Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-2024 Volume 28 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2024 Volume 28 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Temozolomide based treatment in glioblastoma: 6 vs. 12 months

  • Authors:
    • Morena Fasano
    • Mario Pirozzi
    • Vincenzo De Falco
    • Chiara Carmen Miceli
    • Stefano Farese
    • Alessia Zotta
    • Vincenzo Famiglietti
    • Pasquale Vitale
    • Ilaria Di Giovanni
    • Christian Brancati
    • Vincenzo Carfora
    • Domenico Solari
    • Teresa Somma
    • Luigi Maria Cavallo
    • Paolo Cappabianca
    • Manuel Conson
    • Roberto Pacelli
    • Fortunato Ciardiello
    • Raffaele Addeo
  • View Affiliations / Copyright

    Affiliations: Medical Oncology Unit, Department of Precision Medicine, University of Campania Luigi Vanvitelli, I‑80131 Naples, Italy, Oncology Unit, ‘San Giovanni di Dio’ Hospital, ASL Napoli 2 Nord, I‑80020 Frattamaggiore, Italy, Radiation Oncology Unit, Department of Radiation Oncology, ‘San Pio’ Hospital, I‑82100 Benevento, Italy, Division of Neurosurgery, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, I‑80131 Naples, Italy, Department of Advanced Biomedical Sciences, University of Naples Federico II, I‑80131 Naples, Italy
    Copyright: © Fasano et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 418
    |
    Published online on: July 2, 2024
       https://doi.org/10.3892/ol.2024.14551
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The Stupp regimen remains the standard treatment for newly diagnosed glioblastomas, although the prognosis remains poor. Several temozolomide alternative schedules have been studied, with extended adjuvant treatment (>6 cycles of temozolomide) frequently used, although different trials have indicated contrasting results. Survival data of 87 patients who received 6 (‘6C’ group) or 12 (‘12C’ group) cycles of temozolomide were collected between 2012 and 2022. A total of 45 patients were included in the 6C group and 42 patients were included in the 12C group. Data on isocitrate dehydrogenase mutation and methylguanine‑DNA‑methyltransferase (MGMT) promoter methylation status were also collected. The 12C group exhibited statistically significantly improved overall survival [OS; 22.8 vs. 17.5 months; hazard ratio (HR), 0.47; 95% CI, 0.30‑0.73; P=0.001] and progression‑free survival (15.3 vs. 9 months; HR, 0.39; 95% CI, 0.25‑0.62; P=0.001). However, in the subgroup analysis according to MGMT status, OS in the 12C group was significantly superior to OS in the 6C group only in the MGMT unmethylated tumors. The present data suggested that extended adjuvant temozolomide appeared to be more effective than the conventional six cycles.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Crocetti E, Trama A, Stiller C, Caldarella A, Soffietti R, Jaal J, Weber DC, Ricardi U, Slowinski J and Brandes A; RARECARE working group, : Epidemiology of glial and non-glial brain tumours in Europe. Eur J Cancer. 48:1532–1542. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Ostrom QT, Cioffi G, Gittleman H, Patil N, Waite K, Kruchko C and Barnholtz-Sloan JS: CBTRUS statistical report: Primary brain and other central nervous system tumors diagnosed in the United States in 2012–2016. Neuro Oncol. 21 (Suppl 5):v1–v100. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Davis FG, Smith TR, Gittleman HR, Ostrom QT, Kruchko C and Barnholtz-Sloan JS: Glioblastoma incidence rate trends in Canada and the United States compared with England, 1995–2015. Neuro Oncol. 22:301–302. 2020. View Article : Google Scholar : PubMed/NCBI

4 

Philips A, Henshaw DL, Lamburn G and O'Carroll MJ: Brain tumours: Rise in glioblastoma multiforme incidence in England 1995–2015 suggests an adverse environmental or lifestyle factor. J Environ Public Health. 2018:79107542018. View Article : Google Scholar : PubMed/NCBI

5 

Lee JH, Lee JE, Kahng JY, Kim SH, Park JS, Yoon SJ, Um JY, Kim WK, Lee JK, Park J, et al: Human glioblastoma arises from subventricular zone cells with low-level driver mutations. Nature. 560:243–247. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Lah TT, Novak M and Breznik B: Brain malignancies: Glioblastoma and brain metastases. Semin Cancer Biol. 60:262–273. 2020. View Article : Google Scholar : PubMed/NCBI

7 

Sturm D, Witt H, Hovestadt V, Khuong-Quang DA, Jones DT, Konermann C, Pfaff E, Tönjes M, Sill M, Bender S, et al: Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell. 22:425–437. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Wang Q, Hu B, Hu X, Kim H, Squatrito M, Scarpace L, deCarvalho AC, Lyu S, Li P, Li Y, et al: Tumor evolution of glioma-intrinsic gene expression subtypes associates with immunological changes in the microenvironment. Cancer Cell. 32:42–56.e6. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Daniel M, Peek GW and Tollefsbol TO: Regulation of the human catalytic subunit of telomerase (hTERT). Gene. 498:135–146. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Gilbert MR, Wang M, Aldape KD, Stupp R, Hegi ME, Jaeckle KA, Armstrong TS, Wefel JS, Won M, Blumenthal DT, et al: Dose-dense temozolomide for newly diagnosed glioblastoma: A randomized phase III clinical trial. J Clin Oncol. 31:4085–4091. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Stupp R, Taillibert S, Kanner A, Read W, Steinberg D, Lhermitte B, Toms S, Idbaih A, Ahluwalia MS, Fink K, et al: Effect of tumor-treating fields plus maintenance temozolomide vs maintenance temozolomide alone on survival in patients with glioblastoma: a randomized clinical trial. JAMA. 318:2306–2316. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Liu G, Yuan X, Zeng Z, Tunici P, Ng H, Abdulkadir IR, Lu L, Irvin D, Black KL and Yu JS: Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol Cancer. 5:672006. View Article : Google Scholar : PubMed/NCBI

13 

Fountain DM, Bryant A, Barone DG, Waqar M, Hart MG, Bulbeck H, Kernohan A, Watts C and Jenkinson MD: Intraoperative imaging technology to maximise extent of resection for glioma: A network meta-analysis. Cochrane Database Syst Rev. 1:CD0136302021.PubMed/NCBI

14 

Cahill DP, Levine KK, Betensky RA, Codd PJ, Romany CA, Reavie LB, Batchelor TT, Futreal PA, Stratton MR, Curry WT, et al: Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment. Clin Cancer Res. 13:2038–2045. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Weller M: Where does O6-methylguanine DNA methyltransferase promoter methylation assessment place temozolomide in the future standards of care for glioblastoma? Cancer. 124:1316–1318. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Horbinski C, Nabors LB, Portnow J, Baehring J, Bhatia A, Bloch O, Brem S, Butowski N, Cannon DM, Chao S, et al: NCCN Guidelines® Insights: Central Nervous System Cancers, Version 2.2022: Featured Updates to the NCCN Guidelines. J Natl Comp Cancer Network. 21:12–20. 2023. View Article : Google Scholar

17 

Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, et al: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 352:987–996. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC, Ludwin SK, Allgeier A, Fisher B, Belanger K, et al: Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-Year analysis of the EORTC-NCIC trial. Lancet Oncol. 10:459–466. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Roldán Urgoiti GB, Singh AD and Easaw JC: Extended adjuvant temozolomide for treatment of newly diagnosed glioblastoma multiforme. J Neurooncol. 108:173–177. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Malkoun N, Chargari C, Forest F, Fotso MJ, Cartier L, Auberdiac P, Thorin J, Pacaut C, Peoc'h M, Nuti C, et al: Prolonged temozolomide for treatment of glioblastoma: Preliminary clinical results and prognostic value of p53 overexpression. J Neurooncol. 106:127–133. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Hau P, Koch D, Hundsberger T, Marg E, Bauer B, Rudolph R, Rauch M, Brenner A, Rieckmann P, Schuth J, et al: Safety and feasibility of long-term temozolomide treatment in patients with high-grade glioma. Neurology. 68:688–690. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Refae AA, Ezzat A, Salem DA and Mahrous M: Protracted adjuvant temozolomide in glioblastoma multiforme. J Cancer Ther. 6:748–758. 2015. View Article : Google Scholar

23 

Balana C, Vaz MA, Manuel Sepúlveda J, Mesia C, Del Barco S, Pineda E, Muñoz-Langa J, Estival A, de Las Peñas R, Fuster J, et al: A phase II randomized, multicenter, open-label trial of continuing adjuvant temozolomide beyond 6 cycles in patients with glioblastoma (GEINO 14-01). Neuro Oncol. 22:1851–1861. 2020. View Article : Google Scholar : PubMed/NCBI

24 

Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G, et al: The 2021 WHO classification of tumors of the central nervous system: A summary. Neuro Oncol. 23:1231–1251. 2021. View Article : Google Scholar : PubMed/NCBI

25 

Bady P, Sciuscio D, Diserens AC, Bloch J, van den Bent MJ, Marosi C, Dietrich PY, Weller M, Mariani L, Heppner FL, et al: MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status. Acta Neuropathol. 124:547–560. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Vlassenbroeck I, Califice S, Diserens AC, Migliavacca E, Straub J, Di Stefano I, Moreau F, Hamou MF, Renard I, Delorenzi M, et al: Validation of real-time methylation-specific PCR to determine O6-methylguanine-DNA methyltransferase gene promoter methylation in glioma. J Mol Diagn. 10:332–337. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Capper D, Weissert S, Balss J, Habel A, Meyer J, Jäger D, Ackermann U, Tessmer C, Korshunov A, Zentgraf H, et al: Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors. Brain Pathol. 20:245–254. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Franceschi E, Lombardi G, Balestrini D, Buglione M, Caranci F, Castellano A, Ferreri A, Franchino F, Giangaspero F and Mascarin M: Guidelines for brain neoplasies|AIOM. https://www.aiom.it/linee-guida-aiom-2021-neoplasie-cerebrali/June 23–2023

29 

Hegi ME, Diserens AC, Gorlia T, Hamou MF, de Tribolet N, Weller M, Kros JM, Hainfellner JA, Mason W, Mariani L, et al: MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med. 352:997–1003. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Weller M, van den Bent M, Preusser M, Le Rhun E, Tonn JC, Minniti G, Bendszus M, Balana C, Chinot O, Dirven L, et al: EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood. Nat Rev Clin Oncol. 18:170–186. 2021. View Article : Google Scholar : PubMed/NCBI

31 

Balañá C, Vaz MA, Lopez D, de la Peñas R, García-Bueno JM, Molina-Garrido MJ, Sepúlveda JM, Cano JM, Bugés C, Sanz SM, et al: Should we continue temozolomide beyond six cycles in the adjuvant treatment of glioblastoma without an evidence of clinical benefit? A cost analysis based on prescribing patterns in Spain. Clin Transl Oncol. 16:273–279. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Attarian F, Taghizadeh-Hesary F, Fanipakdel A, Javadinia SA, Porouhan P, PeyroShabany B and Fazilat-Panah D: A systematic review and meta-analysis on the number of adjuvant temozolomide cycles in newly diagnosed glioblastoma. Front Oncol. 11:7794912021. View Article : Google Scholar : PubMed/NCBI

33 

Blumenthal DT, Gorlia T, Gilbert MR, Kim MM, Burt Nabors L, Mason WP, Hegi ME, Zhang P, Golfinopoulos V, Perry JR, et al: Is more better? The impact of extended adjuvant temozolomide in newly diagnosed glioblastoma: A secondary analysis of EORTC and NRG oncology/RTOG. Neuro Oncol. 19:1119–1126. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Perry JR, Bélanger K, Mason WP, Fulton D, Kavan P, Easaw J, Shields C, Kirby S, Macdonald DR, Eisenstat DD, et al: Phase II trial of continuous dose-intense temozolomide in recurrent malignant glioma: RESCUE study. J Clin Oncol. 28:2051–2057. 2010. View Article : Google Scholar : PubMed/NCBI

35 

van den Bent MJ, Dubbink HJ, Marie Y, Brandes AA, Taphoorn MJ, Wesseling P, Frenay M, Tijssen CC, Lacombe D, Idbaih A, et al: IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: A report of the European organization for research and treatment of cancer brain tumor group. Clin Cancer Res. 16:1597–1604. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Chen J, Wang T, Liu W, Qiu H, Zhang N, Chen X, Ding X and Zhang L: Extended adjuvant temozolomide in newly diagnosed glioblastoma: A single-center retrospective study. Front Oncol. 12:10005012022. View Article : Google Scholar : PubMed/NCBI

37 

Darlix A, Baumann C, Lorgis V, Ghiringhelli F, Blonski M, Chauffert B, Zouaoui S, Pinelli C, Rech F, Beauchesne P and Taillandier L: Prolonged administration of adjuvant temozolomide improves survival in adult patients with glioblastoma. Anticancer Res. 33:3467–3474. 2013.PubMed/NCBI

38 

Bocangel D, Sengupta S, Mitra S and Bhakat KK: p53-Mediated down-regulation of the human DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) via interaction with Sp1 transcription factor. Anticancer Res. 29:3741–3750. 2009.PubMed/NCBI

39 

Weller M, Felsberg J, Hartmann C, Berger H, Steinbach JP, Schramm J, Westphal M, Schackert G, Simon M, Tonn JC, et al: Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German glioma network. J Clin Oncol. 27:5743–5750. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Pollack IF, Finkelstein SD, Burnham J, Holmes EJ, Hamilton RL, Yates AJ, Finlay JL and Sposto R; Children's Cancer Group, : Age and TP53 mutation frequency in childhood malignant gliomas: Results in a multi-institutional cohort. Cancer Res. 61:7404–7407. 2001.PubMed/NCBI

41 

Miyagami M, Tazoe M and Nakamura S: Expression of vascular endothelial growth factor and p53 protein in association with neovascularization in human malignant gliomas. Brain Tumor Pathol. 15:95–100. 1998. View Article : Google Scholar : PubMed/NCBI

42 

Skardelly M, Dangel E, Gohde J, Noell S, Behling F, Lepski G, Borchers C, Koch M, Schittenhelm J, Bisdas S, et al: Prolonged temozolomide maintenance therapy in newly diagnosed glioblastoma. Oncologist. 22:570–575. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Seiz M, Krafft U, Freyschlag CF, Weiss C, Schmieder K, Lohr F, Wenz F, Thomé C and Tuettenberg J: Long-term adjuvant administration of temozolomide in patients with glioblastoma multiforme: Experience of a single institution. J Cancer Res Clin Oncol. 136:1691–1695. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Hammouch F, Boterberg T, Clement P, Joosens E, Whenham N, Verschaeve V, Devriendt D, Renard L and Baurain JFR: 8744 POSTER extended use of adjuvant TMZ in newly diagnosed GBM patients is safe-results from the safety analysis of the PATSGO trial. Eur J Cancer. 47 (Suppl 1):S5872011. View Article : Google Scholar

45 

Pouratian N, Gasco J, Sherman JH, Shaffrey ME and Schiff D: Toxicity and efficacy of protracted low dose temozolomide for the treatment of low grade gliomas. J Neurooncol. 82:281–288. 2007. View Article : Google Scholar : PubMed/NCBI

46 

Su YB, Sohn S, Krown SE, Livingston PO, Wolchok JD, Quinn C, Williams L, Foster T, Sepkowitz KA and Chapman PB: Selective CD4+ lymphopenia in melanoma patients treated with temozolomide: A toxicity with therapeutic implications. J Clin Oncol. 22:610–616. 2004. View Article : Google Scholar : PubMed/NCBI

47 

Momota H, Narita Y, Miyakita Y and Shibui S: Secondary hematological malignancies associated with temozolomide in patients with glioma. Neuro Oncol. 15:14452013. View Article : Google Scholar : PubMed/NCBI

48 

Ohno M, Miyakita Y, Takahashi M, Yanagisawa S, Tamura Y and Narita Y: Continuing maintenance temozolomide therapy beyond 12 cycles confers no clinical benefit over discontinuation at 12 cycles in patients with IDH1/2-wildtype glioblastoma. Jpn J Clin Oncol. 52:1134–1142. 2022.PubMed/NCBI

49 

Johnson BE, Mazor T, Hong C, Barnes M, Aihara K, McLean CY, Fouse SD, Yamamoto S, Ueda H, Tatsuno K, et al: Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Science. 343:189–193. 2014. View Article : Google Scholar : PubMed/NCBI

50 

Schlesner M and Eils R: Hypermutation takes the driver's seat. Genome Med. 7:312015. View Article : Google Scholar : PubMed/NCBI

51 

Stritzelberger J, Distel L, Buslei R, Fietkau R and Putz F: Acquired temozolomide resistance in human glioblastoma cell line U251 is caused by mismatch repair deficiency and can be overcome by lomustine. Clin Transl Oncol. 20:508–516. 2018. View Article : Google Scholar : PubMed/NCBI

52 

Snyder A, Makarov V, Merghoub T, Yuan J, Zaretsky JM, Desrichard A, Walsh LA, Postow MA, Wong P, Ho TS, et al: Genetic basis for clinical response to CTLA-4 blockade in melanoma. N Engl J Med. 371:2189–2199. 2014. View Article : Google Scholar : PubMed/NCBI

53 

Lombardi G, Barresi V, Indraccolo S, Simbolo M, Fassan M, Mandruzzato S, Simonelli M, Caccese M, Pizzi M, Fassina A, et al: Pembrolizumab activity in recurrent high-grade gliomas with partial or complete loss of mismatch repair protein expression: A monocentric, observational and prospective pilot study. Cancers (Basel). 12:22832020. View Article : Google Scholar : PubMed/NCBI

54 

Bhandari M, Gandhi AK, Devnani B, Kumar P, Sharma DN and Julka PK: Comparative study of adjuvant temozolomide six cycles versus extended 12 cycles in newly diagnosed glioblastoma multiforme. J Clin Diagn Res. 11:XC04–XC08. 2017.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Fasano M, Pirozzi M, De Falco V, Miceli CC, Farese S, Zotta A, Famiglietti V, Vitale P, Giovanni I, Brancati C, Brancati C, et al: Temozolomide based treatment in glioblastoma: 6 vs. 12 months. Oncol Lett 28: 418, 2024.
APA
Fasano, M., Pirozzi, M., De Falco, V., Miceli, C.C., Farese, S., Zotta, A. ... Addeo, R. (2024). Temozolomide based treatment in glioblastoma: 6 vs. 12 months. Oncology Letters, 28, 418. https://doi.org/10.3892/ol.2024.14551
MLA
Fasano, M., Pirozzi, M., De Falco, V., Miceli, C. C., Farese, S., Zotta, A., Famiglietti, V., Vitale, P., Giovanni, I., Brancati, C., Carfora, V., Solari, D., Somma, T., Cavallo, L. M., Cappabianca, P., Conson, M., Pacelli, R., Ciardiello, F., Addeo, R."Temozolomide based treatment in glioblastoma: 6 vs. 12 months". Oncology Letters 28.3 (2024): 418.
Chicago
Fasano, M., Pirozzi, M., De Falco, V., Miceli, C. C., Farese, S., Zotta, A., Famiglietti, V., Vitale, P., Giovanni, I., Brancati, C., Carfora, V., Solari, D., Somma, T., Cavallo, L. M., Cappabianca, P., Conson, M., Pacelli, R., Ciardiello, F., Addeo, R."Temozolomide based treatment in glioblastoma: 6 vs. 12 months". Oncology Letters 28, no. 3 (2024): 418. https://doi.org/10.3892/ol.2024.14551
Copy and paste a formatted citation
x
Spandidos Publications style
Fasano M, Pirozzi M, De Falco V, Miceli CC, Farese S, Zotta A, Famiglietti V, Vitale P, Giovanni I, Brancati C, Brancati C, et al: Temozolomide based treatment in glioblastoma: 6 vs. 12 months. Oncol Lett 28: 418, 2024.
APA
Fasano, M., Pirozzi, M., De Falco, V., Miceli, C.C., Farese, S., Zotta, A. ... Addeo, R. (2024). Temozolomide based treatment in glioblastoma: 6 vs. 12 months. Oncology Letters, 28, 418. https://doi.org/10.3892/ol.2024.14551
MLA
Fasano, M., Pirozzi, M., De Falco, V., Miceli, C. C., Farese, S., Zotta, A., Famiglietti, V., Vitale, P., Giovanni, I., Brancati, C., Carfora, V., Solari, D., Somma, T., Cavallo, L. M., Cappabianca, P., Conson, M., Pacelli, R., Ciardiello, F., Addeo, R."Temozolomide based treatment in glioblastoma: 6 vs. 12 months". Oncology Letters 28.3 (2024): 418.
Chicago
Fasano, M., Pirozzi, M., De Falco, V., Miceli, C. C., Farese, S., Zotta, A., Famiglietti, V., Vitale, P., Giovanni, I., Brancati, C., Carfora, V., Solari, D., Somma, T., Cavallo, L. M., Cappabianca, P., Conson, M., Pacelli, R., Ciardiello, F., Addeo, R."Temozolomide based treatment in glioblastoma: 6 vs. 12 months". Oncology Letters 28, no. 3 (2024): 418. https://doi.org/10.3892/ol.2024.14551
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team