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Article Open Access

SCGB1A1 as a novel biomarker and promising therapeutic target for the management of HNSCC

  • Authors:
    • Jing Wang
    • Qianqian Xu
    • Jiangbo Yu
    • Aotian Xu
    • Lizheng Yu
    • Zhenggang Chen
    • Yang Cao
    • Rongtao Yuan
    • Zhongjie Yu
  • View Affiliations / Copyright

    Affiliations: Center of Oral Medicine, Qingdao Municipal Hospital, Qingdao, Shandong 266000, P.R. China, Qingdao Cancer Institute, School of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao, Shandong 266000, P.R. China, R&D, Qingdao Sino‑cell Biomedicine Co., Ltd., Qingdao, Shandong 266000, P.R. China, Department of Vascular Surgery, Qingdao Medical College, Qingdao University, Qingdao, Shandong 266000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 527
    |
    Published online on: September 3, 2024
       https://doi.org/10.3892/ol.2024.14660
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Abstract

Head and neck cancer (HNC) is the sixth most common type of cancer worldwide, and head and neck squamous cell carcinoma (HNSCC) accounts for 90% of HNC cases. Furthermore, HNSCC accounts for 400,000 cancer‑associated deaths worldwide each year. However, at present there is an absence of a versatile biomarker that can be used for diagnosis, prognosis evaluation and as a therapeutic target for HNSCC. In the present study, bioinformatics analysis was used to assess the relationship between hub genes and the clinical features of patients with HNSCC. The findings from the bioinformatics analysis were then verified using clinical samples and in vitro experiments. A total of 51 overlapping genes were identified from the intersection of differentially expressed genes and co‑expressed genes. The top 10 hub genes were obtained from a protein‑protein interaction network of overlapping genes. Among the hub genes, only secretoglobin family 1A member 1 (SCGB1A1) was significantly associated with both overall and disease‑free survival. Specifically, upregulated SCGB1A1 expression levels were associated with prolonged overall and disease‑free survival. Moreover, the SCGB1A1 expression levels were negatively correlated with drug sensitivity. Notably, it was demonstrated that SCGB1A1 was involved in tumor immunoreaction by affecting the infiltration of cells and checkpoint regulation of immune cells. Additionally, it was shown that SCGB1A1 regulated multiple key cancer‑related signaling pathways, including extracellular matrix receptor interaction, transforming growth factor‑β and tumor metabolism signaling pathways. Based on the results of the present study, SCGB1A1 may serve as a novel biomarker for predicting the diagnosis, prognosis and therapeutic effectiveness of certain drugs in patients with HNSCC. Moreover, SCGB1A1 may serve as a potential therapeutic target for the management of HNSCC.
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View References

1 

Raj S, Kesari KK, Kumar A, Rathi B, Sharma A, Gupta PK, Jha SK, Jha NK, Slama P, Roychoudhury S and Kumar D: Molecular mechanism(s) of regulation(s) of c-MET/HGF signaling in head and neck cancer. Mol Cancer. 21:312022. View Article : Google Scholar : PubMed/NCBI

2 

Tang E, Lahmi L, Meillan N, Pietta G, Albert S and Maingon P: Treatment strategy for distant synchronous metastatic head and neck squamous cell carcinoma. Curr Oncol Rep. 21:1022019. View Article : Google Scholar : PubMed/NCBI

3 

Chow LQM: Head and neck cancer. N Engl J Med. 382:60–72. 2020. View Article : Google Scholar : PubMed/NCBI

4 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Vahabi M, Blandino G and Di Agostino S: MicroRNAs in head and neck squamous cell carcinoma: A possible challenge as biomarkers, determinants for the choice of therapy and targets for personalized molecular therapies. Transl Cancer Res. 10:3090–3110. 2021. View Article : Google Scholar : PubMed/NCBI

6 

Global Burden of Disease Cancer Collaboration, . Fitzmaurice C, Allen C, Barber RM, Barregard L, Bhutta ZA, Brenner H, Dicker DJ, Chimed-Orchir O, Dandona R, et al: Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: A systematic analysis for the global burden of disease study. JAMA Oncol. 3:524–548. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Hakim M, Billan S, Tisch U, Peng G, Dvrokind I, Marom O, Abdah-Bortnyak R, Kuten A and Haick H: Diagnosis of head-and-neck cancer from exhaled breath. Br J Cancer. 104:1649–1655. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Schötz U, Balzer V, Brandt FW, Ziemann F, Subtil FSB, Rieckmann T, Köcher S, Engenhart-Cabillic R, Dikomey E, Wittig A and Arenz A: Dual PI3K/mTOR inhibitor NVP-BEZ235 enhances radiosensitivity of head and neck squamous cell carcinoma (HNSCC) cell lines due to suppressed double-strand break (DSB) repair by non-homologous end joining. Cancers (Basel). 12:4672020. View Article : Google Scholar : PubMed/NCBI

9 

You Y, Tian Z, Du Z, Wu K, Xu G, Dai M, Wang Y and Xiao M: M1-like tumor-associated macrophages cascade a mesenchymal/stem-like phenotype of oral squamous cell carcinoma via the IL6/Stat3/THBS1 feedback loop. J Exp Clin Cancer Res. 41:102022. View Article : Google Scholar : PubMed/NCBI

10 

Tokheim CJ, Papadopoulos N, Kinzler KW, Vogelstein B and Karchin R: Evaluating the evaluation of cancer driver genes. Proc Natl Acad Sci USA. 113:143302016. View Article : Google Scholar : PubMed/NCBI

11 

Andrea S, Paola M, Claudio P, Urbani G, Allegretti M, Pellini R, Mehterov N, Ben-David U, Strano S, Bossi P and Blandino G: Immunosignatures associated with TP53 status and co-mutations classify prognostically head and neck cancer patients. Mol Cancer. 22:1922023. View Article : Google Scholar

12 

Kong W, Han Y, Gu H, Yang H and Zang Y: TP53 mutation-associated immune infiltration and a novel risk score model in HNSCC. Biochem Biophys Rep. 32:1013592022.PubMed/NCBI

13 

El Baroudi M, Machiels JP and Schmitz S: Expression of SESN1, UHRF1BP1, and miR-377-3p as prognostic markers in mutated TP53 squamous cell carcinoma of the head and neck. Cancer Biol Ther. 18:775–782. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Wei Z, Shen Y, Zhou C, Cao Y, Deng H and Shen Z: CD3D: A prognostic biomarker associated with immune infiltration and immunotherapeutic response in head and neck squamous cell carcinoma. Bioengineered. 13:13784–13800. 2022. View Article : Google Scholar : PubMed/NCBI

15 

Chen Y, Yang J, Jin H, Wen W, Xu Y, Zhang X and Wang Y: HtrA3: A promising prognostic biomarker and therapeutic target for head and neck squamous cell carcinoma. PeerJ. 11:e162372023. View Article : Google Scholar : PubMed/NCBI

16 

Chen C, Méndez E, Houck J, Fan W, Lohavanichbutr P, Doody D, Yueh B, Futran ND, Upton M, Farwell DG, et al: Gene expression profiling identifies genes predictive of oral squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 17:2152–2162. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Zhang Y, Luo S, Jia Y and Zhang X: Telomere maintenance mechanism dysregulation serves as an early predictor of adjuvant therapy response and a potential therapeutic target in human cancers. Int J Cancer. 151:313–327. 2022. View Article : Google Scholar : PubMed/NCBI

18 

Leemans CR, Snijders PJF and Brakenhoff RH: The molecular landscape of head and neck cancer. Nat Rev Cancer. 18:269–282. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Han D, Yu Z, Zhang H, Liu H, Wang B and Qian D: Microenvironment-associated gene HSD11B1 may serve as a prognostic biomarker in clear cell renal cell carcinoma: A study based on TCGA, RT-qPCR, Western blotting, and immunohistochemistry. Bioengineered. 12:10891–10904. 2021. View Article : Google Scholar : PubMed/NCBI

20 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

21 

RStudio Team: RStudio: Integrated Development for R. RStudio, Inc.; Boston, MA: 2015

22 

Shippy DC and Ulland TK: Lipid metabolism transcriptomics of murine microglia in Alzheimer's disease and neuroinflammation. Sci Rep. 13:148002023. View Article : Google Scholar : PubMed/NCBI

23 

Luo L, Zhu J, Guo Y and Li C: Mitophagy and immune infiltration in vitiligo: Evidence from bioinformatics analysis. Front Immunol. 14:11641242023. View Article : Google Scholar : PubMed/NCBI

24 

Langfelder P and Horvath S: WGCNA: An R package for weighted correlation network analysis. BMC Bioinformatics. 9:5592008. View Article : Google Scholar : PubMed/NCBI

25 

Liu B, Ma X and Ha W: Identification of potential prognostic biomarkers associated with macrophage M2 infiltration in gastric cancer. Front Genet. 12:8274442022. View Article : Google Scholar : PubMed/NCBI

26 

Pei G, Chen L and Zhang W: WGCNA application to proteomic and metabolomic data analysis. Methods Enzymol. 585:135–158. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Wilkerson MD and Hayes DN: ConsensusClusterPlus: A class discovery tool with confidence assessments and item tracking. Bioinformatics. 26:1572–1573. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Gao CH, Yu G and Cai P: ggVennDiagram: An intuitive, easy-to-use, and highly customizable r package to generate venn diagram. Front Genet. 12:7069072021. View Article : Google Scholar : PubMed/NCBI

29 

Thomas PD: The gene ontology and the meaning of biological function. Methods Mol Biol. 1446:15–24. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Kanehisa M, Furumichi M, Tanabe M, Sato Y and Morishima K: KEGG: New perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 45:D353–D361. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Liberzon A, Birger C, Thorvaldsdóttir H, Ghandi M, Mesirov JP and Tamayo P: The molecular signatures database (MSigDB) hallmark gene set collection. Cell Syst. 1:417–425. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, Simonovic M, Doncheva NT, Morris JH, Bork P, et al: STRING v11: Protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 47:D607–D613. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Chin CH, Chen SH, Wu HH, Ho CW, Ko MT and Lin CY: cytoHubba: Identifying hub objects and sub-networks from complex interactome. BMC Syst Biol. 8 (Suppl 4):S112014. View Article : Google Scholar : PubMed/NCBI

35 

Hess AS and Hess JR: Kaplan-Meier survival curves. Transfusion. 60:670–672. 2020. View Article : Google Scholar : PubMed/NCBI

36 

Goel MK, Khanna P and Kishore J: Understanding survival analysis: Kaplan-Meier estimate. Int J Ayurveda Res. 1:274–278. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Mu H, Wang Z, Zhang X, Qian D, Wang Y, Jiang S, Liang S and Wang B: HCMV-encoded IE2 induces anxiety-depression and cognitive impairment in UL122 genetically-modified mice. Int J Clin Exp Pathol. 12:4087–4095. 2019.PubMed/NCBI

38 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Geeleher P, Cox N and Huang RS: pRRophetic: An R package for prediction of clinical chemotherapeutic response from tumor gene expression levels. PLoS One. 9:e1074682014. View Article : Google Scholar : PubMed/NCBI

40 

Geeleher P, Cox NJ and Huang RS: Clinical drug response can be predicted using baseline gene expression levels and in vitro drug sensitivity in cell lines. Genome Biol. 15:R472014. View Article : Google Scholar : PubMed/NCBI

41 

El-Hachem N, Haibe-Kains B, Khalil A, Kobeissy FH and Nemer G: AutoDock and AutoDockTools for protein-ligand docking: Beta-site amyloid precursor protein cleaving enzyme 1(BACE1) as a case study. Methods Mol Biol. 1598:391–403. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Sugano-Nakamura N, Matoba K, Hirose M, Bashiruddin NK, Matsunaga Y, Yamashita K, Hirata K, Yamamoto M, Arimori T, Suga H and Takagi J: De novo Fc-based receptor dimerizers differentially modulate PlexinB1 function. Structure. 30:1411–1423.e4. 2022. View Article : Google Scholar : PubMed/NCBI

43 

Tao Q, Du J, Li X, Zeng J, Tan B, Xu J, Lin W and Chen XL: Network pharmacology and molecular docking analysis on molecular targets and mechanisms of Huashi Baidu formula in the treatment of COVID-19. Drug Dev Ind Pharm. 46:1345–1353. 2020. View Article : Google Scholar : PubMed/NCBI

44 

Zeng D, Li M, Zhou R, Zhang J, Sun H, Shi M, Bin J, Liao Y, Rao J and Liao W: Tumor microenvironment characterization in gastric cancer identifies prognostic and immunotherapeutically relevant gene signatures. Cancer Immunol Res. 7:737–750. 2019. View Article : Google Scholar : PubMed/NCBI

45 

Sturm G, Finotello F, Petitprez F, Zhang JD, Baumbach J, Fridman WH, List M and Aneichyk T: Comprehensive evaluation of transcriptome-based cell-type quantification methods for immuno-oncology. Bioinformatics. 35:i436–i445. 2019. View Article : Google Scholar : PubMed/NCBI

46 

Li B, Severson E, Pignon JC, Zhao H, Li T, Novak J, Jiang P, Shen H, Aster JC, Rodig S, et al: Comprehensive analyses of tumor immunity: Implications for cancer immunotherapy. Genome Biol. 17:1742016. View Article : Google Scholar : PubMed/NCBI

47 

Aran D, Hu Z and Butte AJ: xCell: Digitally portraying the tissue cellular heterogeneity landscape. Genome Biol. 18:2202017. View Article : Google Scholar : PubMed/NCBI

48 

Li T, Fu J, Zeng Z, Cohen D, Li J, Chen Q, Li B and Liu XS: TIMER2.0 for analysis of tumor-infiltrating immune cells. Nucleic Acids Res. 48:W509–W514. 2020. View Article : Google Scholar : PubMed/NCBI

49 

Wang J, Sun J, Liu LN, Flies DB, Nie X, Toki M, Zhang J, Song C, Zarr M, Zhou X, et al: Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy. Nat Med. 25:656–666. 2019. View Article : Google Scholar : PubMed/NCBI

50 

Frost FG, Cherukuri PF, Milanovich S and Boerkoel CF: Pan-cancer RNA-seq data stratifies tumours by some hallmarks of cancer. J Cell Mol Med. 24:418–430. 2020. View Article : Google Scholar : PubMed/NCBI

51 

Izzi V, Davis MN and Naba A: Pan-cancer analysis of the genomic alterations and mutations of the matrisome. Cancers (Basel). 12:20462020. View Article : Google Scholar : PubMed/NCBI

52 

Zhang Q, Huang R, Hu H, Yu L, Tang Q, Tao Y, Liu Z, Li J and Wang G: Integrative analysis of hypoxia-associated signature in pan-cancer. iScience. 23:1014602020. View Article : Google Scholar : PubMed/NCBI

53 

Franz M, Rodriguez H, Lopes C, Zuberi K, Montojo J, Bader GD and Morris Q: GeneMANIA update 2018. Nucleic Acids Res. 46:W60–W64. 2018. View Article : Google Scholar : PubMed/NCBI

54 

Mayakonda A, Lin DC, Assenov Y, Plass C and Koeffler HP: Maftools: Efficient and comprehensive analysis of somatic variants in cancer. Genome Res. 28:1747–1756. 2018. View Article : Google Scholar : PubMed/NCBI

55 

Jiang L and Liu J: Immunological effect of tyrosine kinase inhibitors on the tumor immune environment in non-small cell lung cancer. Oncol Lett. 23:1652022. View Article : Google Scholar : PubMed/NCBI

56 

Hu FF, Liu CJ, Liu LL, Zhang Q and Guo AY: Expression profile of immune checkpoint genes and their roles in predicting immunotherapy response. Brief Bioinform. 22:bbaa1762021. View Article : Google Scholar : PubMed/NCBI

57 

Barsouk A, Aluru JS, Rawla P, Saginala K and Barsouk A: Epidemiology, risk factors, and prevention of head and neck squamous cell carcinoma. Med Sci (Basel). 11:422023.PubMed/NCBI

58 

Trivedi S, Sun L and Aggarwal C: Immunotherapy for head and neck cancer. Hematol Oncol Clin North Am. 35:1021–1037. 2021. View Article : Google Scholar : PubMed/NCBI

59 

Li XX, Peng T, Gao J, Feng JG, Wu DD, Yang T, Zhong L, Fu WP and Sun C: Allele-specific expression identified rs2509956 as a novel long-distance cis-regulatory SNP for SCGB1A1, an important gene for multiple pulmonary diseases. Am J Physiol Lung Cell Mol Physiol. 317:L456–L463. 2019. View Article : Google Scholar : PubMed/NCBI

60 

Xu M, Yang W, Wang X and Nayak DK: Lung secretoglobin Scgb1a1 influences alveolar macrophage-mediated inflammation and immunity. Front Immunol. 11:5843102020. View Article : Google Scholar : PubMed/NCBI

61 

Yu Y, Liu JY, Yang HJ, Luo XQ, Gao XP, Huang XX, Tang AX, Mary Cheng HY, Liu WC and Zhang P: Circadian disruption during fetal development promotes pathological cardiac remodeling in male mice. iScience. 27:1090082024. View Article : Google Scholar : PubMed/NCBI

62 

Liu Y, Yu HJ, Wang N, Zhang YN, Huang SK, Cui YH and Liu Z: Clara cell 10-kDa protein inhibits T(H)17 responses through modulating dendritic cells in the setting of allergic rhinitis. J Allergy Clin Immunol. 131:387–394.e1-12. 2013. View Article : Google Scholar : PubMed/NCBI

63 

Linnoila RI, Szabo E, DeMayo F, Witschi H, Sabourin C and Malkinson A: The role of CC10 in pulmonary carcinogenesis: From a marker to tumor suppression. Ann N Y Acad Sci. 923:249–267. 2000. View Article : Google Scholar : PubMed/NCBI

64 

Hicks SM, Vassallo JD, Dieter MZ, Lewis CL, Whiteley LO, Fix AS and Lehman-McKeeman LD: Immunohistochemical analysis of Clara cell secretory protein expression in a transgenic model of mouse lung carcinogenesis. Toxicology. 187:217–228. 2003. View Article : Google Scholar : PubMed/NCBI

65 

Pilon AL: Rationale for the development of recombinant human CC10 as a therapeutic for inflammatory and fibrotic disease. Ann N Y Acad Sci. 923:280–299. 2000. View Article : Google Scholar : PubMed/NCBI

66 

Mirlekar B: Tumor promoting roles of IL-10, TGF-β, IL-4, and IL-35: Its implications in cancer immunotherapy. SAGE Open Med. 10:205031212110690122022. View Article : Google Scholar : PubMed/NCBI

67 

Lu J, Linares B, Xu Z and Rui YN: Mechanisms of FA-phagy, a new form of selective autophagy/organellophagy. Front Cell Dev Biol. 9:7991232021. View Article : Google Scholar : PubMed/NCBI

68 

Wu L, Jin Y, Zhao X, Tang K, Zhao Y, Tong L, Yu X, Xiong K, Luo C, Zhu J, et al: Tumor aerobic glycolysis confers immune evasion through modulating sensitivity to T cell-mediated bystander killing via TNF-α. Cell Metab. 35:1580–1596.e9. 2023. View Article : Google Scholar : PubMed/NCBI

69 

Yang FM, Chang HM and Yeh ETH: Regulation of TLR4 signaling through the TRAF6/sNASP axis by reversible phosphorylation mediated by CK2 and PP4. Proc Natl Acad Sci USA. 118:e21070441182021. View Article : Google Scholar : PubMed/NCBI

70 

Economopoulou P, Agelaki S, Perisanidis C, Giotakis EI and Psyrri A: The promise of immunotherapy in head and neck squamous cell carcinoma. Ann Oncol. 27:1675–1685. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Xu Q, Yu J, Xu A, Yu L, Chen Z, Cao Y, Yuan R and Yu Z: SCGB1A1 as a novel biomarker and promising therapeutic target for the management of HNSCC. Oncol Lett 28: 527, 2024.
APA
Wang, J., Xu, Q., Yu, J., Xu, A., Yu, L., Chen, Z. ... Yu, Z. (2024). SCGB1A1 as a novel biomarker and promising therapeutic target for the management of HNSCC. Oncology Letters, 28, 527. https://doi.org/10.3892/ol.2024.14660
MLA
Wang, J., Xu, Q., Yu, J., Xu, A., Yu, L., Chen, Z., Cao, Y., Yuan, R., Yu, Z."SCGB1A1 as a novel biomarker and promising therapeutic target for the management of HNSCC". Oncology Letters 28.5 (2024): 527.
Chicago
Wang, J., Xu, Q., Yu, J., Xu, A., Yu, L., Chen, Z., Cao, Y., Yuan, R., Yu, Z."SCGB1A1 as a novel biomarker and promising therapeutic target for the management of HNSCC". Oncology Letters 28, no. 5 (2024): 527. https://doi.org/10.3892/ol.2024.14660
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Xu Q, Yu J, Xu A, Yu L, Chen Z, Cao Y, Yuan R and Yu Z: SCGB1A1 as a novel biomarker and promising therapeutic target for the management of HNSCC. Oncol Lett 28: 527, 2024.
APA
Wang, J., Xu, Q., Yu, J., Xu, A., Yu, L., Chen, Z. ... Yu, Z. (2024). SCGB1A1 as a novel biomarker and promising therapeutic target for the management of HNSCC. Oncology Letters, 28, 527. https://doi.org/10.3892/ol.2024.14660
MLA
Wang, J., Xu, Q., Yu, J., Xu, A., Yu, L., Chen, Z., Cao, Y., Yuan, R., Yu, Z."SCGB1A1 as a novel biomarker and promising therapeutic target for the management of HNSCC". Oncology Letters 28.5 (2024): 527.
Chicago
Wang, J., Xu, Q., Yu, J., Xu, A., Yu, L., Chen, Z., Cao, Y., Yuan, R., Yu, Z."SCGB1A1 as a novel biomarker and promising therapeutic target for the management of HNSCC". Oncology Letters 28, no. 5 (2024): 527. https://doi.org/10.3892/ol.2024.14660
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