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Review Open Access

MicroRNA‑325: A comprehensive exploration of its multifaceted roles in cancer pathogenesis and therapeutic implications (Review)

  • Authors:
    • Zheng Fu
    • Yang Zhou
    • Yile Zhang
    • Ziyan Zhou
    • Yueqi Yu
    • Chunhui Yuan
    • Jingyin Dong
    • Shiwei Duan
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, P.R. China
    Copyright: © Fu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 459
    |
    Published online on: July 26, 2024
       https://doi.org/10.3892/ol.2024.14592
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Abstract

MicroRNA (miRNA/miR) represents a category of endogenous, short‑chain non‑coding RNA molecules comprising ~22 nucleotides. Specifically, miR‑325 is situated within the first sub‑band of region 2 on the short arm of the X chromosome. Notably, aberrant expression of miR‑325 has been observed across various tumor systems, spanning the nervous, endocrine, respiratory, reproductive and digestive systems. miR‑325 exhibits the capacity to target a minimum of 20 protein‑coding genes, thereby influencing diverse cellular processes, including cell proliferation, epithelial‑mesenchymal transition, apoptosis, invasion and migration. Moreover, miR‑325 serves a pivotal role in the formation of six competing endogenous RNA (ceRNA) regulatory axes, involving one circular RNA, four long non‑coding RNA and one additional miRNA. By participating in various signaling pathways through gene targeting, the abnormal expression of miR‑325 has been associated with clinicopathological conditions in diverse patients with cancer, significantly impacting both the clinicopathology and prognosis of affected individuals. Additionally, miR‑325 has been associated with the development of resistance to oxaliplatin, cisplatin and doxorubicin in cancer cells. Its involvement in the anticancer molecular mechanisms of these agents underscores its potential significance in therapeutic contexts. However, it is noteworthy that the current study did not specifically address sex‑based cell line selection. In conclusion, the present review provides a comprehensive summary of the relevant findings concerning miR‑325, offering valuable insights for future research endeavors focused on determining the molecular mechanisms associated with this miRNA.
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Copy and paste a formatted citation
Spandidos Publications style
Fu Z, Zhou Y, Zhang Y, Zhou Z, Yu Y, Yuan C, Dong J and Duan S: MicroRNA‑325: A comprehensive exploration of its multifaceted roles in cancer pathogenesis and therapeutic implications (Review). Oncol Lett 28: 459, 2024.
APA
Fu, Z., Zhou, Y., Zhang, Y., Zhou, Z., Yu, Y., Yuan, C. ... Duan, S. (2024). MicroRNA‑325: A comprehensive exploration of its multifaceted roles in cancer pathogenesis and therapeutic implications (Review). Oncology Letters, 28, 459. https://doi.org/10.3892/ol.2024.14592
MLA
Fu, Z., Zhou, Y., Zhang, Y., Zhou, Z., Yu, Y., Yuan, C., Dong, J., Duan, S."MicroRNA‑325: A comprehensive exploration of its multifaceted roles in cancer pathogenesis and therapeutic implications (Review)". Oncology Letters 28.4 (2024): 459.
Chicago
Fu, Z., Zhou, Y., Zhang, Y., Zhou, Z., Yu, Y., Yuan, C., Dong, J., Duan, S."MicroRNA‑325: A comprehensive exploration of its multifaceted roles in cancer pathogenesis and therapeutic implications (Review)". Oncology Letters 28, no. 4 (2024): 459. https://doi.org/10.3892/ol.2024.14592
Copy and paste a formatted citation
x
Spandidos Publications style
Fu Z, Zhou Y, Zhang Y, Zhou Z, Yu Y, Yuan C, Dong J and Duan S: MicroRNA‑325: A comprehensive exploration of its multifaceted roles in cancer pathogenesis and therapeutic implications (Review). Oncol Lett 28: 459, 2024.
APA
Fu, Z., Zhou, Y., Zhang, Y., Zhou, Z., Yu, Y., Yuan, C. ... Duan, S. (2024). MicroRNA‑325: A comprehensive exploration of its multifaceted roles in cancer pathogenesis and therapeutic implications (Review). Oncology Letters, 28, 459. https://doi.org/10.3892/ol.2024.14592
MLA
Fu, Z., Zhou, Y., Zhang, Y., Zhou, Z., Yu, Y., Yuan, C., Dong, J., Duan, S."MicroRNA‑325: A comprehensive exploration of its multifaceted roles in cancer pathogenesis and therapeutic implications (Review)". Oncology Letters 28.4 (2024): 459.
Chicago
Fu, Z., Zhou, Y., Zhang, Y., Zhou, Z., Yu, Y., Yuan, C., Dong, J., Duan, S."MicroRNA‑325: A comprehensive exploration of its multifaceted roles in cancer pathogenesis and therapeutic implications (Review)". Oncology Letters 28, no. 4 (2024): 459. https://doi.org/10.3892/ol.2024.14592
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