinauer MJ, Schneider SW, Berghoff AS, Robador JR, Tehranian C, Karreman MA, Venkataramani V, Solecki G, Grosch JK, Gunkel K, et al: Local blood coagulation drives cancer cell arrest and brain metastasis in a mouse model. Blood. 137:1219–1232. 2021. View Article : Google Scholar : PubMed/NCBI

25 

Siegel RL, Miller KD, Wagle NS and Jemal A: Cancer statistics, 2023. CA Cancer J Clin. 73:17–48. 2023. View Article : Google Scholar : PubMed/NCBI

26 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

27 

Blann AD, Gurney D, Wadley M, Bareford D, Stonelake P and Lip GY: Increased soluble P-selectin in patients with haematological and breast cancer: A comparison with fibrinogen, plasminogen activator inhibitor and von Willebrand factor. Blood Coagul Fibrinolysis. 12:43–50. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Blann AD, Balakrishnan B, Shantsila E, Ryan P and Lip GY: Endothelial progenitor cells and circulating endothelial cells in early prostate cancer: A comparison with plasma vascular markers. Prostate. 71:1047–1053. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Wang WS, Lin JK, Lin TC, Chiou TJ, Liu JH, Yen CC and Chen PM: Plasma von Willebrand factor level as a prognostic indicator of patients with metastatic colorectal carcinoma. World J Gastroenterol. 11:2166–2170. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Gil-Bazo I, Catalán Goni V, Alonso Gutiérrez A, Rodríguez Rodríguez J, Páramo Fernández JA, de la Cámara Gómez J, Hernández Lizoain JL and García-Foncillas López J: Impact of surgery and chemotherapy on von Willebrand factor and vascular endothelial growth factor levels in colorectal cancer. Clin Transl Oncol. 7:150–155. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Yang AJ, Wang M, Wang Y, Cai W, Li Q, Zhao TT, Zhang LH, Houck K, Chen X, Jin YL, et al: Cancer cell-derived von Willebrand factor enhanced metastasis of gastric adenocarcinoma. Oncogenesis. 7:122018. View Article : Google Scholar : PubMed/NCBI

32 

Colonne CK, Favaloro EJ and Pasalic L: The intriguing connections between von Willebrand factor, ADAMTS13 and cancer. Healthcare (Basel). 10:5572022. View Article : Google Scholar : PubMed/NCBI

33 

Meschengieser S, Blanco A, Woods A, Maugeri N, Fernandez J, Dupont J and Lazzari MA: Intraplatelet levels of vWF:Ag and fibrinogen in myeloproliferative disorders. Thromb Res. 48:311–319. 1987. View Article : Google Scholar : PubMed/NCBI

34 

Franchini M, Di Perna C, Santoro C, Castaman G, Siboni SM, Zanon E, Linari S, Gresele P, Pasca S, Coppola A, et al: Cancers in patients with von Willebrand disease: A survey from the italian association of haemophilia centres. Semin Thromb Hemost. 42:36–41. 2016.PubMed/NCBI

35 

Ablin RJ, Bartkus JM and Gonder MJ: Immunoquantitation of factor VIII-related antigen (von Willebrand factor antigen) in prostate cancer. Cancer Lett. 40:283–289. 1988. View Article : Google Scholar : PubMed/NCBI

36 

Athale U, Moghrabi A, Nayiager T, Delva YL, Thabane L and Chan AKC: von Willebrand factor and thrombin activation in children with newly diagnosed acute lymphoblastic leukemia: An impact of peripheral blasts. Pediatr Blood Cancer. 54:963–969. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Damin DC, Rosito MA, Gus P, Roisemberg I, Bandinelli E and Schwartsmann G: Von Willebrand factor in colorectal cancer. Int J Colorectal Dis. 17:42–45. 2002. View Article : Google Scholar : PubMed/NCBI

38 

Guo R, Yang J, Liu X, Wu J and Chen Y: Increased von Willebrand factor over decreased ADAMTS-13 activity is associated with poor prognosis in patients with advanced non-small-cell lung cancer. J Clin Lab Anal. 32:e222192018. View Article : Google Scholar : PubMed/NCBI

39 

Mannucci PM, Karimi M, Mosalaei A, Canciani MT and Peyvandi F: Patients with localized and disseminated tumors have reduced but measurable levels of ADAMTS-13 (von Willebrand factor cleaving protease). Haematologica. 88:454–458. 2003.PubMed/NCBI

40 

Pépin M, Kleinjan A, Hajage D, Büller HR, Di Nisio M, Kamphuisen PW, Salomon L, Veyradier A, Stepanian A and Mahé I: ADAMTS-13 and von Willebrand factor predict venous thromboembolism in patients with cancer. J Thromb Haemost. 14:306–315. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Röhsig LM, Damin DC, Stefani SD, Castro CG Jr, Roisenberg I and Schwartsmann G: von Willebrand factor antigen levels in plasma of patients with malignant breast disease. Braz J Med Biol Res. 34:1125–1129. 2001. View Article : Google Scholar : PubMed/NCBI

42 

Yigit E, Gönüllü G, Yücel I, Turgut M, Erdem D and Cakar B: Relation between hemostatic parameters and prognostic/predictive factors in breast cancer. Eur J Intern Med. 19:602–607. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Zietek Z, Iwan-Zietek I, Paczulski R, Kotschy M and Wolski Z: von Willebrand factor antigen in blood plasma of patients with urinary bladder carcinoma. Thromb Res. 83:399–402. 1996. View Article : Google Scholar : PubMed/NCBI

44 

Dhami SPS, Patmore S, Comerford C, Byrne CM, Cavanagh B, Castle J, Kirwan CC, Kenny M, Schoen I, O'Donnell JS and O'Sullivan JM: Breast cancer cells mediate endothelial cell activation, promoting von Willebrand factor release, tumor adhesion, and transendothelial migration. J Thromb Haemost. 20:2350–2365. 2022. View Article : Google Scholar : PubMed/NCBI

45 

Lehrer S, Green S, Dembitzer FR, Rheinstein PH and Rosenzweig KE: Increased RNA expression of von willebrand factor gene is associated with infiltrating lobular breast cancer and normal PAM50 subtype. Cancer Genomics Proteomics. 16:147–153. 2019. View Article : Google Scholar : PubMed/NCBI

46 

Knöfler R, Lange BS, Paul F, Tiebel O and Suttorp M: Bleeding signs due to acquired von Willebrand syndrome at diagnosis of chronic myeloid leukaemia in children. Br J Haematol. 188:701–706. 2020. View Article : Google Scholar : PubMed/NCBI

47 

Conlan MG, Folsom AR, Finch A, Davis CE, Sorlie P, Marcucci G and Wu KK: Associations of factor VIII and von Willebrand factor with age, race, sex, and risk factors for atherosclerosis. The atherosclerosis risk in communities (ARIC) study. Thromb Haemost. 70:380–385. 1993. View Article : Google Scholar : PubMed/NCBI

48 

Bick RL: Alterations of hemostasis associated with malignancy: Etiology, pathophysiology, diagnosis and management. Semin Thromb Hemost. 5:1–26. 1978. View Article : Google Scholar : PubMed/NCBI

49 

Kwaan HC and Lindholm PF: Fibrin and fibrinolysis in cancer. Semin Thromb Hemost. 45:413–422. 2019. View Article : Google Scholar : PubMed/NCBI

50 

Senger DR: Molecular framework for angiogenesis: A complex web of interactions between extravasated plasma proteins and endothelial cell proteins induced by angiogenic cytokines. Am J Pathol. 149:1–7. 1996.PubMed/NCBI

51 

Lip GYH, Chin BSP and Blann AD: Cancer and the prothrombotic state. Lancet Oncol. 3:27–34. 2002. View Article : Google Scholar : PubMed/NCBI

52 

Sørensen HT, Mellemkjaer L, Steffensen FH, Olsen JH and Nielsen GL: The risk of a diagnosis of cancer after primary deep venous thrombosis or pulmonary embolism. N Engl J Med. 338:1169–1173. 1998. View Article : Google Scholar : PubMed/NCBI

53 

Li Y, Li L, Dong F, Guo L, Hou Y, Hu H, Yan S, Zhou X, Liao L, Allen TD and Liu JU: Plasma von Willebrand factor level is transiently elevated in a rat model of acute myocardial infarction. Exp Ther Med. 10:1743–1749. 2015. View Article : Google Scholar : PubMed/NCBI

54 

Liu J, Kanki Y, Okada Y, Jin E, Yano K, Shih SC, Minami T and Aird WC: A +220 GATA motif mediates basal but not endotoxin-repressible expression of the von Willebrand factor promoter in Hprt-targeted transgenic mice. J Thromb Haemost. 7:1384–1392. 2009. View Article : Google Scholar : PubMed/NCBI

55 

Xu Y, Pan S, Liu J, Dong F, Cheng Z, Zhang J, Qi R, Zang Q, Zhang C, Wang X, et al: GATA3-induced vWF upregulation in the lung adenocarcinoma vasculature. Oncotarget. 8:110517–110529. 2017. View Article : Google Scholar : PubMed/NCBI

56 

Fan M, Wang X, Peng X, Feng S, Zhao J, Liao L, Zhang Y, Hou Y and Liu J: Prognostic value of plasma von Willebrand factor levels in major adverse cardiovascular events: a systematic review and meta-analysis. BMC Cardiovasc Disord. 20:722020. View Article : Google Scholar : PubMed/NCBI

57 

Peng X, Wang X, Fan M, Zhao J, Lin L and Liu J: Plasma levels of von Willebrand factor in type 2 diabetes patients with and without cardiovascular diseases: A meta-analysis. Diabetes Metab Res Rev. 36:e31932020. View Article : Google Scholar : PubMed/NCBI

58 

Wang X, Zhao J, Zhang Y, Xue X, Yin J, Liao L, Xu C, Hou Y, Yan S and Liu J: Kinetics of plasma von Willebrand factor in acute myocardial infarction patients: A meta-analysis. Oncotarget. 8:90371–90379. 2017. View Article : Google Scholar : PubMed/NCBI

59 

Comerford C, Glavey S, Quinn J and O'Sullivan JM: The role of VWF/FVIII in thrombosis and cancer progression in multiple myeloma and other hematological malignancies. J Thromb Haemost. 20:1766–1777. 2022. View Article : Google Scholar : PubMed/NCBI

60 

Terraube V, Marx I and Denis CV: Role of von Willebrand factor in tumor metastasis. Thromb Res. 120 (Suppl 2):S64–S70. 2007. View Article : Google Scholar : PubMed/NCBI

61 

Suter CM, Hogg PJ, Price JT, Chong BH and Ward RL: Identification and characterisation of a platelet GPIb/V/IX-like complex on human breast cancers: Implications for the metastatic process. Jpn J Cancer Res. 92:1082–1092. 2001. View Article : Google Scholar : PubMed/NCBI

62 

Wang X, Starodubtseva MN, Kapron CM and Liu J: Cadmium, von Willebrand factor and vascular aging. NPJ Aging. 9:112023. View Article : Google Scholar : PubMed/NCBI

63 

Wang X, Dong F, Wang F, Yan S, Chen X, Tozawa H, Ushijima T, Kapron CM, Wada Y and Liu J: Low dose cadmium upregulates the expression of von Willebrand factor in endothelial cells. Toxicol Lett. 290:46–54. 2018. View Article : Google Scholar : PubMed/NCBI

64 

Fares J, Fares MY, Khachfe HH, Salhab HA and Fares Y: Molecular principles of metastasis: A hallmark of cancer revisited. Signal Transduct Target Ther. 5:282020. View Article : Google Scholar : PubMed/NCBI

65 

Nierodzik ML, Plotkin A, Kajumo F and Karpatkin S: Thrombin stimulates tumor-platelet adhesion in vitro and metastasis in vivo. J Clin Invest. 87:229–236. 1991. View Article : Google Scholar : PubMed/NCBI

66 

Schulze EB, Hedley BD, Goodale D, Postenka CO, Al-Katib W, Tuck AB, Chambers AF and Allan AL: The thrombin inhibitor Argatroban reduces breast cancer malignancy and metastasis via osteopontin-dependent and osteopontin-independent mechanisms. Breast Cancer Res Treat. 112:243–254. 2008. View Article : Google Scholar : PubMed/NCBI

67 

Nierodzik ML, Kajumo F and Karpatkin S: Effect of thrombin treatment of tumor cells on adhesion of tumor cells to platelets in vitro and tumor metastasis in vivo. Cancer Res. 52:3267–3272. 1992.PubMed/NCBI

68 

Floyd CM, Irani K, Kind PD and Kessler CM: von Willebrand factor interacts with malignant hematopoietic cell lines: Evidence for the presence of specific binding sites and modification of von Willebrand factor structure and function. J Lab Clin Med. 119:467–476. 1992.PubMed/NCBI

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Spandidos Publications style
Wang X, Zhang X, Zhang C, Qi L and Liu J: Plasma von Willebrand factor levels in patients with cancer: A meta‑analysis. Oncol Lett 28: 399, 2024.
APA
Wang, X., Zhang, X., Zhang, C., Qi, L., & Liu, J. (2024). Plasma von Willebrand factor levels in patients with cancer: A meta‑analysis. Oncology Letters, 28, 399. https://doi.org/10.3892/ol.2024.14532
MLA
Wang, X., Zhang, X., Zhang, C., Qi, L., Liu, J."Plasma von Willebrand factor levels in patients with cancer: A meta‑analysis". Oncology Letters 28.2 (2024): 399.
Chicago
Wang, X., Zhang, X., Zhang, C., Qi, L., Liu, J."Plasma von Willebrand factor levels in patients with cancer: A meta‑analysis". Oncology Letters 28, no. 2 (2024): 399. https://doi.org/10.3892/ol.2024.14532
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Zhang X, Zhang C, Qi L and Liu J: Plasma von Willebrand factor levels in patients with cancer: A meta‑analysis. Oncol Lett 28: 399, 2024.
APA
Wang, X., Zhang, X., Zhang, C., Qi, L., & Liu, J. (2024). Plasma von Willebrand factor levels in patients with cancer: A meta‑analysis. Oncology Letters, 28, 399. https://doi.org/10.3892/ol.2024.14532
MLA
Wang, X., Zhang, X., Zhang, C., Qi, L., Liu, J."Plasma von Willebrand factor levels in patients with cancer: A meta‑analysis". Oncology Letters 28.2 (2024): 399.
Chicago
Wang, X., Zhang, X., Zhang, C., Qi, L., Liu, J."Plasma von Willebrand factor levels in patients with cancer: A meta‑analysis". Oncology Letters 28, no. 2 (2024): 399. https://doi.org/10.3892/ol.2024.14532
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