|
1
|
Siegel RL, Miller KD, Wagle NS and Jemal
A: Cancer statistics, 2023. CA Cancer J Clin. 73:17–48. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Dekker E, Tanis PJ, Vleugels JLA, Kasi PM
and Wallace MB: Colorectal cancer. Lancet. 394:1467–1480. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Patel SG, Karlitz JJ, Yen T, Lieu CH and
Boland CR: The rising tide of early-onset colorectal cancer: A
comprehensive review of epidemiology, clinical features, biology,
risk factors, prevention, and early detection. Lancet Gastroenterol
Hepatol. 7:262–274. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Harada S and Morlote D: Molecular
pathology of colorectal cancer. Adv Anat Pathol. 27:20–26. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Derynck R and Budi EH: Specificity,
versatility, and control of TGF-β family signaling. Sci Signal.
12:eaav51832019. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Peng D, Fu M, Wang M, Wei Y and Wei X:
Targeting TGF-β signal transduction for fibrosis and cancer
therapy. Mol Cancer. 21:1042022. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Ali S, Rehman MU, Yatoo AM, Arafah A, Khan
A, Rashid S, Majid S, Ali A and Ali MN: TGF-β signaling pathway:
Therapeutic targeting and potential for anti-cancer immunity. Eur J
Pharmacol. 947:1756782023. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Colak S and Ten Dijke P: Targeting TGF-β
signaling in cancer. Trends Cancer. 3:56–71. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Derynck R, Turley SJ and Akhurst RJ: TGFβ
biology in cancer progression and immunotherapy. Nat Rev Clin
Oncol. 18:9–34. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Itatani Y, Kawada K and Sakai Y:
Transforming growth factor-β signaling pathway in colorectal cancer
and its tumor microenvironment. Int J Mol Sci. 20:58222019.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Liu A, Yu C, Qiu C, Wu Q, Huang C, Li X,
She X, Wan K, Liu L, Li M, et al: PRMT5 methylating SMAD4 activates
TGF-β signaling and promotes colorectal cancer metastasis.
Oncogene. 42:1572–1584. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Perez LG, Kempski J, McGee HM, Pelzcar P,
Agalioti T, Giannou A, Konczalla L, Brockmann L, Wahib R, Xu H, et
al: TGF-β signaling in Th17 cells promotes IL-22 production and
colitis-associated colon cancer. Nat Commun. 11:26082020.
View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Dongre A and Weinberg RA: New insights
into the mechanisms of epithelial-mesenchymal transition and
implications for cancer. Nat Rev Mol Cell Biol. 20:69–84. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Yang J, Antin P, Berx G, Blanpain C,
Brabletz T, Bronner M, Campbell K, Cano A, Casanova J, Christofori
G, et al: Guidelines and definitions for research on
epithelial-mesenchymal transition. Nat Rev Mol Cell Biol.
21:341–352. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Lambert AW and Weinberg RA: Linking EMT
programmes to normal and neoplastic epithelial stem cells. Nat Rev
Cancer. 21:325–338. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Lu J, Kornmann M and Traub B: Role of
epithelial to mesenchymal transition in colorectal cancer. Int J
Mol Sci. 24:148152023. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Stine ZE, Schug ZT, Salvino JM and Dang
CV: Targeting cancer metabolism in the era of precision oncology.
Nat Rev Drug Discov. 21:141–162. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Gyamfi J, Kim J and Choi J: Cancer as a
Metabolic Disorder. Int J Mol Sci. 23:11552022. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
La Vecchia S and Sebastián C: Metabolic
pathways regulating colorectal cancer initiation and progression.
Semin Cell Dev Biol. 98:63–70. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Pan C, Li B and Simon MC: Moonlighting
functions of metabolic enzymes and metabolites in cancer. Mol Cell.
81:3760–3774. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Martínez-Reyes I and Chandel NS: Cancer
metabolism: Looking forward. Nat Rev Cancer. 21:669–680. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Shi X, Yang J, Deng S, Xu H, Wu D, Zeng Q,
Wang S, Hu T, Wu F and Zhou H: TGF-β signaling in the tumor
metabolic microenvironment and targeted therapies. J Hematol Oncol.
15:1352022. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Hua W, Ten Dijke P, Kostidis S, Giera M
and Hornsveld M: TGFβ-induced metabolic reprogramming during
epithelial-to-mesenchymal transition in cancer. Cell Mol Life Sci.
77:2103–2123. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Nakasuka F, Tabata S, Sakamoto T, Hirayama
A, Ebi H, Yamada T, Umetsu K, Ohishi M, Ueno A, Goto H, et al:
TGF-β-dependent reprogramming of amino acid metabolism induces
epithelial-mesenchymal transition in non-small cell lung cancers.
Commun Biol. 4:7822021. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Soukupova J, Malfettone A, Bertran E,
Hernández-Alvarez MI, Peñuelas-Haro I, Dituri F, Giannelli G,
Zorzano A and Fabregat I: Epithelial-Mesenchymal Transition (EMT)
Induced by TGF-β in hepatocellular carcinoma cells reprograms lipid
metabolism. Int J Mol Sci. 22:55432021. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Corbet C, Bastien E, Santiago de Jesus JP,
Dierge E, Martherus R, Vander Linden C, Doix B, Degavre C, Guilbaud
C, Petit L, et al: TGFβ2-induced formation of lipid droplets
supports acidosis-driven EMT and the metastatic spreading of cancer
cells. Nat Commun. 11:4542020. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Robinson MD, McCarthy DJ and Smyth GK:
edgeR: A Bioconductor package for differential expression analysis
of digital gene expression data. Bioinformatics. 26:139–140. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Luo W and Brouwer C: Pathview: An
R/Bioconductor package for pathway-based data integration and
visualization. Bioinformatics. 29:1830–1831. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Vaghari-Tabari M, Ferns GA, Qujeq D,
Andevari AN, Sabahi Z and Moein S: Signaling, metabolism, and
cancer: An important relationship for therapeutic intervention. J
Cell Physiol. 236:5512–5532. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Cristalli G, Costanzi S, Lambertucci C,
Lupidi G, Vittori S, Volpini R and Camaioni E: Adenosine deaminase:
Functional implications and different classes of inhibitors. Med
Res Rev. 21:105–128. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Tzavlaki K and Moustakas A: TGF-β
Signaling. Biomolecules. 10:4872020. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Batlle E and Massagué J: Transforming
growth factor-β signaling in immunity and cancer. Immunity.
50:924–940. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Jaykumar AB, Plumber S, Barry DM, Binns D,
Wichaidit C, Grzemska M, Earnest S, Goldsmith EJ, Cleaver O and
Cobb MH: WNK1 collaborates with TGF-β in endothelial cell junction
turnover and angiogenesis. Proc Natl Acad Sci USA.
119:e22037431192022. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Zaiatz-Bittencourt V, Finlay DK and
Gardiner CM: Canonical TGF-β signaling pathway represses human NK
cell metabolism. J Immunol. 200:3934–3941. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Guido C, Whitaker-Menezes D, Capparelli C,
Balliet R, Lin Z, Pestell RG, Howell A, Aquila S, Andò S,
Martinez-Outschoorn U, et al: Metabolic reprogramming of
cancer-associated fibroblasts by TGF-β drives tumor growth:
Connecting TGF-β signaling with ‘Warburg-like’ cancer metabolism
and L-lactate production. Cell Cycle. 11:3019–3035. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Cader MZ, de Almeida Rodrigues RP, West
JA, Sewell GW, Md-Ibrahim MN, Reikine S, Sirago G, Unger LW,
Iglesias-Romero AB, Ramshorn K, et al: FAMIN is a multifunctional
purine enzyme enabling the purine nucleotide cycle. Cell.
180:278–295.e23. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Assadi G, Saleh R, Hadizadeh F, Vesterlund
L, Bonfiglio F, Halfvarson J, Törkvist L, Eriksson AS, Harris HE,
Sundberg E and D'Amato M: LACC1 polymorphisms in inflammatory bowel
disease and juvenile idiopathic arthritis. Genes Immun. 17:261–264.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Wakil SM, Monies DM, Abouelhoda M,
Al-Tassan N, Al-Dusery H, Naim EA, Al-Younes B, Shinwari J,
Al-Mohanna FA, Meyer BF and Al-Mayouf S: Association of a mutation
in LACC1 with a monogenic form of systemic juvenile idiopathic
arthritis. Arthritis Rheumatol. 67:288–295. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Kallinich T, Thorwarth A, von Stuckrad SL,
Rösen-Wolff A, Luksch H, Hundsdoerfer P, Minden K and Krawitz P:
Juvenile arthritis caused by a novel FAMIN (LACC1) mutation in two
children with systemic and extended oligoarticular course. Pediatr
Rheumatol Online J. 14:632016. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Linden J, Koch-Nolte F and Dahl G: Purine
release, metabolism, and signaling in the inflammatory response.
Annu Rev Immunol. 37:325–347. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Yin J, Ren W, Huang X, Deng J, Li T and
Yin Y: Potential mechanisms connecting purine metabolism and cancer
therapy. Front Immunol. 9:16972018. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Zhang C, Wang K and Wang H: Adenosine in
cancer immunotherapy: Taking off on a new plane. Biochim Biophys
Acta Rev Cancer. 1878:1890052023. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Huo A and Xiong X: PAICS as a potential
target for cancer therapy linking purine biosynthesis to cancer
progression. Life Sci. 331:1220702023. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Kim IS and Jo EK: Inosine: A bioactive
metabolite with multimodal actions in human diseases. Front
Pharmacol. 13:10439702022. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Srinivasan S, Torres AG and Ribas de
Pouplana L: Inosine in biology and disease. Genes (Basel).
12:6002021. View Article : Google Scholar : PubMed/NCBI
|
