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Efficacy and safety of nanoparticle albumin‑bound paclitaxel compared with solvent‑based paclitaxel in adjuvant therapy for breast cancer: A retrospective study

  • Authors:
    • Huina Lv
    • Yanyan Hong
    • Yuting Zhang
    • Siyu Li
    • Bingbing Li
    • Mingjun Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China, Department of Oncology, Fuyang Hospital of Anhui Medical University, Fuyang, Anhui 236000, P.R. China
    Copyright: © Lv et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 509
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    Published online on: August 23, 2024
       https://doi.org/10.3892/ol.2024.14642
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Abstract

The current evidence for the use of nanoparticle albumin‑bound paclitaxel (nab‑PTX) for adjuvant breast cancer chemotherapy is insufficient. The present study aimed to assess the efficacy and toxicity of nab‑PTX in comparison with solvent‑based paclitaxel (sb‑PTX) in postoperative adjuvant breast cancer treatment. A total of 345 patients were included in the study and separated into nab‑PTX (n=289) and sb‑PTX (n=56) groups based on the type of taxane used in the adjuvant chemotherapy regimen. The study evaluated the baseline characteristics in both groups and the risk factors for postoperative recurrence of mammary cancer. Furthermore, data concerning disease‑free survival (DFS) and adverse effects were obtained and analyzed, and group confounding variables were addressed using 1:2 propensity score matching (PSM). Comparisons before PSM revealed significant differences in baseline characteristics including age, underlying disease, lymph node involvement, vascular invasion, human epidermal growth factor receptor 2 and axillary surgery (P<0.05). Following PSM, there were 90 patients in the nab‑PTX group and 56 in the sb‑PTX group, with no significant differences in the baseline differences (P>0.05). Before PSM, the 73‑month DFS rate was 97.9% in the nab‑PTX group compared with 91.1% in the sb‑PTX group. However, there were no significant differences between the groups before or after PSM (P=0.15 and P=0.49, respectively). Additionally, Cox regression analysis demonstrated a significantly lower chance of recurrence in patients aged >45 years [hazard ratio (HR), 0.197; 95% confidence interval (CI), 0.052‑0.753; P=0.018], whereas underlying disease (HR, 5.352; 95% CI, 1.310‑21.854; P=0.019) and lymph node infiltration (HR, 8.930; 95% CI, 1.121‑71.161; P=0.039) significantly increased the risk of recurrence. Regarding safety, the sb‑PTX group had a significantly greater incidence of anaphylaxis, whereas the nab‑PTX group had significantly increased rates of anemia and peripheral neuropathy (P<0.05). In summary, the 73‑month DFS rate of the nab‑PTX cohort exceeded that of the sb‑PTX cohort, but no significant difference was detected between them. Underlying disease, lymph node metastasis and an age of ≤45 years are significant predictors of postoperative recurrence of breast cancer. 
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Copy and paste a formatted citation
Spandidos Publications style
Lv H, Hong Y, Zhang Y, Li S, Li B and Zhang M: Efficacy and safety of nanoparticle albumin‑bound paclitaxel compared with solvent‑based paclitaxel in adjuvant therapy for breast cancer: A retrospective study. Oncol Lett 28: 509, 2024.
APA
Lv, H., Hong, Y., Zhang, Y., Li, S., Li, B., & Zhang, M. (2024). Efficacy and safety of nanoparticle albumin‑bound paclitaxel compared with solvent‑based paclitaxel in adjuvant therapy for breast cancer: A retrospective study. Oncology Letters, 28, 509. https://doi.org/10.3892/ol.2024.14642
MLA
Lv, H., Hong, Y., Zhang, Y., Li, S., Li, B., Zhang, M."Efficacy and safety of nanoparticle albumin‑bound paclitaxel compared with solvent‑based paclitaxel in adjuvant therapy for breast cancer: A retrospective study". Oncology Letters 28.5 (2024): 509.
Chicago
Lv, H., Hong, Y., Zhang, Y., Li, S., Li, B., Zhang, M."Efficacy and safety of nanoparticle albumin‑bound paclitaxel compared with solvent‑based paclitaxel in adjuvant therapy for breast cancer: A retrospective study". Oncology Letters 28, no. 5 (2024): 509. https://doi.org/10.3892/ol.2024.14642
Copy and paste a formatted citation
x
Spandidos Publications style
Lv H, Hong Y, Zhang Y, Li S, Li B and Zhang M: Efficacy and safety of nanoparticle albumin‑bound paclitaxel compared with solvent‑based paclitaxel in adjuvant therapy for breast cancer: A retrospective study. Oncol Lett 28: 509, 2024.
APA
Lv, H., Hong, Y., Zhang, Y., Li, S., Li, B., & Zhang, M. (2024). Efficacy and safety of nanoparticle albumin‑bound paclitaxel compared with solvent‑based paclitaxel in adjuvant therapy for breast cancer: A retrospective study. Oncology Letters, 28, 509. https://doi.org/10.3892/ol.2024.14642
MLA
Lv, H., Hong, Y., Zhang, Y., Li, S., Li, B., Zhang, M."Efficacy and safety of nanoparticle albumin‑bound paclitaxel compared with solvent‑based paclitaxel in adjuvant therapy for breast cancer: A retrospective study". Oncology Letters 28.5 (2024): 509.
Chicago
Lv, H., Hong, Y., Zhang, Y., Li, S., Li, B., Zhang, M."Efficacy and safety of nanoparticle albumin‑bound paclitaxel compared with solvent‑based paclitaxel in adjuvant therapy for breast cancer: A retrospective study". Oncology Letters 28, no. 5 (2024): 509. https://doi.org/10.3892/ol.2024.14642
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