Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-2024 Volume 28 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2024 Volume 28 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Comparing survival after proximal gastrectomy vs. total gastrectomy in advanced gastric cancer: A systematic review and meta‑analysis

  • Authors:
    • Ping-Jui Su
    • Yen-Ta Huang
    • Ting-Kai Liao
    • Wei-Hsun Lu
    • Chih-Jung Wang
    • Ying-Jui Chao
    • Yan-Shen Shan
  • View Affiliations / Copyright

    Affiliations: Division of General Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan, R.O.C., Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan, R.O.C.
    Copyright: © Su et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 427
    |
    Published online on: July 5, 2024
       https://doi.org/10.3892/ol.2024.14560
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present systematic review and meta‑analysis aimed to compare long‑term survival after proximal gastrectomy (PG) and total gastrectomy (TG) for locally advanced proximal gastric cancer (GC). The PubMed, EMBASE and Cochrane CENTRAL databases were searched from their inception to May 2023. Only published two‑arm prospective or retrospective studies were included. The selected studies included patients with locally advanced GC who underwent PG or TG and reported quantitative survival outcomes. The primary outcome was overall survival (OS) after gastrectomy. Three studies involving a total of 4,815 patients met the inclusion criteria. The age of the patients ranged from 57.03‑64.46 years and 78.80% were male. The estimated 5‑year OS probability after TG varied from 30.14 to 72.0%, and from 42.06 to 74.9% after PG. Results of the meta‑analyses revealed a significant association between PG and improved OS compared with that of TG, with a pooled hazard ratio of 1.15 (95% CI, 1.05‑1.25). No heterogeneity was observed in the included studies (I2=0%). Overall, in managing locally advanced GC, PG demonstrated comparable or marginally improved OS compared with TG during postoperative follow‑up; however, further meta-analyses are required to provide stronger evidence.
View Figures

Figure 1

Figure 2

View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F; Global Cancer Statistics 2020, : GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Lin Y, Zheng Y, Wang HL and Wu J: Global patterns and trends in gastric cancer incidence rates (1988–2012) and predictions to 2030. Gastroenterology. 161:116–127.e8. 2021. View Article : Google Scholar : PubMed/NCBI

3 

Mukaisho K, Nakayama T, Hagiwara T, Hattori T and Sugihara H: Two distinct etiologies of gastric cardia adenocarcinoma: Interactions among pH, Helicobacter pylori, and bile acids. Front Microbiol. 6:4122015. View Article : Google Scholar : PubMed/NCBI

4 

Clinton SK, Giovannucci EL and Hursting SD: The World Cancer Research Fund/American Institute for Cancer Research Third Expert Report on Diet, Nutrition, Physical Activity, and Cancer: Impact and Future Directions. J Nutr. 150:663–671. 2020. View Article : Google Scholar : PubMed/NCBI

5 

Rawla P and Barsouk A: Epidemiology of gastric cancer: Global trends, risk factors and prevention. Prz Gastroenterol. 14:26–38. 2019.PubMed/NCBI

6 

Thrift AP, Wenker TN and El-Serag HB: Global burden of gastric cancer: Epidemiological trends, risk factors, screening and prevention. Nat Rev Clin Oncol. 20:338–349. 2023. View Article : Google Scholar : PubMed/NCBI

7 

Yusefi AR, Bagheri Lankarani K, Bastani P, Radinmanesh M and Kavosi Z: Risk factors for gastric cancer: A systematic review. Asian Pac J Cancer Prev. 19:591–603. 2018.PubMed/NCBI

8 

Balakrishnan M, George R, Sharma A and Graham DY: Changing trends in stomach cancer throughout the world. Curr Gastroenterol Rep. 19:362017. View Article : Google Scholar : PubMed/NCBI

9 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Zhao L, Ling R, Chen J, Shi A, Chai C, Ma F, Zhao D and Chen Y: Clinical outcomes of proximal gastrectomy versus total gastrectomy for proximal gastric cancer: A systematic review and meta-analysis. Dig Surg. 38:1–13. 2021. View Article : Google Scholar : PubMed/NCBI

11 

Wei J, Yang P, Huang Q, Chen Z, Zhang T, He F, Hu H, Zhong J, Li W, Wei F, et al: Proximal versus total gastrectomy for proximal gastric cancer: A surveillance, epidemiology, and end results program database analysis. Future Oncol. 17:1185–1195. 2021. View Article : Google Scholar : PubMed/NCBI

12 

Rosa F, Quero G, Fiorillo C, Bissolati M, Cipollari C, Rausei S, Chiari D, Ruspi L, de Manzoni G, Costamagna G, et al: Total vs proximal gastrectomy for adenocarcinoma of the upper third of the stomach: A propensity-score-matched analysis of a multicenter western experience (on behalf of the Italian research group for gastric cancer-GIRCG). Gastric Cancer. 21:845–852. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Schrope B, Coons B, Rosario V and Toledano S: Proximal gastrectomy is a viable alternative to total gastrectomy in early stage proximal gastric cancer. JSLS. 25:e2021.00017. 2021. View Article : Google Scholar : PubMed/NCBI

14 

Sugoor P, Shah S, Dusane R, Desouza A, Goel M and Shrikhande SV: Proximal gastrectomy versus total gastrectomy for proximal third gastric cancer: Total gastrectomy is not always necessary. Langenbecks Arch Surg. 401:687–697. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Ushimaru Y, Fujiwara Y, Shishido Y, Yanagimoto Y, Moon JH, Sugimura K, Omori T, Miyata H and Yano M: Clinical outcomes of gastric cancer patients who underwent proximal or total gastrectomy: A propensity score-matched analysis. World J Surg. 42:1477–1484. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Ri M, Kumagai K, Namikawa K, Atsumi S, Hayami M, Makuuchi R, Ida S, Ohashi M, Sano T and Nunobe S: Is proximal gastrectomy indicated for locally advanced cancer in the upper third of the stomach? Ann Gastroenterol Surg. 5:767–775. 2021. View Article : Google Scholar : PubMed/NCBI

17 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, et al: The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ. 372:n712021. View Article : Google Scholar : PubMed/NCBI

18 

Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J and Moher D: The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. PLoS Med. 6:e10001002009. View Article : Google Scholar : PubMed/NCBI

19 

Amin MB, Greene FL, Edge SB, Compton CC, Gershenwald JE, Brookland RK, Meyer L, Gress DM, Byrd DR and Winchester DP: The eighth edition AJCC cancer staging manual: Continuing to build a bridge from a population-based to a more ‘personalized’ approach to cancer staging. CA Cancer J Clin. 67:93–99. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Stang A: Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 25:603–605. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Higgins J, Thomas J, Chandler J, Cumpston M, Li T, Page M and Welch V: Cochrane Handbook for Systematic Reviews of Interventions. Version 6.4. 2023.https://training.cochrane.org/handbook/currentMarch 1–2023

22 

Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P and Schünemann HJ; GRADE Working Group, : GRADE: An emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 336:924–926. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Sterne JA, Sutton AJ, Ioannidis JPA, Terrin N, Jones DR, Lau J, Carpenter J, Rücker G, Harbord RM, Schmid CH, et al: Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ. 343:d40022011. View Article : Google Scholar : PubMed/NCBI

24 

Peng R, Yue C, Wei W, Zhou B, Wen X, Gu RM, Ming XZ, Li G, Chen HQ and Xu ZK: Proximal gastrectomy may be a reasonable choice for patients with selected proximal advanced gastric cancer: A propensity score-matched analysis. Asian J Surg. 45:1823–1831. 2022. View Article : Google Scholar : PubMed/NCBI

25 

Tang S, Liu F, Li Y, Zhao L, Wang X, Khan SA, Chen Y and Zhang Y: Treatment selection and survival outcomes in locally advanced proximal gastric cancer: A national cancer data base analysis. Front Oncol. 10:5370512020. View Article : Google Scholar : PubMed/NCBI

26 

Zhao L, Ling R, Ma F, Ren H, Zhou H, Wang T, Chen Y, Hu S and Zhao D: Clinical outcomes of proximal gastrectomy versus total gastrectomy for locally advanced proximal gastric cancer: A propensity score matching analysis. Transl Cancer Res. 9:2769–2779. 2020. View Article : Google Scholar : PubMed/NCBI

27 

An JY, Youn HG, Choi MG, Noh JH, Sohn TS and Kim S: The difficult choice between total and proximal gastrectomy in proximal early gastric cancer. Am J Surg. 196:587–591. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Zhu K, Xu Y, Fu J, Mohamud FA, Duan Z, Tan S, Zhao Z, Chen P and Zong L: Proximal gastrectomy versus total gastrectomy for Siewert type II adenocarcinoma of the esophagogastric junction: A comprehensive analysis of data from the SEER registry. Dis Markers. 2019:96379722019. View Article : Google Scholar : PubMed/NCBI

29 

Wen L, Chen XZ, Wu B, Chen XL, Wang L, Yang K, Zhang B, Chen ZX, Chen JP, Zhou ZG, et al: Total vs proximal gastrectomy for proximal gastric cancer: A systematic review and meta-analysis. Hepatogastroenterology. 59:633–640. 2012.PubMed/NCBI

30 

Chevallay M, Bollschweiler E, Chandramohan SM, Schmidt T, Koch O, Demanzoni G, Mönig S and Allum W: Cancer of the gastroesophageal junction: A diagnosis, classification, and management review. Ann N Y Acad Sci. 1434:132–138. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Voron T, Gronnier C, Pasquer A, Thereaux J, Gagniere J, Lebreton G, Meunier B, Collet D, Piessen G and Paye F; FREGAT working group-FRENCH, : Adenocarcinoma of the oesophagogastric junction Siewert II: An oesophageal cancer better cured with total gastrectomy. Eur J Surg Oncol. 45:2473–2481. 2019. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Su P, Huang Y, Liao T, Lu W, Wang C, Chao Y and Shan Y: Comparing survival after proximal gastrectomy vs. total gastrectomy in advanced gastric cancer: A systematic review and meta‑analysis. Oncol Lett 28: 427, 2024.
APA
Su, P., Huang, Y., Liao, T., Lu, W., Wang, C., Chao, Y., & Shan, Y. (2024). Comparing survival after proximal gastrectomy vs. total gastrectomy in advanced gastric cancer: A systematic review and meta‑analysis. Oncology Letters, 28, 427. https://doi.org/10.3892/ol.2024.14560
MLA
Su, P., Huang, Y., Liao, T., Lu, W., Wang, C., Chao, Y., Shan, Y."Comparing survival after proximal gastrectomy vs. total gastrectomy in advanced gastric cancer: A systematic review and meta‑analysis". Oncology Letters 28.3 (2024): 427.
Chicago
Su, P., Huang, Y., Liao, T., Lu, W., Wang, C., Chao, Y., Shan, Y."Comparing survival after proximal gastrectomy vs. total gastrectomy in advanced gastric cancer: A systematic review and meta‑analysis". Oncology Letters 28, no. 3 (2024): 427. https://doi.org/10.3892/ol.2024.14560
Copy and paste a formatted citation
x
Spandidos Publications style
Su P, Huang Y, Liao T, Lu W, Wang C, Chao Y and Shan Y: Comparing survival after proximal gastrectomy vs. total gastrectomy in advanced gastric cancer: A systematic review and meta‑analysis. Oncol Lett 28: 427, 2024.
APA
Su, P., Huang, Y., Liao, T., Lu, W., Wang, C., Chao, Y., & Shan, Y. (2024). Comparing survival after proximal gastrectomy vs. total gastrectomy in advanced gastric cancer: A systematic review and meta‑analysis. Oncology Letters, 28, 427. https://doi.org/10.3892/ol.2024.14560
MLA
Su, P., Huang, Y., Liao, T., Lu, W., Wang, C., Chao, Y., Shan, Y."Comparing survival after proximal gastrectomy vs. total gastrectomy in advanced gastric cancer: A systematic review and meta‑analysis". Oncology Letters 28.3 (2024): 427.
Chicago
Su, P., Huang, Y., Liao, T., Lu, W., Wang, C., Chao, Y., Shan, Y."Comparing survival after proximal gastrectomy vs. total gastrectomy in advanced gastric cancer: A systematic review and meta‑analysis". Oncology Letters 28, no. 3 (2024): 427. https://doi.org/10.3892/ol.2024.14560
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team