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MicroRNA‑mediated approaches in ovarian cancer therapy: A comprehensive systematic review

  • Authors:
    • Henny Meitri Andrie Rachmasari Putri
    • Putri Wikie Novianti
    • Heru Pradjatmo
    • Sofia Mubarika Haryana
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    Affiliations: Department of Obstetrics and Gynecology, Indonesia Army Hospital, Central Jakarta 10410, Indonesia, Siena Clinical, Central Jakarta 10340, Indonesia, Department of Obstetrics and Gynecology, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Depok, Yogyakarta 55281, Indonesia, Department of Histology and Cell Biology, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Depok, Yogyakarta 55281, Indonesia
    Copyright: © Putri et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 491
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    Published online on: August 12, 2024
       https://doi.org/10.3892/ol.2024.14624
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Abstract

Ovarian cancer (OC) poses a significant health risk to women worldwide, with late diagnoses and chemotherapy resistance leading to high mortality rates. Despite several histological subtypes, the primary challenge remains the subtle nature of its symptoms, resulting in advanced‑stage diagnosis and reduced treatment success rates. With platinum‑based therapies showing relative efficacy but limited survival enhancements, the emergence of chemotherapy resistance during recurrence remains a critical obstacle. Precision medicine development has aimed to address these challenges in the context of the molecular diversity of OC. The present review explored the landscape of microRNA (miRNA)‑mediated approaches in OC treatment. miRNAs have emerged as regulators of gene expression, serving as both oncogenes and tumor suppressors in OC. Dysregulated miRNAs are associated with disease progression and chemotherapy resistance, underscoring their significance in diagnosis and tailored treatment strategies. The present review extracted 295 publications from the PUBMED database. Out of the 73 eligible studies, 55 miRNAs were assessed. A total of three of these miRNAs were not associated with any disease or cancer, whilst eight were associated with OC, albeit also associated with other diseases. The present review encompassed three dimensions: i) The role of miRNAs in treatment efficacy; ii) the use of miRNAs to enhance therapy outcomes; and iii) adjunctive strategies for improved treatment results. Furthermore, it offered insights into potential avenues for improving OC treatment using miRNA‑based approaches.
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Copy and paste a formatted citation
Spandidos Publications style
Putri HR, Novianti PW, Pradjatmo H and Haryana SM: MicroRNA‑mediated approaches in ovarian cancer therapy: A comprehensive systematic review. Oncol Lett 28: 491, 2024.
APA
Putri, H.R., Novianti, P.W., Pradjatmo, H., & Haryana, S.M. (2024). MicroRNA‑mediated approaches in ovarian cancer therapy: A comprehensive systematic review. Oncology Letters, 28, 491. https://doi.org/10.3892/ol.2024.14624
MLA
Putri, H. R., Novianti, P. W., Pradjatmo, H., Haryana, S. M."MicroRNA‑mediated approaches in ovarian cancer therapy: A comprehensive systematic review". Oncology Letters 28.4 (2024): 491.
Chicago
Putri, H. R., Novianti, P. W., Pradjatmo, H., Haryana, S. M."MicroRNA‑mediated approaches in ovarian cancer therapy: A comprehensive systematic review". Oncology Letters 28, no. 4 (2024): 491. https://doi.org/10.3892/ol.2024.14624
Copy and paste a formatted citation
x
Spandidos Publications style
Putri HR, Novianti PW, Pradjatmo H and Haryana SM: MicroRNA‑mediated approaches in ovarian cancer therapy: A comprehensive systematic review. Oncol Lett 28: 491, 2024.
APA
Putri, H.R., Novianti, P.W., Pradjatmo, H., & Haryana, S.M. (2024). MicroRNA‑mediated approaches in ovarian cancer therapy: A comprehensive systematic review. Oncology Letters, 28, 491. https://doi.org/10.3892/ol.2024.14624
MLA
Putri, H. R., Novianti, P. W., Pradjatmo, H., Haryana, S. M."MicroRNA‑mediated approaches in ovarian cancer therapy: A comprehensive systematic review". Oncology Letters 28.4 (2024): 491.
Chicago
Putri, H. R., Novianti, P. W., Pradjatmo, H., Haryana, S. M."MicroRNA‑mediated approaches in ovarian cancer therapy: A comprehensive systematic review". Oncology Letters 28, no. 4 (2024): 491. https://doi.org/10.3892/ol.2024.14624
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