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Article

Evaluation of malignancy in gallbladder tumors using the apparent diffusion coefficient obtained by diffusion‑weighted MRI

  • Authors:
    • Shinichiro Yamada
    • Yuji Morine
    • Tetsuya Ikemoto
    • Yu Saito
    • Hiroki Teraoku
    • Yuhei Waki
    • Chiharu Nakasu
    • Takayuki Noma
    • Mitsuo Shimada
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Tokushima University Hospital, Tokushima University, Tokushima 770‑8503, Japan
  • Article Number: 533
    |
    Published online on: September 4, 2024
       https://doi.org/10.3892/ol.2024.14666
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Abstract

The utility of the apparent diffusion coefficient (ADC) of diffusion‑weighted image (DWI) magnetic resonance imaging was examined for evaluating malignancy and prognosis in gallbladder tumors. A total of 63 patients (benign tumors, n=33; cancer, n=30) were included after surgical resection for gallbladder tumors, and their mean ADC values by DWI were obtained. Cases of advanced gallbladder cancer (n=25) were divided into ADCHigh and ADCLow groups, and clinicopathological factors were compared. In 63 cases, ADC values in advanced gallbladder cancer were significantly lower compared with benign tumors and non‑advanced gallbladder cancer (P<0.05), and ADC values in early gallbladder cancer were also significantly lower compared with benign tumors (P<0.05). In 25 advanced gallbladder cancer cases, the ADCLow group tended to have a higher rate of advanced stage disease (P=0.09). Disease‑free survival and overall survival (OS) of the ADCLow group were worse compared with the ADCHigh group (P<0.01). In the multivariate analysis of OS, poor differentiation and low ADC value were independent prognostic factors. ADC values may be useful for evaluating tumor malignancies in gallbladder tumors.
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Copy and paste a formatted citation
Spandidos Publications style
Yamada S, Morine Y, Ikemoto T, Saito Y, Teraoku H, Waki Y, Nakasu C, Noma T and Shimada M: Evaluation of malignancy in gallbladder tumors using the apparent diffusion coefficient obtained by diffusion‑weighted MRI. Oncol Lett 28: 533, 2024.
APA
Yamada, S., Morine, Y., Ikemoto, T., Saito, Y., Teraoku, H., Waki, Y. ... Shimada, M. (2024). Evaluation of malignancy in gallbladder tumors using the apparent diffusion coefficient obtained by diffusion‑weighted MRI. Oncology Letters, 28, 533. https://doi.org/10.3892/ol.2024.14666
MLA
Yamada, S., Morine, Y., Ikemoto, T., Saito, Y., Teraoku, H., Waki, Y., Nakasu, C., Noma, T., Shimada, M."Evaluation of malignancy in gallbladder tumors using the apparent diffusion coefficient obtained by diffusion‑weighted MRI". Oncology Letters 28.5 (2024): 533.
Chicago
Yamada, S., Morine, Y., Ikemoto, T., Saito, Y., Teraoku, H., Waki, Y., Nakasu, C., Noma, T., Shimada, M."Evaluation of malignancy in gallbladder tumors using the apparent diffusion coefficient obtained by diffusion‑weighted MRI". Oncology Letters 28, no. 5 (2024): 533. https://doi.org/10.3892/ol.2024.14666
Copy and paste a formatted citation
x
Spandidos Publications style
Yamada S, Morine Y, Ikemoto T, Saito Y, Teraoku H, Waki Y, Nakasu C, Noma T and Shimada M: Evaluation of malignancy in gallbladder tumors using the apparent diffusion coefficient obtained by diffusion‑weighted MRI. Oncol Lett 28: 533, 2024.
APA
Yamada, S., Morine, Y., Ikemoto, T., Saito, Y., Teraoku, H., Waki, Y. ... Shimada, M. (2024). Evaluation of malignancy in gallbladder tumors using the apparent diffusion coefficient obtained by diffusion‑weighted MRI. Oncology Letters, 28, 533. https://doi.org/10.3892/ol.2024.14666
MLA
Yamada, S., Morine, Y., Ikemoto, T., Saito, Y., Teraoku, H., Waki, Y., Nakasu, C., Noma, T., Shimada, M."Evaluation of malignancy in gallbladder tumors using the apparent diffusion coefficient obtained by diffusion‑weighted MRI". Oncology Letters 28.5 (2024): 533.
Chicago
Yamada, S., Morine, Y., Ikemoto, T., Saito, Y., Teraoku, H., Waki, Y., Nakasu, C., Noma, T., Shimada, M."Evaluation of malignancy in gallbladder tumors using the apparent diffusion coefficient obtained by diffusion‑weighted MRI". Oncology Letters 28, no. 5 (2024): 533. https://doi.org/10.3892/ol.2024.14666
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