Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2024 Volume 28 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2024 Volume 28 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Periprostatic adipose tissue inhibits tumor progression by secreting apoptotic factors: A natural barrier induced by the immune response during the early stages of prostate cancer

  • Authors:
    • I-Hung Shao
    • Tzu-Hsuan Chang
    • Ying-Hsu Chang
    • Yu-Hsin Hsieh
    • Ting-Wen Sheng
    • Li-Jen Wang
    • Yu-Hsuan Chien
    • Liang-Kang Huang
    • Yuan-Cheng Chu
    • Hung-Cheng Kan
    • Po-Hung Lin
    • Kai-Jie Yu
    • Ming-Li Hsieh
    • Cheng-Keng Chuang
    • Chun-Te Wu
    • Chin-Hsuan Hsieh
    • See-Tong Pang
  • View Affiliations / Copyright

    Affiliations: Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 333423, Taiwan, R.O.C., School of Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan, R.O.C., Department of Medical Imaging and Intervention, New Taipei Municipal Tucheng Hospital, New Taipei 236017, Taiwan, R.O.C.
    Copyright: © Shao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 485
    |
    Published online on: August 8, 2024
       https://doi.org/10.3892/ol.2024.14617
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Prostate cancer (PCa) is the second most prevalent malignancy in men worldwide. The risk factors for PCa include obesity, age and family history. Increased visceral fat has been associated with high PCa risk, which has prompted previous researchers to investigate the influence of body composition and fat distribution on PCa prognosis. However, there is a lack of studies focusing on the mechanisms and interactions between periprostatic adipose tissue (PPAT) and PCa cells. The present study investigated the association between the composition of pelvic adipose tissue and PCa aggressiveness to understand the role played by this tissue in PCa progression. Moreover, PPAT‑conditioned medium (CM) was prepared to assess the influence of the PPAT secretome on the pathophysiology of PCa. The present study included 50 patients with localized PCa who received robot‑assisted radical prostatectomy. Medical records were collected, magnetic resonance imaging scans were analyzed and body compositions were calculated to identify the associations between adipose tissue volume and clinical PCa aggressiveness. In addition, CM was prepared from PPAT and perivesical adipose tissue (PVAT) collected from 25 patients during surgery, and its effects on the PCa cell lines C4‑2 and LNCaP, and the prostate epithelial cell line PZ‑HPV‑7, were investigated using a cell proliferation assay and RNA sequencing (RNA‑seq). The results revealed that the initial prostate‑specific antigen level was significantly correlated with pelvic and periprostatic adipose tissue volumes. In addition, PPAT volume was significantly higher in patients with extracapsular tumor extension. PCa cell proliferation was significantly reduced when the cells were cultured in PPAT‑CM compared with when they were cultured in control‑ and PVAT‑CM. RNA‑seq revealed that immune responses, and the cell death and apoptosis pathways were enriched in PPAT‑CM‑cultured cells indicating that the cytokines or other factors secreted from PPAT‑CM induced PCa cell apoptosis. These findings revealed that the PPAT secretome may inhibit PCa cell proliferation by activating immune responses and promoting cancer cell apoptosis. This mechanism may act as a first‑line defense during the early stages of PCa.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Siegel RL, Miller KD, Fuchs HE and Jemal A: Cancer statistics, 2022. CA Cancer J Clin. 72:7–33. 2022. View Article : Google Scholar : PubMed/NCBI

2 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

3 

López Fontana C, Maselli ME, Pérez Elizalde R, Di Milta N, Corica Alberto P and López Laur JD: Obesity modifies prostatic specific antigen in men over 45 years. Arch Esp Urol. 64:35–42. 2011.PubMed/NCBI

4 

Parikesit D, Mochtar CA, Umbas R and Hamid ARAH: The impact of obesity towards prostate diseases. Prostate Int. 4:1–6. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Cataño JG, Ramos-Hernández A, Bravo-Balado A, Mariño-Álvarez AM, Caicedo JI, Trujillo CG and Plata M: Obesity and radical prostatectomy: The enigma continues. Arch Esp Urol. 71:517–522. 2018.(In Spanish). PubMed/NCBI

6 

Williams G: Aromatase up-regulation, insulin and raised intracellular oestrogens in men, induce adiposity, metabolic syndrome and prostate disease, via aberrant ER-α and GPER signalling. Mol Cell Endocrinol. 351:269–278. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Caine M, Raz S and Zeigler M: Adrenergic and cholinergic receptors in the human prostate, prostatic capsule and bladder neck. Br J Urol. 47:193–202. 1975. View Article : Google Scholar : PubMed/NCBI

8 

Giovannucci E, Rimm EB, Chute CG, Kawachi I, Colditz GA, Stampfer MJ and Willett WC: Obesity and benign prostatic hyperplasia. Am J Epidemiol. 140:989–1002. 1994. View Article : Google Scholar : PubMed/NCBI

9 

Hamid ARAH, Umbas R and Mochtar CA: Recent role of inflammation in prostate diseases: Chemoprevention development opportunity. Acta Med Indones. 43:59–65. 2011.PubMed/NCBI

10 

Alukal JP and Lepor H: Testosterone deficiency and the prostate. Urol Clin North Am. 43:203–208. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Schnoeller T, Jentzmik F, Rinnab L, Cronauer MV, Damjanoski I, Zengerling F, Ghazal AA, Schrader M and Schrader AJ: Circulating free testosterone is an independent predictor of advanced disease in patients with clinically localized prostate cancer. World J Urol. 31:253–259. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Theoret MR, Ning YM, Zhang JJ, Justice R, Keegan P and Pazdur R: The risks and benefits of 5α-reductase inhibitors for prostate-cancer prevention. N Engl J Med. 365:97–99. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Gallagher EJ and LeRoith D: The proliferating role of insulin and insulin-like growth factors in cancer. Trends Endocrinol Metab. 21:610–618. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Ribeiro R, Lopes C and Medeiros R: Leptin and prostate: Implications for cancer prevention-overview of genetics and molecular interactions. Eur J Cancer Prev. 13:359–368. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Izadi V, Farabad E and Azadbakht L: Serum adiponectin level and different kinds of cancer: A review of recent evidence. ISRN Oncol. 2012:9827692012.PubMed/NCBI

16 

Amling CL, Riffenburgh RH, Sun L, Moul JW, Lance RS, Kusuda L, Sexton WJ, Soderdahl DW, Donahue TF, Foley JP, et al: Pathologic variables and recurrence rates as related to obesity and race in men with prostate cancer undergoing radical prostatectomy. J Clin Oncol. 22:439–445. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Rodriguez C, Freedland SJ, Deka A, Jacobs EJ, McCullough ML, Patel AV, Thun MJ and Calle EE: Body mass index, weight change, and risk of prostate cancer in the cancer prevention study II nutrition cohort. Cancer Epidemiol Biomarkers Prev. 16:63–69. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Renehan AG, Tyson M, Egger M, Heller RF and Zwahlen M: Body-mass index and incidence of cancer: A systematic review and meta-analysis of prospective observational studies. Lancet. 371:569–578. 2008. View Article : Google Scholar : PubMed/NCBI

19 

MacInnis RJ and English DR: Body size and composition and prostate cancer risk: Systematic review and meta-regression analysis. Cancer Causes Control. 17:989–1003. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Bergström A, Pisani P, Tenet V, Wolk A and Adami HO: Overweight as an avoidable cause of cancer in Europe. Int J Cancer. 91:421–430. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Cao Y and Ma J: Body mass index, prostate cancer-specific mortality, and biochemical recurrence: A systematic review and meta-analysis. Cancer Prev Res (Phila). 4:486–501. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Duong MN, Geneste A, Fallone F, Li X, Dumontet C and Muller C: The fat and the bad: Mature adipocytes, key actors in tumor progression and resistance. Oncotarget. 8:57622–57641. 2017. View Article : Google Scholar : PubMed/NCBI

23 

van Roermund JG and Witjes JA: The impact of obesity on prostate cancer. World J Urol. 25:491–497. 2007. View Article : Google Scholar : PubMed/NCBI

24 

von Hafe P, Pina F, Pérez A, Tavares M and Barros H: Visceral fat accumulation as a risk factor for prostate cancer. Obes Res. 12:1930–1935. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Zimmermann M, Delouya G, Barkati M, Campeau S, Rompotinos D and Taussky D: Impact of visceral fat volume and fat density on biochemical outcome after radical prostatectomy and postoperative radiotherapy. Horm Mol Biol Clin Investig. 26:173–178. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Cheng L, Darson MF, Bergstralh EJ, Slezak J, Myers RP and Bostwick DG: Correlation of margin status and extraprostatic extension with progression of prostate carcinoma. Cancer. 86:1775–1782. 1999. View Article : Google Scholar : PubMed/NCBI

27 

Miladinovic D, Cusick T, Mahon KL, Haynes AM, Cortie CH, Meyer BJ, Stricker PD, Wittert GA, Butler LM, Horvath LG and Hoy AJ: Assessment of periprostatic and subcutaneous adipose tissue lipolysis and adipocyte size from men with localized prostate cancer. Cancers (Basel). 12:13852020. View Article : Google Scholar : PubMed/NCBI

28 

van Roermund JG, Hinnen KA, Tolman CJ, Bol GH, Witjes JA, Bosch JL, Kiemeney LA and van Vulpen M: Periprostatic fat correlates with tumour aggressiveness in prostate cancer patients. BJU Int. 107:1775–1779. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Laurent V, Guérard A, Mazerolles C, Le Gonidec S, Toulet A, Nieto L, Zaidi F, Majed B, Garandeau D, Socrier Y, et al: Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity. Nat Commun. 7:102302016. View Article : Google Scholar : PubMed/NCBI

30 

Laurent V, Toulet A, Attané C, Milhas D, Dauvillier S, Zaidi F, Clement E, Cinato M, Le Gonidec S, Guérard A, et al: Periprostatic adipose tissue favors prostate cancer cell invasion in an obesity-dependent manner: Role of oxidative stress. Mol Cancer Res. 17:821–835. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Ribeiro R, Monteiro C, Cunha V, Oliveira MJ, Freitas M, Fraga A, Príncipe P, Lobato C, Lobo F, Morais A, et al: Human periprostatic adipose tissue promotes prostate cancer aggressiveness in vitro. J Exp Clin Cancer Res. 31:322012. View Article : Google Scholar : PubMed/NCBI

32 

Finley DS, Calvert VS, Inokuchi J, Lau A, Narula N, Petricoin EF, Zaldivar F, Santos R, Tyson DR and Ornstein DK: Periprostatic adipose tissue as a modulator of prostate cancer aggressiveness. J Urol. 182:1621–1627. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Kaneko A, Satoh Y, Tokuda Y, Fujiyama C, Udo K and Uozumi J: Effects of adipocytes on the proliferation and differentiation of prostate cancer cells in a 3-D culture model. Int J Urol. 17:369–376. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Estève D, Roumiguié M, Manceau C, Milhas D and Muller C: Periprostatic adipose tissue: A heavy player in prostate cancer progression. Curr Opin Endocr Metab Res. 10:29–35. 2020. View Article : Google Scholar : PubMed/NCBI

35 

Kulasegaran T and Oliveira N: Metastatic castration-resistant prostate cancer: Advances in treatment and symptom management. Curr Treat Options Oncol. 25:914–931. 2024. View Article : Google Scholar : PubMed/NCBI

36 

Venkatachalam S, McFarland TR, Agarwal N and Swami U: Immune checkpoint inhibitors in prostate cancer. Cancers (Basel). 13:21872021. View Article : Google Scholar : PubMed/NCBI

37 

Gourdin T: Highlighting recent progress in the treatment of men with advanced prostate cancer. Curr Opin Oncol. 36:174–179. 2024. View Article : Google Scholar : PubMed/NCBI

38 

Gillette CM, Yette GA, Cramer SD and Graham LS: Management of advanced prostate cancer in the precision oncology era. Cancers (Basel). 15:25522023. View Article : Google Scholar : PubMed/NCBI

39 

Abida W, Armenia J, Gopalan A, Brennan R, Walsh M, Barron D, Danila D, Rathkopf D, Morris M, Slovin S, et al: Prospective Genomic profiling of prostate cancer across disease states reveals germline and somatic alterations that may affect clinical decision making. JCO Precis Oncol. 2017.PO.17.00029, 2017. View Article : Google Scholar : PubMed/NCBI

40 

Zhang Y, Ming A, Wang J, Chen W and Fang Z: PROTACs targeting androgen receptor signaling: Potential therapeutic agents for castration-resistant prostate cancer. Pharmacol Res. 205:1072342024. View Article : Google Scholar : PubMed/NCBI

41 

Sallam M, Nguyen NT, Sainsbury F, Kimizuka N, Muyldermans S and Benešová-Schäfer M: PSMA-targeted radiotheranostics in modern nuclear medicine: Then, now, and what of the future? Theranostics. 14:3043–3079. 2024. View Article : Google Scholar : PubMed/NCBI

42 

Current K, Meyer C, Magyar CE, Mona CE, Almajano J, Slavik R, Stuparu AD, Cheng C, Dawson DW, Radu CG, et al: Investigating PSMA-targeted radioligand therapy efficacy as a function of cellular PSMA levels and intratumoral PSMA heterogeneity. Clin Cancer Res. 26:2946–2955. 2020. View Article : Google Scholar : PubMed/NCBI

43 

Isaacsson Velho P, Qazi F, Hassan S, Carducci MA, Denmeade SR, Markowski MC, Thorek DL, DeWeese TL, Song DY, Tran PT, et al: Efficacy of radium-223 in bone-metastatic castration-resistant prostate cancer with and without homologous repair gene defects. Eur Urol. 76:170–176. 2019. View Article : Google Scholar : PubMed/NCBI

44 

Buyyounouski MK, Choyke PL, McKenney JK, Sartor O, Sandler HM, Amin MB, Kattan MW and Lin DW: Prostate cancer-major changes in the American joint committee on cancer eighth edition cancer staging manual. CA Cancer J Clin. 67:245–253. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Chien YH, Hsieh ML, Sheng TW, Chang YH, Wang LJ, Chuang CK, Pang ST, Wu CT and Shao IH: Body composition and pelvic fat distribution are associated with prostate cancer aggressiveness and can predict biochemical recurrence. Medicine (Baltimore). 101:e310762022. View Article : Google Scholar : PubMed/NCBI

46 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES and Mesirov JP: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 102:15545–15550. 2005. View Article : Google Scholar : PubMed/NCBI

47 

Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstråle M, Laurila E, et al: PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet. 34:267–273. 2003. View Article : Google Scholar : PubMed/NCBI

48 

Liberzon A, Birger C, Thorvaldsdóttir H, Ghandi M, Mesirov JP and Tamayo P: The molecular signatures database (MSigDB) hallmark gene set collection. Cell Syst. 1:417–425. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Woo S, Cho JY, Kim SY and Kim SH: Periprostatic fat thickness on MRI: Correlation with Gleason score in prostate cancer. AJR Am J Roentgenol. 204:W43–W47. 2015. View Article : Google Scholar : PubMed/NCBI

50 

Zhang Q, Sun LJ, Qi J, Yang ZG, Huang T and Huo RC: Periprostatic adiposity measured on magnetic resonance imaging correlates with prostate cancer aggressiveness. Urol J. 11:1793–1799. 2014.PubMed/NCBI

51 

Bhindi B, Trottier G, Elharram M, Fernandes KA, Lockwood G, Toi A, Hersey KM, Finelli A, Evans A, van der Kwast TH and Fleshner NE: Measurement of peri-prostatic fat thickness using transrectal ultrasonography (TRUS): A new risk factor for prostate cancer. BJU Int. 110:980–986. 2012. View Article : Google Scholar : PubMed/NCBI

52 

Taussky D, Barkati M, Campeau S, Zerouali K, Nadiri A, Saad F and Delouya G: Changes in periprostatic adipose tissue induced by 5α-reductase inhibitors. Andrology. 5:511–515. 2017. View Article : Google Scholar : PubMed/NCBI

53 

Tiberi D, Gruszczynski N, Meissner A, Delouya G and Taussky D: Influence of body mass index and periprostatic fat on rectal dosimetry in permanent seed prostate brachytherapy. Radiat Oncol. 9:932014. View Article : Google Scholar : PubMed/NCBI

54 

van Roermund JG, Bol GH, Witjes JA, Ruud Bosch JL, Kiemeney LA and van Vulpen M: Periprostatic fat measured on computed tomography as a marker for prostate cancer aggressiveness. World J Urol. 28:699–704. 2010. View Article : Google Scholar : PubMed/NCBI

55 

Valastyan S and Weinberg RA: Tumor metastasis: Molecular insights and evolving paradigms. Cell. 147:275–292. 2011. View Article : Google Scholar : PubMed/NCBI

56 

Nassar ZD, Aref AT, Miladinovic D, Mah CY, Raj GV, Hoy AJ and Butler LM: Peri-prostatic adipose tissue: The metabolic microenvironment of prostate cancer. BJU Int. 121 (Suppl 3):S9–S21. 2018. View Article : Google Scholar : PubMed/NCBI

57 

Sacca PA, Creydt VP, Choi H, Mazza ON, Fletcher SJ, Vallone VB, Scorticati C, Chasseing NA and Calvo JC: Human periprostatic adipose tissue: Its influence on prostate cancer cells. Cell Physiol Biochem. 30:113–122. 2012. View Article : Google Scholar : PubMed/NCBI

58 

Tokuda Y, Satoh Y, Fujiyama C, Toda S, Sugihara H and Masaki Z: Prostate cancer cell growth is modulated by adipocyte-cancer cell interaction. BJU Int. 91:716–720. 2003. View Article : Google Scholar : PubMed/NCBI

59 

König JJ, Kamst E, Hagemeijer A, Romijn JC, Horoszewicz J and Schröder FH: Cytogenetic characterization of several androgen responsive and unresponsive sublines of the human prostatic carcinoma cell line LNCaP. Urol Res. 17:79–86. 1989. View Article : Google Scholar : PubMed/NCBI

60 

Wu HC, Hsieh JT, Gleave ME, Brown NM, Pathak S and Chung LW: Derivation of androgen-independent human LNCaP prostatic cancer cell sublines: Role of bone stromal cells. Int J Cancer. 57:406–412. 1994. View Article : Google Scholar : PubMed/NCBI

61 

Liu AY, Brubaker KD, Goo YA, Quinn JE, Kral S, Sorensen CM, Vessella RL, Belldegrun AS and Hood LE: Lineage relationship between LNCaP and LNCaP-derived prostate cancer cell lines. Prostate. 60:98–108. 2004. View Article : Google Scholar : PubMed/NCBI

62 

Kaighn ME, Narayan KS, Ohnuki Y, Lechner JF and Jones LW: Establishment and characterization of a human prostatic carcinoma cell line (PC-3). Invest Urol. 17:16–23. 1979.PubMed/NCBI

63 

Stone KR, Mickey DD, Wunderli H, Mickey GH and Paulson DF: Isolation of a human prostate carcinoma cell line (DU 145). Int J Cancer. 21:274–281. 1978. View Article : Google Scholar : PubMed/NCBI

64 

Alimirah F, Chen J, Basrawala Z, Xin H and Choubey D: DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: Implications for the androgen receptor functions and regulation. FEBS Lett. 580:2294–2300. 2006. View Article : Google Scholar : PubMed/NCBI

65 

Sramkoski RM, Pretlow TG II, Giaconia JM, Pretlow TP, Schwartz S, Sy MS, Marengo SR, Rhim JS, Zhang D and Jacobberger JW: A new human prostate carcinoma cell line, 22Rv1. In Vitro Cell Dev Biol Anim. 35:403–409. 1999. View Article : Google Scholar : PubMed/NCBI

66 

Wu Y, Kim JY, Zhou S and Smas CM: Differential screening identifies transcripts with depot-dependent expression in white adipose tissues. BMC Genomics. 9:3972008. View Article : Google Scholar : PubMed/NCBI

67 

Mistry T, Digby JE, Desai KM and Randeva HS: Obesity and prostate cancer: A role for adipokines. Eur Urol. 52:46–53. 2007. View Article : Google Scholar : PubMed/NCBI

68 

Fletcher SJ, Sacca PA, Pistone-Creydt M, Coló FA, Serra MF, Santino FE, Sasso CV, Lopez-Fontana CM, Carón RW, Calvo JC and Pistone-Creydt V: Human breast adipose tissue: Characterization of factors that change during tumor progression in human breast cancer. J Exp Clin Cancer Res. 36:262017. View Article : Google Scholar : PubMed/NCBI

69 

Karagiannis GS, Pavlou MP and Diamandis EP: Cancer secretomics reveal pathophysiological pathways in cancer molecular oncology. Mol Oncol. 4:496–510. 2010. View Article : Google Scholar : PubMed/NCBI

70 

Kim KY, Baek A, Park YS, Park MY, Kim JH, Lim JS, Lee MS, Yoon SR, Lee HG, Yoon Y, et al: Adipocyte culture medium stimulates invasiveness of MDA-MB-231 cell via CCL20 production. Oncol Rep. 22:1497–1504. 2009.PubMed/NCBI

71 

Schnäbele K, Roser S, Rechkemmer G, Hauner H and Skurk T: Effects of adipocyte-secreted factors on cell cycle progression in HT29 cells. Eur J Nutr. 48:154–161. 2009. View Article : Google Scholar : PubMed/NCBI

72 

Culig Z and Puhr M: Interleukin-6 and prostate cancer: Current developments and unsolved questions. Mol Cell Endocrinol. 462:25–30. 2018. View Article : Google Scholar : PubMed/NCBI

73 

Lopez Fontana CM, Maselli Artola ME, Di Milta Monaco N, Recalde Rincon GM, Vanrell Rodriguez MC, Uvilla Recupero A, Messina Lombino D, Perez Elizalde RF and Lopez Laur JD: Influence of leptin and adiponectin on prostate cancer. Arch Esp Urol. 62:103–108. 2009. View Article : Google Scholar : PubMed/NCBI

74 

Hu X, Hu C, Zhang C, Zhang M, Long S and Cao Z: Role of adiponectin in prostate cancer. Int Braz J Urol. 45:220–228. 2019. View Article : Google Scholar : PubMed/NCBI

75 

Balkwill F: Tumour necrosis factor and cancer. Nat Rev Cancer. 9:361–371. 2009. View Article : Google Scholar : PubMed/NCBI

76 

Sacca PA, Mazza ON, Scorticati C, Vitagliano G, Casas G and Calvo JC: Human periprostatic adipose tissue: secretome from patients with prostate cancer or benign prostate hyperplasia. Cancer Genomics Proteomics. 16:29–58. 2019. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Shao I, Chang T, Chang Y, Hsieh Y, Sheng T, Wang L, Chien Y, Huang L, Chu Y, Kan H, Kan H, et al: Periprostatic adipose tissue inhibits tumor progression by secreting apoptotic factors: A natural barrier induced by the immune response during the early stages of prostate cancer. Oncol Lett 28: 485, 2024.
APA
Shao, I., Chang, T., Chang, Y., Hsieh, Y., Sheng, T., Wang, L. ... Pang, S. (2024). Periprostatic adipose tissue inhibits tumor progression by secreting apoptotic factors: A natural barrier induced by the immune response during the early stages of prostate cancer. Oncology Letters, 28, 485. https://doi.org/10.3892/ol.2024.14617
MLA
Shao, I., Chang, T., Chang, Y., Hsieh, Y., Sheng, T., Wang, L., Chien, Y., Huang, L., Chu, Y., Kan, H., Lin, P., Yu, K., Hsieh, M., Chuang, C., Wu, C., Hsieh, C., Pang, S."Periprostatic adipose tissue inhibits tumor progression by secreting apoptotic factors: A natural barrier induced by the immune response during the early stages of prostate cancer". Oncology Letters 28.4 (2024): 485.
Chicago
Shao, I., Chang, T., Chang, Y., Hsieh, Y., Sheng, T., Wang, L., Chien, Y., Huang, L., Chu, Y., Kan, H., Lin, P., Yu, K., Hsieh, M., Chuang, C., Wu, C., Hsieh, C., Pang, S."Periprostatic adipose tissue inhibits tumor progression by secreting apoptotic factors: A natural barrier induced by the immune response during the early stages of prostate cancer". Oncology Letters 28, no. 4 (2024): 485. https://doi.org/10.3892/ol.2024.14617
Copy and paste a formatted citation
x
Spandidos Publications style
Shao I, Chang T, Chang Y, Hsieh Y, Sheng T, Wang L, Chien Y, Huang L, Chu Y, Kan H, Kan H, et al: Periprostatic adipose tissue inhibits tumor progression by secreting apoptotic factors: A natural barrier induced by the immune response during the early stages of prostate cancer. Oncol Lett 28: 485, 2024.
APA
Shao, I., Chang, T., Chang, Y., Hsieh, Y., Sheng, T., Wang, L. ... Pang, S. (2024). Periprostatic adipose tissue inhibits tumor progression by secreting apoptotic factors: A natural barrier induced by the immune response during the early stages of prostate cancer. Oncology Letters, 28, 485. https://doi.org/10.3892/ol.2024.14617
MLA
Shao, I., Chang, T., Chang, Y., Hsieh, Y., Sheng, T., Wang, L., Chien, Y., Huang, L., Chu, Y., Kan, H., Lin, P., Yu, K., Hsieh, M., Chuang, C., Wu, C., Hsieh, C., Pang, S."Periprostatic adipose tissue inhibits tumor progression by secreting apoptotic factors: A natural barrier induced by the immune response during the early stages of prostate cancer". Oncology Letters 28.4 (2024): 485.
Chicago
Shao, I., Chang, T., Chang, Y., Hsieh, Y., Sheng, T., Wang, L., Chien, Y., Huang, L., Chu, Y., Kan, H., Lin, P., Yu, K., Hsieh, M., Chuang, C., Wu, C., Hsieh, C., Pang, S."Periprostatic adipose tissue inhibits tumor progression by secreting apoptotic factors: A natural barrier induced by the immune response during the early stages of prostate cancer". Oncology Letters 28, no. 4 (2024): 485. https://doi.org/10.3892/ol.2024.14617
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team