Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2024 Volume 28 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2024 Volume 28 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article

Role of ultrasound‑guided fine‑needle aspiration cytology combined with thyroid peroxidase and thyroglobulin antibodies in evaluating cervical lymph node metastasis in thyroid cancer

  • Authors:
    • Lifeng Weng
  • View Affiliations / Copyright

    Affiliations: Department of Ultrasound Medicine, Nanjing Medical University Affiliated Changzhou Second People's Hospital, Changzhou, Jiangsu 213004, P.R. China
  • Article Number: 512
    |
    Published online on: August 27, 2024
       https://doi.org/10.3892/ol.2024.14645
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study was designed to explore the role of ultrasound‑guided fine‑needle aspiration (FNA) cytology combined with thyroid peroxidase antibody (TPO‑Ab) and thyroglobulin antibody (Tg‑Ab) in evaluating cervical lymph node metastasis in thyroid cancer. The aim was to propose more effective diagnostic strategies for cervical lymph node metastasis in patients with thyroid cancer. Firstly, the present retrospective case‑control study selected 294 patients with thyroid cancer treated at Changzhou Second People's Hospital (Changzhou, China). High‑resolution ultrasound equipment was used for ultrasound and FNA examinations. Additionally, a retrospective analysis of the patient's comprehensive thyroid function tests, including TPO-Ab and Tg-Ab levels, was conducted. Subsequently, univariate and multivariate logistic regression models were employed to analyze the association between various factors and cervical lymph node metastasis. The overall diagnostic accuracy of the model was evaluated using the receiver operating characteristic curve and its area under the curve. Finally, the performance of the diagnostic model was quantitatively assessed through calculating sensitivity, specificity, positive predictive and negative predictive values. According to the experimental results, sex, tumor stage and the levels of thyroid autoantibodies were associated with the risk of cervical lymph node metastasis in thyroid cancer. Moreover, ultrasound features, such as cystic lesions, loss of hilum of the lymph nodes, abundant vascular supply, heterogeneous echo and microcalcification were also closely related to cervical lymph node metastasis. Logistic regression analysis also showed that tumor stage, serum levels of TPO‑Ab and Tg‑Ab, and cystic lesions were independent predictors of cervical lymph node metastasis. Furthermore, the combined use of ultrasound, FNA, TPO‑Ab and Tg‑Ab significantly improved diagnostic sensitivity and specificity. Overall, ultrasound‑guided FNA combined with TPO‑Ab and Tg‑Ab may have a significant role in the evaluation of cervical lymph node metastasis in thyroid cancer. This combined diagnostic approach could significantly enhance diagnostic accuracy, providing a more effective strategy for the clinical management of cervical lymph node metastasis in thyroid cancer.
View Figures
View References

1 

Siegel RL, Giaquinto AN and Jemal A: Cancer statistics, 2024. CA Cancer J Clin. 74:12–49. 2024. View Article : Google Scholar : PubMed/NCBI

2 

Han B, Zheng R, Zeng H, Wang S, Sun K, Chen R, Li L, Wei W and He J: Cancer incidence and mortality in China, 2022. J Natl Cancer Cent. 4:47–53. 2024. View Article : Google Scholar : PubMed/NCBI

3 

Shakil J, Cubb TD, Yehya A, Zand A, Xu J and Robbins RJ: Clinical features in differentiated thyroid carcinoma stratified by lymph node status. Endocr Pract. 26:909–914. 2020. View Article : Google Scholar : PubMed/NCBI

4 

Kaur J, Nadarajan A, Janardhan D, George NA, Thomas S, Varghese BT and Krishna J: Predictive factors for nodal recurrence in differentiated thyroid cancers. Cancer Treat Res Commun. 36:1007282023. View Article : Google Scholar : PubMed/NCBI

5 

Lan L, Luo Y, Zhou M, Huo L, Chen H, Zuo Q and Deng W: Comparison of diagnostic accuracy of thyroid cancer with ultrasound-guided fine-needle aspiration and core-needle biopsy: A systematic review and meta-analysis. Front Endocrinol (Lausanne). 11:442020. View Article : Google Scholar : PubMed/NCBI

6 

Liu RB, Zhou DL, Xu BH, Yang XH, Liu Q, Zhang X, Tang T, Ye ZL and Li Y: Comparison of the diagnostic performances of US-guided fine needle aspiration cytology and thyroglobulin measurement for lymph node metastases in patients with differentiated thyroid carcinoma: A meta-analysis. Eur Radiol. 31:2903–2914. 2021. View Article : Google Scholar : PubMed/NCBI

7 

Das S, Dey MK, Devireddy R and Gartia MR: Biomarkers in cancer detection, diagnosis, and prognosis. Sensors (Basel). 24:372023. View Article : Google Scholar : PubMed/NCBI

8 

Li X and Cheng R: TPO as an indicator of lymph node metastasis and recurrence in papillary thyroid carcinoma. Sci Rep. 13:108482023. View Article : Google Scholar : PubMed/NCBI

9 

de Meer SGA, Vorselaars WMCM, Kist JW, Stokkel MPM, de Keizer B, Valk GD, Borel Rinkes IHM and Vriens MR: Follow-up of patients with thyroglobulin-antibodies: Rising Tg-Ab trend is a risk factor for recurrence of differentiated thyroid cancer. Endocr Res. 42:302–310. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Bartz-Kurycki MA, Oluwo OE and Morris-Wiseman LF: Medullary thyroid carcinoma: Recent advances in identification, treatment, and prognosis. Ther Adv Endocrinol Metab. 12:204201882110496112021. View Article : Google Scholar : PubMed/NCBI

11 

Wu X, Zhang L, Sun J, Huang Y, Yu E, Gu D, Wang W, Sun M, Wang K, Wang J, et al: Correlation between sonographic features and pathological findings of cervical lymph node metastasis of differentiated thyroid carcinoma. Gland Surg. 10:1736–1743. 2021. View Article : Google Scholar : PubMed/NCBI

12 

Chasen NN, Wang JR, Gan Q and Ahmed S: Imaging of cervical lymph nodes in thyroid cancer: Ultrasound and computed tomography. Neuroimaging Clin N Am. 31:313–326. 2021. View Article : Google Scholar : PubMed/NCBI

13 

Gao L, Li X, Xia Y, Liu R, Liu C, Shi X, Wu Y, Ma L and Jiang Y: Large-volume lateral lymph node metastasis predicts worse prognosis in papillary thyroid carcinoma patients with N1b. Front Endocrinol (Lausanne). 12:8152072022. View Article : Google Scholar : PubMed/NCBI

14 

Issa PP, Mueller L, Hussein M, Albuck A, Shama M, Toraih E and Kandil E: Radiologist versus non-radiologist detection of lymph node metastasis in papillary thyroid carcinoma by ultrasound: A meta-analysis. Biomedicines. 10:25752022. View Article : Google Scholar : PubMed/NCBI

15 

Baldini E, Sorrenti S, Di Gioia C, De Vito C, Antonelli A, Gnessi L, Carbotta G, D'Armiento E, Miccoli P, De Antoni E and Ulisse S: Cervical lymph node metastases from thyroid cancer: Does thyroglobulin and calcitonin measurement in fine needle aspirates improve the diagnostic value of cytology? BMC Clin Pathol. 13:72013. View Article : Google Scholar : PubMed/NCBI

16 

Chen JV, Morgan TA, Liu C, Khanafshar E and Choi HH: Cervical lymph node features predictive of suboptimal adequacy during ultrasound-guided fine-needle aspiration in thyroid cancer patients. J Ultrasound Med. 41:135–145. 2022. View Article : Google Scholar : PubMed/NCBI

17 

Zhang K, Qian L, Chen J, Zhu Q and Chang C: Preoperative prediction of central cervical lymph node metastasis in fine-needle aspiration reporting suspicious papillary thyroid cancer or papillary thyroid cancer without lateral neck metastasis. Front Oncol. 12:7127232022. View Article : Google Scholar : PubMed/NCBI

18 

Ren W, Zhu Y, Wang Q, Song Y, Fan Z, Bai Y and Lin D: Deep learning prediction model for central lymph node metastasis in papillary thyroid microcarcinoma based on cytology. Cancer Sci. 114:4114–4124. 2023. View Article : Google Scholar : PubMed/NCBI

19 

Chen YA, Lin SJ, Teng HY and Yang CS: Atypical histiocytoid cells in fine-needle aspiration cytology of metastatic papillary thyroid carcinoma: A potential diagnostic pitfall. Diagn Cytopathol. 50:133–140. 2022. View Article : Google Scholar : PubMed/NCBI

20 

Aydoğan Bİ, Mutlu ABB, Yüksel S, Güllü S, Emral R, Demir Ö, Şahin M, Gedik VT, Çorapçıoğlu D, Sak SD and Erdoğan MF: The association of histologically proven chronic lymphocytic thyroiditis with clinicopathological features, lymph node metastasis, and recurrence rates of differentiated thyroid cancer. Endocr Pathol. 32:280–287. 2021. View Article : Google Scholar : PubMed/NCBI

21 

Rakib SA, Sharif SB, Nahar A and Alam SM: Prediction of thyroid malignancies by thyroid auto antibodies. Mymensingh Med J. 27:585–595. 2018.PubMed/NCBI

22 

Shield PW, Crouch SJ, Papadimos DJ and Walsh MD: Identification of metastatic papillary thyroid carcinoma in FNA specimens using thyroid peroxidase immunohistochemistry. Cytopathology. 29:227–232. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Wu X, Liu Y, Li K, Yang Y, Lai P, Li J and Kou S: Predictive value of FNA-Tg and TgAb in cervical lymph node metastasis of papillary thyroid carcinoma. Technol Cancer Res Treat. 21:153303382211276052022. View Article : Google Scholar : PubMed/NCBI

24 

Cabibi D, Giannone AG, Bellavia S, Lo Coco R, Lo Bianco A, Formisano E, Scerrino G and Graceffa G: Serum anti-thyroglobulin autoantibodies are specific in predicting the presence of papillary-like nuclear features and lymphocytic infiltrate in the thyroid gland. Diagnostics (Basel). 13:20422023. View Article : Google Scholar : PubMed/NCBI

25 

Kitahara CM and Schneider AB: Epidemiology of thyroid cancer. Cancer Cancer Epidemiol Biomarkers Prev. 31:1284–1297. 2022. View Article : Google Scholar : PubMed/NCBI

26 

Flemban AF, Kabrah S, Alahmadi H, Alqurashi RK, Turaes AS, Almaghrabi R, Al Harbi S and Khogeer AA: Patterns of thyroid cancer mortality and incidence in Saudi Arabia: A 30-year study. Diagnostics (Basel). 12:27162022. View Article : Google Scholar : PubMed/NCBI

27 

Sun J, Li P, Chen X, Yu Q and Li L: The influence of thyroid status, serum Tg, TSH, and TgAb on FNA-Tg in cervical metastatic lymph nodes of papillary thyroid carcinoma. Laryngoscope Investig Otolaryngol. 7:274–282. 2021. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Weng L: Role of ultrasound‑guided fine‑needle aspiration cytology combined with thyroid peroxidase and thyroglobulin antibodies in evaluating cervical lymph node metastasis in thyroid cancer. Oncol Lett 28: 512, 2024.
APA
Weng, L. (2024). Role of ultrasound‑guided fine‑needle aspiration cytology combined with thyroid peroxidase and thyroglobulin antibodies in evaluating cervical lymph node metastasis in thyroid cancer. Oncology Letters, 28, 512. https://doi.org/10.3892/ol.2024.14645
MLA
Weng, L."Role of ultrasound‑guided fine‑needle aspiration cytology combined with thyroid peroxidase and thyroglobulin antibodies in evaluating cervical lymph node metastasis in thyroid cancer". Oncology Letters 28.5 (2024): 512.
Chicago
Weng, L."Role of ultrasound‑guided fine‑needle aspiration cytology combined with thyroid peroxidase and thyroglobulin antibodies in evaluating cervical lymph node metastasis in thyroid cancer". Oncology Letters 28, no. 5 (2024): 512. https://doi.org/10.3892/ol.2024.14645
Copy and paste a formatted citation
x
Spandidos Publications style
Weng L: Role of ultrasound‑guided fine‑needle aspiration cytology combined with thyroid peroxidase and thyroglobulin antibodies in evaluating cervical lymph node metastasis in thyroid cancer. Oncol Lett 28: 512, 2024.
APA
Weng, L. (2024). Role of ultrasound‑guided fine‑needle aspiration cytology combined with thyroid peroxidase and thyroglobulin antibodies in evaluating cervical lymph node metastasis in thyroid cancer. Oncology Letters, 28, 512. https://doi.org/10.3892/ol.2024.14645
MLA
Weng, L."Role of ultrasound‑guided fine‑needle aspiration cytology combined with thyroid peroxidase and thyroglobulin antibodies in evaluating cervical lymph node metastasis in thyroid cancer". Oncology Letters 28.5 (2024): 512.
Chicago
Weng, L."Role of ultrasound‑guided fine‑needle aspiration cytology combined with thyroid peroxidase and thyroglobulin antibodies in evaluating cervical lymph node metastasis in thyroid cancer". Oncology Letters 28, no. 5 (2024): 512. https://doi.org/10.3892/ol.2024.14645
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team