Renal cell carcinoma preceded by a rheumatoid‑like paraneoplastic syndrome: A case report

Yoshimura,Yusuke; Suwabe,Tatsuya; Miki,Katsuyuki; Yokoyama,Takayoshi; Kono,Kei; Kinowaki,Keiichi; Kato,Ikuma; Nagashima,Yoji; Nishikori,Asami; Sato,Yasuharu; Kurihara,Shigekazu; Oba,Yuki; Mizuno,Hiroki; Sekine,Akinari; Yamanouchi,Masayuki; Kamiyama,Manabu; Ishii,Yasuo; Nakamura,Yuki; Ubara,Yoshifumi; Sawa,Naoki

doi:10.3892/ol.2024.14581

October-2024 Volume 28 Issue 4

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October-2024 Volume 28 Issue 4

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Article

Renal cell carcinoma preceded by a rheumatoid‑like paraneoplastic syndrome: A case report

Authors:
- Yusuke Yoshimura
- Tatsuya Suwabe
- Katsuyuki Miki
- Takayoshi Yokoyama
- Kei Kono
- Keiichi Kinowaki
- Ikuma Kato
- Yoji Nagashima
- Asami Nishikori
- Yasuharu Sato
- Shigekazu Kurihara
- Yuki Oba
- Hiroki Mizuno
- Akinari Sekine
- Masayuki Yamanouchi
- Manabu Kamiyama
- Yasuo Ishii
- Yuki Nakamura
- Yoshifumi Ubara
- Naoki Sawa
View Affiliations / Copyright

Affiliations: Nephrology Center, Toranomon Hospital Kajigaya, Kawasaki, Kanagawa 213‑8587, Japan, Department of Pathology, Toranomon Hospital, Tokyo 105‑8470, Japan, Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236‑0004, Japan, Department of Surgical Pathology, Tokyo Women's Medical University, Tokyo 162‑8666, Japan, Department of Molecular Hematopathology, Okayama University Graduate School of Health Sciences, Okayama 700‑8530, Japan, Department of Urology, Toranomon Hospital Kajigaya, Kawasaki, Kanagawa 213‑8587, Japan
Article Number: 448
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Published online on: July 22, 2024

https://doi.org/10.3892/ol.2024.14581
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Abstract

A man with polycystic kidney disease and a history of renal transplantation at the age of 55 years developed seronegative rheumatoid arthritis (RA) at the age of 68 years. Treatment with a biological derivative led to remission; however, the patient relapsed 2 years later. After being switched to baricitinib, the patient again achieved remission. After 2 years, when the patient was aged 72 years, RA recurred, and the right native kidney became enlarged due to the presence of a large tumor. Surgical nephrectomy was performed, and the tumor was classified as renal cell carcinoma (RCC), not otherwise specified. The cancer tissue comprised sarcomatoid and rhabdoid cells with marked neutrophil infiltration, and the tumor cells were positive for interleukin‑6. The patient, aged 73 years, experienced a resolution of joint pain following surgical intervention; however, they died because of systemic metastases ~10 weeks post‑operation. Based on the clinical course, the RA‑like lesions and subsequent RCC were considered to represent a paraneoplastic syndrome.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Renal cell carcinoma preceded by a rheumatoid‑like paraneoplastic syndrome: A case report

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