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Case Report Open Access

Possible role of a malfunctioning immune system in discordant lymphoma with peripheral T‑cell lymphoma secondary to classical Hodgkin lymphoma: A case report

  • Authors:
    • Liling Song
    • Ning Zhu
    • Yu Pan
    • Wenjie Wang
    • Yuan Gao
    • Ying Yin
    • Jun Wang
    • Shishou Wu
    • Yunjun Wang
    • Ping Yang
    • Xiaolong Sui
    • Yan Yang
    • Guohua Yu
  • View Affiliations / Copyright

    Affiliations: The Second School of Clinical Medicine, Binzhou Medical University, Yantai, Shandong 264100, P.R. China, Department of Pathology, Binzhou Medical University, College of Basic Medical Sciences, Yantai, Shandong 264003, P.R. China, School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong 261000, P.R. China, Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong 264000, P.R. China, Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong 264000, P.R. China
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 450
    |
    Published online on: July 23, 2024
       https://doi.org/10.3892/ol.2024.14583
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Abstract

The present case report investigated the clinicopathological features and potential mechanisms underlying the transformation to peripheral T‑cell lymphoma, not otherwise specified (PTCL‑NOS), following treatment for classical Hodgkin lymphoma (CHL) in a 73‑year‑old man. The patient was admitted to hospital in 2012 and underwent a left cervical lymph node biopsy, which confirmed CHL of the nodular sclerosing type, with evident bone marrow involvement. The patient received four cycles of doxorubicin, bleomycin, vinblastine and dacarbazine chemotherapy, after which they achieved complete remission. However, after 3 years, the patient presented with enlarged left inguinal lymph nodes and a biopsy revealed PTCL‑NOS. Molecular studies indicated a T‑cell receptor‑γ gene rearrangement. A literature review, together with the current case, identified 11 patients with CHL that transformed into PTCL‑NOS. Among these, nine patients (81.82%) were middle‑aged or elderly (>45 years old), and eight (72.73%) experienced transformation within 3 years post‑treatment of CHL. Among these eight patients, seven (87.50%) predominantly exhibited the nodular sclerosis subtype, with a median recurrence time of 26 months. Five (45.45%) patients died of the disease. The rare transformation of CHL to PTCL‑NOS, primarily among men, underscores its clinical significance. Notably, nodular sclerosing‑type CHL appears to be particularly prone to transformation into PTCL‑NOS. The poor prognosis in such cases may be attributed to the complex tumor microenvironment of CHL.
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Copy and paste a formatted citation
Spandidos Publications style
Song L, Zhu N, Pan Y, Wang W, Gao Y, Yin Y, Wang J, Wu S, Wang Y, Yang P, Yang P, et al: Possible role of a malfunctioning immune system in discordant lymphoma with peripheral T‑cell lymphoma secondary to classical Hodgkin lymphoma: A case report. Oncol Lett 28: 450, 2024.
APA
Song, L., Zhu, N., Pan, Y., Wang, W., Gao, Y., Yin, Y. ... Yu, G. (2024). Possible role of a malfunctioning immune system in discordant lymphoma with peripheral T‑cell lymphoma secondary to classical Hodgkin lymphoma: A case report. Oncology Letters, 28, 450. https://doi.org/10.3892/ol.2024.14583
MLA
Song, L., Zhu, N., Pan, Y., Wang, W., Gao, Y., Yin, Y., Wang, J., Wu, S., Wang, Y., Yang, P., Sui, X., Yang, Y., Yu, G."Possible role of a malfunctioning immune system in discordant lymphoma with peripheral T‑cell lymphoma secondary to classical Hodgkin lymphoma: A case report". Oncology Letters 28.4 (2024): 450.
Chicago
Song, L., Zhu, N., Pan, Y., Wang, W., Gao, Y., Yin, Y., Wang, J., Wu, S., Wang, Y., Yang, P., Sui, X., Yang, Y., Yu, G."Possible role of a malfunctioning immune system in discordant lymphoma with peripheral T‑cell lymphoma secondary to classical Hodgkin lymphoma: A case report". Oncology Letters 28, no. 4 (2024): 450. https://doi.org/10.3892/ol.2024.14583
Copy and paste a formatted citation
x
Spandidos Publications style
Song L, Zhu N, Pan Y, Wang W, Gao Y, Yin Y, Wang J, Wu S, Wang Y, Yang P, Yang P, et al: Possible role of a malfunctioning immune system in discordant lymphoma with peripheral T‑cell lymphoma secondary to classical Hodgkin lymphoma: A case report. Oncol Lett 28: 450, 2024.
APA
Song, L., Zhu, N., Pan, Y., Wang, W., Gao, Y., Yin, Y. ... Yu, G. (2024). Possible role of a malfunctioning immune system in discordant lymphoma with peripheral T‑cell lymphoma secondary to classical Hodgkin lymphoma: A case report. Oncology Letters, 28, 450. https://doi.org/10.3892/ol.2024.14583
MLA
Song, L., Zhu, N., Pan, Y., Wang, W., Gao, Y., Yin, Y., Wang, J., Wu, S., Wang, Y., Yang, P., Sui, X., Yang, Y., Yu, G."Possible role of a malfunctioning immune system in discordant lymphoma with peripheral T‑cell lymphoma secondary to classical Hodgkin lymphoma: A case report". Oncology Letters 28.4 (2024): 450.
Chicago
Song, L., Zhu, N., Pan, Y., Wang, W., Gao, Y., Yin, Y., Wang, J., Wu, S., Wang, Y., Yang, P., Sui, X., Yang, Y., Yu, G."Possible role of a malfunctioning immune system in discordant lymphoma with peripheral T‑cell lymphoma secondary to classical Hodgkin lymphoma: A case report". Oncology Letters 28, no. 4 (2024): 450. https://doi.org/10.3892/ol.2024.14583
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