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Case Report Open Access

Combined large‑cell neuroendocrine carcinoma and small‑cell lung cancer: A case report

  • Authors:
    • Xiangyang Kong
    • Junjie Yang
    • Yiqian Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Radiotherapy, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang 311200, P.R. China, Department of Pathology, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang 311200, P.R. China
    Copyright: © Kong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 484
    |
    Published online on: August 8, 2024
       https://doi.org/10.3892/ol.2024.14618
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Abstract

Combined large‑cell neuroendocrine carcinoma (LCNEC) and small‑cell lung cancer (SCLC) is extremely rare, with only a few reports available in the literature. An accurate diagnosis is difficult to make due to the overlapping clinical features between LCNEC and SCLC, and a standardized treatment option is lacking. A 53‑year‑old female patient was admitted to Xiaoshan Affiliated Hospital of Wenzhou Medical University (Hangzhou, China) due to symptoms of dyspnea and phlegm, with blood in the sputum. Computed tomography revealed a 52x32x26‑mm irregular soft‑tissue mass in the left upper lung. Pathological examination of the biopsy specimen showed a poorly differentiated neuroendocrine carcinoma with compression injury, consistent with a mixed type of large and small cell carcinoma. The patient was administered chemotherapy, radiotherapy and targeted therapy, and as of October 2023, the patient had a survival period of 29 months. LCNEC combined with SCLC is a sporadic tumor with a high potential for malignancy. Multidisciplinary treatment and close follow‑up are recommended. The multidisciplinary treatment strategy used in the present study is expected to help inform future therapeutic decisions.
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Copy and paste a formatted citation
Spandidos Publications style
Kong X, Yang J and Jiang Y: Combined large‑cell neuroendocrine carcinoma and small‑cell lung cancer: A case report. Oncol Lett 28: 484, 2024.
APA
Kong, X., Yang, J., & Jiang, Y. (2024). Combined large‑cell neuroendocrine carcinoma and small‑cell lung cancer: A case report. Oncology Letters, 28, 484. https://doi.org/10.3892/ol.2024.14618
MLA
Kong, X., Yang, J., Jiang, Y."Combined large‑cell neuroendocrine carcinoma and small‑cell lung cancer: A case report". Oncology Letters 28.4 (2024): 484.
Chicago
Kong, X., Yang, J., Jiang, Y."Combined large‑cell neuroendocrine carcinoma and small‑cell lung cancer: A case report". Oncology Letters 28, no. 4 (2024): 484. https://doi.org/10.3892/ol.2024.14618
Copy and paste a formatted citation
x
Spandidos Publications style
Kong X, Yang J and Jiang Y: Combined large‑cell neuroendocrine carcinoma and small‑cell lung cancer: A case report. Oncol Lett 28: 484, 2024.
APA
Kong, X., Yang, J., & Jiang, Y. (2024). Combined large‑cell neuroendocrine carcinoma and small‑cell lung cancer: A case report. Oncology Letters, 28, 484. https://doi.org/10.3892/ol.2024.14618
MLA
Kong, X., Yang, J., Jiang, Y."Combined large‑cell neuroendocrine carcinoma and small‑cell lung cancer: A case report". Oncology Letters 28.4 (2024): 484.
Chicago
Kong, X., Yang, J., Jiang, Y."Combined large‑cell neuroendocrine carcinoma and small‑cell lung cancer: A case report". Oncology Letters 28, no. 4 (2024): 484. https://doi.org/10.3892/ol.2024.14618
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