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Case Report Open Access

Malignant melanoma complicated with cataract and secondary glaucoma: A case report

  • Authors:
    • Yu Wang
    • Qinqin Sun
    • Zhijian Li
    • Fei Leng
    • Xuelian Han
    • Qiqi Su
    • Sheng Su
  • View Affiliations / Copyright

    Affiliations: Eye Hospital, The First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, Department of Ophthalmology, Beijing Children's Hospital Affiliated with Capital Medical University, National Center for Children's Health, Beijing 100045, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 520
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    Published online on: August 30, 2024
       https://doi.org/10.3892/ol.2024.14653
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Abstract

Uveal melanoma is the most common intraocular malignant tumor in adults. For patients presenting with cataracts and glaucoma, it is recommended to assess whether an intraocular lesion is present as the primary cause. The present study describes the case of a 52‑year‑old man with primary intraocular malignant melanoma. The patient experienced painless vision loss in the right eye for 1 year, with recent onset of eye swelling and pain in the week prior to seeking medical attention. A slit‑lamp examination revealed a shallow anterior chamber in the right eye, a visibly opaque lens and a faint reflection of the tumor surface in the vitreous humor. In addition, the intraocular pressure of this eye was >60 mmHg. Magnetic resonance imaging revealed a large tumor behind the lens measuring 16x18x14 mm. Pathological examination confirmed the diagnosis of malignant melanoma. No BRCA‑associated protein‑1 somatic mutation was detected, whereas germline mutations of MutL protein homolog 1, RAD54 like, and SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 were identified. Extensive systemic examination excluded the possibility that the tumors originated from another part of the body. The present case report highlights the crucial role of slit‑lamp examination in the detection of ocular tumors. It is advocated that for patients presenting with cataracts, attention should be paid to the possibility of intraocular tumors. Meticulous slit‑lamp microscopy may reveal a reflection of the surface of a malignant melanoma, preventing misdiagnosis.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Sun Q, Li Z, Leng F, Han X, Su Q and Su S: Malignant melanoma complicated with cataract and secondary glaucoma: A case report. Oncol Lett 28: 520, 2024.
APA
Wang, Y., Sun, Q., Li, Z., Leng, F., Han, X., Su, Q., & Su, S. (2024). Malignant melanoma complicated with cataract and secondary glaucoma: A case report. Oncology Letters, 28, 520. https://doi.org/10.3892/ol.2024.14653
MLA
Wang, Y., Sun, Q., Li, Z., Leng, F., Han, X., Su, Q., Su, S."Malignant melanoma complicated with cataract and secondary glaucoma: A case report". Oncology Letters 28.5 (2024): 520.
Chicago
Wang, Y., Sun, Q., Li, Z., Leng, F., Han, X., Su, Q., Su, S."Malignant melanoma complicated with cataract and secondary glaucoma: A case report". Oncology Letters 28, no. 5 (2024): 520. https://doi.org/10.3892/ol.2024.14653
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Sun Q, Li Z, Leng F, Han X, Su Q and Su S: Malignant melanoma complicated with cataract and secondary glaucoma: A case report. Oncol Lett 28: 520, 2024.
APA
Wang, Y., Sun, Q., Li, Z., Leng, F., Han, X., Su, Q., & Su, S. (2024). Malignant melanoma complicated with cataract and secondary glaucoma: A case report. Oncology Letters, 28, 520. https://doi.org/10.3892/ol.2024.14653
MLA
Wang, Y., Sun, Q., Li, Z., Leng, F., Han, X., Su, Q., Su, S."Malignant melanoma complicated with cataract and secondary glaucoma: A case report". Oncology Letters 28.5 (2024): 520.
Chicago
Wang, Y., Sun, Q., Li, Z., Leng, F., Han, X., Su, Q., Su, S."Malignant melanoma complicated with cataract and secondary glaucoma: A case report". Oncology Letters 28, no. 5 (2024): 520. https://doi.org/10.3892/ol.2024.14653
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