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Using heart rate variability to evaluate the association between the autonomic nervous system and coagulation function in patients with endometrial cancer

  • Authors:
    • Yongqiang Wang
    • Weizheng Guan
    • Yifang Zhang
    • Yuling Wang
    • Bo Shi
    • Jian Liu
    • Sai Zhang
  • View Affiliations / Copyright

    Affiliations: School of Medical Imaging, Bengbu Medical University, Bengbu, Anhui 233030, P.R. China, Department of Gynecological Oncology, The First Affiliated Hospital, Bengbu Medical University, Bengbu, Anhui 233004, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 499
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    Published online on: August 14, 2024
       https://doi.org/10.3892/ol.2024.14632
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Abstract

The incidence of endometrial cancer (EC) is increasing worldwide, but the specific mechanism of coagulation dysfunction in EC is not fully understood. The objective of the present study was to explore the relationship between autonomic nervous system function and coagulation function in patients with EC using heart rate variability (HRV) analysis. The study included 100 patients with EC who were treated at the Department of Gynecological Oncology of The First Affiliated Hospital of Bengbu Medical University (Bengbu, China) from December 2021 to March 2023. A 5‑min resting electrocardiogram was collected from each patient to analyze HRV parameters, including the time domain parameters standard deviation of the normal‑normal intervals (SDNN) and root mean square of successive interval differences (RMSSD), and the frequency domain parameters low‑frequency power and high‑frequency power (HF). Blood samples were submitted to biochemistry tests to measure coagulation markers, namely prothrombin time (PT), international normalized ratio of PT (PT‑INR), prothrombin activity (PTA), activated partial thromboplastin time (APTT) and fibrinogen. Bivariate Spearman correlation analyses revealed that PT, PT‑INR and APTT were significantly positively correlated with SDNN, RMSSD and HF, while PTA was significantly negatively correlated with RMSSD. Following adjustments for confounding factors, namely age, body mass index, menopause, ligation of the fallopian tubes, diabetes, hypertension, adjuvant chemotherapy and mean heart rate, linear regression analysis demonstrated that SDNN, RMSSD and HF were independent factors influencing PT and PT‑INR in patients with EC. The findings of the present study indicate that certain HRV parameters correlate with coagulation markers in EC and provide new insight into the occurrence of cancer‑associated coagulation dysfunction.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Guan W, Zhang Y, Wang Y, Shi B, Liu J and Zhang S: Using heart rate variability to evaluate the association between the autonomic nervous system and coagulation function in patients with endometrial cancer. Oncol Lett 28: 499, 2024.
APA
Wang, Y., Guan, W., Zhang, Y., Wang, Y., Shi, B., Liu, J., & Zhang, S. (2024). Using heart rate variability to evaluate the association between the autonomic nervous system and coagulation function in patients with endometrial cancer. Oncology Letters, 28, 499. https://doi.org/10.3892/ol.2024.14632
MLA
Wang, Y., Guan, W., Zhang, Y., Wang, Y., Shi, B., Liu, J., Zhang, S."Using heart rate variability to evaluate the association between the autonomic nervous system and coagulation function in patients with endometrial cancer". Oncology Letters 28.4 (2024): 499.
Chicago
Wang, Y., Guan, W., Zhang, Y., Wang, Y., Shi, B., Liu, J., Zhang, S."Using heart rate variability to evaluate the association between the autonomic nervous system and coagulation function in patients with endometrial cancer". Oncology Letters 28, no. 4 (2024): 499. https://doi.org/10.3892/ol.2024.14632
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Guan W, Zhang Y, Wang Y, Shi B, Liu J and Zhang S: Using heart rate variability to evaluate the association between the autonomic nervous system and coagulation function in patients with endometrial cancer. Oncol Lett 28: 499, 2024.
APA
Wang, Y., Guan, W., Zhang, Y., Wang, Y., Shi, B., Liu, J., & Zhang, S. (2024). Using heart rate variability to evaluate the association between the autonomic nervous system and coagulation function in patients with endometrial cancer. Oncology Letters, 28, 499. https://doi.org/10.3892/ol.2024.14632
MLA
Wang, Y., Guan, W., Zhang, Y., Wang, Y., Shi, B., Liu, J., Zhang, S."Using heart rate variability to evaluate the association between the autonomic nervous system and coagulation function in patients with endometrial cancer". Oncology Letters 28.4 (2024): 499.
Chicago
Wang, Y., Guan, W., Zhang, Y., Wang, Y., Shi, B., Liu, J., Zhang, S."Using heart rate variability to evaluate the association between the autonomic nervous system and coagulation function in patients with endometrial cancer". Oncology Letters 28, no. 4 (2024): 499. https://doi.org/10.3892/ol.2024.14632
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