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Analysis of metastasis‑related risk factors and clinical relevance in adult soft‑tissue sarcoma

  • Authors:
    • Shuai Han
    • Xin Song
    • Jialiang Liu
    • Jingfen Zhou
    • Zhipeng Wu
    • Haihan Song
    • Jun Tao
    • Jian Wang
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Shanghai Pudong New Area People's Hospital, Shanghai 201299, P.R. China, Department of Orthopedic Oncology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, P.R. China, Central Laboratory of Shanghai Key Laboratory of Pathogenic Fungi Medical Testing, Shanghai Pudong New Area People's Hospital, Shanghai 201299, P.R. China, Department of Orthopedics, Weihai Central Hospital, Qingdao University, Shandong 264499, P.R. China
    Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 515
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    Published online on: August 28, 2024
       https://doi.org/10.3892/ol.2024.14647
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Abstract

Metastasis occurs in nearly 50% of cases of adult soft‑tissue sarcoma (ASTS), leading to a dismal prognosis, with a 2‑year survival rate of ~30%. Consequently, a prognostic model that incorporates metastatic characteristics may be instrumental in predicting survival time and in crafting optimal personalized therapeutic strategies for patients with ASTS. In the present study, a prognostic prediction model for ASTS was developed by examining genes that are differentially expressed between non‑metastatic and metastatic patients in the Gene Expression Omnibus dataset. The prognostic model, which includes five featured genes [actin γ2 (ACTG2), apolipoprotein D, coatomer protein complex subunit γ2 imprinted transcript 1, collagen type VI α6 chain and osteomodulin], was further validated in patients with ASTS from the Cancer Genome Atlas dataset. Based on these five‑gene signatures, patients were categorized into high‑ and low‑risk groups. Functional and pathway analyses revealed disparities in stemness, extracellular matrix and cell adhesion‑related pathways between the two risk groups, particularly noting the activation of the PI3K‑Akt pathway in high‑risk cases. Analysis of immune infiltration also revealed variations in immune microenvironment changes between the two risk groups. Immunohistochemical staining substantiated the prognostic significance of these gene signatures in a specific sarcoma subtype. Additionally, wound‑healing and Transwell assays demonstrated that inhibition of ACTG2 by shRNAs curbed cell migration and invasion in a sarcoma HOS cell line, underscoring its role in sarcoma metastasis. In conclusion, the present study successfully developed and validated a metastasis‑based prognosis prediction model. This model not only reliably forecasts the survival of patients with ASTS, but also may pave the way for further investigation into the processes underlying sarcoma metastasis, ultimately aiding in the design of tailored therapeutic regimens.
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1 

Li Z, Duan Z, Jia K, Yao Y, Liu K, Qiao Y, Gao Q, Yang Y, Li G and Shang A: A combined risk score model to assess prognostic value in patients with soft tissue sarcomas. Cells. 11:40772022. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Gamboa AC, Gronchi A and Cardona K: Soft-tissue sarcoma in adults: An update on the current state of histiotype-specific management in an era of personalized medicine. CA Cancer J Clin. 70:200–229. 2020. View Article : Google Scholar : PubMed/NCBI

4 

Ardakani AHG, Woollard A, Ware H and Gikas P: Soft tissue sarcoma: Recognizing a rare disease. Cleve Clin J Med. 89:73–80. 2022. View Article : Google Scholar : PubMed/NCBI

5 

Chen HH, Zhang TN, Zhang FY and Zhang T: Non-coding RNAs in drug and radiation resistance of bone and soft-tissue sarcoma: A systematic review. Elife. 11:e796552022. View Article : Google Scholar : PubMed/NCBI

6 

Xu R, Qi L, Ren X, Zhang W, Li C, Liu Z, Tu C and Li Z: Integrated analysis of TME and hypoxia identifies a classifier to predict prognosis and therapeutic biomarkers in soft tissue sarcomas. Cancers (Basel). 14:56752022. View Article : Google Scholar : PubMed/NCBI

7 

Gu HY, Lin LL, Zhang C, Yang M, Zhong HC and Wei RX: The potential of five immune-related prognostic genes to predict survival and response to immune checkpoint inhibitors for soft tissue sarcomas based on multi-omic study. Front Oncol. 10:13172020. View Article : Google Scholar : PubMed/NCBI

8 

Chibon F, Lagarde P, Salas S, Pérot G, Brouste V, Tirode F, Lucchesi C, de Reynies A, Kauffmann A, Bui B, et al: Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature related to genome complexity. Nat Med. 16:781–787. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Proost JH and Eleveld DJ: Performance of an iterative two-stage bayesian technique for population pharmacokinetic analysis of rich data sets. Pharm Res. 23:2748–2759. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Zhang H, Wang T, Gong HY, Jiang RY, Zhou W, Sun HT, Huang R, Wang Y, Wu Z, Xu W, et al: A novel molecular classification method for osteosarcoma based on tumor cell differentiation trajectories. Bone Res. 11:12023. View Article : Google Scholar : PubMed/NCBI

12 

Lepucki A, Orlińska K, Mielczarek-Palacz A, Kabut J, Olczyk P and Komosińska-Vassev K: The role of extracellular matrix proteins in breast cancer. J Clin Med. 11:12502022. View Article : Google Scholar : PubMed/NCBI

13 

Song Y, Ma X, Zhang M, Wang M, Wang G, Ye Y and Xia W: Ezrin mediates invasion and metastasis in tumorigenesis: A review. Front Cell Dev Biol. 8:5888012020. View Article : Google Scholar : PubMed/NCBI

14 

Rømer AMA, Thorseth ML and Madsen DH: Immune modulatory properties of collagen in cancer. Front Immunol. 12:7914532021. View Article : Google Scholar : PubMed/NCBI

15 

Yan JY, Gong HY, Han S, Liu JL, Wu ZP, Wang ZH and Wang T: GALNT5 functions as a suppressor of ferroptosis and a predictor of poor prognosis in pancreatic adenocarcinoma. Am J Cancer Res. 13:4579–4596. 2023.PubMed/NCBI

16 

Crombé A, Roulleau-Dugage M and Italiano A: The diagnosis, classification, and treatment of sarcoma in this era of artificial intelligence and immunotherapy. Cancer Commun (Lond). 42:1288–1313. 2022. View Article : Google Scholar : PubMed/NCBI

17 

Lynch MM, Alexiev BA, Schroeder BA and Pollack SM: Combinations of chemotherapy and PD-1/PD-L1 inhibitors in sarcoma. Curr Treat Options Oncol. 23:1861–1876. 2022. View Article : Google Scholar : PubMed/NCBI

18 

Milunsky A, Baldwin C, Zhang X, Primack D, Curnow A and Milunsky J: Diagnosis of chronic intestinal pseudo-obstruction and megacystis by sequencing the ACTG2 gene. J Pediatr Gastroenterol Nutr. 65:384–387. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Zhao B, Baloch Z, Ma Y, Wan Z, Huo Y, Li F and Zhao Y: Identification of potential key genes and pathways in early-onset colorectal cancer through bioinformatics analysis. Cancer Control. 26:10732748198312602019. View Article : Google Scholar : PubMed/NCBI

20 

Tang G, Wu D, Guo M and Li H: LncRNA MIR497HG inhibits colorectal cancer progression by the miR-3918/ACTG2 axis. J Genet. 101:272022. View Article : Google Scholar : PubMed/NCBI

21 

Wu Y, Liu ZG, Shi MQ, Yu HZ, Jiang XY, Yang AH, Fu XS, Xu Y, Yang S, Ni H, et al: Identification of ACTG2 functions as a promoter gene in hepatocellular carcinoma cells migration and tumor metastasis. Biochem Biophys Res Commun. 491:537–544. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Davis LE, Nusser KD, Przybyl J, Pittsenbarger J, Hofmann NE, Varma S, Vennam S, Debiec-Rychter M, van de Rijn M and Davare MA: Discovery and characterization of recurrent, targetable ALK fusions in leiomyosarcoma. Mol Cancer Res. 17:676–685. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Beck AH, Lee CH, Witten DM, Gleason BC, Edris B, Espinosa I, Zhu S, Li R, Montgomery KD, Marinelli RJ, et al: Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling. Oncogene. 29:845–854. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Jankovic-Karasoulos T, Bianco-Miotto T, Butler MS, Butler LM, McNeil CM, O'Toole SA, Millar EKA, Sakko AJ, Ruiz AI, Birrell SN, et al: Elevated levels of tumour apolipoprotein D independently predict poor outcome in breast cancer patients. Histopathology. 76:976–987. 2020. View Article : Google Scholar : PubMed/NCBI

25 

Zhang Y, Qin Y, Li D and Yang Y: A risk prediction model mediated by genes of APOD/APOC1/SQLE associates with prognosis in cervical cancer. BMC Womens Health. 22:5342022. View Article : Google Scholar : PubMed/NCBI

26 

Ruchong P, Haiping T and Xiang W: A five-gene prognostic nomogram predicting disease-free survival of differentiated thyroid cancer. Dis Markers. 2021:55107802021. View Article : Google Scholar : PubMed/NCBI

27 

Palmerini E, Gambarotti M, Staals EL, Zanella L, Sieberova G, Longhi A, Cesari M, Bonarelli S, Picci P, Ruggieri P, et al: Fibrosarcomatous changes and expression of CD34+ and apolipoprotein-D in dermatofibrosarcoma protuberans. Clin Sarcoma Res. 2:42012. View Article : Google Scholar : PubMed/NCBI

28 

Green BB, Kappil M, Lambertini L, Armstrong DA, Guerin DJ, Sharp AJ, Lester BM, Chen J and Marsit CJ: Expression of imprinted genes in placenta is associated with infant neurobehavioral development. Epigenetics. 10:834–841. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Mai X, Mai Q, Li T and Zhou C: Dynamic expression patterns of imprinted genes in human embryonic stem cells following prolonged passaging and differentiation. J Assist Reprod Genet. 28:315–323. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Kang SH, Oh SY, Lee HJ, Kwon TG, Kim JW, Lee ST, Choi SY and Hong SH: Cancer-associated fibroblast subgroups showing differential promoting effect on HNSCC progression. Cancers (Basel). 13:6542021. View Article : Google Scholar : PubMed/NCBI

31 

Long R, Liu Z, Li J and Yu H: COL6A6 interacted with P4HA3 to suppress the growth and metastasis of pituitary adenoma via blocking PI3K-Akt pathway. Aging (Albany NY). 11:8845–8859. 2019. View Article : Google Scholar : PubMed/NCBI

32 

Qiao H, Feng Y and Tang H: COL6A6 inhibits the proliferation and metastasis of non-small cell lung cancer through the JAK signalling pathway. Transl Cancer Res. 10:4514–4522. 2021. View Article : Google Scholar : PubMed/NCBI

33 

Ma Y, Qiu M, Guo H, Chen H, Li J, Li X and Yang F: Comprehensive analysis of the immune and prognostic implication of COL6A6 in lung adenocarcinoma. Front Oncol. 11:6334202021. View Article : Google Scholar : PubMed/NCBI

34 

Skenteris NT, Seime T, Witasp A, Karlöf E, Wasilewski GB, Heuschkel MA, Jaminon AMG, Oduor L, Dzhanaev R, Kronqvist M, et al: Osteomodulin attenuates smooth muscle cell osteogenic transition in vascular calcification. Clin Transl Med. 12:e6822022. View Article : Google Scholar : PubMed/NCBI

35 

Hamaya E, Fujisawa T and Tamura M: Osteoadherin serves roles in the regulation of apoptosis and growth in MC3T3-E1 osteoblast cells. Int J Mol Med. 44:2336–2344. 2019.PubMed/NCBI

36 

Papadaki V, Asada K, Watson JK, Tamura T, Leung A, Hopkins J, Dellett M, Sasai N, Davaapil H, Nik-Zainal S, et al: Two secreted proteoglycans, activators of urothelial cell-cell adhesion, negatively contribute to bladder cancer initiation and progression. Cancers (Basel). 12:33622020. View Article : Google Scholar : PubMed/NCBI

37 

Nallasamy P, Nimmakayala RK, Parte S, Are AC, Batra SK and Ponnusamy MP: Tumor microenvironment enriches the stemness features: The architectural event of therapy resistance and metastasis. Mol Cancer. 21:2252022. View Article : Google Scholar : PubMed/NCBI

38 

Rodrigues FS, Ciccarelli FD and Malanchi I: Reflected stemness as a potential driver of the tumour microenvironment. Trends Cell Biol. 32:979–987. 2022. View Article : Google Scholar : PubMed/NCBI

39 

Gao Y, Fan WH, Song Z, Lou H and Kang X: Comparison of circulating tumor cell (CTC) detection rates with epithelial cell adhesion molecule (EpCAM) and cell surface vimentin (CSV) antibodies in different solid tumors: A retrospective study. PeerJ. 9:e107772021. View Article : Google Scholar : PubMed/NCBI

40 

Ventura E, Xie C, Buraschi S, Belfiore A, Iozzo RV, Giordano A and Morrione A: Complexity of progranulin mechanisms of action in mesothelioma. J Exp Clin Cancer Res. 41:3332022. View Article : Google Scholar : PubMed/NCBI

41 

Fromme JE and Zigrino P: The role of extracellular matrix remodeling in skin tumor progression and therapeutic resistance. Front Mol Biosci. 9:8643022022. View Article : Google Scholar : PubMed/NCBI

42 

Kolesnikoff N, Chen CH and Samuel MS: Interrelationships between the extracellular matrix and the immune microenvironment that govern epithelial tumour progression. Clin Sci (Lond). 136:361–377. 2022. View Article : Google Scholar : PubMed/NCBI

43 

Abu Zaid MI, Radovich M, Althouse S, Liu H, Spittler AJ, Solzak J, Badve S and Loehrer PJ Sr: A phase II study of buparlisib in relapsed or refractory thymomas. Front Oncol. 12:8913832022. View Article : Google Scholar : PubMed/NCBI

44 

Heudel P, Frenel JS, Dalban C, Bazan F, Joly F, Arnaud A, Abdeddaim C, Chevalier-Place A, Augereau P, Pautier P, et al: Safety and efficacy of the mTOR inhibitor, vistusertib, combined with anastrozole in patients with hormone receptor-positive recurrent or metastatic endometrial cancer: The VICTORIA multicenter, open-label, phase 1/2 randomized clinical trial. JAMA Oncol. 8:1001–1009. 2022. View Article : Google Scholar : PubMed/NCBI

45 

Savas P, Lo LL, Luen SJ, Blackley EF, Callahan J, Moodie K, van Geelen CT, Ko YA, Weng CF, Wein L, et al: Alpelisib monotherapy for PI3K-altered, pretreated advanced breast cancer: A phase II study. Cancer Discov. 12:2058–2073. 2022. View Article : Google Scholar : PubMed/NCBI

46 

Xu C, Wang Z, Zhang L, Feng Y, Lv J, Wu Z, Yang R, Wu T, Li J, Zhou R, et al: Periostin promotes the proliferation and metastasis of osteosarcoma by increasing cell survival and activates the PI3K/Akt pathway. Cancer Cell Int. 22:342022. View Article : Google Scholar : PubMed/NCBI

47 

Yu RH, Zhang XY, Xu W, Li ZK and Zhu XD: Apolipoprotein D alleviates glucocorticoid-induced osteogenesis suppression in bone marrow mesenchymal stem cells via the PI3K/Akt pathway. J Orthop Surg Res. 15:3072020. View Article : Google Scholar : PubMed/NCBI

48 

Guntur AR, Rosen CJ and Naski MC: N-cadherin adherens junctions mediate osteogenesis through PI3K signaling. Bone. 50:54–62. 2012. View Article : Google Scholar : PubMed/NCBI

49 

Patente TA, Pinho MP, Oliveira AA, Evangelista GCM, Bergami-Santos PC and Barbuto JAM: Human dendritic cells: Their heterogeneity and clinical application potential in cancer immunotherapy. Front Immunol. 9:31762019. View Article : Google Scholar : PubMed/NCBI

50 

Liu D, Heij LR, Czigany Z, Dahl E, Lang SA, Ulmer TF, Luedde T, Neumann UP and Bednarsch J: The role of tumor-infiltrating lymphocytes in cholangiocarcinoma. J Exp Clin Cancer Res. 41:1272022. View Article : Google Scholar : PubMed/NCBI

51 

Li H, Han D, Hou Y, Chen H and Chen Z: Statistical inference methods for two crossing survival curves: A comparison of methods. PLoS One. 10:e01167742015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Han S, Song X, Liu J, Zhou J, Wu Z, Song H, Tao J and Wang J: Analysis of metastasis‑related risk factors and clinical relevance in adult soft‑tissue sarcoma. Oncol Lett 28: 515, 2024.
APA
Han, S., Song, X., Liu, J., Zhou, J., Wu, Z., Song, H. ... Wang, J. (2024). Analysis of metastasis‑related risk factors and clinical relevance in adult soft‑tissue sarcoma. Oncology Letters, 28, 515. https://doi.org/10.3892/ol.2024.14647
MLA
Han, S., Song, X., Liu, J., Zhou, J., Wu, Z., Song, H., Tao, J., Wang, J."Analysis of metastasis‑related risk factors and clinical relevance in adult soft‑tissue sarcoma". Oncology Letters 28.5 (2024): 515.
Chicago
Han, S., Song, X., Liu, J., Zhou, J., Wu, Z., Song, H., Tao, J., Wang, J."Analysis of metastasis‑related risk factors and clinical relevance in adult soft‑tissue sarcoma". Oncology Letters 28, no. 5 (2024): 515. https://doi.org/10.3892/ol.2024.14647
Copy and paste a formatted citation
x
Spandidos Publications style
Han S, Song X, Liu J, Zhou J, Wu Z, Song H, Tao J and Wang J: Analysis of metastasis‑related risk factors and clinical relevance in adult soft‑tissue sarcoma. Oncol Lett 28: 515, 2024.
APA
Han, S., Song, X., Liu, J., Zhou, J., Wu, Z., Song, H. ... Wang, J. (2024). Analysis of metastasis‑related risk factors and clinical relevance in adult soft‑tissue sarcoma. Oncology Letters, 28, 515. https://doi.org/10.3892/ol.2024.14647
MLA
Han, S., Song, X., Liu, J., Zhou, J., Wu, Z., Song, H., Tao, J., Wang, J."Analysis of metastasis‑related risk factors and clinical relevance in adult soft‑tissue sarcoma". Oncology Letters 28.5 (2024): 515.
Chicago
Han, S., Song, X., Liu, J., Zhou, J., Wu, Z., Song, H., Tao, J., Wang, J."Analysis of metastasis‑related risk factors and clinical relevance in adult soft‑tissue sarcoma". Oncology Letters 28, no. 5 (2024): 515. https://doi.org/10.3892/ol.2024.14647
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