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Clinical values of preoperative red blood cell distribution width and platelet parameters in patients with papillary thyroid carcinoma

  • Authors:
    • Jingying Han
    • Jing Wang
    • Qian Wang
    • Yuan Li
    • Tian Li
    • Jian Zhang
    • Hui Sun

  • View Affiliations

  • Published online on: July 26, 2024     https://doi.org/10.3892/ol.2024.14593
  • Article Number: 460
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Abstract

The prevalence of thyroid carcinoma is increasing, and papillary thyroid carcinoma (PTC) is the most frequent subtype. More and more attention is being concentrated on the association between inflammation indicators and malignant tumors. The aim of the present study was to analyze whether the preoperative red blood cell distribution width (RDW) and platelet parameters, including mean platelet volume (MPV) and platelet distribution width (PDW), can be applied to distinguish between patients with PTC or papillary thyroid microcarcinoma (PTMC) and healthy controls, and to explore the associations with clinicopathological characteristics. The study retrospectively compared the RDW, MPV and PDW values of 780 patients with PTC or PTMC against a healthy control group. Receiver operating characteristic (ROC) curves were conducted to determine diagnostic accuracy. Furthermore, the clinicopathological features of the patients with PTC or PTMC were compared between higher and lower platelet parameter groups based on the RDW, MPV and PDW values. Significantly higher preoperative RDW, MPV and PDW values were found in patients with PTC or PTMC compared with those of the healthy group. ROC curve analysis showed that the area under the curve (AUC) plus 95% confidence interval (95% CI) values of RDW, MPV and PDW were 0.808 (0.780‑0.835), 0.771 (0.743‑0.799) and 0.711 (0.681‑0.742), respectively. When RDW and MPV were combined together, the AUC (95% CI) value was enhanced to 0.858 (0.835‑0.881) for the patients with PTC. For the patients with PTMC, RDW, MPV and PDW had AUC (95% CI) values of 0.812 (0.783‑0.840), 0.779 (0.749‑0.808) and 0.718 (0.685‑0.751), respectively. When RDW and MPV were combined together, the AUC (95% CI) value was enhanced to 0.858 (0.835‑0.881). A higher RDW was significantly associated with being female, deeper tumor infiltration, and normal FT3 and FT4 levels. A higher PDW was significantly associated with elevated thyrotropin receptor antibody levels. In conclusion, as convenient and available inflammation indicators, RDW, PDW and MPV have diagnostic ability and can distinguish between patients with PTC or PTMC and healthy controls. In addition, the combined application of RDW and MPV can improve the diagnostic power. The values of RDW and MPV were associated with clinicopathological characteristics. To the best of our knowledge, this is the first study to prove the usefulness of preoperative RDW combined with MPV in diagnosing patients with PTC or PTMC.
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October-2024
Volume 28 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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  • Impact Factor: 2.5
  • Ranked Oncology
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  • CiteScore: 5.7
  • CiteScore Rank: Q2: #139/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.574
  • SCImago Journal Rank (SJR): 0.644
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Spandidos Publications style
Han J, Wang J, Wang Q, Li Y, Li T, Zhang J and Sun H: Clinical values of preoperative red blood cell distribution width and platelet parameters in patients with papillary thyroid carcinoma. Oncol Lett 28: 460, 2024.
APA
Han, J., Wang, J., Wang, Q., Li, Y., Li, T., Zhang, J., & Sun, H. (2024). Clinical values of preoperative red blood cell distribution width and platelet parameters in patients with papillary thyroid carcinoma. Oncology Letters, 28, 460. https://doi.org/10.3892/ol.2024.14593
MLA
Han, J., Wang, J., Wang, Q., Li, Y., Li, T., Zhang, J., Sun, H."Clinical values of preoperative red blood cell distribution width and platelet parameters in patients with papillary thyroid carcinoma". Oncology Letters 28.4 (2024): 460.
Chicago
Han, J., Wang, J., Wang, Q., Li, Y., Li, T., Zhang, J., Sun, H."Clinical values of preoperative red blood cell distribution width and platelet parameters in patients with papillary thyroid carcinoma". Oncology Letters 28, no. 4 (2024): 460. https://doi.org/10.3892/ol.2024.14593