Macrocystic secretory carcinoma arising from the buccal minor salivary gland clinically mimicking a mucocele: A case report

Chida,Tadashi; Teramoto‑Nagae,Akari; Usami,Yu; Hirose,Katsutoshi; Kishimoto,Satoko; Wakabayashi,Ken; Kanesaki,Tomohiko; Morita,Yoshihiro; Uzawa,Narikazu

doi:10.3892/ol.2024.14626

Macrocystic secretory carcinoma arising from the buccal minor salivary gland clinically mimicking a mucocele: A case report

Authors:
- Tadashi Chida
- Akari Teramoto‑Nagae
- Yu Usami
- Katsutoshi Hirose
- Satoko Kishimoto
- Ken Wakabayashi
- Tomohiko Kanesaki
- Yoshihiro Morita
- Narikazu Uzawa
View Affiliations

Affiliations: Department of Oral and Maxillofacial Surgery, Saiseikai Senri Hospital, Suita‑shi, Osaka 565‑0862, Japan, Department of Oral and Maxillofacial Oncology and Surgery, Osaka University Graduate School of Dentistry, Suita‑shi, Osaka 565‑0871, Japan, Department of Oral and Maxillofacial Pathology, Osaka University Graduate School of Dentistry, Suita‑shi, Osaka 565‑0871, Japan
Published online on: August 12, 2024 https://doi.org/10.3892/ol.2024.14626
Article Number: 493
Copyright: © Chida et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Secretory carcinoma (SC) is an uncommon salivary gland tumor that has been recently conceptualized. The present report describes a case of SC that was diagnosed as a mucocele on preoperative examination. A 46‑year‑old man presented to the Department of Oral and Maxillofacial Surgery at Saiseikai Senri Hospital (Suita‑shi, Japan) with a main complaint of swelling of the right buccal mucosa. A mobile, elastic, hard mass was found beneath the right normal‑appearing buccal mucosa. T2‑weighted magnetic resonance imaging revealed a well‑defined, internally homogeneous high‑signal area with a maximum diameter of 18 mm. Based on the clinical diagnosis of mucocele, the buccal lesion was excised. Histopathological, immunohistochemical and fluorescence in situ hybridization analyses revealed the cystic lesion to be a macrocystic SC of a minor salivary gland. SC may have a mucocele‑like appearance on magnetic resonance imaging. Even if a non‑neoplastic lesion is suspected, the possibility of a malignant lesion such as SC must be considered for salivary gland disease.

View Figures

View References

1	Skálová A, Vanecek T, Sima R, Laco J, Weinreb I, Perez-Ordonez B, Starek I, Geierova M, Simpson RHW, Passador-Santos F, et al: Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: A hitherto undescribed salivary gland tumor entity. Am J Surg Pathol. 34:599–608. 2010. View Article : Google Scholar : PubMed/NCBI
2	El-Naggar AK, Chan JKC, Grandis JR, Takata T and Slootweg PJ: World Health Organization Classification of Head and Neck Tumours. 4th edition. IARC Press; Lyon: 2017
3	Chiosea SI, Griffith C, Assaad A and Seethala RR: Clinicopathological characterization of mammary analogue secretory carcinoma of salivary glands. Histopathology. 61:387–394. 2012. View Article : Google Scholar : PubMed/NCBI
4	Alves LDB, de Melo AC, Farinha TA, de Lima Araujo LH, Thiago LS, Dias FL, Antunes HS, Amaral Eisenberg AL, Santos Thuler LC and Cohen Goldemberg D: A systematic review of secretory carcinoma of the salivary gland: where are we? Oral Surg Oral Med Oral Pathol Oral Radiol. 132:e143–e152. 2021. View Article : Google Scholar : PubMed/NCBI
5	Takita H, Takeshita T, Shimono T, Tanaka H, Iguchi H, Hashimoto S, Kuwae Y, Ohsawa M and Miki Y: Cystic lesions of the parotid gland: Radiologic-pathologic correlation according to the latest World Health Organization 2017 classification of head and neck tumours. Jpn J Radiol. 35:629–647. 2017. View Article : Google Scholar : PubMed/NCBI
6	Layfield LJ and Gopez EV: Cystic lesions of the salivary glands: Cytologic features in fine-needle aspiration biopsies. Diagn Cytopathol. 27:197–204. 2002. View Article : Google Scholar : PubMed/NCBI
7	Pinto A, Nosé V, Rojas C, Fan YS and Gomez-Fernandez C: Searching for mammary analogue [corrected] secretory carcinoma of salivary gland among its mimics. Mod Pathol. 27:30–37. 2014. View Article : Google Scholar : PubMed/NCBI
8	Hoang VT, Trinh CT, Nguyen CH, Chansomphou V, Chansomphou V and Tran TTT: Overview of epidermoid cyst. Eur J Radiol Open. 6:291–301. 2019. View Article : Google Scholar : PubMed/NCBI
9	Michal M, Hrabal P and Skálová A: Oncocytic cystadenoma of the parotid gland with prominent signet-ring cell features. Pathol Int. 48:629–633. 1998. View Article : Google Scholar : PubMed/NCBI
10	Weber A, Langhanki L, Schütz A, Gerstner A, Bootz F, Wittekind C and Tannapfel A: Expression profiles of p53, p63, and p73 in benign salivary gland tumors. Virchows Arch. 441:428–436. 2002. View Article : Google Scholar : PubMed/NCBI
11	Di Palma S: Carcinoma ex pleomorphic adenoma, with particular emphasis on early lesions. Head Neck Pathol. 7 (Suppl 1):S68–S76. 2013. View Article : Google Scholar : PubMed/NCBI
12	Hung YP, Fletcher CDM and Hornick JL: Evaluation of pan-TRK immunohistochemistry in infantile fibrosarcoma, lipofibromatosis-like neural tumour and histological mimics. Histopathology. 73:634–644. 2018. View Article : Google Scholar : PubMed/NCBI
13	Hernandez-Prera JC, Holmes BJ, Valentino A, Harshan M, Bacchi CE, Petersson F, Liu KK, Najfeld V and Wenig BM: Macrocystic (mammary analogue) secretory carcinoma: An unusual variant and a pitfall in the differential diagnosis of cystic lesions in the head and neck. Am J Surg Pathol. 43:1483–1492. 2019. View Article : Google Scholar : PubMed/NCBI
14	Maleki Z, Allison DB, Butcher M, Kawamoto S, Eisele DW and Pantanowitz L: Application of the Milan system for reporting salivary gland cytopathology to cystic salivary gland lesions. Cancer Cytopathol. 129:214–225. 2021. View Article : Google Scholar : PubMed/NCBI
15	Gupta K, Patwa HS, Niehaus AG, Filho GOF and Lack CM: Mammary analogue secretory carcinoma presenting as a cystic parotid mass. Radiol Case Rep. 14:1103–1108. 2019. View Article : Google Scholar : PubMed/NCBI
16	Helmy D, Chang J, Bishop JW, Vong A, Raslan O and Ozturk A: MR imaging findings of a rare pediatric parotid tumor: Mammary analogue secretory carcinoma. Radiol Case Rep. 15:1460–1463. 2020. View Article : Google Scholar : PubMed/NCBI
17	Black M, Liu CZ, Onozato M, Iafrate AJ, Darvishian F, Jour G and Cotzia P: Concurrent identification of novel EGFR-SEPT14 fusion and ETV6-RET fusion in secretory carcinoma of the salivary gland. Head Neck Pathol. 14:817–821. 2020. View Article : Google Scholar : PubMed/NCBI
18	Shibata E, Morita KI, Kayamori K, Maruiwa M, Michi Y, Sato Y, Takeuchi K, Ikeda T, Harada H and Yoda T: Secretory carcinoma around Stensen's duct misdiagnosed as salivary duct cyst. Int J Clin Exp Pathol. 13:2211–2217. 2020.PubMed/NCBI
19	Rameeza A and Hemalata M: Fine-needle aspiration cytology of salivary gland lesions. J Oral Maxillofac Pathol. 26:52–56. 2022. View Article : Google Scholar : PubMed/NCBI