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Exploring the potential of the TCR repertoire as a tumor biomarker (Review)

  • Authors:
    • An-Li Huang
    • Yan-Zhao He
    • Yong Yang
    • Min Pang
    • Guo-Ping Zheng
    • Hai-Long Wang
  • View Affiliations / Copyright

    Affiliations: Institute of Cancer Biology, Basic Medical Sciences Center, School of Basic Medicine, Shanxi Medical University, Jinzhong, Shanxi 030600, P.R. China, NHC Key Laboratory of Pneumoconiosis, Shanxi Province Key Laboratory of Respiratory Disease, Department of Pulmonary and Critical Care Medicine, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China, Centre for Transplant and Renal Research, Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales 2145, Australia
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 413
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    Published online on: June 28, 2024
       https://doi.org/10.3892/ol.2024.14546
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Abstract

T cells play an important role in adaptive immunity. Mature T cells specifically recognize antigens on major histocompatibility complex molecules through T‑cell receptors (TCRs). As the TCR repertoire is highly diverse, its analysis is vital in the assessment of T cells. Advances in sequencing technology have provided convenient methods for further investigation of the TCR repertoire. In the present review, the TCR structure and the mechanisms by which TCRs function in tumor recognition are described. In addition, the potential value of the TCR repertoire in tumor diagnosis is reviewed. Furthermore, the role of the TCR repertoire in tumor immunotherapy is introduced, and the relationships between the TCR repertoire and the effects of different tumor immunotherapies are discussed. Based on the reviewed literature, it may be concluded that the TCR repertoire has the potential to serve as a biomarker for tumor prognosis. However, a wider range of cancer types and more diverse subjects require evaluation in future research to establish the TCR repertoire as a biomarker of tumor immunity.
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Copy and paste a formatted citation
Spandidos Publications style
Huang A, He Y, Yang Y, Pang M, Zheng G and Wang H: Exploring the potential of the TCR repertoire as a tumor biomarker (Review). Oncol Lett 28: 413, 2024.
APA
Huang, A., He, Y., Yang, Y., Pang, M., Zheng, G., & Wang, H. (2024). Exploring the potential of the TCR repertoire as a tumor biomarker (Review). Oncology Letters, 28, 413. https://doi.org/10.3892/ol.2024.14546
MLA
Huang, A., He, Y., Yang, Y., Pang, M., Zheng, G., Wang, H."Exploring the potential of the TCR repertoire as a tumor biomarker (Review)". Oncology Letters 28.3 (2024): 413.
Chicago
Huang, A., He, Y., Yang, Y., Pang, M., Zheng, G., Wang, H."Exploring the potential of the TCR repertoire as a tumor biomarker (Review)". Oncology Letters 28, no. 3 (2024): 413. https://doi.org/10.3892/ol.2024.14546
Copy and paste a formatted citation
x
Spandidos Publications style
Huang A, He Y, Yang Y, Pang M, Zheng G and Wang H: Exploring the potential of the TCR repertoire as a tumor biomarker (Review). Oncol Lett 28: 413, 2024.
APA
Huang, A., He, Y., Yang, Y., Pang, M., Zheng, G., & Wang, H. (2024). Exploring the potential of the TCR repertoire as a tumor biomarker (Review). Oncology Letters, 28, 413. https://doi.org/10.3892/ol.2024.14546
MLA
Huang, A., He, Y., Yang, Y., Pang, M., Zheng, G., Wang, H."Exploring the potential of the TCR repertoire as a tumor biomarker (Review)". Oncology Letters 28.3 (2024): 413.
Chicago
Huang, A., He, Y., Yang, Y., Pang, M., Zheng, G., Wang, H."Exploring the potential of the TCR repertoire as a tumor biomarker (Review)". Oncology Letters 28, no. 3 (2024): 413. https://doi.org/10.3892/ol.2024.14546
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