Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-2024 Volume 28 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2024 Volume 28 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.pdf
Article Open Access

Cancer marker TNFRSF1A: From single‑cell heterogeneity of renal cell carcinoma to functional validation

  • Authors:
    • Ping Xu
    • Zusheng Du
    • Xiaohong Xie
    • Lifei Yang
    • Jingjing Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Ultrasound, Ningbo Yinzhou No. 2 Hospital, Ningbo, Zhejiang 315153, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 425
    |
    Published online on: July 5, 2024
       https://doi.org/10.3892/ol.2024.14559
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

During the progression of renal cell carcinoma (RCC), tumor growth, metastasis and treatment response heterogeneity are regulated by both the tumor itself and the tumor microenvironment (TME). The aim of the present study was to investigate the role of the TME in RCC and construct a crosstalk network for clear cell RCC (ccRCC). An additional aim was to evaluate whether TNF receptor superfamily member 1A (TNFRSF1A) is a potential therapeutic target for ccRCC. Single‑cell data analysis of RCC was performed using the GSE152938 dataset, focusing on key cellular components and their involvement in the ccRCC TME. Additionally, cell‑cell communication was analyzed to elucidate the complex network of the ccRCC microenvironment. Analyses of data from The Cancer Genome Atlas and Clinical Proteomic Tumor Analysis Consortium databases were performed to further mine the key TNF receptor genes, with a particular focus on the prediction and assessment of the cancer‑associated features of TNFRSF1A. In addition, following the silencing of TNFRSF1A using small interfering RNA in the 786‑O ccRCC cell line, a number of in vitro experiments were conducted to further investigate the cancer‑promoting characteristics of TNFRSF1A. These included 5‑ethynyl‑2'‑deoxyuridine incorporation, Cell Counting Kit‑8, colony formation, Transwell, cell cycle and apoptosis assays. The TNF signaling pathway was found to have a critical role in the development of ccRCC. Based on the specific crosstalk identified between TNF and TNFRSF1A, the communication of this signaling pathway within the TME was elucidated. The results of the cellular phenotype experiments indicated that TNFRSF1A promotes the proliferation, migration and invasion of ccRCC cells. Consequently, it is proposed that targeting TNFRSF1A may disrupt tumor progression and serve as a therapeutic strategy. In conclusion, by understanding the TME and identifying significant crosstalk within the TNF signaling pathway, the potential of TNFRSF1A as a therapeutic target is highlighted. This may facilitate an advance in precision medicine and improve the prognosis for patients with RCC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Capitanio U, Bensalah K, Bex A, Boorjian SA, Bray F, Coleman J, Gore JL, Sun M, Wood C and Russo P: Epidemiology of renal cell carcinoma. Eur Urol. 75:74–84. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Cirillo L, Innocenti S and Becherucci F: Global epidemiology of kidney cancer. Nephrol Dial Transplant. 39:920–928. 2024. View Article : Google Scholar : PubMed/NCBI

3 

Choueiri TK: Renal cell carcinoma. Hematol Oncol Clin North Am. 25:xiii–xiv. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Diaz-Montero CM, Rini BI and Finke JH: The immunology of renal cell carcinoma. Nat Rev Nephrol. 16:721–735. 2020. View Article : Google Scholar : PubMed/NCBI

5 

Chowdhury N and Drake CG: Kidney cancer: An overview of current therapeutic approaches. Urol Clin North Am. 47:419–431. 2020. View Article : Google Scholar : PubMed/NCBI

6 

Bahadoram S, Davoodi M, Hassanzadeh S, Bahadoram M, Barahman M and Mafakher L: Renal cell carcinoma: An overview of the epidemiology, diagnosis, and treatment. G Ital Nefrol. 39:2022–vol3. 2022.PubMed/NCBI

7 

Gray RE and Harris GT: Renal cell carcinoma: Diagnosis and management. Am Fam Physician. 99:179–184. 2019.PubMed/NCBI

8 

Hancock SB and Georgiades CS: Kidney cancer. Cancer J. 22:387–392. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Li F, Aljahdali IAM, Zhang R, Nastiuk KL, Krolewski JJ and Ling X: Kidney cancer biomarkers and targets for therapeutics: Survivin (BIRC5), XIAP, MCL-1, HIF1alpha, HIF2alpha, NRF2, MDM2, MDM4, p53, KRAS and AKT in renal cell carcinoma. J Exp Clin Cancer Res. 40:2542021. View Article : Google Scholar : PubMed/NCBI

10 

Sharma R, Kadife E, Myers M, Kannourakis G, Prithviraj P and Ahmed N: Determinants of resistance to VEGF-TKI and immune checkpoint inhibitors in metastatic renal cell carcinoma. J Exp Clin Cancer Res. 40:1862021. View Article : Google Scholar : PubMed/NCBI

11 

Tonooka A and Ohashi R: Current trends in anti-cancer molecular targeted therapies: Renal complications and their histological features. J Nippon Med Sch. 89:128–138. 2022. View Article : Google Scholar : PubMed/NCBI

12 

Miao D, Margolis CA, Gao W, Voss MH, Li W, Martini DJ, Norton C, Bossé D, Wankowicz SM, Cullen D, et al: Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma. Science. 359:801–806. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Topalian SL, Taube JM, Anders RA and Pardoll DM: Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy. Nat Rev Cancer. 16:275–287. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Fischer R, Kontermann RE and Pfizenmaier K: Selective targeting of TNF receptors as a novel therapeutic approach. Front Cell Dev Biol. 8:4012020. View Article : Google Scholar : PubMed/NCBI

15 

Liu W, Yan B, Yu H, Ren J, Peng M, Zhu L, Wang Y, Jin X and Yi L: OTUD1 stabilizes PTEN to inhibit the PI3K/AKT and TNF-alpha/NF-kappaB signaling pathways and sensitize ccRCC to TKIs. Int J Biol Sci. 18:1401–1414. 2022. View Article : Google Scholar : PubMed/NCBI

16 

Richter F, Williams SK, John K, Huber C, Vaslin C, Zanker H, Fairless R, Pichi K, Marhenke S, Vogel A, et al: The TNFR1 antagonist atrosimab is therapeutic in mouse models of acute and chronic inflammation. Front Immunol. 12:7054852021. View Article : Google Scholar : PubMed/NCBI

17 

Su C, Lv Y, Lu W, Yu Z, Ye Y, Guo B, Liu D, Yan H, Li T, Zhang Q, et al: Single-Cell RNA sequencing in multiple pathologic types of renal cell carcinoma revealed novel potential tumor-specific markers. Front Oncol. 11:7195642021. View Article : Google Scholar : PubMed/NCBI

18 

Liu J, Fan Z, Zhao W and Zhou X: Machine intelligence in single-cell data analysis: Advances and new challenges. Front Genet. 12:6555362021. View Article : Google Scholar : PubMed/NCBI

19 

Street K, Risso D, Fletcher RB, Das D, Ngai J, Yosef N, Purdom E and Dudoit S: Slingshot: Cell lineage and pseudotime inference for single-cell transcriptomics. BMC Genomics. 19:4772018. View Article : Google Scholar : PubMed/NCBI

20 

Armingol E, Officer A, Harismendy O and Lewis NE: Deciphering cell-cell interactions and communication from gene expression. Nat Rev Genet. 22:71–88. 2021. View Article : Google Scholar : PubMed/NCBI

21 

Jin S, Guerrero-Juarez CF, Zhang L, Chang I, Ramos R, Kuan CH, Myung P, Plikus MV and Nie Q: Inference and analysis of cell-cell communication using CellChat. Nat Commun. 12:10882021. View Article : Google Scholar : PubMed/NCBI

22 

Chandrashekar DS, Karthikeyan SK, Korla PK, Patel H, Shovon AR, Athar M, Netto GJ, Qin ZS, Kumar S, Manne U, et al: UALCAN: An update to the integrated cancer data analysis platform. Neoplasia. 25:18–27. 2022. View Article : Google Scholar : PubMed/NCBI

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Balkwill F: Tumour necrosis factor and cancer. Nat Rev Cancer. 9:361–371. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Saha P and Smith A: TNF-α (Tumor Necrosis Factor-α). Arterioscler Thromb Vasc Biol. 38:2542–2543. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Eisenman ST, Gibbons SJ, Verhulst PJ, Cipriani G, Saur D and Farrugia G: Tumor necrosis factor alpha derived from classically activated ‘M1’ macrophages reduces interstitial cell of Cajal numbers. Neurogastroenterol Motil. 29:10.1111. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Shapouri-Moghaddam A, Mohammadian S, Vazini H, Taghadosi M, Esmaeili SA, Mardani F, Seifi B, Mohammadi A, Afshari JT and Sahebkar A: Macrophage plasticity, polarization, and function in health and disease. J Cell Physiol. 233:6425–6440. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Garancher A, Suzuki H, Haricharan S, Chau LQ, Masihi MB, Rusert JM, Norris PS, Carrette F, Romero MM, Morrissy SA, et al: Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma. Nat Neurosci. 23:842–853. 2020. View Article : Google Scholar : PubMed/NCBI

29 

Masola V, Greco N, Tozzo P, Caenazzo L and Onisto M: The role of SPATA2 in TNF signaling, cancer, and spermatogenesis. Cell Death Dis. 13:9772022. View Article : Google Scholar : PubMed/NCBI

30 

Yu H, Lin L, Zhang Z, Zhang H and Hu H: Targeting NF-κB pathway for the therapy of diseases: Mechanism and clinical study. Signal Transduct Target Ther. 5:2092020. View Article : Google Scholar : PubMed/NCBI

31 

Balkwill F: TNF-alpha in promotion and progression of cancer. Cancer Metastasis Rev. 25:409–416. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Tacke F and Zimmermann HW: Macrophage heterogeneity in liver injury and fibrosis. J Hepatol. 60:1090–1096. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Takahashi H, Yoshimatsu G and Faustman DL: The roles of TNFR2 signaling in cancer cells and the tumor microenvironment and the potency of TNFR2 targeted therapy. Cells. 11:19522022. View Article : Google Scholar : PubMed/NCBI

34 

Speeckaert MM, Speeckaert R, Laute M, Vanholder R and Delanghe JR: Tumor necrosis factor receptors: Biology and therapeutic potential in kidney diseases. Am J Nephrol. 36:261–270. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Hwang HS, Park YY, Shin SJ, Go H, Park JM, Yoon SY, Lee JL and Cho YM: Involvement of the TNF-α pathway in TKI resistance and suggestion of TNFR1 as a predictive biomarker for TKI responsiveness in clear cell renal cell carcinoma. J Korean Med Sci. 35:e312020. View Article : Google Scholar : PubMed/NCBI

36 

Dong B, Miao J, Wang Y, Luo W, Ji Z, Lai H, Zhang M, Cheng X, Wang J, Fang Y, et al: Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer. Commun Biol. 3:7782020. View Article : Google Scholar : PubMed/NCBI

37 

Couturier CP, Ayyadhury S, Le PU, Nadaf J, Monlong J, Riva G, Allache R, Baig S, Yan X, Bourgey M, et al: Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy. Nat Commun. 11:34062020. View Article : Google Scholar : PubMed/NCBI

38 

Braun DA, Hou Y, Bakouny Z, Ficial M, Angelo MS, Forman J, Ross-Macdonald P, Berger AC, Jegede OA, Elagina L, et al: Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma. Nat Med. 26:909–918. 2020. View Article : Google Scholar : PubMed/NCBI

39 

Au L, Hatipoglu E, de Massy M, Litchfield K, Beattie G, Rowan A, Schnidrig D, Thompson R, Byrne F, Horswell S, et al: Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma. Cancer Cell. 39:1497–1518. e14112021. View Article : Google Scholar : PubMed/NCBI

40 

Wajant H: The role of TNF in cancer. Results Probl Cell Differ. 49:1–15. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Gao M, Li X, Yang M, Feng W, Lin Y and He T: TNFAIP3 mediates FGFR1 activation-induced breast cancer angiogenesis by promoting VEGFA expression and secretion. Clin Transl Oncol. 24:2453–2465. 2022. View Article : Google Scholar : PubMed/NCBI

42 

Messeha SS, Zarmouh NO, Antonie L and Soliman KFA: Sanguinarine inhibition of TNF-α-induced CCL2, IKBKE/NF-κB/ERK1/2 signaling pathway, and cell migration in human triple-negative breast cancer cells. Int J Mol Sci. 23:83292022. View Article : Google Scholar : PubMed/NCBI

43 

Tomolonis JA, Xu X, Dholakia KH, Zhang C, Guo L, Courtney AN, Wang S, Balzeau J, Barragán GA, Tian G, et al: Interaction between tumor cell TNFR2 and monocyte membrane-bound TNF-α triggers tumorigenic inflammation in neuroblastoma. J Immunother Cancer. 11:e0054782023. View Article : Google Scholar : PubMed/NCBI

44 

Naserian S, Abdelgawad ME, Bakshloo MA, Ha G, Arouche N, Cohen JL, Salomon BL and Uzan G: The TNF/TNFR2 signaling pathway is a key regulatory factor in endothelial progenitor cell immunosuppressive effect. Cell Commun Signal. 18:942020. View Article : Google Scholar : PubMed/NCBI

45 

Siegmund D, Wagner J and Wajant H: TNF receptor associated factor 2 (TRAF2) signaling in cancer. Cancers (Basel). 14:40552022. View Article : Google Scholar : PubMed/NCBI

46 

Hira K and Begum AS: Methods for evaluation of TNF-α inhibition effect. Methods Mol Biol. 2248:271–279. 2021. View Article : Google Scholar : PubMed/NCBI

47 

Xing-Rong W, Sheng-Qian X, Wen L, Shan Q, Fa-Ming P and Jian-Hua X: Role of TNFRSF1A and TNFRSF1B polymorphisms in susceptibility, severity, and therapeutic efficacy of etanercept in human leukocyte antigen-B27-positive Chinese Han patients with ankylosing spondylitis. Medicine (Baltimore). 97:e116772018. View Article : Google Scholar : PubMed/NCBI

48 

Shi G and Hu Y: TNFR1 and TNFR2, which link NF-κB activation, drive lung cancer progression, cell dedifferentiation, and metastasis. Cancers (Basel). 15:42992023. View Article : Google Scholar : PubMed/NCBI

49 

Miller PG, Bonn MB and McKarns SC: Transmembrane TNF-TNFR2 impairs Th17 differentiation by promoting Il2 expression. J Immunol. 195:2633–2647. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xu P, Du Z, Xie X, Yang L and Zhang J: Cancer marker TNFRSF1A: From single‑cell heterogeneity of renal cell carcinoma to functional validation. Oncol Lett 28: 425, 2024.
APA
Xu, P., Du, Z., Xie, X., Yang, L., & Zhang, J. (2024). Cancer marker TNFRSF1A: From single‑cell heterogeneity of renal cell carcinoma to functional validation. Oncology Letters, 28, 425. https://doi.org/10.3892/ol.2024.14559
MLA
Xu, P., Du, Z., Xie, X., Yang, L., Zhang, J."Cancer marker TNFRSF1A: From single‑cell heterogeneity of renal cell carcinoma to functional validation". Oncology Letters 28.3 (2024): 425.
Chicago
Xu, P., Du, Z., Xie, X., Yang, L., Zhang, J."Cancer marker TNFRSF1A: From single‑cell heterogeneity of renal cell carcinoma to functional validation". Oncology Letters 28, no. 3 (2024): 425. https://doi.org/10.3892/ol.2024.14559
Copy and paste a formatted citation
x
Spandidos Publications style
Xu P, Du Z, Xie X, Yang L and Zhang J: Cancer marker TNFRSF1A: From single‑cell heterogeneity of renal cell carcinoma to functional validation. Oncol Lett 28: 425, 2024.
APA
Xu, P., Du, Z., Xie, X., Yang, L., & Zhang, J. (2024). Cancer marker TNFRSF1A: From single‑cell heterogeneity of renal cell carcinoma to functional validation. Oncology Letters, 28, 425. https://doi.org/10.3892/ol.2024.14559
MLA
Xu, P., Du, Z., Xie, X., Yang, L., Zhang, J."Cancer marker TNFRSF1A: From single‑cell heterogeneity of renal cell carcinoma to functional validation". Oncology Letters 28.3 (2024): 425.
Chicago
Xu, P., Du, Z., Xie, X., Yang, L., Zhang, J."Cancer marker TNFRSF1A: From single‑cell heterogeneity of renal cell carcinoma to functional validation". Oncology Letters 28, no. 3 (2024): 425. https://doi.org/10.3892/ol.2024.14559
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team